YDR457W / TOM1

E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR457W / TOM1

Click on Significant Values for Screen Details ID:SGTC_62|Compound:0180-0423|FD-Score:8.21|P-value:1.75E-18 ID:SGTC_71|Compound:0417-1750|FD-Score:3.27|P-value:2.39E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-4.71|P-value:4.57E-7 ID:SGTC_77|Compound:0828-0286|FD-Score:6.14|P-value:3.66E-11 ID:SGTC_181|Compound:1447-1644|FD-Score:3.68|P-value:4.38E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:6.23|P-value:1.87E-11 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:10.30|P-value:8.87E-28 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:9.34|P-value:2.41E-23 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:7.88|P-value:3.58E-17 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:9.52|P-value:3.53E-24 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:11.50|P-value:2.02E-34 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:7.61|P-value:3.79E-16 ID:SGTC_301|Compound:4119-0100|FD-Score:2.92|P-value:8.77E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-2.99|P-value:9.74E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.59|P-value:9.54E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:3.09|P-value:4.71E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.12|P-value:4.31E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.50|P-value:1.41E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:2.96|P-value:7.60E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.67|P-value:4.42E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:2.95|P-value:8.06E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:3.41|P-value:1.38E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.10|P-value:4.49E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:11.10|P-value:5.57E-32 ID:SGTC_722|Compound:3534-0461|FD-Score:3.38|P-value:1.55E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.75|P-value:4.90E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:4.15|P-value:4.92E-6 ID:SGTC_1029|Compound:k015-0030|FD-Score:5.44|P-value:3.70E-9 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.07|P-value:5.14E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.74|P-value:3.32E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.03|P-value:8.44E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-4.02|P-value:1.44E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:4.68|P-value:3.22E-7 ID:SGTC_1041|Compound:0206-0046|FD-Score:-9.80|P-value:4.90E-25 ID:SGTC_1043|Compound:0916-0009|FD-Score:4.86|P-value:1.21E-7 ID:SGTC_1044|Compound:1222-0021|FD-Score:-3.61|P-value:8.83E-5 ID:SGTC_1111|Compound:tnp00062|FD-Score:3.29|P-value:2.17E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:4.26|P-value:2.87E-6 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.23|P-value:2.79E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.40|P-value:1.41E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:-4.61|P-value:7.76E-7 ID:SGTC_1275|Compound:0867-0008|FD-Score:2.98|P-value:7.19E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.28|P-value:2.30E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:-3.28|P-value:3.32E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:-3.34|P-value:2.71E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.73|P-value:3.43E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.97|P-value:1.11E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.11|P-value:8.71E-11 ID:SGTC_1563|Compound:conessine|FD-Score:-3.44|P-value:1.78E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-5.43|P-value:7.47E-9 ID:SGTC_1568|Compound:digitonin|FD-Score:3.15|P-value:3.85E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:-4.37|P-value:2.76E-6 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.42|P-value:1.97E-4 ID:SGTC_1712|Compound:st032288|FD-Score:2.96|P-value:7.78E-4 ID:SGTC_1740|Compound:st038286|FD-Score:4.31|P-value:2.20E-6 ID:SGTC_1917|Compound:st066507|FD-Score:-3.32|P-value:2.88E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.34|P-value:1.83E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.10|P-value:4.57E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-3.04|P-value:8.27E-4 ID:SGTC_2083|Compound:5306046|FD-Score:4.29|P-value:2.52E-6 ID:SGTC_2113|Compound:5491891|FD-Score:3.68|P-value:4.33E-5 ID:SGTC_2174|Compound:5790901|FD-Score:3.01|P-value:6.29E-4 ID:SGTC_2218|Compound:6965428|FD-Score:3.71|P-value:3.75E-5 ID:SGTC_2240|Compound:6690706|FD-Score:-5.11|P-value:5.07E-8 ID:SGTC_2252|Compound:omeprazole|FD-Score:4.44|P-value:1.13E-6 ID:SGTC_2315|Compound:7733312|FD-Score:4.73|P-value:2.45E-7 ID:SGTC_2358|Compound:9037157|FD-Score:4.13|P-value:5.53E-6 ID:SGTC_2443|Compound:5493264|FD-Score:2.95|P-value:7.91E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-3.06|P-value:7.64E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:4.33|P-value:2.02E-6 ID:SGTC_2557|Compound:derrustone|FD-Score:3.80|P-value:2.49E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.35|P-value:1.70E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.54|P-value:7.82E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.18|P-value:4.96E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.59|P-value:6.42E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:9.14|P-value:1.86E-22 ID:SGTC_2753|Compound:fluvastatin|FD-Score:5.03|P-value:4.42E-8 ID:SGTC_2896|Compound:9052656|FD-Score:3.40|P-value:1.43E-4 ID:SGTC_2933|Compound:9026794|FD-Score:5.91|P-value:1.71E-10 ID:SGTC_2945|Compound:9067681|FD-Score:5.07|P-value:3.62E-8 ID:SGTC_2949|Compound:9072542|FD-Score:4.62|P-value:4.40E-7 ID:SGTC_2993|Compound:9054257|FD-Score:-3.46|P-value:1.63E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.63|P-value:5.43E-5 ID:SGTC_3043|Compound:9092303|FD-Score:2.90|P-value:9.68E-4 ID:SGTC_3097|Compound:9117246|FD-Score:3.04|P-value:5.66E-4 ID:SGTC_3148|Compound:9097893|FD-Score:4.29|P-value:2.47E-6 ID:SGTC_3337|Compound:9144342|FD-Score:10.00|P-value:1.72E-26 ID:SGTC_62|Compound:0180-0423|FD-Score:8.21|P-value:1.75E-18 ID:SGTC_71|Compound:0417-1750|FD-Score:3.27|P-value:2.39E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-4.71|P-value:4.57E-7 ID:SGTC_77|Compound:0828-0286|FD-Score:6.14|P-value:3.66E-11 ID:SGTC_181|Compound:1447-1644|FD-Score:3.68|P-value:4.38E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:6.23|P-value:1.87E-11 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:10.30|P-value:8.87E-28 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:9.34|P-value:2.41E-23 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:7.88|P-value:3.58E-17 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:9.52|P-value:3.53E-24 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:11.50|P-value:2.02E-34 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:7.61|P-value:3.79E-16 ID:SGTC_301|Compound:4119-0100|FD-Score:2.92|P-value:8.77E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-2.99|P-value:9.74E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.59|P-value:9.54E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:3.09|P-value:4.71E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.12|P-value:4.31E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.50|P-value:1.41E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:2.96|P-value:7.60E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.67|P-value:4.42E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:2.95|P-value:8.06E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:3.41|P-value:1.38E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.10|P-value:4.49E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:11.10|P-value:5.57E-32 ID:SGTC_722|Compound:3534-0461|FD-Score:3.38|P-value:1.55E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.75|P-value:4.90E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:4.15|P-value:4.92E-6 ID:SGTC_1029|Compound:k015-0030|FD-Score:5.44|P-value:3.70E-9 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.07|P-value:5.14E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.74|P-value:3.32E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.03|P-value:8.44E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-4.02|P-value:1.44E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:4.68|P-value:3.22E-7 ID:SGTC_1041|Compound:0206-0046|FD-Score:-9.80|P-value:4.90E-25 ID:SGTC_1043|Compound:0916-0009|FD-Score:4.86|P-value:1.21E-7 ID:SGTC_1044|Compound:1222-0021|FD-Score:-3.61|P-value:8.83E-5 ID:SGTC_1111|Compound:tnp00062|FD-Score:3.29|P-value:2.17E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:4.26|P-value:2.87E-6 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.23|P-value:2.79E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.40|P-value:1.41E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:-4.61|P-value:7.76E-7 ID:SGTC_1275|Compound:0867-0008|FD-Score:2.98|P-value:7.19E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.28|P-value:2.30E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:-3.28|P-value:3.32E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:-3.34|P-value:2.71E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.73|P-value:3.43E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.97|P-value:1.11E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.11|P-value:8.71E-11 ID:SGTC_1563|Compound:conessine|FD-Score:-3.44|P-value:1.78E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-5.43|P-value:7.47E-9 ID:SGTC_1568|Compound:digitonin|FD-Score:3.15|P-value:3.85E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:-4.37|P-value:2.76E-6 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.42|P-value:1.97E-4 ID:SGTC_1712|Compound:st032288|FD-Score:2.96|P-value:7.78E-4 ID:SGTC_1740|Compound:st038286|FD-Score:4.31|P-value:2.20E-6 ID:SGTC_1917|Compound:st066507|FD-Score:-3.32|P-value:2.88E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.34|P-value:1.83E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.10|P-value:4.57E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-3.04|P-value:8.27E-4 ID:SGTC_2083|Compound:5306046|FD-Score:4.29|P-value:2.52E-6 ID:SGTC_2113|Compound:5491891|FD-Score:3.68|P-value:4.33E-5 ID:SGTC_2174|Compound:5790901|FD-Score:3.01|P-value:6.29E-4 ID:SGTC_2218|Compound:6965428|FD-Score:3.71|P-value:3.75E-5 ID:SGTC_2240|Compound:6690706|FD-Score:-5.11|P-value:5.07E-8 ID:SGTC_2252|Compound:omeprazole|FD-Score:4.44|P-value:1.13E-6 ID:SGTC_2315|Compound:7733312|FD-Score:4.73|P-value:2.45E-7 ID:SGTC_2358|Compound:9037157|FD-Score:4.13|P-value:5.53E-6 ID:SGTC_2443|Compound:5493264|FD-Score:2.95|P-value:7.91E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-3.06|P-value:7.64E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:4.33|P-value:2.02E-6 ID:SGTC_2557|Compound:derrustone|FD-Score:3.80|P-value:2.49E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.35|P-value:1.70E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.54|P-value:7.82E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.18|P-value:4.96E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.59|P-value:6.42E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:9.14|P-value:1.86E-22 ID:SGTC_2753|Compound:fluvastatin|FD-Score:5.03|P-value:4.42E-8 ID:SGTC_2896|Compound:9052656|FD-Score:3.40|P-value:1.43E-4 ID:SGTC_2933|Compound:9026794|FD-Score:5.91|P-value:1.71E-10 ID:SGTC_2945|Compound:9067681|FD-Score:5.07|P-value:3.62E-8 ID:SGTC_2949|Compound:9072542|FD-Score:4.62|P-value:4.40E-7 ID:SGTC_2993|Compound:9054257|FD-Score:-3.46|P-value:1.63E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.63|P-value:5.43E-5 ID:SGTC_3043|Compound:9092303|FD-Score:2.90|P-value:9.68E-4 ID:SGTC_3097|Compound:9117246|FD-Score:3.04|P-value:5.66E-4 ID:SGTC_3148|Compound:9097893|FD-Score:4.29|P-value:2.47E-6 ID:SGTC_3337|Compound:9144342|FD-Score:10.00|P-value:1.72E-26

Top fitness defect scores for YDR457W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 11.50 4.6 µM 2.02E-34 heat shock/prefoldin 5 5.29E-31
2 SGTC_641 4092-0595 11.10 30.0 µM 5.57E-32 1 8.26E-29
3 SGTC_238 5hr heat shock (37°C) + nsc-638432 10.30 8.9 µM 8.87E-28 heat shock/prefoldin 5 4.95E-25
4 SGTC_3337 9144342 10.00 33.5 µM 1.72E-26 3 7.11E-24
5 SGTC_241 5hr heat shock (37°C) + cantharidin 9.52 155.4 µM 3.53E-24 cell wall signaling 12 8.52E-22
6 SGTC_239 5hr heat shock (37°C) + mitomycin C 9.34 819.4 µM 2.41E-23 heat shock/prefoldin 5 4.77E-21
7 SGTC_2751 anetholtrithion 9.14 17.2 µM 1.86E-22 1 3.00E-20
8 SGTC_62 0180-0423 8.21 3.2 µM 1.75E-18 60S ribosome export 2 1.11E-16
9 SGTC_240 5hr heat shock (37°C) + Streptovitacin 7.88 300.0 µM 3.58E-17 heat shock/prefoldin 9 1.67E-15
10 SGTC_243 5hr heat shock (37°C) + splitomicin 7.61 1.0 µM 3.79E-16 heat shock/prefoldin 10 1.40E-14
11 SGTC_212 3807-4682 6.23 38.8 µM 1.87E-11 tubulin folding & SWR complex 23 2.28E-10
12 SGTC_77 0828-0286 6.14 12.5 µM 3.66E-11 TSC3-RPN4 4 4.17E-10
13 SGTC_2933 9026794 5.91 32.5 µM 1.71E-10 3 1.66E-9
14 SGTC_1029 k015-0030 5.44 64.7 µM 3.70E-9 10 2.63E-8
15 SGTC_2945 9067681 5.07 61.8 µM 3.62E-8 7 2.03E-7
16 SGTC_2753 fluvastatin 5.03 17.1 µM 4.42E-8 azole & statin 15 2.43E-7
17 SGTC_1043 0916-0009 4.86 19.3 µM 1.21E-7 7 6.02E-7
18 SGTC_2315 7733312 4.73 200.0 µM 2.45E-7 12 1.13E-6
19 SGTC_1040 k898-0338 4.68 155.0 µM 3.22E-7 10 1.44E-6
20 SGTC_2949 9072542 4.62 2.2 µM 4.40E-7 TSC3-RPN4 22 1.91E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.357 2.08E-101 YLR027C AAT2 hom Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.348 6.11E-96 YOR001W RRP6 hom Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.344 1.05E-93 YDR260C SWM1 hom Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation
0.280 1.30E-61 YLR200W YKE2 hom Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
0.262 8.36E-54 YCR063W BUD31 hom Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis
0.246 1.23E-47 YNL140C_p YNL140C_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C
0.195 3.35E-30 YNL098C RAS2 hom GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes
0.190 1.45E-28 YDR069C DOA4 hom Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole
0.181 3.44E-26 YCR077C PAT1 hom Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress
0.174 2.33E-24 YAL047C SPC72 hom Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization
0.169 8.19E-23 YKL007W CAP1 hom Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress
0.167 2.28E-22 YPL017C IRC15 hom Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci
0.165 7.37E-22 YML094C-A_d YML094C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO
0.153 4.87E-19 YHR041C SRB2 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
0.141 2.52E-16 YCR064C_d YCR064C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31