YDR482C / CWC21

Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR482C / CWC21

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:3.38|P-value:8.10E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.86|P-value:1.60E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:5.24|P-value:4.82E-7 ID:SGTC_161|Compound:4065-0411|FD-Score:-4.46|P-value:1.45E-5 ID:SGTC_162|Compound:k030-0015|FD-Score:5.19|P-value:6.20E-7 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.61|P-value:3.54E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:3.92|P-value:1.27E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:3.43|P-value:6.79E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:-3.45|P-value:6.03E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.37|P-value:8.42E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:-4.11|P-value:5.89E-5 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-3.46|P-value:5.81E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:-3.47|P-value:5.72E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.95|P-value:1.14E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:-3.55|P-value:4.41E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.52|P-value:5.15E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:-3.39|P-value:7.34E-4 ID:SGTC_1912|Compound:st060209|FD-Score:4.75|P-value:4.52E-6 ID:SGTC_1962|Compound:st076595|FD-Score:4.45|P-value:1.62E-5 ID:SGTC_1987|Compound:st072290|FD-Score:4.43|P-value:1.77E-5 ID:SGTC_2021|Compound:4019055|FD-Score:4.67|P-value:6.49E-6 ID:SGTC_2710|Compound:st078562|FD-Score:4.46|P-value:1.58E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:3.32|P-value:9.74E-4 ID:SGTC_2817|Compound:7995342|FD-Score:4.02|P-value:8.75E-5 ID:SGTC_2896|Compound:9052656|FD-Score:3.36|P-value:8.61E-4 ID:SGTC_2975|Compound:9084847|FD-Score:-3.61|P-value:3.62E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.90|P-value:1.38E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-4.57|P-value:9.15E-6 ID:SGTC_2999|Compound:9069765|FD-Score:-4.89|P-value:2.34E-6 ID:SGTC_3037|Compound:9091026|FD-Score:-3.33|P-value:9.07E-4 ID:SGTC_3238|Compound:9133470|FD-Score:-3.53|P-value:4.71E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:3.38|P-value:8.10E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.86|P-value:1.60E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:5.24|P-value:4.82E-7 ID:SGTC_161|Compound:4065-0411|FD-Score:-4.46|P-value:1.45E-5 ID:SGTC_162|Compound:k030-0015|FD-Score:5.19|P-value:6.20E-7 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.61|P-value:3.54E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:3.92|P-value:1.27E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:3.43|P-value:6.79E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:-3.45|P-value:6.03E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.37|P-value:8.42E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:-4.11|P-value:5.89E-5 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-3.46|P-value:5.81E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:-3.47|P-value:5.72E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.95|P-value:1.14E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:-3.55|P-value:4.41E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.52|P-value:5.15E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:-3.39|P-value:7.34E-4 ID:SGTC_1912|Compound:st060209|FD-Score:4.75|P-value:4.52E-6 ID:SGTC_1962|Compound:st076595|FD-Score:4.45|P-value:1.62E-5 ID:SGTC_1987|Compound:st072290|FD-Score:4.43|P-value:1.77E-5 ID:SGTC_2021|Compound:4019055|FD-Score:4.67|P-value:6.49E-6 ID:SGTC_2710|Compound:st078562|FD-Score:4.46|P-value:1.58E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:3.32|P-value:9.74E-4 ID:SGTC_2817|Compound:7995342|FD-Score:4.02|P-value:8.75E-5 ID:SGTC_2896|Compound:9052656|FD-Score:3.36|P-value:8.61E-4 ID:SGTC_2975|Compound:9084847|FD-Score:-3.61|P-value:3.62E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.90|P-value:1.38E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-4.57|P-value:9.15E-6 ID:SGTC_2999|Compound:9069765|FD-Score:-4.89|P-value:2.34E-6 ID:SGTC_3037|Compound:9091026|FD-Score:-3.33|P-value:9.07E-4 ID:SGTC_3238|Compound:9133470|FD-Score:-3.53|P-value:4.71E-4

Top fitness defect scores for YDR482C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_159 3970-0959 5.24 50.0 µM 4.82E-7 34 7.82E-8
2 SGTC_162 k030-0015 5.19 37.8 µM 6.20E-7 iron homeostasis 8 1.04E-7
3 SGTC_1912 st060209 4.75 90.8 µM 4.52E-6 19 1.00E-6
4 SGTC_2021 4019055 4.67 173.0 µM 6.49E-6 endomembrane recycling 80 1.51E-6
5 SGTC_2710 st078562 4.46 53.7 µM 1.58E-5 7 4.16E-6
6 SGTC_1962 st076595 4.45 64.5 µM 1.62E-5 redox potentiating 17 4.27E-6
7 SGTC_1987 st072290 4.43 61.9 µM 1.77E-5 9 4.72E-6
8 SGTC_2817 7995342 4.02 71.4 µM 8.75E-5 22 2.92E-5
9 SGTC_736 0958-0254 3.95 92.6 µM 1.14E-4 Golgi 31 3.93E-5
10 SGTC_235 0330-0087 3.92 5.0 mM 1.27E-4 TSC3-RPN4 24 4.44E-5
11 SGTC_2991 9074669 3.90 71.4 µM 1.38E-4 azole & statin 69 4.88E-5
12 SGTC_8 0354-0001 3.86 70.0 µM 1.60E-4 81 5.79E-5
13 SGTC_1116 jasmonic acid 3.52 1.6 µM 5.15E-4 31 2.18E-4
14 SGTC_295 k015-0027 3.43 31.0 µM 6.79E-4 PDR1 20 2.99E-4
15 SGTC_3 0833-0587 3.38 95.6 µM 8.10E-4 redox potentiating 37 3.66E-4
16 SGTC_369 0957-0393 3.37 4.5 µM 8.42E-4 cell wall signaling 48 3.82E-4
17 SGTC_2896 9052656 3.36 71.4 µM 8.61E-4 endomembrane recycling 161 3.92E-4
18 SGTC_2739 tacrine 3.32 100.9 µM 9.74E-4 heme requiring 34 4.51E-4
19 SGTC_2155 5570423 3.30 76.0 µM 0.00104 ergosterol biosynthesis 25 4.84E-4
20 SGTC_1720 st037298 3.28 9.5 µM 0.00109 67 5.13E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 8.10E-13 YMR230W-A_p YMR230W-A_p hom Putative protein of unknown function
0.121 2.26E-12 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.120 3.08E-12 YGL079W_p KXD1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome
0.112 6.85E-11 YMR134W ERG29 het Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes
0.103 2.23E-9 YGL111W NSA1 het Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
0.102 3.71E-9 YDR330W UBX5 hom UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
0.098 1.09E-8 YGR125W_p YGR125W_p hom Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.098 1.27E-8 YGR008C STF2 hom Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress
0.096 2.23E-8 YGR098C ESP1 het Separase, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; relative distribution to the nucleus increases upon DNA replication stress
0.094 4.22E-8 YLR408C_p BLS1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene
0.091 1.16E-7 YER044C-A MEI4 hom Meiosis-specific protein involved in double-strand break formation during meiotic recombination; required for chromosome synapsis and production of viable spores
0.084 9.86E-7 YDR446W ECM11 hom Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
0.084 1.03E-6 YDR049W VMS1 hom Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans
0.083 1.49E-6 YKR095W MLP1 hom Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs
0.083 1.52E-6 YDL175C AIR2 hom RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication