HIPHOP chemogenomics database
YDR464W / SPP41 
Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YDR464W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.430 | 5.97E-151 | YLR029C | RPL15A | het | Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication |
| 0.123 | 7.64E-13 | YLL037W_d | YLL037W_d | het | Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor |
| 0.115 | 2.80E-11 | YHR110W | ERP5 | hom | Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport |
| 0.112 | 8.66E-11 | YBR142W | MAK5 | het | Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits |
| 0.111 | 1.03E-10 | YMR226C | YMR226C | hom | NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments |
| 0.111 | 1.32E-10 | YDR245W | MNN10 | hom | Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family |
| 0.100 | 6.70E-9 | YLR342W | FKS1 | hom | Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling |
| 0.097 | 1.98E-8 | YGL111W | NSA1 | het | Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis |
| 0.096 | 2.27E-8 | YBL059W_p | YBL059W_p | hom | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication |
| 0.095 | 3.11E-8 | YHR079C-A | SAE3 | hom | Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p |
| 0.094 | 5.58E-8 | YDL034W_d | YDL034W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps with verified gene GPR1/YDL035C; YDL034W is not an essential gene |
| 0.093 | 7.15E-8 | YHR025W | THR1 | hom | Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway |
| 0.093 | 7.49E-8 | YLR142W | PUT1 | hom | Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source |
| 0.092 | 8.39E-8 | YHR080C | YHR080C | hom | Protein of unknown function; may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YHR080C has a paralog, YSP2, that arose from the whole genome duplication |
| 0.091 | 1.12E-7 | YDL195W | SEC31 | het | Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance |