HIPHOP chemogenomics database
YDR460W / TFB3 
Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit
Zygosity: Heterozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YDR460W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.173 | 4.45E-24 | YKL194C | MST1 | hom | Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro |
| 0.173 | 6.48E-24 | YMR151W_d | YIM2_d | hom | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1 |
| 0.157 | 4.88E-20 | YJL022W_d | YJL022W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130 |
| 0.152 | 9.85E-19 | YPL013C | MRPS16 | hom | Mitochondrial ribosomal protein of the small subunit |
| 0.149 | 3.65E-18 | YLL009C | COX17 | hom | Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs |
| 0.144 | 6.67E-17 | YGR183C | QCR9 | hom | Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex |
| 0.143 | 8.85E-17 | YNL181W_p | YNL181W_p | het | Putative oxidoreductase; required for cell viability |
| 0.142 | 1.41E-16 | YEL059C-A | SOM1 | hom | Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs |
| 0.141 | 2.48E-16 | YKL155C | RSM22 | hom | Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase |
| 0.136 | 2.28E-15 | YNR018W | RCF2 | hom | Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast |
| 0.132 | 1.34E-14 | YKL001C | MET14 | hom | Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism |
| 0.132 | 1.39E-14 | YNL213C | RRG9 | hom | Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
| 0.130 | 3.83E-14 | YDL067C | COX9 | hom | Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain |
| 0.128 | 8.65E-14 | YOR296W_p | YOR296W_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene |
| 0.124 | 4.53E-13 | YGR076C | MRPL25 | hom | Mitochondrial ribosomal protein of the large subunit; mutation confers increased replicative lifespan |