YDR469W / SDC1

Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR469W / SDC1

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:3.67|P-value:4.87E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:4.56|P-value:2.00E-5 ID:SGTC_62|Compound:0180-0423|FD-Score:-6.27|P-value:6.27E-9 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.89|P-value:2.03E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.65|P-value:4.51E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.52|P-value:7.70E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:5.03|P-value:3.01E-6 ID:SGTC_295|Compound:k015-0027|FD-Score:3.49|P-value:8.56E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.85|P-value:2.30E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:3.56|P-value:6.92E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.47|P-value:9.04E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:4.74|P-value:9.70E-6 ID:SGTC_794|Compound:k038-0031|FD-Score:3.60|P-value:5.98E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.55|P-value:6.12E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.74|P-value:3.31E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:4.92|P-value:4.79E-6 ID:SGTC_976|Compound:1348-1067|FD-Score:5.18|P-value:1.52E-6 ID:SGTC_988|Compound:1497-1057|FD-Score:-4.36|P-value:3.71E-5 ID:SGTC_1053|Compound:3366-3204|FD-Score:-4.13|P-value:8.62E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.19|P-value:8.05E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.58|P-value:1.86E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:4.59|P-value:1.81E-5 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.93|P-value:2.04E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:-3.48|P-value:7.76E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.62|P-value:5.67E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.21|P-value:7.47E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.93|P-value:1.73E-4 ID:SGTC_1646|Compound:st011709|FD-Score:4.01|P-value:1.55E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.38|P-value:5.12E-7 ID:SGTC_1745|Compound:st081495|FD-Score:6.05|P-value:2.45E-8 ID:SGTC_1754|Compound:st042065|FD-Score:3.46|P-value:9.31E-4 ID:SGTC_1759|Compound:st043059|FD-Score:3.49|P-value:8.48E-4 ID:SGTC_1774|Compound:st048371|FD-Score:4.04|P-value:1.41E-4 ID:SGTC_1814|Compound:st052110|FD-Score:3.57|P-value:6.56E-4 ID:SGTC_1818|Compound:st052136|FD-Score:4.32|P-value:5.12E-5 ID:SGTC_1871|Compound:st057448|FD-Score:3.95|P-value:1.91E-4 ID:SGTC_1923|Compound:st058458|FD-Score:4.96|P-value:3.98E-6 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:-3.53|P-value:6.57E-4 ID:SGTC_2082|Compound:5219693|FD-Score:4.68|P-value:1.28E-5 ID:SGTC_2090|Compound:5301565|FD-Score:4.64|P-value:1.46E-5 ID:SGTC_2292|Compound:7671323|FD-Score:3.53|P-value:7.47E-4 ID:SGTC_2297|Compound:7971671|FD-Score:4.00|P-value:1.58E-4 ID:SGTC_2342|Compound:7990637|FD-Score:4.92|P-value:4.75E-6 ID:SGTC_2351|Compound:9026858|FD-Score:5.44|P-value:4.67E-7 ID:SGTC_2387|Compound:9077560|FD-Score:3.96|P-value:1.86E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.53|P-value:7.48E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.69|P-value:4.54E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.94|P-value:2.00E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.46|P-value:9.43E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.88|P-value:4.63E-6 ID:SGTC_2858|Compound:9025781|FD-Score:5.40|P-value:5.86E-7 ID:SGTC_2871|Compound:9038510|FD-Score:-4.85|P-value:5.18E-6 ID:SGTC_2905|Compound:7799065|FD-Score:3.68|P-value:4.65E-4 ID:SGTC_2941|Compound:9056145|FD-Score:4.52|P-value:2.41E-5 ID:SGTC_2947|Compound:9072639|FD-Score:-4.03|P-value:1.25E-4 ID:SGTC_3037|Compound:9091026|FD-Score:6.12|P-value:1.75E-8 ID:SGTC_3054|Compound:9094397|FD-Score:4.20|P-value:7.93E-5 ID:SGTC_3098|Compound:9119039|FD-Score:3.71|P-value:4.28E-4 ID:SGTC_3106|Compound:9121286|FD-Score:-4.05|P-value:1.13E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-4.44|P-value:2.70E-5 ID:SGTC_3143|Compound:9086658|FD-Score:4.89|P-value:5.36E-6 ID:SGTC_3202|Compound:9113761|FD-Score:-3.64|P-value:4.57E-4 ID:SGTC_3203|Compound:9113543|FD-Score:-3.63|P-value:4.82E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.64|P-value:4.66E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-3.42|P-value:9.19E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:3.67|P-value:4.87E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:4.56|P-value:2.00E-5 ID:SGTC_62|Compound:0180-0423|FD-Score:-6.27|P-value:6.27E-9 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.89|P-value:2.03E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.65|P-value:4.51E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.52|P-value:7.70E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:5.03|P-value:3.01E-6 ID:SGTC_295|Compound:k015-0027|FD-Score:3.49|P-value:8.56E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.85|P-value:2.30E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:3.56|P-value:6.92E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.47|P-value:9.04E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:4.74|P-value:9.70E-6 ID:SGTC_794|Compound:k038-0031|FD-Score:3.60|P-value:5.98E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.55|P-value:6.12E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.74|P-value:3.31E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:4.92|P-value:4.79E-6 ID:SGTC_976|Compound:1348-1067|FD-Score:5.18|P-value:1.52E-6 ID:SGTC_988|Compound:1497-1057|FD-Score:-4.36|P-value:3.71E-5 ID:SGTC_1053|Compound:3366-3204|FD-Score:-4.13|P-value:8.62E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.19|P-value:8.05E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.58|P-value:1.86E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:4.59|P-value:1.81E-5 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.93|P-value:2.04E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:-3.48|P-value:7.76E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.62|P-value:5.67E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.21|P-value:7.47E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.93|P-value:1.73E-4 ID:SGTC_1646|Compound:st011709|FD-Score:4.01|P-value:1.55E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.38|P-value:5.12E-7 ID:SGTC_1745|Compound:st081495|FD-Score:6.05|P-value:2.45E-8 ID:SGTC_1754|Compound:st042065|FD-Score:3.46|P-value:9.31E-4 ID:SGTC_1759|Compound:st043059|FD-Score:3.49|P-value:8.48E-4 ID:SGTC_1774|Compound:st048371|FD-Score:4.04|P-value:1.41E-4 ID:SGTC_1814|Compound:st052110|FD-Score:3.57|P-value:6.56E-4 ID:SGTC_1818|Compound:st052136|FD-Score:4.32|P-value:5.12E-5 ID:SGTC_1871|Compound:st057448|FD-Score:3.95|P-value:1.91E-4 ID:SGTC_1923|Compound:st058458|FD-Score:4.96|P-value:3.98E-6 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:-3.53|P-value:6.57E-4 ID:SGTC_2082|Compound:5219693|FD-Score:4.68|P-value:1.28E-5 ID:SGTC_2090|Compound:5301565|FD-Score:4.64|P-value:1.46E-5 ID:SGTC_2292|Compound:7671323|FD-Score:3.53|P-value:7.47E-4 ID:SGTC_2297|Compound:7971671|FD-Score:4.00|P-value:1.58E-4 ID:SGTC_2342|Compound:7990637|FD-Score:4.92|P-value:4.75E-6 ID:SGTC_2351|Compound:9026858|FD-Score:5.44|P-value:4.67E-7 ID:SGTC_2387|Compound:9077560|FD-Score:3.96|P-value:1.86E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.53|P-value:7.48E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.69|P-value:4.54E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.94|P-value:2.00E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.46|P-value:9.43E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.88|P-value:4.63E-6 ID:SGTC_2858|Compound:9025781|FD-Score:5.40|P-value:5.86E-7 ID:SGTC_2871|Compound:9038510|FD-Score:-4.85|P-value:5.18E-6 ID:SGTC_2905|Compound:7799065|FD-Score:3.68|P-value:4.65E-4 ID:SGTC_2941|Compound:9056145|FD-Score:4.52|P-value:2.41E-5 ID:SGTC_2947|Compound:9072639|FD-Score:-4.03|P-value:1.25E-4 ID:SGTC_3037|Compound:9091026|FD-Score:6.12|P-value:1.75E-8 ID:SGTC_3054|Compound:9094397|FD-Score:4.20|P-value:7.93E-5 ID:SGTC_3098|Compound:9119039|FD-Score:3.71|P-value:4.28E-4 ID:SGTC_3106|Compound:9121286|FD-Score:-4.05|P-value:1.13E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-4.44|P-value:2.70E-5 ID:SGTC_3143|Compound:9086658|FD-Score:4.89|P-value:5.36E-6 ID:SGTC_3202|Compound:9113761|FD-Score:-3.64|P-value:4.57E-4 ID:SGTC_3203|Compound:9113543|FD-Score:-3.63|P-value:4.82E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.64|P-value:4.66E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-3.42|P-value:9.19E-4

Top fitness defect scores for YDR469W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3037 9091026 6.12 49.5 µM 1.75E-8 NEO1-PIK1 47 4.73E-10
2 SGTC_1745 st081495 6.05 74.0 µM 2.45E-8 RNA processing & uracil transport 25 7.13E-10
3 SGTC_2351 9026858 5.44 72.3 µM 4.67E-7 RNA processing & uracil transport 7 2.59E-8
4 SGTC_2858 9025781 5.40 9.0 µM 5.86E-7 sphingolipid biosynthesis & PDR1 56 3.42E-8
5 SGTC_976 1348-1067 5.18 47.6 µM 1.52E-6 60S ribosome export 8 1.10E-7
6 SGTC_255 tunicamycin 5.03 200.5 nM 3.01E-6 unfolded protein response 44 2.51E-7
7 SGTC_1923 st058458 4.96 19.1 µM 3.98E-6 14 3.54E-7
8 SGTC_2342 7990637 4.92 118.9 µM 4.75E-6 RNA processing & uracil transport 15 4.39E-7
9 SGTC_970 1315-0089 4.92 19.5 µM 4.79E-6 RSC & ERG11 8 4.43E-7
10 SGTC_3143 9086658 4.89 49.5 µM 5.36E-6 17 5.08E-7
11 SGTC_727 3032-0951 4.74 202.0 µM 9.70E-6 16 1.05E-6
12 SGTC_2082 5219693 4.68 150.0 µM 1.28E-5 RNA processing & uracil transport 14 1.47E-6
13 SGTC_2090 5301565 4.64 104.5 µM 1.46E-5 TSC3-RPN4 30 1.71E-6
14 SGTC_1076 itraconazole 4.59 331.0 nM 1.81E-5 20 2.23E-6
15 SGTC_1067 clotrimazole 4.58 1.4 µM 1.86E-5 azole & statin 27 2.30E-6
16 SGTC_54 0159-0055 4.56 9.0 µM 2.00E-5 ERG2 35 2.53E-6
17 SGTC_2941 9056145 4.52 11.2 µM 2.41E-5 12 3.16E-6
18 SGTC_1818 st052136 4.32 56.3 µM 5.12E-5 NEO1-PIK1 36 7.93E-6
19 SGTC_1627 st003713 4.21 25.6 µM 7.47E-5 calcium & mitochondrial duress 61 1.25E-5
20 SGTC_3054 9094397 4.20 49.5 µM 7.93E-5 fatty acid desaturase (OLE1) 25 1.35E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.200 1.98E-31 YBR021W FUR4 hom Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation
0.175 1.78E-24 YLR418C CDC73 hom Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress
0.174 2.68E-24 YPL055C LGE1 hom Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division
0.160 1.14E-20 YDL074C BRE1 hom E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control
0.154 2.84E-19 YGL244W RTF1 hom Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay
0.139 6.17E-16 YLR015W BRE2 hom Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L
0.124 5.22E-13 YOL145C CTR9 hom Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats
0.123 9.13E-13 YNL307C MCK1 hom Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family
0.123 9.30E-13 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.121 1.93E-12 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.119 5.26E-12 YEL031W SPF1 hom P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1
0.113 6.14E-11 YLR420W URA4 hom Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
0.108 4.13E-10 YGL100W SEH1 hom Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1
0.107 4.46E-10 YML106W URA5 hom Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication
0.104 1.65E-9 YER119C-A_d YER119C-A_d hom Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2