YDR463W / STP1

Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR463W / STP1

Click on Significant Values for Screen Details ID:SGTC_29|Compound:0299-0004|FD-Score:-3.83|P-value:4.81E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:4.64|P-value:1.29E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-5.11|P-value:6.63E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:4.68|P-value:1.15E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:-5.37|P-value:2.40E-6 ID:SGTC_151|Compound:3013-0144|FD-Score:-11.80|P-value:3.14E-23 ID:SGTC_156|Compound:3474-0145|FD-Score:-6.88|P-value:3.08E-9 ID:SGTC_157|Compound:1348-1695|FD-Score:-4.51|P-value:5.62E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:-4.50|P-value:5.84E-5 ID:SGTC_269|Compound:exalamide|FD-Score:4.67|P-value:1.21E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:4.48|P-value:2.17E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:-4.04|P-value:2.53E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:4.25|P-value:4.39E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:-3.68|P-value:7.30E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:-4.40|P-value:8.17E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:-4.06|P-value:2.41E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-4.21|P-value:1.51E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:-4.40|P-value:8.05E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:5.19|P-value:2.02E-5 ID:SGTC_581|Compound:0958-0271|FD-Score:4.63|P-value:1.34E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:-4.17|P-value:1.70E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:4.01|P-value:8.74E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:-3.65|P-value:8.00E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.63|P-value:8.51E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:-3.91|P-value:3.72E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:-4.33|P-value:1.03E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:4.84|P-value:6.78E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:5.15|P-value:2.32E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.44|P-value:6.98E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:5.66|P-value:3.65E-6 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-5.53|P-value:1.29E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:-4.43|P-value:7.38E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:4.60|P-value:1.49E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:-4.35|P-value:9.56E-5 ID:SGTC_1422|Compound:4031-0024|FD-Score:-4.07|P-value:2.29E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:-6.34|P-value:3.99E-8 ID:SGTC_1679|Compound:4130-1276|FD-Score:-5.69|P-value:6.85E-7 ID:SGTC_1715|Compound:st032160|FD-Score:-5.67|P-value:7.48E-7 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.55|P-value:4.92E-5 ID:SGTC_1721|Compound:st082152|FD-Score:4.27|P-value:4.12E-4 ID:SGTC_1759|Compound:st043059|FD-Score:4.08|P-value:7.10E-4 ID:SGTC_1764|Compound:st044502|FD-Score:5.10|P-value:2.78E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.32|P-value:1.04E-4 ID:SGTC_1884|Compound:5633444|FD-Score:-3.98|P-value:3.02E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.91|P-value:3.76E-4 ID:SGTC_2124|Compound:5246320|FD-Score:4.30|P-value:3.76E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-4.86|P-value:1.66E-5 ID:SGTC_2225|Compound:6654152|FD-Score:-4.46|P-value:6.60E-5 ID:SGTC_2238|Compound:6671620|FD-Score:4.63|P-value:1.33E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-4.03|P-value:2.62E-4 ID:SGTC_2243|Compound:6634756|FD-Score:4.53|P-value:1.88E-4 ID:SGTC_2246|Compound:7293507|FD-Score:-5.84|P-value:3.59E-7 ID:SGTC_2281|Compound:7943571|FD-Score:4.83|P-value:6.99E-5 ID:SGTC_2326|Compound:6164455|FD-Score:-4.60|P-value:4.18E-5 ID:SGTC_2336|Compound:9001819|FD-Score:-4.86|P-value:1.64E-5 ID:SGTC_2363|Compound:9053361|FD-Score:-6.24|P-value:6.38E-8 ID:SGTC_2379|Compound:9035213|FD-Score:4.44|P-value:2.47E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-3.88|P-value:4.12E-4 ID:SGTC_2444|Compound:5485484|FD-Score:5.23|P-value:1.76E-5 ID:SGTC_2460|Compound:5552655|FD-Score:4.32|P-value:3.48E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-4.32|P-value:1.06E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:-3.93|P-value:3.50E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:4.24|P-value:4.44E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.61|P-value:9.04E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-4.32|P-value:1.07E-4 ID:SGTC_2710|Compound:st078562|FD-Score:4.30|P-value:3.77E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:-4.40|P-value:8.00E-5 ID:SGTC_2727|Compound:riluzole|FD-Score:5.35|P-value:1.15E-5 ID:SGTC_2740|Compound:felodipine|FD-Score:4.35|P-value:3.26E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-4.41|P-value:7.78E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.97|P-value:3.17E-4 ID:SGTC_2810|Compound:7959871|FD-Score:-3.75|P-value:5.96E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-3.63|P-value:8.32E-4 ID:SGTC_3023|Compound:9089636|FD-Score:4.29|P-value:3.89E-4 ID:SGTC_3042|Compound:9091578|FD-Score:-4.37|P-value:8.81E-5 ID:SGTC_3149|Compound:9097855|FD-Score:-4.02|P-value:2.66E-4 ID:SGTC_3151|Compound:9099821|FD-Score:-3.89|P-value:3.94E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-7.75|P-value:3.48E-11 ID:SGTC_3274|Compound:9138298|FD-Score:4.38|P-value:2.97E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:-3.83|P-value:4.81E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:4.64|P-value:1.29E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-5.11|P-value:6.63E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:4.68|P-value:1.15E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:-5.37|P-value:2.40E-6 ID:SGTC_151|Compound:3013-0144|FD-Score:-11.80|P-value:3.14E-23 ID:SGTC_156|Compound:3474-0145|FD-Score:-6.88|P-value:3.08E-9 ID:SGTC_157|Compound:1348-1695|FD-Score:-4.51|P-value:5.62E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:-4.50|P-value:5.84E-5 ID:SGTC_269|Compound:exalamide|FD-Score:4.67|P-value:1.21E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:4.48|P-value:2.17E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:-4.04|P-value:2.53E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:4.25|P-value:4.39E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:-3.68|P-value:7.30E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:-4.40|P-value:8.17E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:-4.06|P-value:2.41E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-4.21|P-value:1.51E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:-4.40|P-value:8.05E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:5.19|P-value:2.02E-5 ID:SGTC_581|Compound:0958-0271|FD-Score:4.63|P-value:1.34E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:-4.17|P-value:1.70E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:4.01|P-value:8.74E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:-3.65|P-value:8.00E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.63|P-value:8.51E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:-3.91|P-value:3.72E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:-4.33|P-value:1.03E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:4.84|P-value:6.78E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:5.15|P-value:2.32E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.44|P-value:6.98E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:5.66|P-value:3.65E-6 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-5.53|P-value:1.29E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:-4.43|P-value:7.38E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:4.60|P-value:1.49E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:-4.35|P-value:9.56E-5 ID:SGTC_1422|Compound:4031-0024|FD-Score:-4.07|P-value:2.29E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:-6.34|P-value:3.99E-8 ID:SGTC_1679|Compound:4130-1276|FD-Score:-5.69|P-value:6.85E-7 ID:SGTC_1715|Compound:st032160|FD-Score:-5.67|P-value:7.48E-7 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.55|P-value:4.92E-5 ID:SGTC_1721|Compound:st082152|FD-Score:4.27|P-value:4.12E-4 ID:SGTC_1759|Compound:st043059|FD-Score:4.08|P-value:7.10E-4 ID:SGTC_1764|Compound:st044502|FD-Score:5.10|P-value:2.78E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.32|P-value:1.04E-4 ID:SGTC_1884|Compound:5633444|FD-Score:-3.98|P-value:3.02E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.91|P-value:3.76E-4 ID:SGTC_2124|Compound:5246320|FD-Score:4.30|P-value:3.76E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-4.86|P-value:1.66E-5 ID:SGTC_2225|Compound:6654152|FD-Score:-4.46|P-value:6.60E-5 ID:SGTC_2238|Compound:6671620|FD-Score:4.63|P-value:1.33E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-4.03|P-value:2.62E-4 ID:SGTC_2243|Compound:6634756|FD-Score:4.53|P-value:1.88E-4 ID:SGTC_2246|Compound:7293507|FD-Score:-5.84|P-value:3.59E-7 ID:SGTC_2281|Compound:7943571|FD-Score:4.83|P-value:6.99E-5 ID:SGTC_2326|Compound:6164455|FD-Score:-4.60|P-value:4.18E-5 ID:SGTC_2336|Compound:9001819|FD-Score:-4.86|P-value:1.64E-5 ID:SGTC_2363|Compound:9053361|FD-Score:-6.24|P-value:6.38E-8 ID:SGTC_2379|Compound:9035213|FD-Score:4.44|P-value:2.47E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-3.88|P-value:4.12E-4 ID:SGTC_2444|Compound:5485484|FD-Score:5.23|P-value:1.76E-5 ID:SGTC_2460|Compound:5552655|FD-Score:4.32|P-value:3.48E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-4.32|P-value:1.06E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:-3.93|P-value:3.50E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:4.24|P-value:4.44E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.61|P-value:9.04E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-4.32|P-value:1.07E-4 ID:SGTC_2710|Compound:st078562|FD-Score:4.30|P-value:3.77E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:-4.40|P-value:8.00E-5 ID:SGTC_2727|Compound:riluzole|FD-Score:5.35|P-value:1.15E-5 ID:SGTC_2740|Compound:felodipine|FD-Score:4.35|P-value:3.26E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-4.41|P-value:7.78E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.97|P-value:3.17E-4 ID:SGTC_2810|Compound:7959871|FD-Score:-3.75|P-value:5.96E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-3.63|P-value:8.32E-4 ID:SGTC_3023|Compound:9089636|FD-Score:4.29|P-value:3.89E-4 ID:SGTC_3042|Compound:9091578|FD-Score:-4.37|P-value:8.81E-5 ID:SGTC_3149|Compound:9097855|FD-Score:-4.02|P-value:2.66E-4 ID:SGTC_3151|Compound:9099821|FD-Score:-3.89|P-value:3.94E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-7.75|P-value:3.48E-11 ID:SGTC_3274|Compound:9138298|FD-Score:4.38|P-value:2.97E-4

Top fitness defect scores for YDR463W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1045 1348-1485 5.66 165.0 µM 3.65E-6 6 7.74E-9
2 SGTC_2727 riluzole 5.35 51.8 µM 1.15E-5 mitochondrial processes 4 4.36E-8
3 SGTC_2444 5485484 5.23 36.4 µM 1.76E-5 11 8.35E-8
4 SGTC_538 2922-0838 5.19 53.3 µM 2.02E-5 Golgi 12 1.03E-7
5 SGTC_1041 0206-0046 5.15 107.0 µM 2.32E-5 12 1.27E-7
6 SGTC_1764 st044502 5.10 93.5 µM 2.78E-5 17 1.66E-7
7 SGTC_961 1252-1571 4.84 372.0 µM 6.78E-5 17 6.43E-7
8 SGTC_2281 7943571 4.83 200.0 µM 6.99E-5 2 6.72E-7
9 SGTC_146 3448-8650 4.68 53.1 µM 1.15E-4 NEO1-PIK1 101 1.42E-6
10 SGTC_269 exalamide 4.67 29.0 µM 1.21E-4 ergosterol biosynthesis 11 1.54E-6
11 SGTC_129 0088-0017 4.64 176.6 µM 1.29E-4 54 1.71E-6
12 SGTC_2238 6671620 4.63 73.2 µM 1.33E-4 15 1.79E-6
13 SGTC_581 0958-0271 4.63 211.0 µM 1.34E-4 34 1.81E-6
14 SGTC_1184 1269-1718 4.60 139.0 µM 1.49E-4 15 2.11E-6
15 SGTC_2243 6634756 4.53 200.0 µM 1.88E-4 10 3.02E-6
16 SGTC_274 sirtinol 4.48 40.1 µM 2.17E-4 13 3.74E-6
17 SGTC_2379 9035213 4.44 200.0 µM 2.47E-4 10 4.54E-6
18 SGTC_3274 9138298 4.38 49.5 µM 2.97E-4 14 6.00E-6
19 SGTC_2740 felodipine 4.35 17.1 µM 3.26E-4 16 6.92E-6
20 SGTC_2460 5552655 4.32 174.2 µM 3.48E-4 amide catabolism 23 7.66E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.288 1.17E-64 YBR069C TAT1 hom Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress
0.165 6.15E-22 YIR023W DAL81 hom Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
0.138 9.06E-16 YML123C PHO84 hom High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity
0.108 3.52E-10 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.101 4.47E-9 YDR519W FPR2 hom Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress
0.092 1.08E-7 YHR143W-A RPC10 het RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress
0.088 3.74E-7 YDR332W IRC3 hom Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.087 4.71E-7 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.085 9.38E-7 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.085 9.86E-7 YDR008C_d YDR008C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.083 1.69E-6 YBR168W PEX32 hom Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
0.082 1.76E-6 YIL070C MAM33 hom Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R
0.082 1.83E-6 YDL056W MBP1 hom Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes
0.082 1.89E-6 YLR295C ATP14 hom Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress
0.081 2.83E-6 YDR354W TRP4 hom Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis