HIPHOP chemogenomics database

YDR478W / SNM1

Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP

Zygosity: Heterozygous strain

fixedexpanded
Profile for YDR478W / SNM1

Click on Significant Values for Screen Details

Top fitness defect scores for YDR478W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_2966	9084041	6.50	48.0 µM	5.16E-10		1	4.02E-11	2.56
2	SGTC_78	0336-0123	5.31	156.8 µM	3.14E-7		4	5.59E-8	0.82
3	SGTC_2351	9026858	4.40	72.3 µM	1.84E-5	RNA processing & uracil transport	8	5.50E-6	0.03
4	SGTC_1049	3226-0134	4.31	66.0 µM	2.57E-5		6	8.01E-6	0.28
5	SGTC_1240	0356-0016	4.13	42.1 µM	5.21E-5	mitochondrial response to ROS	5	1.78E-5	0.23
6	SGTC_2801	7907800	4.06	81.8 µM	7.01E-5		6	2.49E-5	0.35
7	SGTC_3349	9149703	3.94	23.0 µM	1.08E-4		1	4.05E-5	0.45
8	SGTC_1930	st074634	3.92	34.3 µM	1.18E-4	RNA pol III & RNase P/MRP	13	4.47E-5	0.01
9	SGTC_896	0964-0007	3.91	44.5 µM	1.21E-4		11	4.59E-5	0.41
10	SGTC_2296	7971656	3.90	126.5 µM	1.28E-4		7	4.90E-5	0.02
11	SGTC_453	enantio-paf c16	3.88	10.0 µM	1.35E-4		23	5.19E-5	0.25
12	SGTC_454	lyso-paf C-16	3.86	6.7 µM	1.44E-4		4	5.60E-5	0.05
13	SGTC_1629	st005085	3.75	44.9 µM	2.18E-4	RPP1 & pyrimidine depletion	14	8.92E-5	0.01
14	SGTC_1126	isoteolin	3.70	1.0 µM	2.55E-4		7	1.06E-4	0.10
15	SGTC_2085	5307070	3.69	144.1 µM	2.63E-4	superoxide	10	1.10E-4	0.06
16	SGTC_2203	7227154	3.63	166.4 µM	3.31E-4		3	1.43E-4	0.89
17	SGTC_1308	1187-1617	3.54	41.4 µM	4.50E-4	fatty acid desaturase (OLE1)	18	2.02E-4	0.10
18	SGTC_68	0986-0284	3.52	82.8 µM	4.84E-4		16	2.19E-4	0.02
19	SGTC_1664	st014217	3.47	9.0 µM	5.63E-4	60S ribosome export	11	2.59E-4	0.24
20	SGTC_2155	5570423	3.41	76.0 µM	6.91E-4	ergosterol biosynthesis	7	3.26E-4	0.04

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.272	4.75E-58	YDL060W	TSR1	het	Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.270	4.14E-57	YHR166C	CDC23	het	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.249	1.21E-48	YJL143W	TIM17	het	Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex
0.218	2.50E-37	YER171W	RAD3	het	5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress
0.198	6.13E-31	YGR036C	CAX4	hom	Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
0.195	3.73E-30	YBR155W	CNS1	het	TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.194	6.22E-30	YNR017W	TIM23	het	Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel
0.190	1.13E-28	YNL161W	CBK1	het	Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
0.185	2.28E-27	YDR023W	SES1	het	Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.183	1.23E-26	YOR159C	SME1	het	Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.163	2.10E-21	YIL147C	SLN1	het	Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
0.148	7.84E-18	YDR397C	NCB2	het	Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta
0.146	1.64E-17	YDL007W	RPT2	het	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
0.146	1.82E-17	YMR270C	RRN9	het	Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I
0.146	2.25E-17	YPR103W	PRE2	het	Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome