YDR468C / TLG1

Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR468C / TLG1

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:3.65|P-value:1.23E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.34|P-value:6.63E-6 ID:SGTC_61|Compound:0978-8327|FD-Score:3.45|P-value:2.60E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:-3.41|P-value:3.79E-4 ID:SGTC_263|Compound:alizarin|FD-Score:3.55|P-value:1.76E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.22|P-value:5.84E-4 ID:SGTC_277|Compound:nystatin|FD-Score:3.27|P-value:5.05E-4 ID:SGTC_493|Compound:zm226600|FD-Score:-3.22|P-value:7.61E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:5.44|P-value:2.44E-8 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.38|P-value:3.41E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:5.72|P-value:4.96E-9 ID:SGTC_767|Compound:0929-0023|FD-Score:3.27|P-value:4.95E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:3.49|P-value:2.27E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:4.59|P-value:2.02E-6 ID:SGTC_927|Compound:2425-1185|FD-Score:3.65|P-value:1.22E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.15|P-value:7.51E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.86|P-value:5.29E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.84|P-value:5.72E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:4.14|P-value:1.58E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.38|P-value:3.37E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.41|P-value:3.03E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.24|P-value:5.57E-4 ID:SGTC_1954|Compound:st077032|FD-Score:4.63|P-value:1.72E-6 ID:SGTC_2063|Compound:5246145|FD-Score:3.11|P-value:8.62E-4 ID:SGTC_2325|Compound:6158266|FD-Score:4.61|P-value:1.86E-6 ID:SGTC_2335|Compound:9018011|FD-Score:3.67|P-value:1.11E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.18|P-value:6.89E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.75|P-value:8.27E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.47|P-value:2.42E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-3.86|P-value:6.86E-5 ID:SGTC_2795|Compound:7780010|FD-Score:-3.44|P-value:3.48E-4 ID:SGTC_2814|Compound:7977482|FD-Score:5.18|P-value:1.05E-7 ID:SGTC_2819|Compound:7996655|FD-Score:3.44|P-value:2.72E-4 ID:SGTC_2827|Compound:7993847|FD-Score:4.23|P-value:1.09E-5 ID:SGTC_2828|Compound:7998861|FD-Score:3.35|P-value:3.74E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.15|P-value:9.47E-4 ID:SGTC_2953|Compound:9074162|FD-Score:4.61|P-value:1.87E-6 ID:SGTC_3062|Compound:9077494|FD-Score:-4.18|P-value:1.80E-5 ID:SGTC_3152|Compound:9099253|FD-Score:3.60|P-value:1.44E-4 ID:SGTC_3260|Compound:9137109|FD-Score:3.13|P-value:8.20E-4 ID:SGTC_3278|Compound:9139605|FD-Score:5.94|P-value:1.29E-9 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.65|P-value:1.23E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.34|P-value:6.63E-6 ID:SGTC_61|Compound:0978-8327|FD-Score:3.45|P-value:2.60E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:-3.41|P-value:3.79E-4 ID:SGTC_263|Compound:alizarin|FD-Score:3.55|P-value:1.76E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.22|P-value:5.84E-4 ID:SGTC_277|Compound:nystatin|FD-Score:3.27|P-value:5.05E-4 ID:SGTC_493|Compound:zm226600|FD-Score:-3.22|P-value:7.61E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:5.44|P-value:2.44E-8 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.38|P-value:3.41E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:5.72|P-value:4.96E-9 ID:SGTC_767|Compound:0929-0023|FD-Score:3.27|P-value:4.95E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:3.49|P-value:2.27E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:4.59|P-value:2.02E-6 ID:SGTC_927|Compound:2425-1185|FD-Score:3.65|P-value:1.22E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.15|P-value:7.51E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.86|P-value:5.29E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.84|P-value:5.72E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:4.14|P-value:1.58E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.38|P-value:3.37E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.41|P-value:3.03E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.24|P-value:5.57E-4 ID:SGTC_1954|Compound:st077032|FD-Score:4.63|P-value:1.72E-6 ID:SGTC_2063|Compound:5246145|FD-Score:3.11|P-value:8.62E-4 ID:SGTC_2325|Compound:6158266|FD-Score:4.61|P-value:1.86E-6 ID:SGTC_2335|Compound:9018011|FD-Score:3.67|P-value:1.11E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.18|P-value:6.89E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.75|P-value:8.27E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.47|P-value:2.42E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-3.86|P-value:6.86E-5 ID:SGTC_2795|Compound:7780010|FD-Score:-3.44|P-value:3.48E-4 ID:SGTC_2814|Compound:7977482|FD-Score:5.18|P-value:1.05E-7 ID:SGTC_2819|Compound:7996655|FD-Score:3.44|P-value:2.72E-4 ID:SGTC_2827|Compound:7993847|FD-Score:4.23|P-value:1.09E-5 ID:SGTC_2828|Compound:7998861|FD-Score:3.35|P-value:3.74E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.15|P-value:9.47E-4 ID:SGTC_2953|Compound:9074162|FD-Score:4.61|P-value:1.87E-6 ID:SGTC_3062|Compound:9077494|FD-Score:-4.18|P-value:1.80E-5 ID:SGTC_3152|Compound:9099253|FD-Score:3.60|P-value:1.44E-4 ID:SGTC_3260|Compound:9137109|FD-Score:3.13|P-value:8.20E-4 ID:SGTC_3278|Compound:9139605|FD-Score:5.94|P-value:1.29E-9

Top fitness defect scores for YDR468C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3278 9139605 5.94 49.5 µM 1.29E-9 2 1.39E-9 0.54
2 SGTC_764 1951-2361 5.72 146.0 µM 4.96E-9 6 5.34E-9 1.23
3 SGTC_664 1222-0054 5.44 14.9 µM 2.44E-8 sphingolipid biosynthesis & PDR1 4 2.64E-8 0.41
4 SGTC_2814 7977482 5.18 43.0 µM 1.05E-7 3 1.14E-7 0.03
5 SGTC_1954 st077032 4.63 68.9 µM 1.72E-6 2 1.87E-6 0.09
6 SGTC_2325 6158266 4.61 200.0 µM 1.86E-6 4 2.02E-6 0.38
7 SGTC_2953 9074162 4.61 66.5 µM 1.87E-6 3 2.03E-6 0.36
8 SGTC_829 1635-0120 4.59 117.0 µM 2.02E-6 DNA damage response 40 2.19E-6 0.27
9 SGTC_58 0957-0393 4.34 9.0 µM 6.63E-6 cell wall 46 7.19E-6 0.04
10 SGTC_2827 7993847 4.23 71.4 µM 1.09E-5 6 1.18E-5 0.12
11 SGTC_1150 3909-7983 4.14 10.9 µM 1.58E-5 3 1.72E-5 0.29
12 SGTC_1030 k029-0042 3.86 36.7 µM 5.29E-5 TSC3-RPN4 5 5.73E-5 0.13
13 SGTC_1133 3473-0247 3.84 50.0 µM 5.72E-5 RSC complex & mRNA processing 49 6.20E-5 0.03
14 SGTC_2506 ethyl hematommate 3.75 54.2 µM 8.27E-5 RPP1 & pyrimidine depletion 5 8.95E-5 0.17
15 SGTC_2335 9018011 3.67 154.2 µM 1.11E-4 14 1.20E-4 0.16
16 SGTC_927 2425-1185 3.65 123.0 µM 1.22E-4 6 1.32E-4 0.16
17 SGTC_46 0329-0187a 3.65 2.2 µM 1.23E-4 14 1.33E-4 0.09
18 SGTC_3152 9099253 3.60 49.5 µM 1.44E-4 NEO1-PIK1 29 1.56E-4 0.08
19 SGTC_263 alizarin 3.55 107.9 µM 1.76E-4 iron homeostasis 20 1.90E-4 0.00
20 SGTC_770 0389-1121 3.49 67.2 µM 2.27E-4 RPP1 & pyrimidine depletion 18 2.45E-4 0.15

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 3.25E-14 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.127 1.87E-13 YNL107W YAF9 hom Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain
0.126 2.16E-13 YDR413C_d YDR413C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing
0.125 3.23E-13 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.124 6.38E-13 YLR424W SPP382 het Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation
0.115 2.73E-11 YLR101C_d YLR101C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W
0.112 7.06E-11 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.109 2.79E-10 YER051W JHD1 hom JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe
0.109 2.82E-10 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.107 4.51E-10 YLR173W_p YLR173W_p hom Putative protein of unknown function
0.106 6.19E-10 YCL037C SRO9 hom Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication
0.106 6.28E-10 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.106 6.79E-10 YHR070W TRM5 het tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya
0.105 1.09E-9 YDR020C_p DAS2_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases
0.105 1.19E-9 YJL089W SIP4 hom C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus