YDR451C / YHP1

Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR451C / YHP1

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:4.93|P-value:1.64E-5 ID:SGTC_9|Compound:0092-0002|FD-Score:-3.65|P-value:6.70E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:3.81|P-value:7.15E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:-3.62|P-value:7.32E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:8.07|P-value:3.67E-12 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.77|P-value:7.83E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.28|P-value:1.27E-10 ID:SGTC_70|Compound:0141-0289|FD-Score:5.15|P-value:7.10E-6 ID:SGTC_122|Compound:0236-0016|FD-Score:5.39|P-value:2.65E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:3.99|P-value:4.08E-4 ID:SGTC_252|Compound:miconazole|FD-Score:4.25|P-value:1.76E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.81|P-value:4.10E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.84|P-value:6.39E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:4.83|P-value:2.37E-5 ID:SGTC_595|Compound:3909-8003|FD-Score:-4.16|P-value:1.30E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:4.69|P-value:3.89E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:4.56|P-value:6.34E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:4.79|P-value:2.70E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:4.38|P-value:1.16E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:5.07|P-value:9.43E-6 ID:SGTC_1010|Compound:4112-3296|FD-Score:-4.16|P-value:1.30E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:-3.63|P-value:7.10E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.89|P-value:5.49E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:-4.05|P-value:1.90E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:5.20|P-value:5.73E-6 ID:SGTC_1024|Compound:4507-0395|FD-Score:-3.71|P-value:5.54E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:11.10|P-value:1.83E-21 ID:SGTC_1084|Compound:voriconazole|FD-Score:4.22|P-value:1.95E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.06|P-value:3.29E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.80|P-value:7.35E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:4.01|P-value:3.80E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.78|P-value:7.59E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:4.71|P-value:3.65E-5 ID:SGTC_1581|Compound:himbacine|FD-Score:6.32|P-value:4.52E-8 ID:SGTC_1679|Compound:4130-1276|FD-Score:11.40|P-value:1.39E-22 ID:SGTC_1733|Compound:st037357|FD-Score:-4.06|P-value:1.84E-4 ID:SGTC_1842|Compound:st055362|FD-Score:4.24|P-value:1.84E-4 ID:SGTC_2394|Compound:5221648|FD-Score:4.23|P-value:1.87E-4 ID:SGTC_2488|Compound:5268135|FD-Score:-3.66|P-value:6.45E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.79|P-value:7.47E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-4.19|P-value:1.20E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.95|P-value:4.65E-4 ID:SGTC_2698|Compound:st077697|FD-Score:5.78|P-value:5.09E-7 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.73|P-value:8.83E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.76|P-value:8.18E-4 ID:SGTC_2790|Compound:5423970|FD-Score:4.11|P-value:2.75E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-4.38|P-value:6.09E-5 ID:SGTC_3138|Compound:9097216|FD-Score:5.10|P-value:8.41E-6 ID:SGTC_3142|Compound:9086498|FD-Score:-8.32|P-value:2.59E-13 ID:SGTC_3153|Compound:9100258|FD-Score:-3.86|P-value:3.42E-4 ID:SGTC_3157|Compound:9099274|FD-Score:-3.78|P-value:4.39E-4 ID:SGTC_3214|Compound:9129694|FD-Score:4.63|P-value:4.79E-5 ID:SGTC_3227|Compound:9130768|FD-Score:4.04|P-value:3.47E-4 ID:SGTC_3244|Compound:9134489|FD-Score:-5.72|P-value:3.09E-7 ID:SGTC_3303|Compound:9125618|FD-Score:3.98|P-value:4.23E-4 ID:SGTC_3304|Compound:9125678|FD-Score:4.70|P-value:3.80E-5 ID:SGTC_3353|Compound:9151644|FD-Score:4.47|P-value:8.44E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:4.93|P-value:1.64E-5 ID:SGTC_9|Compound:0092-0002|FD-Score:-3.65|P-value:6.70E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:3.81|P-value:7.15E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:-3.62|P-value:7.32E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:8.07|P-value:3.67E-12 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.77|P-value:7.83E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.28|P-value:1.27E-10 ID:SGTC_70|Compound:0141-0289|FD-Score:5.15|P-value:7.10E-6 ID:SGTC_122|Compound:0236-0016|FD-Score:5.39|P-value:2.65E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:3.99|P-value:4.08E-4 ID:SGTC_252|Compound:miconazole|FD-Score:4.25|P-value:1.76E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.81|P-value:4.10E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.84|P-value:6.39E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:4.83|P-value:2.37E-5 ID:SGTC_595|Compound:3909-8003|FD-Score:-4.16|P-value:1.30E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:4.69|P-value:3.89E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:4.56|P-value:6.34E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:4.79|P-value:2.70E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:4.38|P-value:1.16E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:5.07|P-value:9.43E-6 ID:SGTC_1010|Compound:4112-3296|FD-Score:-4.16|P-value:1.30E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:-3.63|P-value:7.10E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.89|P-value:5.49E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:-4.05|P-value:1.90E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:5.20|P-value:5.73E-6 ID:SGTC_1024|Compound:4507-0395|FD-Score:-3.71|P-value:5.54E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:11.10|P-value:1.83E-21 ID:SGTC_1084|Compound:voriconazole|FD-Score:4.22|P-value:1.95E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.06|P-value:3.29E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.80|P-value:7.35E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:4.01|P-value:3.80E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.78|P-value:7.59E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:4.71|P-value:3.65E-5 ID:SGTC_1581|Compound:himbacine|FD-Score:6.32|P-value:4.52E-8 ID:SGTC_1679|Compound:4130-1276|FD-Score:11.40|P-value:1.39E-22 ID:SGTC_1733|Compound:st037357|FD-Score:-4.06|P-value:1.84E-4 ID:SGTC_1842|Compound:st055362|FD-Score:4.24|P-value:1.84E-4 ID:SGTC_2394|Compound:5221648|FD-Score:4.23|P-value:1.87E-4 ID:SGTC_2488|Compound:5268135|FD-Score:-3.66|P-value:6.45E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.79|P-value:7.47E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-4.19|P-value:1.20E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.95|P-value:4.65E-4 ID:SGTC_2698|Compound:st077697|FD-Score:5.78|P-value:5.09E-7 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.73|P-value:8.83E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.76|P-value:8.18E-4 ID:SGTC_2790|Compound:5423970|FD-Score:4.11|P-value:2.75E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-4.38|P-value:6.09E-5 ID:SGTC_3138|Compound:9097216|FD-Score:5.10|P-value:8.41E-6 ID:SGTC_3142|Compound:9086498|FD-Score:-8.32|P-value:2.59E-13 ID:SGTC_3153|Compound:9100258|FD-Score:-3.86|P-value:3.42E-4 ID:SGTC_3157|Compound:9099274|FD-Score:-3.78|P-value:4.39E-4 ID:SGTC_3214|Compound:9129694|FD-Score:4.63|P-value:4.79E-5 ID:SGTC_3227|Compound:9130768|FD-Score:4.04|P-value:3.47E-4 ID:SGTC_3244|Compound:9134489|FD-Score:-5.72|P-value:3.09E-7 ID:SGTC_3303|Compound:9125618|FD-Score:3.98|P-value:4.23E-4 ID:SGTC_3304|Compound:9125678|FD-Score:4.70|P-value:3.80E-5 ID:SGTC_3353|Compound:9151644|FD-Score:4.47|P-value:8.44E-5

Top fitness defect scores for YDR451C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1679 4130-1276 11.40 6.7 µM 1.39E-22 Golgi 5 2.11E-30
2 SGTC_1026 k007-1105 11.10 30.6 µM 1.83E-21 ERAD & cell cycle 8 7.12E-29
3 SGTC_43 0570-0105 8.07 72.5 µM 3.67E-12 ERG2 16 3.49E-16
4 SGTC_1581 himbacine 6.32 57.9 µM 4.52E-8 Golgi 16 1.33E-10
5 SGTC_2698 st077697 5.78 67.5 µM 5.09E-7 2 3.64E-9
6 SGTC_122 0236-0016 5.39 402.4 µM 2.65E-6 RNA processing & uracil transport 12 3.45E-8
7 SGTC_1019 4262-0212 5.20 3.4 µM 5.73E-6 ergosterol depletion effects on membrane 32 9.87E-8
8 SGTC_70 0141-0289 5.15 43.3 µM 7.10E-6 mitochondrial stress 110 1.32E-7
9 SGTC_3138 9097216 5.10 49.5 µM 8.41E-6 6 1.67E-7
10 SGTC_1009 4106-0057 5.07 9.9 µM 9.43E-6 4 1.95E-7
11 SGTC_8 0354-0001 4.93 70.0 µM 1.64E-5 45 4.14E-7
12 SGTC_437 s-farnesyl-l-cysteine methyl ester 4.83 6.7 µM 2.37E-5 3 6.85E-7
13 SGTC_792 4534-1957 4.79 155.0 µM 2.70E-5 18 8.16E-7
14 SGTC_1266 0828-0227 4.71 32.9 µM 3.65E-5 10 1.23E-6
15 SGTC_3304 9125678 4.70 46.1 µM 3.80E-5 27 1.30E-6
16 SGTC_612 0302-0167 4.69 22.4 µM 3.89E-5 copper-dependent oxidative stress 18 1.34E-6
17 SGTC_3214 9129694 4.63 49.5 µM 4.79E-5 10 1.79E-6
18 SGTC_625 k213-0058 4.56 121.0 µM 6.34E-5 translation 70 2.62E-6
19 SGTC_3353 9151644 4.47 39.3 µM 8.44E-5 8 3.87E-6
20 SGTC_970 1315-0089 4.38 19.5 µM 1.16E-4 RSC & ERG11 15 5.97E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.203 1.09E-32 YMR079W SEC14 het Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs
0.124 4.96E-13 YDL133W SRF1 hom Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients
0.118 7.31E-12 YGR289C MAL11 hom Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization
0.115 2.00E-11 YDR389W SAC7 hom GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate
0.113 5.61E-11 YJL195C_d YJL195C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6
0.111 1.06E-10 YDR378C LSM6 hom Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
0.110 1.75E-10 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.109 2.15E-10 YOL072W THP1 hom Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding
0.108 3.21E-10 YOR030W DFG16 hom Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p
0.108 3.62E-10 YOR070C GYP1 hom Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion
0.107 4.96E-10 YGL095C VPS45 hom Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment
0.106 7.44E-10 YNL278W CAF120 hom Part of the CCR4-NOT transcriptional regulatory complex; involved in controlling mRNA initiation, elongation, and degradation; CAF120 has a paralog, SKG3, that arose from the whole genome duplication
0.106 8.76E-10 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.104 1.39E-9 YDR159W SAC3 hom Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)
0.104 1.36E-9 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC