YDR480W / DIG2

MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR480W / DIG2

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-5.68|P-value:3.54E-9 ID:SGTC_88|Compound:0180-0332|FD-Score:4.56|P-value:1.34E-6 ID:SGTC_96|Compound:0929-0093|FD-Score:3.80|P-value:4.52E-5 ID:SGTC_128|Compound:0906-2981|FD-Score:3.05|P-value:8.24E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.24|P-value:5.00E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:3.25|P-value:3.94E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:3.46|P-value:1.80E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:-3.39|P-value:2.86E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.11|P-value:6.69E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:6.41|P-value:2.28E-11 ID:SGTC_501|Compound:nsc-95397|FD-Score:-3.14|P-value:7.22E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.15|P-value:5.82E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:3.32|P-value:3.10E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:3.38|P-value:2.40E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.59|P-value:1.08E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.03|P-value:8.90E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.28|P-value:3.60E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.35|P-value:2.73E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-4.18|P-value:1.06E-5 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.04|P-value:8.57E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.36|P-value:2.59E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.36|P-value:2.62E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.93|P-value:2.58E-5 ID:SGTC_1452|Compound:4194-0072|FD-Score:-3.13|P-value:7.30E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.62|P-value:5.21E-9 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.12|P-value:1.40E-5 ID:SGTC_1731|Compound:st035964|FD-Score:3.57|P-value:1.18E-4 ID:SGTC_1739|Compound:st037196|FD-Score:4.15|P-value:9.36E-6 ID:SGTC_1748|Compound:st037455|FD-Score:3.08|P-value:7.44E-4 ID:SGTC_1749|Compound:st037932|FD-Score:5.07|P-value:9.25E-8 ID:SGTC_1780|Compound:st038448|FD-Score:4.51|P-value:1.68E-6 ID:SGTC_1855|Compound:st056195|FD-Score:3.54|P-value:1.33E-4 ID:SGTC_1857|Compound:st056007|FD-Score:-3.31|P-value:3.87E-4 ID:SGTC_1895|Compound:st058434|FD-Score:3.62|P-value:9.29E-5 ID:SGTC_1982|Compound:st072467|FD-Score:3.45|P-value:1.87E-4 ID:SGTC_2324|Compound:6149169|FD-Score:5.50|P-value:7.60E-9 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.31|P-value:3.22E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.43|P-value:2.02E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.88|P-value:3.22E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.46|P-value:1.82E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.33|P-value:3.00E-4 ID:SGTC_2731|Compound:amoxapine|FD-Score:-3.13|P-value:7.35E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.60|P-value:1.29E-4 ID:SGTC_2797|Compound:7859098|FD-Score:4.72|P-value:5.81E-7 ID:SGTC_2807|Compound:7945238|FD-Score:4.15|P-value:9.42E-6 ID:SGTC_3307|Compound:9126885|FD-Score:3.30|P-value:3.34E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.97|P-value:2.11E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.68|P-value:3.54E-9 ID:SGTC_88|Compound:0180-0332|FD-Score:4.56|P-value:1.34E-6 ID:SGTC_96|Compound:0929-0093|FD-Score:3.80|P-value:4.52E-5 ID:SGTC_128|Compound:0906-2981|FD-Score:3.05|P-value:8.24E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.24|P-value:5.00E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:3.25|P-value:3.94E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:3.46|P-value:1.80E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:-3.39|P-value:2.86E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.11|P-value:6.69E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:6.41|P-value:2.28E-11 ID:SGTC_501|Compound:nsc-95397|FD-Score:-3.14|P-value:7.22E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.15|P-value:5.82E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:3.32|P-value:3.10E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:3.38|P-value:2.40E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.59|P-value:1.08E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.03|P-value:8.90E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.28|P-value:3.60E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.35|P-value:2.73E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-4.18|P-value:1.06E-5 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.04|P-value:8.57E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.36|P-value:2.59E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.36|P-value:2.62E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.93|P-value:2.58E-5 ID:SGTC_1452|Compound:4194-0072|FD-Score:-3.13|P-value:7.30E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.62|P-value:5.21E-9 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.12|P-value:1.40E-5 ID:SGTC_1731|Compound:st035964|FD-Score:3.57|P-value:1.18E-4 ID:SGTC_1739|Compound:st037196|FD-Score:4.15|P-value:9.36E-6 ID:SGTC_1748|Compound:st037455|FD-Score:3.08|P-value:7.44E-4 ID:SGTC_1749|Compound:st037932|FD-Score:5.07|P-value:9.25E-8 ID:SGTC_1780|Compound:st038448|FD-Score:4.51|P-value:1.68E-6 ID:SGTC_1855|Compound:st056195|FD-Score:3.54|P-value:1.33E-4 ID:SGTC_1857|Compound:st056007|FD-Score:-3.31|P-value:3.87E-4 ID:SGTC_1895|Compound:st058434|FD-Score:3.62|P-value:9.29E-5 ID:SGTC_1982|Compound:st072467|FD-Score:3.45|P-value:1.87E-4 ID:SGTC_2324|Compound:6149169|FD-Score:5.50|P-value:7.60E-9 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.31|P-value:3.22E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.43|P-value:2.02E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.88|P-value:3.22E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.46|P-value:1.82E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.33|P-value:3.00E-4 ID:SGTC_2731|Compound:amoxapine|FD-Score:-3.13|P-value:7.35E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.60|P-value:1.29E-4 ID:SGTC_2797|Compound:7859098|FD-Score:4.72|P-value:5.81E-7 ID:SGTC_2807|Compound:7945238|FD-Score:4.15|P-value:9.42E-6 ID:SGTC_3307|Compound:9126885|FD-Score:3.30|P-value:3.34E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.97|P-value:2.11E-5

Top fitness defect scores for YDR480W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_427 1354-0053 6.41 47.3 µM 2.28E-11 1 7.46E-11
2 SGTC_2324 6149169 5.50 200.0 µM 7.60E-9 5 1.88E-8
3 SGTC_1749 st037932 5.07 54.2 µM 9.25E-8 17 2.02E-7
4 SGTC_2797 7859098 4.72 81.8 µM 5.81E-7 16 1.16E-6
5 SGTC_88 0180-0332 4.56 8.7 µM 1.34E-6 12 2.58E-6
6 SGTC_1780 st038448 4.51 24.5 µM 1.68E-6 iron homeostasis 5 3.19E-6
7 SGTC_1739 st037196 4.15 92.5 µM 9.36E-6 16 1.63E-5
8 SGTC_2807 7945238 4.15 52.0 µM 9.42E-6 16 1.64E-5
9 SGTC_3332 9141069 3.97 11.2 µM 2.11E-5 15 3.53E-5
10 SGTC_1230 0170-0365 3.93 3.8 µM 2.58E-5 endomembrane recycling 67 4.27E-5
11 SGTC_2544 sphondin 3.88 68.5 µM 3.22E-5 RNA pol III & RNase P/MRP 27 5.28E-5
12 SGTC_96 0929-0093 3.80 37.3 µM 4.52E-5 calcium & mitochondrial duress 16 7.29E-5
13 SGTC_1895 st058434 3.62 18.3 µM 9.29E-5 20 1.45E-4
14 SGTC_813 k007-0158 3.59 173.0 µM 1.08E-4 fatty acid desaturase (OLE1) 60 1.67E-4
15 SGTC_1731 st035964 3.57 63.0 µM 1.18E-4 43 1.81E-4
16 SGTC_1855 st056195 3.54 39.6 µM 1.33E-4 60S ribosome export 28 2.03E-4
17 SGTC_338 4055-0136 3.46 114.0 µM 1.80E-4 19 2.71E-4
18 SGTC_2594 a-mangostin 3.46 100.0 µM 1.82E-4 49 2.75E-4
19 SGTC_1982 st072467 3.45 71.9 µM 1.87E-4 57 2.81E-4
20 SGTC_2460 5552655 3.43 174.2 µM 2.02E-4 amide catabolism 47 3.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.241 1.82E-45 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.187 1.13E-27 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.185 2.85E-27 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.176 1.22E-24 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.171 1.74E-23 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.171 2.48E-23 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.169 8.05E-23 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.167 2.12E-22 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.161 8.43E-21 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.155 1.38E-19 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.153 4.04E-19 YGR072W UPF3 hom Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance
0.152 8.29E-19 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.151 1.69E-18 YDL199C_p YDL199C_p hom Putative transporter, member of the sugar porter family
0.143 7.19E-17 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.143 1.05E-16 YKL130C SHE2 hom RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud