YDR450W / RPS18A

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18A has a paralog, RPS18B, that arose from the whole genome duplication; protein increases in abundance and relocalizes from cytoplasm to nuclear foci upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR450W / RPS18A

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:3.49|P-value:4.80E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-4.57|P-value:7.15E-6 ID:SGTC_41|Compound:0478-0632|FD-Score:3.94|P-value:9.61E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.07|P-value:5.56E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:4.77|P-value:3.03E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.47|P-value:5.00E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:4.77|P-value:3.05E-6 ID:SGTC_327|Compound:1273-0057|FD-Score:-3.97|P-value:8.31E-5 ID:SGTC_364|Compound:0083-0097|FD-Score:3.42|P-value:6.01E-4 ID:SGTC_398|Compound:bronopol|FD-Score:-3.49|P-value:4.69E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.32|P-value:8.01E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.34|P-value:2.11E-7 ID:SGTC_853|Compound:0419-0306|FD-Score:3.73|P-value:2.06E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.45|P-value:5.41E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:5.37|P-value:1.83E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:4.73|P-value:3.67E-6 ID:SGTC_965|Compound:1291-5240|FD-Score:6.06|P-value:4.66E-9 ID:SGTC_1059|Compound:3448-6867|FD-Score:-5.02|P-value:9.71E-7 ID:SGTC_1707|Compound:st032323|FD-Score:-4.38|P-value:1.64E-5 ID:SGTC_1717|Compound:st033143|FD-Score:-4.00|P-value:7.39E-5 ID:SGTC_1740|Compound:st038286|FD-Score:3.62|P-value:2.99E-4 ID:SGTC_1900|Compound:st060200|FD-Score:4.61|P-value:6.34E-6 ID:SGTC_1968|Compound:st069590|FD-Score:-3.96|P-value:8.50E-5 ID:SGTC_2127|Compound:5253358|FD-Score:3.37|P-value:6.97E-4 ID:SGTC_2177|Compound:5811945|FD-Score:-3.73|P-value:2.02E-4 ID:SGTC_2280|Compound:7785178|FD-Score:4.52|P-value:9.02E-6 ID:SGTC_2330|Compound:7979373|FD-Score:5.84|P-value:1.55E-8 ID:SGTC_2335|Compound:9018011|FD-Score:-4.60|P-value:6.46E-6 ID:SGTC_2336|Compound:9001819|FD-Score:-6.25|P-value:1.54E-9 ID:SGTC_2448|Compound:5185112|FD-Score:4.33|P-value:2.00E-5 ID:SGTC_2479|Compound:5617353|FD-Score:4.42|P-value:1.42E-5 ID:SGTC_2528|Compound:xanthyletin|FD-Score:4.40|P-value:1.52E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.12|P-value:4.66E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-5.27|P-value:2.86E-7 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.72|P-value:3.80E-6 ID:SGTC_2610|Compound:ononetin|FD-Score:3.81|P-value:1.54E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.60|P-value:3.21E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.60|P-value:6.42E-6 ID:SGTC_2757|Compound:clomiphene|FD-Score:-4.52|P-value:8.94E-6 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.34|P-value:7.84E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.57|P-value:3.54E-4 ID:SGTC_2893|Compound:9048488|FD-Score:5.40|P-value:1.54E-7 ID:SGTC_3038|Compound:9091290|FD-Score:3.82|P-value:1.47E-4 ID:SGTC_3068|Compound:9116768|FD-Score:-3.51|P-value:4.36E-4 ID:SGTC_3125|Compound:9127534|FD-Score:-3.74|P-value:1.90E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-3.46|P-value:5.14E-4 ID:SGTC_3144|Compound:9087057|FD-Score:4.48|P-value:1.08E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:3.49|P-value:4.80E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-4.57|P-value:7.15E-6 ID:SGTC_41|Compound:0478-0632|FD-Score:3.94|P-value:9.61E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.07|P-value:5.56E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:4.77|P-value:3.03E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.47|P-value:5.00E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:4.77|P-value:3.05E-6 ID:SGTC_327|Compound:1273-0057|FD-Score:-3.97|P-value:8.31E-5 ID:SGTC_364|Compound:0083-0097|FD-Score:3.42|P-value:6.01E-4 ID:SGTC_398|Compound:bronopol|FD-Score:-3.49|P-value:4.69E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.32|P-value:8.01E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.34|P-value:2.11E-7 ID:SGTC_853|Compound:0419-0306|FD-Score:3.73|P-value:2.06E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.45|P-value:5.41E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:5.37|P-value:1.83E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:4.73|P-value:3.67E-6 ID:SGTC_965|Compound:1291-5240|FD-Score:6.06|P-value:4.66E-9 ID:SGTC_1059|Compound:3448-6867|FD-Score:-5.02|P-value:9.71E-7 ID:SGTC_1707|Compound:st032323|FD-Score:-4.38|P-value:1.64E-5 ID:SGTC_1717|Compound:st033143|FD-Score:-4.00|P-value:7.39E-5 ID:SGTC_1740|Compound:st038286|FD-Score:3.62|P-value:2.99E-4 ID:SGTC_1900|Compound:st060200|FD-Score:4.61|P-value:6.34E-6 ID:SGTC_1968|Compound:st069590|FD-Score:-3.96|P-value:8.50E-5 ID:SGTC_2127|Compound:5253358|FD-Score:3.37|P-value:6.97E-4 ID:SGTC_2177|Compound:5811945|FD-Score:-3.73|P-value:2.02E-4 ID:SGTC_2280|Compound:7785178|FD-Score:4.52|P-value:9.02E-6 ID:SGTC_2330|Compound:7979373|FD-Score:5.84|P-value:1.55E-8 ID:SGTC_2335|Compound:9018011|FD-Score:-4.60|P-value:6.46E-6 ID:SGTC_2336|Compound:9001819|FD-Score:-6.25|P-value:1.54E-9 ID:SGTC_2448|Compound:5185112|FD-Score:4.33|P-value:2.00E-5 ID:SGTC_2479|Compound:5617353|FD-Score:4.42|P-value:1.42E-5 ID:SGTC_2528|Compound:xanthyletin|FD-Score:4.40|P-value:1.52E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.12|P-value:4.66E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-5.27|P-value:2.86E-7 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.72|P-value:3.80E-6 ID:SGTC_2610|Compound:ononetin|FD-Score:3.81|P-value:1.54E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.60|P-value:3.21E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.60|P-value:6.42E-6 ID:SGTC_2757|Compound:clomiphene|FD-Score:-4.52|P-value:8.94E-6 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.34|P-value:7.84E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.57|P-value:3.54E-4 ID:SGTC_2893|Compound:9048488|FD-Score:5.40|P-value:1.54E-7 ID:SGTC_3038|Compound:9091290|FD-Score:3.82|P-value:1.47E-4 ID:SGTC_3068|Compound:9116768|FD-Score:-3.51|P-value:4.36E-4 ID:SGTC_3125|Compound:9127534|FD-Score:-3.74|P-value:1.90E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-3.46|P-value:5.14E-4 ID:SGTC_3144|Compound:9087057|FD-Score:4.48|P-value:1.08E-5

Top fitness defect scores for YDR450W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_965 1291-5240 6.06 308.0 µM 4.66E-9 4 6.86E-10
2 SGTC_2330 7979373 5.84 200.0 µM 1.55E-8 60S ribosome export 9 2.60E-9
3 SGTC_2893 9048488 5.40 26.0 µM 1.54E-7 fatty acid desaturase (OLE1) 5 3.33E-8
4 SGTC_957 1187-1561 5.37 14.1 µM 1.83E-7 6 4.02E-8
5 SGTC_800 3448-7362 5.34 155.0 µM 2.11E-7 translation 73 4.72E-8
6 SGTC_77 0828-0286 4.77 12.5 µM 3.03E-6 TSC3-RPN4 14 9.02E-7
7 SGTC_177 1327-0068 4.77 8.4 µM 3.05E-6 31 9.09E-7
8 SGTC_961 1252-1571 4.73 372.0 µM 3.67E-6 18 1.12E-6
9 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 4.72 100.0 µM 3.80E-6 18 1.16E-6
10 SGTC_1900 st060200 4.61 72.8 µM 6.34E-6 14 2.05E-6
11 SGTC_2688 kanamycin b 4.60 96.7 µM 6.42E-6 calcium & mitochondrial duress 284 2.08E-6
12 SGTC_2280 7785178 4.52 200.0 µM 9.02E-6 6 3.02E-6
13 SGTC_3144 9087057 4.48 49.5 µM 1.08E-5 9 3.69E-6
14 SGTC_2479 5617353 4.42 43.9 µM 1.42E-5 21 5.02E-6
15 SGTC_2528 xanthyletin 4.40 44.8 µM 1.52E-5 19 5.41E-6
16 SGTC_2448 5185112 4.33 27.2 µM 2.00E-5 9 7.30E-6
17 SGTC_41 0478-0632 3.94 82.6 µM 9.61E-5 29 4.15E-5
18 SGTC_3038 9091290 3.82 49.5 µM 1.47E-4 18 6.66E-5
19 SGTC_2610 ononetin 3.81 44.2 µM 1.54E-4 48 7.01E-5
20 SGTC_853 0419-0306 3.73 21.0 µM 2.06E-4 19 9.67E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.135 4.07E-15 YGR159C NSR1 hom Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.122 1.27E-12 YDR447C RPS17B hom Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.118 7.33E-12 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.103 2.68E-9 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.102 2.76E-9 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.102 3.20E-9 YGR118W RPS23A hom Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal
0.100 6.48E-9 YGR214W RPS0A hom Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;
0.100 6.80E-9 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.099 9.27E-9 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.099 9.41E-9 YPL125W KAP120 hom Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p
0.098 1.24E-8 YML026C RPS18B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.096 2.70E-8 YBR048W RPS11B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication
0.095 3.51E-8 YLR148W PEP3 hom Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis
0.095 3.61E-8 YLR068W FYV7 hom Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
0.094 4.24E-8 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation