YDR460W / TFB3

Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR460W / TFB3

Click on Significant Values for Screen Details ID:SGTC_275|Compound:trichlorophene|FD-Score:3.25|P-value:2.79E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.70|P-value:3.88E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:3.75|P-value:3.32E-5 ID:SGTC_631|Compound:k072-0230|FD-Score:3.77|P-value:3.07E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:-2.96|P-value:7.66E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:4.64|P-value:4.07E-7 ID:SGTC_854|Compound:0422-0053|FD-Score:3.07|P-value:5.51E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.56|P-value:7.82E-5 ID:SGTC_895|Compound:0964-0006|FD-Score:3.80|P-value:2.77E-5 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.96|P-value:7.84E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:5.83|P-value:2.81E-10 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.36|P-value:1.64E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.35|P-value:1.70E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.58|P-value:7.27E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:-3.35|P-value:1.72E-4 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.41|P-value:1.47E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:2.98|P-value:7.66E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:-3.07|P-value:5.24E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.29|P-value:2.43E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.13|P-value:4.53E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:-3.26|P-value:2.44E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:-3.52|P-value:8.48E-5 ID:SGTC_1391|Compound:3442-0225|FD-Score:-4.07|P-value:6.87E-6 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.06|P-value:5.70E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:-3.04|P-value:5.75E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:2.99|P-value:7.46E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-3.40|P-value:1.39E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.20|P-value:3.45E-4 ID:SGTC_1624|Compound:st003710|FD-Score:-4.51|P-value:7.39E-7 ID:SGTC_1628|Compound:st004252|FD-Score:-4.49|P-value:8.31E-7 ID:SGTC_1635|Compound:st007035|FD-Score:4.87|P-value:1.15E-7 ID:SGTC_1673|Compound:st016611|FD-Score:-4.12|P-value:5.37E-6 ID:SGTC_1727|Compound:st034309|FD-Score:6.00|P-value:8.80E-11 ID:SGTC_1728|Compound:st035614|FD-Score:3.09|P-value:5.12E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-2.99|P-value:7.07E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.04|P-value:6.27E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.18|P-value:3.64E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-5.58|P-value:1.27E-9 ID:SGTC_2020|Compound:4017018|FD-Score:-3.24|P-value:2.67E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.38|P-value:1.63E-4 ID:SGTC_2086|Compound:5274770|FD-Score:4.11|P-value:6.23E-6 ID:SGTC_2264|Compound:7948757|FD-Score:-3.98|P-value:1.05E-5 ID:SGTC_2267|Compound:7931562|FD-Score:-4.16|P-value:4.37E-6 ID:SGTC_2329|Compound:6138490|FD-Score:3.02|P-value:6.71E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.34|P-value:1.99E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:5.52|P-value:2.16E-9 ID:SGTC_2596|Compound:sinensetin|FD-Score:-4.47|P-value:9.18E-7 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.52|P-value:9.08E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:3.70|P-value:4.28E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:7.31|P-value:3.68E-15 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-4.88|P-value:9.39E-8 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.07|P-value:5.19E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:9.08|P-value:2.21E-22 ID:SGTC_2691|Compound:st077356|FD-Score:4.02|P-value:9.53E-6 ID:SGTC_2974|Compound:9094440|FD-Score:3.56|P-value:7.86E-5 ID:SGTC_2980|Compound:9014342|FD-Score:3.36|P-value:1.78E-4 ID:SGTC_3170|Compound:9103054|FD-Score:2.95|P-value:8.58E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-3.33|P-value:1.84E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.76|P-value:3.24E-5 ID:SGTC_3233|Compound:9132340|FD-Score:-3.33|P-value:1.89E-4 ID:SGTC_3318|Compound:9139014|FD-Score:2.92|P-value:9.80E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.25|P-value:2.79E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.70|P-value:3.88E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:3.75|P-value:3.32E-5 ID:SGTC_631|Compound:k072-0230|FD-Score:3.77|P-value:3.07E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:-2.96|P-value:7.66E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:4.64|P-value:4.07E-7 ID:SGTC_854|Compound:0422-0053|FD-Score:3.07|P-value:5.51E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.56|P-value:7.82E-5 ID:SGTC_895|Compound:0964-0006|FD-Score:3.80|P-value:2.77E-5 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.96|P-value:7.84E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:5.83|P-value:2.81E-10 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.36|P-value:1.64E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.35|P-value:1.70E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.58|P-value:7.27E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:-3.35|P-value:1.72E-4 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.41|P-value:1.47E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:2.98|P-value:7.66E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:-3.07|P-value:5.24E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.29|P-value:2.43E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.13|P-value:4.53E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:-3.26|P-value:2.44E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:-3.52|P-value:8.48E-5 ID:SGTC_1391|Compound:3442-0225|FD-Score:-4.07|P-value:6.87E-6 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.06|P-value:5.70E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:-3.04|P-value:5.75E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:2.99|P-value:7.46E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-3.40|P-value:1.39E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.20|P-value:3.45E-4 ID:SGTC_1624|Compound:st003710|FD-Score:-4.51|P-value:7.39E-7 ID:SGTC_1628|Compound:st004252|FD-Score:-4.49|P-value:8.31E-7 ID:SGTC_1635|Compound:st007035|FD-Score:4.87|P-value:1.15E-7 ID:SGTC_1673|Compound:st016611|FD-Score:-4.12|P-value:5.37E-6 ID:SGTC_1727|Compound:st034309|FD-Score:6.00|P-value:8.80E-11 ID:SGTC_1728|Compound:st035614|FD-Score:3.09|P-value:5.12E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-2.99|P-value:7.07E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.04|P-value:6.27E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.18|P-value:3.64E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-5.58|P-value:1.27E-9 ID:SGTC_2020|Compound:4017018|FD-Score:-3.24|P-value:2.67E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.38|P-value:1.63E-4 ID:SGTC_2086|Compound:5274770|FD-Score:4.11|P-value:6.23E-6 ID:SGTC_2264|Compound:7948757|FD-Score:-3.98|P-value:1.05E-5 ID:SGTC_2267|Compound:7931562|FD-Score:-4.16|P-value:4.37E-6 ID:SGTC_2329|Compound:6138490|FD-Score:3.02|P-value:6.71E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.34|P-value:1.99E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:5.52|P-value:2.16E-9 ID:SGTC_2596|Compound:sinensetin|FD-Score:-4.47|P-value:9.18E-7 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.52|P-value:9.08E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:3.70|P-value:4.28E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:7.31|P-value:3.68E-15 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-4.88|P-value:9.39E-8 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.07|P-value:5.19E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:9.08|P-value:2.21E-22 ID:SGTC_2691|Compound:st077356|FD-Score:4.02|P-value:9.53E-6 ID:SGTC_2974|Compound:9094440|FD-Score:3.56|P-value:7.86E-5 ID:SGTC_2980|Compound:9014342|FD-Score:3.36|P-value:1.78E-4 ID:SGTC_3170|Compound:9103054|FD-Score:2.95|P-value:8.58E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-3.33|P-value:1.84E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.76|P-value:3.24E-5 ID:SGTC_3233|Compound:9132340|FD-Score:-3.33|P-value:1.89E-4 ID:SGTC_3318|Compound:9139014|FD-Score:2.92|P-value:9.80E-4

Top fitness defect scores for YDR460W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2640 pentamidine 9.08 10.4 µM 2.21E-22 mitochondrial processes 1 5.47E-20 1.48
2 SGTC_2629 bisabolol 7.31 100.0 µM 3.68E-15 2 1.32E-13 1.34
3 SGTC_1727 st034309 6.00 9.9 µM 8.80E-11 1 9.85E-10 0.45
4 SGTC_941 3237-0776 5.83 460.0 µM 2.81E-10 1 2.75E-9 0.93
5 SGTC_2593 nobiletin 5.52 86.2 µM 2.16E-9 3 1.68E-8 0.75
6 SGTC_1635 st007035 4.87 42.4 µM 1.15E-7 12 5.68E-7 0.27
7 SGTC_664 1222-0054 4.64 14.9 µM 4.07E-7 sphingolipid biosynthesis & PDR1 7 1.74E-6 0.56
8 SGTC_2086 5274770 4.11 176.6 µM 6.23E-6 10 1.96E-5 0.01
9 SGTC_2691 st077356 4.02 60.2 µM 9.53E-6 9 2.86E-5 0.24
10 SGTC_895 0964-0006 3.80 13.7 µM 2.77E-5 15 7.37E-5 0.07
11 SGTC_631 k072-0230 3.77 41.5 µM 3.07E-5 60S ribosome export 7 8.09E-5 0.05
12 SGTC_3217 9129673 3.76 49.5 µM 3.24E-5 12 8.48E-5 0.03
13 SGTC_386 1509-0011 3.75 3.1 µM 3.32E-5 7 8.67E-5 0.07
14 SGTC_2620 irigenin 3.70 100.0 µM 4.28E-5 17 1.09E-4 0.01
15 SGTC_1061 3448-9325 3.58 110.0 µM 7.27E-5 9 1.74E-4 0.01
16 SGTC_884 0851-0618 3.56 334.0 µM 7.82E-5 8 1.86E-4 0.20
17 SGTC_2974 9094440 3.56 9.7 µM 7.86E-5 ergosterol biosynthesis 19 1.87E-4 0.01
18 SGTC_2617 dihydrotanshinone i 3.52 20.8 µM 9.08E-5 copper-dependent oxidative stress 28 2.12E-4 0.11
19 SGTC_1139 k015-0024 3.41 46.9 µM 1.47E-4 PDR1 5 3.27E-4 0.10
20 SGTC_2066 5222451 3.38 176.0 µM 1.63E-4 heme biosynthesis & mitochondrial translocase 34 3.58E-4 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.173 4.45E-24 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.173 6.48E-24 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.157 4.88E-20 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.152 9.85E-19 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.149 3.65E-18 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.144 6.67E-17 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.143 8.85E-17 YNL181W_p YNL181W_p het Putative oxidoreductase; required for cell viability
0.142 1.41E-16 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.141 2.48E-16 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.136 2.28E-15 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.132 1.34E-14 YKL001C MET14 hom Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
0.132 1.39E-14 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.130 3.83E-14 YDL067C COX9 hom Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.128 8.65E-14 YOR296W_p YOR296W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene
0.124 4.53E-13 YGR076C MRPL25 hom Mitochondrial ribosomal protein of the large subunit; mutation confers increased replicative lifespan