YDR472W / TRS31

One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR472W / TRS31

Click on Significant Values for Screen Details ID:SGTC_91|Compound:0417-1751|FD-Score:3.39|P-value:9.21E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.62|P-value:3.63E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-3.61|P-value:3.81E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-6.66|P-value:2.97E-10 ID:SGTC_701|Compound:4424-0219|FD-Score:-3.86|P-value:1.60E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.64|P-value:4.02E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:4.49|P-value:1.75E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:7.90|P-value:1.47E-13 ID:SGTC_883|Compound:0850-0245|FD-Score:5.46|P-value:2.39E-7 ID:SGTC_896|Compound:0964-0007|FD-Score:-3.36|P-value:8.56E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:5.00|P-value:2.02E-6 ID:SGTC_1068|Compound:loratadine|FD-Score:3.65|P-value:4.00E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.37|P-value:8.21E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:-3.50|P-value:5.43E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.82|P-value:4.50E-6 ID:SGTC_1472|Compound:k841-0093|FD-Score:-3.44|P-value:6.54E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:3.63|P-value:4.25E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:-4.25|P-value:3.70E-5 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.81|P-value:2.27E-4 ID:SGTC_1865|Compound:st057639|FD-Score:3.82|P-value:2.18E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.44|P-value:7.95E-4 ID:SGTC_1919|Compound:st067113|FD-Score:6.61|P-value:5.26E-10 ID:SGTC_1922|Compound:5578187|FD-Score:-3.50|P-value:5.45E-4 ID:SGTC_2424|Compound:5537928|FD-Score:5.29|P-value:5.48E-7 ID:SGTC_2661|Compound:dactinomycin|FD-Score:4.43|P-value:2.24E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.32|P-value:2.83E-9 ID:SGTC_2709|Compound:st078560|FD-Score:-3.34|P-value:9.06E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:-3.91|P-value:1.34E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.76|P-value:2.75E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.40|P-value:7.61E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.62|P-value:4.40E-4 ID:SGTC_2927|Compound:9011802|FD-Score:5.36|P-value:3.96E-7 ID:SGTC_2981|Compound:9013952|FD-Score:3.84|P-value:2.03E-4 ID:SGTC_3192|Compound:9110362|FD-Score:-3.36|P-value:8.51E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.66|P-value:3.79E-4 ID:SGTC_3213|Compound:9129884|FD-Score:3.77|P-value:2.65E-4 ID:SGTC_3220|Compound:9131269|FD-Score:4.03|P-value:1.06E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:3.39|P-value:9.21E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.62|P-value:3.63E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-3.61|P-value:3.81E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-6.66|P-value:2.97E-10 ID:SGTC_701|Compound:4424-0219|FD-Score:-3.86|P-value:1.60E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.64|P-value:4.02E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:4.49|P-value:1.75E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:7.90|P-value:1.47E-13 ID:SGTC_883|Compound:0850-0245|FD-Score:5.46|P-value:2.39E-7 ID:SGTC_896|Compound:0964-0007|FD-Score:-3.36|P-value:8.56E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:5.00|P-value:2.02E-6 ID:SGTC_1068|Compound:loratadine|FD-Score:3.65|P-value:4.00E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.37|P-value:8.21E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:-3.50|P-value:5.43E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.82|P-value:4.50E-6 ID:SGTC_1472|Compound:k841-0093|FD-Score:-3.44|P-value:6.54E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:3.63|P-value:4.25E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:-4.25|P-value:3.70E-5 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.81|P-value:2.27E-4 ID:SGTC_1865|Compound:st057639|FD-Score:3.82|P-value:2.18E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.44|P-value:7.95E-4 ID:SGTC_1919|Compound:st067113|FD-Score:6.61|P-value:5.26E-10 ID:SGTC_1922|Compound:5578187|FD-Score:-3.50|P-value:5.45E-4 ID:SGTC_2424|Compound:5537928|FD-Score:5.29|P-value:5.48E-7 ID:SGTC_2661|Compound:dactinomycin|FD-Score:4.43|P-value:2.24E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.32|P-value:2.83E-9 ID:SGTC_2709|Compound:st078560|FD-Score:-3.34|P-value:9.06E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:-3.91|P-value:1.34E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.76|P-value:2.75E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.40|P-value:7.61E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.62|P-value:4.40E-4 ID:SGTC_2927|Compound:9011802|FD-Score:5.36|P-value:3.96E-7 ID:SGTC_2981|Compound:9013952|FD-Score:3.84|P-value:2.03E-4 ID:SGTC_3192|Compound:9110362|FD-Score:-3.36|P-value:8.51E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.66|P-value:3.79E-4 ID:SGTC_3213|Compound:9129884|FD-Score:3.77|P-value:2.65E-4 ID:SGTC_3220|Compound:9131269|FD-Score:4.03|P-value:1.06E-4

Top fitness defect scores for YDR472W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_878 0828-0289 7.90 13.7 µM 1.47E-13 8 1.34E-15 1.55
2 SGTC_1919 st067113 6.61 52.3 µM 5.26E-10 TSC3-RPN4 3 1.88E-11 1.08
3 SGTC_2679 rapamycin 6.32 1.0 nM 2.83E-9 27 1.33E-10 0.10
4 SGTC_883 0850-0245 5.46 24.6 µM 2.39E-7 cell wall 2 2.35E-8 0.85
5 SGTC_2927 9011802 5.36 47.9 µM 3.96E-7 3 4.23E-8 0.25
6 SGTC_2424 5537928 5.29 59.2 µM 5.48E-7 2 6.18E-8 0.06
7 SGTC_956 1185-0240 5.00 191.0 µM 2.02E-6 1 2.83E-7 1.27
8 SGTC_1377 2944-0135 4.82 198.0 µM 4.50E-6 calcium & mitochondrial duress 3 7.19E-7 0.19
9 SGTC_764 1951-2361 4.49 146.0 µM 1.75E-5 7 3.50E-6 0.03
10 SGTC_2661 dactinomycin 4.43 13.0 µM 2.24E-5 redox potentiating 1 4.65E-6 0.74
11 SGTC_3220 9131269 4.03 49.5 µM 1.06E-4 2 2.85E-5 0.24
12 SGTC_2981 9013952 3.84 39.0 µM 2.03E-4 10 6.03E-5 0.01
13 SGTC_1865 st057639 3.82 52.2 µM 2.18E-4 4 6.57E-5 0.38
14 SGTC_1502 4534-4282 3.81 27.7 µM 2.27E-4 2 6.89E-5 0.18
15 SGTC_3213 9129884 3.77 49.5 µM 2.65E-4 5 8.23E-5 0.28
16 SGTC_2821 7996764 3.76 71.4 µM 2.75E-4 12 8.60E-5 0.25
17 SGTC_3197 9113331 3.66 49.5 µM 3.79E-4 12 1.25E-4 0.04
18 SGTC_1068 loratadine 3.65 26.9 µM 4.00E-4 7 1.33E-4 0.12
19 SGTC_745 0469-0705 3.64 296.0 µM 4.02E-4 mitochondrial processes 26 1.34E-4 0.05
20 SGTC_1491 4138-0063 3.63 26.5 µM 4.25E-4 4 1.43E-4 0.09

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 2.21E-16 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.125 4.13E-13 YMR312W ELP6 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
0.121 2.08E-12 YOL146W PSF3 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.120 2.66E-12 YDL160C DHH1 hom Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress
0.105 8.97E-10 YLL011W SOF1 het Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
0.104 1.70E-9 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.103 2.58E-9 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.102 3.41E-9 YOL149W DCP1 het Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress
0.100 6.38E-9 YGR245C SDA1 het Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
0.097 1.74E-8 YGR200C ELP2 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
0.096 2.54E-8 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.096 2.78E-8 YEL019C MMS21 het SUMO ligase and component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination
0.092 1.09E-7 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.090 1.62E-7 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.089 2.55E-7 YIL078W THS1 het Threonyl-tRNA synthetase, essential cytoplasmic protein