YDR476C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR476C / YDR476C

Click on Significant Values for Screen Details ID:SGTC_188|Compound:3229-0966|FD-Score:3.32|P-value:2.02E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.40|P-value:1.48E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:-3.03|P-value:5.84E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:-3.56|P-value:6.99E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.88|P-value:1.75E-5 ID:SGTC_416|Compound:estradiol valerate|FD-Score:4.27|P-value:2.66E-6 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.13|P-value:4.25E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.02|P-value:6.41E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.03|P-value:5.94E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.00|P-value:6.52E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.58|P-value:6.71E-5 ID:SGTC_665|Compound:3914-0008|FD-Score:3.11|P-value:4.57E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.18|P-value:3.52E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-2.89|P-value:9.85E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:2.99|P-value:7.21E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.24|P-value:2.66E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:4.31|P-value:2.14E-6 ID:SGTC_1078|Compound:idebenone|FD-Score:3.44|P-value:1.22E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.30|P-value:2.19E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.86|P-value:1.98E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:4.24|P-value:3.06E-6 ID:SGTC_1314|Compound:1222-0010|FD-Score:2.96|P-value:8.21E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.27|P-value:2.44E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:4.10|P-value:6.10E-6 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.91|P-value:1.56E-5 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.91|P-value:1.55E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:2.97|P-value:7.79E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.18|P-value:3.58E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.83|P-value:2.03E-5 ID:SGTC_1731|Compound:st035964|FD-Score:3.39|P-value:1.54E-4 ID:SGTC_1735|Compound:st034310|FD-Score:6.66|P-value:5.80E-13 ID:SGTC_1736|Compound:st036774|FD-Score:5.76|P-value:4.01E-10 ID:SGTC_1761|Compound:st044296|FD-Score:-3.12|P-value:4.18E-4 ID:SGTC_1848|Compound:st056003|FD-Score:-3.26|P-value:2.39E-4 ID:SGTC_2196|Compound:6573537|FD-Score:-3.18|P-value:3.34E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-4.00|P-value:9.34E-6 ID:SGTC_2415|Compound:st077333|FD-Score:3.73|P-value:3.50E-5 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-2.94|P-value:8.12E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.63|P-value:5.10E-5 ID:SGTC_2467|Compound:5474540|FD-Score:-3.48|P-value:9.63E-5 ID:SGTC_2472|Compound:5377652|FD-Score:-2.99|P-value:6.79E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.16|P-value:3.73E-4 ID:SGTC_2478|Compound:5763493|FD-Score:4.11|P-value:5.91E-6 ID:SGTC_2482|Compound:5981709|FD-Score:4.72|P-value:2.47E-7 ID:SGTC_2833|Compound:9001315|FD-Score:-3.06|P-value:5.17E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.32|P-value:2.03E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-4.58|P-value:4.89E-7 ID:SGTC_2939|Compound:9044578|FD-Score:-4.74|P-value:2.02E-7 ID:SGTC_3126|Compound:9127922|FD-Score:3.50|P-value:9.52E-5 ID:SGTC_3336|Compound:9143619|FD-Score:3.39|P-value:1.50E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.32|P-value:2.02E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.40|P-value:1.48E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:-3.03|P-value:5.84E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:-3.56|P-value:6.99E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.88|P-value:1.75E-5 ID:SGTC_416|Compound:estradiol valerate|FD-Score:4.27|P-value:2.66E-6 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.13|P-value:4.25E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.02|P-value:6.41E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.03|P-value:5.94E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.00|P-value:6.52E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.58|P-value:6.71E-5 ID:SGTC_665|Compound:3914-0008|FD-Score:3.11|P-value:4.57E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.18|P-value:3.52E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-2.89|P-value:9.85E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:2.99|P-value:7.21E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.24|P-value:2.66E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:4.31|P-value:2.14E-6 ID:SGTC_1078|Compound:idebenone|FD-Score:3.44|P-value:1.22E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.30|P-value:2.19E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.86|P-value:1.98E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:4.24|P-value:3.06E-6 ID:SGTC_1314|Compound:1222-0010|FD-Score:2.96|P-value:8.21E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.27|P-value:2.44E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:4.10|P-value:6.10E-6 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.91|P-value:1.56E-5 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.91|P-value:1.55E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:2.97|P-value:7.79E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.18|P-value:3.58E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.83|P-value:2.03E-5 ID:SGTC_1731|Compound:st035964|FD-Score:3.39|P-value:1.54E-4 ID:SGTC_1735|Compound:st034310|FD-Score:6.66|P-value:5.80E-13 ID:SGTC_1736|Compound:st036774|FD-Score:5.76|P-value:4.01E-10 ID:SGTC_1761|Compound:st044296|FD-Score:-3.12|P-value:4.18E-4 ID:SGTC_1848|Compound:st056003|FD-Score:-3.26|P-value:2.39E-4 ID:SGTC_2196|Compound:6573537|FD-Score:-3.18|P-value:3.34E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-4.00|P-value:9.34E-6 ID:SGTC_2415|Compound:st077333|FD-Score:3.73|P-value:3.50E-5 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-2.94|P-value:8.12E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.63|P-value:5.10E-5 ID:SGTC_2467|Compound:5474540|FD-Score:-3.48|P-value:9.63E-5 ID:SGTC_2472|Compound:5377652|FD-Score:-2.99|P-value:6.79E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.16|P-value:3.73E-4 ID:SGTC_2478|Compound:5763493|FD-Score:4.11|P-value:5.91E-6 ID:SGTC_2482|Compound:5981709|FD-Score:4.72|P-value:2.47E-7 ID:SGTC_2833|Compound:9001315|FD-Score:-3.06|P-value:5.17E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.32|P-value:2.03E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-4.58|P-value:4.89E-7 ID:SGTC_2939|Compound:9044578|FD-Score:-4.74|P-value:2.02E-7 ID:SGTC_3126|Compound:9127922|FD-Score:3.50|P-value:9.52E-5 ID:SGTC_3336|Compound:9143619|FD-Score:3.39|P-value:1.50E-4

Top fitness defect scores for YDR476C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1735 st034310 6.66 56.8 µM 5.80E-13 Golgi 2 1.33E-11
2 SGTC_1736 st036774 5.76 51.0 µM 4.01E-10 9 4.19E-9
3 SGTC_2482 5981709 4.72 142.7 µM 2.47E-7 PDR1 26 1.21E-6
4 SGTC_1066 ketoconazole 4.31 628.0 nM 2.14E-6 12 8.08E-6
5 SGTC_416 estradiol valerate 4.27 100.0 µM 2.66E-6 3 9.81E-6
6 SGTC_1257 0669-0121 4.24 16.0 µM 3.06E-6 17 1.11E-5
7 SGTC_2478 5763493 4.11 32.3 µM 5.91E-6 22 1.99E-5
8 SGTC_1356 1502-0781 4.10 85.8 µM 6.10E-6 fatty acid desaturase (OLE1) 14 2.04E-5
9 SGTC_1379 2144-0755 3.91 36.5 µM 1.55E-5 25 4.65E-5
10 SGTC_1360 1598-0022 3.91 39.8 µM 1.56E-5 ERG2 28 4.67E-5
11 SGTC_407 eburnamonine 3.88 100.0 µM 1.75E-5 12 5.17E-5
12 SGTC_1243 0416-0003 3.86 5.7 µM 1.98E-5 PDR1 33 5.77E-5
13 SGTC_2415 st077333 3.73 57.7 µM 3.50E-5 56 9.55E-5
14 SGTC_534 k292-0788 3.58 63.4 µM 6.71E-5 mitochondrial processes 42 1.70E-4
15 SGTC_3126 9127922 3.50 49.5 µM 9.52E-5 fatty acid desaturase (OLE1) 52 2.31E-4
16 SGTC_1078 idebenone 3.44 36.1 µM 1.22E-4 Golgi 60 2.88E-4
17 SGTC_358 0075-0058 3.40 9.4 µM 1.48E-4 93 3.42E-4
18 SGTC_3336 9143619 3.39 71.4 µM 1.50E-4 35 3.46E-4
19 SGTC_1731 st035964 3.39 63.0 µM 1.54E-4 52 3.54E-4
20 SGTC_188 3229-0966 3.32 278.5 µM 2.02E-4 54 4.52E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.42E-13 YBL064C PRX1 hom Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress
0.116 1.75E-11 YBL035C POL12 het B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation
0.113 4.83E-11 YDR422C SIP1 hom Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions
0.107 5.28E-10 YDR295C HDA2 hom Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance
0.107 5.63E-10 YDR426C_d YDR426C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41
0.106 8.38E-10 YCR030C SYP1 hom Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization
0.105 1.12E-9 YHR044C DOG1 hom 2-deoxyglucose-6-phosphate phosphatase; paralogous to DOG2; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified
0.103 2.49E-9 YPL152W-A_p YPL152W-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.101 4.16E-9 YGL185C_p YGL185C_p hom Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.097 1.57E-8 YPR113W PIS1 het Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins
0.096 2.20E-8 YNL104C LEU4 hom Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication
0.091 1.42E-7 YKL001C MET14 hom Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
0.086 6.02E-7 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.085 7.46E-7 YDR370C DXO1 hom Protein with decapping and 5′-3′ exoRNase activity; similar to Rai1p
0.084 1.07E-6 YDR528W HLR1 hom Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A;
HLR1 has a paralog, LRE1, that arose from the whole genome duplication