YDR475C / JIP4

Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR475C / JIP4

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:3.35|P-value:3.28E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:3.86|P-value:4.36E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:4.28|P-value:6.80E-6 ID:SGTC_121|Compound:0557-0495|FD-Score:5.86|P-value:1.41E-9 ID:SGTC_138|Compound:0850-0259|FD-Score:5.58|P-value:7.61E-9 ID:SGTC_161|Compound:4065-0411|FD-Score:-3.95|P-value:3.41E-5 ID:SGTC_187|Compound:1488-2104|FD-Score:5.98|P-value:6.60E-10 ID:SGTC_312|Compound:4092-0653|FD-Score:4.76|P-value:6.67E-7 ID:SGTC_314|Compound:1671-0008|FD-Score:4.09|P-value:1.60E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.72|P-value:7.89E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:3.90|P-value:3.70E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.28|P-value:4.72E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.77|P-value:6.31E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:3.27|P-value:4.40E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:4.34|P-value:5.15E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:52.70|P-value:0 ID:SGTC_530|Compound:4358-1714|FD-Score:4.73|P-value:7.87E-7 ID:SGTC_531|Compound:3788-1495|FD-Score:3.81|P-value:5.36E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:10.70|P-value:1.47E-27 ID:SGTC_690|Compound:glyoxal|FD-Score:4.83|P-value:4.70E-7 ID:SGTC_886|Compound:0866-0150|FD-Score:3.34|P-value:3.36E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.08|P-value:9.57E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:-3.13|P-value:8.03E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.78|P-value:6.07E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.63|P-value:1.13E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.24|P-value:4.93E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:9.43|P-value:5.83E-22 ID:SGTC_1712|Compound:st032288|FD-Score:17.60|P-value:1.68E-71 ID:SGTC_1800|Compound:st050079|FD-Score:3.51|P-value:1.78E-4 ID:SGTC_1812|Compound:st052057|FD-Score:3.11|P-value:7.71E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.07|P-value:1.78E-5 ID:SGTC_2333|Compound:9017922|FD-Score:3.34|P-value:3.38E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.39|P-value:3.12E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.21|P-value:5.48E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.25|P-value:4.71E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.52|P-value:1.89E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.74|P-value:2.12E-15 ID:SGTC_2810|Compound:7959871|FD-Score:4.64|P-value:1.24E-6 ID:SGTC_2927|Compound:9011802|FD-Score:3.14|P-value:7.04E-4 ID:SGTC_2958|Compound:9077254|FD-Score:3.38|P-value:2.91E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.12|P-value:7.56E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.68|P-value:9.09E-5 ID:SGTC_3194|Compound:9111903|FD-Score:3.23|P-value:5.10E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-4.59|P-value:1.80E-6 ID:SGTC_17|Compound:0960-0276|FD-Score:3.35|P-value:3.28E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:3.86|P-value:4.36E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:4.28|P-value:6.80E-6 ID:SGTC_121|Compound:0557-0495|FD-Score:5.86|P-value:1.41E-9 ID:SGTC_138|Compound:0850-0259|FD-Score:5.58|P-value:7.61E-9 ID:SGTC_161|Compound:4065-0411|FD-Score:-3.95|P-value:3.41E-5 ID:SGTC_187|Compound:1488-2104|FD-Score:5.98|P-value:6.60E-10 ID:SGTC_312|Compound:4092-0653|FD-Score:4.76|P-value:6.67E-7 ID:SGTC_314|Compound:1671-0008|FD-Score:4.09|P-value:1.60E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.72|P-value:7.89E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:3.90|P-value:3.70E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.28|P-value:4.72E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.77|P-value:6.31E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:3.27|P-value:4.40E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:4.34|P-value:5.15E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:52.70|P-value:0 ID:SGTC_530|Compound:4358-1714|FD-Score:4.73|P-value:7.87E-7 ID:SGTC_531|Compound:3788-1495|FD-Score:3.81|P-value:5.36E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:10.70|P-value:1.47E-27 ID:SGTC_690|Compound:glyoxal|FD-Score:4.83|P-value:4.70E-7 ID:SGTC_886|Compound:0866-0150|FD-Score:3.34|P-value:3.36E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.08|P-value:9.57E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:-3.13|P-value:8.03E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.78|P-value:6.07E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.63|P-value:1.13E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.24|P-value:4.93E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:9.43|P-value:5.83E-22 ID:SGTC_1712|Compound:st032288|FD-Score:17.60|P-value:1.68E-71 ID:SGTC_1800|Compound:st050079|FD-Score:3.51|P-value:1.78E-4 ID:SGTC_1812|Compound:st052057|FD-Score:3.11|P-value:7.71E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.07|P-value:1.78E-5 ID:SGTC_2333|Compound:9017922|FD-Score:3.34|P-value:3.38E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.39|P-value:3.12E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.21|P-value:5.48E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.25|P-value:4.71E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.52|P-value:1.89E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.74|P-value:2.12E-15 ID:SGTC_2810|Compound:7959871|FD-Score:4.64|P-value:1.24E-6 ID:SGTC_2927|Compound:9011802|FD-Score:3.14|P-value:7.04E-4 ID:SGTC_2958|Compound:9077254|FD-Score:3.38|P-value:2.91E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.12|P-value:7.56E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.68|P-value:9.09E-5 ID:SGTC_3194|Compound:9111903|FD-Score:3.23|P-value:5.10E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-4.59|P-value:1.80E-6

Top fitness defect scores for YDR475C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_528 3492-0019 52.70 172.0 µM 0 calcium & mitochondrial duress 1 0
2 SGTC_1712 st032288 17.60 53.4 µM 1.68E-71 calcium & mitochondrial duress 1 1.05E-69
3 SGTC_582 0987-0078 10.70 156.0 µM 1.47E-27 calcium & mitochondrial duress 7 7.16E-27
4 SGTC_1597 7-benzyloxygramine 9.43 47.5 µM 5.83E-22 calcium & mitochondrial duress 15 2.05E-21
5 SGTC_2688 kanamycin b 7.74 96.7 µM 2.12E-15 calcium & mitochondrial duress 76 5.06E-15
6 SGTC_187 1488-2104 5.98 32.7 µM 6.60E-10 calcium & mitochondrial duress 15 1.14E-9
7 SGTC_121 0557-0495 5.86 61.3 µM 1.41E-9 calcium & mitochondrial duress 20 2.38E-9
8 SGTC_138 0850-0259 5.58 40.9 µM 7.61E-9 cell wall 120 1.23E-8
9 SGTC_690 glyoxal 4.83 20.3 µM 4.70E-7 60 6.84E-7
10 SGTC_312 4092-0653 4.76 6.8 µM 6.67E-7 ergosterol depletion effects on membrane 63 9.61E-7
11 SGTC_530 4358-1714 4.73 28.0 µM 7.87E-7 23 1.13E-6
12 SGTC_2810 7959871 4.64 45.5 µM 1.24E-6 copper-dependent oxidative stress 26 1.76E-6
13 SGTC_525 k781-2675 4.34 26.7 µM 5.15E-6 redox potentiating 45 7.03E-6
14 SGTC_117 lucigenin 4.28 22.1 µM 6.80E-6 redox potentiating 70 9.21E-6
15 SGTC_314 1671-0008 4.09 2.7 µM 1.60E-5 46 2.12E-5
16 SGTC_2021 4019055 4.07 173.0 µM 1.78E-5 endomembrane recycling 117 2.36E-5
17 SGTC_429 1112-0049 3.90 25.5 µM 3.70E-5 DNA damage response 34 4.80E-5
18 SGTC_99 0109-0120 3.86 622.8 µM 4.36E-5 17 5.63E-5
19 SGTC_531 3788-1495 3.81 174.0 µM 5.36E-5 unfolded protein response 19 6.88E-5
20 SGTC_1215 3852-0577 3.78 11.2 µM 6.07E-5 20 7.77E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.575 4.30E-294 YOR086C TCB1 hom Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.558 4.67E-273 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.483 3.89E-196 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.432 5.35E-153 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.405 1.89E-132 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.400 4.10E-129 YBL051C PIN4 hom Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
0.395 7.48E-126 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.384 3.29E-118 YOL016C CMK2 hom Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication
0.372 1.92E-110 YJL129C TRK1 hom Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication
0.362 2.79E-104 YLR404W FLD1 hom Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy
0.361 3.82E-104 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.359 7.89E-103 YNL264C PDR17 hom Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition
0.340 1.29E-91 YBL022C PIM1 hom ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
0.340 3.01E-91 YGR237C_p YGR237C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.339 9.81E-91 YIL105C SLM1 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication