YDR473C / PRP3

Splicing factor, component of the U4/U6-U5 snRNP complex

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR473C / PRP3

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:4.18|P-value:1.46E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:4.66|P-value:2.74E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:3.77|P-value:5.49E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:4.36|P-value:7.97E-5 ID:SGTC_575|Compound:k072-0246|FD-Score:3.83|P-value:4.55E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:-3.63|P-value:8.17E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:4.72|P-value:2.22E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:3.70|P-value:6.79E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:3.78|P-value:5.35E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:-3.89|P-value:3.63E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.77|P-value:5.56E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.86|P-value:4.15E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:4.63|P-value:3.02E-5 ID:SGTC_1330|Compound:1469-0054|FD-Score:-3.62|P-value:8.35E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:-3.85|P-value:4.10E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:4.14|P-value:1.71E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:4.96|P-value:8.78E-6 ID:SGTC_1378|Compound:2093-0007|FD-Score:4.11|P-value:1.87E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.79|P-value:1.67E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.81|P-value:4.91E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.99|P-value:2.77E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:4.46|P-value:5.60E-5 ID:SGTC_1638|Compound:st008370|FD-Score:5.47|P-value:1.08E-6 ID:SGTC_1669|Compound:st015249|FD-Score:3.60|P-value:9.28E-4 ID:SGTC_1771|Compound:st048882|FD-Score:4.29|P-value:1.03E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.64|P-value:8.22E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-4.40|P-value:6.61E-5 ID:SGTC_2053|Compound:5265679|FD-Score:-3.92|P-value:3.33E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-3.57|P-value:9.64E-4 ID:SGTC_2304|Compound:7443016|FD-Score:3.57|P-value:9.92E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.65|P-value:8.01E-4 ID:SGTC_2461|Compound:5755302|FD-Score:-4.09|P-value:1.88E-4 ID:SGTC_2570|Compound:licareol|FD-Score:4.74|P-value:2.05E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:5.87|P-value:1.86E-7 ID:SGTC_2646|Compound:retinol|FD-Score:4.00|P-value:2.65E-4 ID:SGTC_2707|Compound:st078556|FD-Score:-4.88|P-value:1.12E-5 ID:SGTC_2943|Compound:9068529|FD-Score:4.60|P-value:3.47E-5 ID:SGTC_2970|Compound:9090938|FD-Score:-3.66|P-value:7.29E-4 ID:SGTC_2987|Compound:9018338|FD-Score:4.92|P-value:1.05E-5 ID:SGTC_2995|Compound:9067767|FD-Score:-3.84|P-value:4.21E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-3.84|P-value:4.29E-4 ID:SGTC_3078|Compound:9116413|FD-Score:4.70|P-value:2.35E-5 ID:SGTC_3102|Compound:9121669|FD-Score:4.12|P-value:1.81E-4 ID:SGTC_3213|Compound:9129884|FD-Score:3.87|P-value:4.05E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:4.18|P-value:1.46E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:4.66|P-value:2.74E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:3.77|P-value:5.49E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:4.36|P-value:7.97E-5 ID:SGTC_575|Compound:k072-0246|FD-Score:3.83|P-value:4.55E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:-3.63|P-value:8.17E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:4.72|P-value:2.22E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:3.70|P-value:6.79E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:3.78|P-value:5.35E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:-3.89|P-value:3.63E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.77|P-value:5.56E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.86|P-value:4.15E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:4.63|P-value:3.02E-5 ID:SGTC_1330|Compound:1469-0054|FD-Score:-3.62|P-value:8.35E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:-3.85|P-value:4.10E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:4.14|P-value:1.71E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:4.96|P-value:8.78E-6 ID:SGTC_1378|Compound:2093-0007|FD-Score:4.11|P-value:1.87E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.79|P-value:1.67E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.81|P-value:4.91E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.99|P-value:2.77E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:4.46|P-value:5.60E-5 ID:SGTC_1638|Compound:st008370|FD-Score:5.47|P-value:1.08E-6 ID:SGTC_1669|Compound:st015249|FD-Score:3.60|P-value:9.28E-4 ID:SGTC_1771|Compound:st048882|FD-Score:4.29|P-value:1.03E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.64|P-value:8.22E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-4.40|P-value:6.61E-5 ID:SGTC_2053|Compound:5265679|FD-Score:-3.92|P-value:3.33E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-3.57|P-value:9.64E-4 ID:SGTC_2304|Compound:7443016|FD-Score:3.57|P-value:9.92E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.65|P-value:8.01E-4 ID:SGTC_2461|Compound:5755302|FD-Score:-4.09|P-value:1.88E-4 ID:SGTC_2570|Compound:licareol|FD-Score:4.74|P-value:2.05E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:5.87|P-value:1.86E-7 ID:SGTC_2646|Compound:retinol|FD-Score:4.00|P-value:2.65E-4 ID:SGTC_2707|Compound:st078556|FD-Score:-4.88|P-value:1.12E-5 ID:SGTC_2943|Compound:9068529|FD-Score:4.60|P-value:3.47E-5 ID:SGTC_2970|Compound:9090938|FD-Score:-3.66|P-value:7.29E-4 ID:SGTC_2987|Compound:9018338|FD-Score:4.92|P-value:1.05E-5 ID:SGTC_2995|Compound:9067767|FD-Score:-3.84|P-value:4.21E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-3.84|P-value:4.29E-4 ID:SGTC_3078|Compound:9116413|FD-Score:4.70|P-value:2.35E-5 ID:SGTC_3102|Compound:9121669|FD-Score:4.12|P-value:1.81E-4 ID:SGTC_3213|Compound:9129884|FD-Score:3.87|P-value:4.05E-4

Top fitness defect scores for YDR473C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2613 3',4'-dimethoxydalbergione 5.87 24.6 µM 1.86E-7 2 2.18E-9 0.89
2 SGTC_1638 st008370 5.47 60.6 µM 1.08E-6 ergosterol biosynthesis 7 2.22E-8 0.12
3 SGTC_1336 1486-0901 4.96 104.0 µM 8.78E-6 1 3.52E-7 0.66
4 SGTC_2987 9018338 4.92 71.4 µM 1.05E-5 RPP1 & pyrimidine depletion 3 4.43E-7 0.51
5 SGTC_1383 3049-0032 4.79 20.7 µM 1.67E-5 60S ribosome export 5 8.19E-7 0.20
6 SGTC_2570 licareol 4.74 100.0 µM 2.05E-5 2 1.07E-6 0.49
7 SGTC_662 k832-1615 4.72 104.0 µM 2.22E-5 1 1.20E-6 0.30
8 SGTC_3078 9116413 4.70 49.5 µM 2.35E-5 unfolded protein response 2 1.29E-6 0.42
9 SGTC_128 0906-2981 4.66 13.4 µM 2.74E-5 4 1.58E-6 0.40
10 SGTC_1071 trifluoperazine 4.63 6.3 µM 3.02E-5 3 1.79E-6 0.34
11 SGTC_2943 9068529 4.60 45.3 µM 3.47E-5 11 2.15E-6 0.83
12 SGTC_1576 erythromycin ethylsuccinate 4.46 23.2 µM 5.60E-5 3 4.04E-6 0.31
13 SGTC_572 0960-0087 4.36 17.7 µM 7.97E-5 8 6.41E-6 0.03
14 SGTC_1771 st048882 4.29 4.2 µM 1.03E-4 RPP1 & pyrimidine depletion 7 9.00E-6 0.16
15 SGTC_37 0566-0070 4.18 1.6 µM 1.46E-4 3 1.43E-5 0.08
16 SGTC_1335 1486-0900 4.14 202.0 µM 1.71E-4 2 1.75E-5 0.03
17 SGTC_3102 9121669 4.12 49.5 µM 1.81E-4 4 1.89E-5 0.68
18 SGTC_1378 2093-0007 4.11 380.0 nM 1.87E-4 3 1.96E-5 0.06
19 SGTC_2646 retinol 4.00 96.8 µM 2.65E-4 2 3.11E-5 0.33
20 SGTC_1507 4075-3230 3.99 155.0 µM 2.77E-4 3 3.29E-5 0.45

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.093 6.91E-8 YLR263W RED1 hom Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p
0.086 7.23E-7 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.078 7.11E-6 YPR068C HOS1 hom Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex
0.075 1.23E-5 YDR489W SLD5 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.071 3.73E-5 YOR142W LSC1 hom Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated
0.069 5.79E-5 YOR279C RFM1 hom DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance
0.067 1.17E-4 YBR241C_p YBR241C_p hom Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene
0.063 2.82E-4 YLR053C_p YLR053C_p hom Putative protein of unknown function
0.062 3.57E-4 YKL130C SHE2 hom RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud
0.062 3.69E-4 YGR145W ENP2 het Essential nucleolar protein, required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p
0.061 3.89E-4 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.061 4.01E-4 YGR233C PHO81 hom Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress
0.060 5.05E-4 YGR094W VAS1 het Mitochondrial and cytoplasmic valyl-tRNA synthetase
0.060 5.17E-4 YJL078C PRY3 hom Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p
0.059 6.05E-4 YGR287C IMA1 hom Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; specificity for isomaltose, alpha-methylglucoside, and palatinose; member of the IMA isomaltase family