YDR485C / VPS72

Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR485C / VPS72

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:3.86|P-value:7.93E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:4.74|P-value:5.01E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:10.50|P-value:2.63E-18 ID:SGTC_86|Compound:0417-1630|FD-Score:4.24|P-value:2.53E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:6.01|P-value:3.76E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:5.66|P-value:1.61E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:9.31|P-value:7.64E-15 ID:SGTC_158|Compound:k038-0087|FD-Score:6.76|P-value:1.28E-8 ID:SGTC_172|Compound:1112-0046|FD-Score:5.34|P-value:5.76E-6 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.68|P-value:9.70E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:10.40|P-value:4.28E-18 ID:SGTC_212|Compound:3807-4682|FD-Score:9.34|P-value:6.32E-15 ID:SGTC_214|Compound:4373-3496|FD-Score:4.43|P-value:1.43E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:7.35|P-value:6.92E-10 ID:SGTC_227|Compound:fluconazole|FD-Score:5.58|P-value:2.28E-6 ID:SGTC_229|Compound:benomyl|FD-Score:10.70|P-value:5.38E-19 ID:SGTC_286|Compound:k060-0067|FD-Score:4.35|P-value:1.84E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:5.42|P-value:4.23E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:5.62|P-value:1.94E-6 ID:SGTC_366|Compound:0181-0206|FD-Score:3.94|P-value:6.31E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:8.55|P-value:8.60E-13 ID:SGTC_408|Compound:cantharidin|FD-Score:3.87|P-value:7.80E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.08|P-value:1.50E-5 ID:SGTC_447|Compound:ml7|FD-Score:4.92|P-value:2.70E-5 ID:SGTC_502|Compound:l-744,832|FD-Score:4.73|P-value:5.28E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:10.30|P-value:1.12E-17 ID:SGTC_528|Compound:3492-0019|FD-Score:4.10|P-value:3.90E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:4.10|P-value:3.96E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.05|P-value:4.57E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:7.42|P-value:4.94E-10 ID:SGTC_642|Compound:0335-0876|FD-Score:4.18|P-value:3.06E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:8.32|P-value:3.46E-12 ID:SGTC_794|Compound:k038-0031|FD-Score:6.48|P-value:4.78E-8 ID:SGTC_825|Compound:1988-2224|FD-Score:4.88|P-value:3.10E-5 ID:SGTC_871|Compound:0574-0004|FD-Score:7.62|P-value:1.71E-10 ID:SGTC_897|Compound:1000-0139|FD-Score:10.50|P-value:1.99E-18 ID:SGTC_975|Compound:1335-0046|FD-Score:6.24|P-value:1.40E-7 ID:SGTC_987|Compound:1497-1013|FD-Score:-5.04|P-value:1.16E-5 ID:SGTC_1090|Compound:efavirenz|FD-Score:4.11|P-value:3.84E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.89|P-value:7.24E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:4.37|P-value:1.71E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:-3.84|P-value:6.06E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:4.10|P-value:3.96E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:4.39|P-value:1.60E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:9.69|P-value:6.16E-16 ID:SGTC_1374|Compound:2889-5571|FD-Score:7.62|P-value:1.66E-10 ID:SGTC_1433|Compound:4060-0023|FD-Score:5.34|P-value:5.66E-6 ID:SGTC_1636|Compound:st007707|FD-Score:-4.18|P-value:2.23E-4 ID:SGTC_1643|Compound:st009866|FD-Score:8.33|P-value:3.17E-12 ID:SGTC_1712|Compound:st032288|FD-Score:3.85|P-value:8.09E-4 ID:SGTC_1730|Compound:st033808|FD-Score:4.14|P-value:3.44E-4 ID:SGTC_1754|Compound:st042065|FD-Score:5.71|P-value:1.35E-6 ID:SGTC_1755|Compound:st041960|FD-Score:5.67|P-value:1.55E-6 ID:SGTC_1760|Compound:st045453|FD-Score:5.39|P-value:4.77E-6 ID:SGTC_1803|Compound:st050068|FD-Score:6.80|P-value:1.06E-8 ID:SGTC_1875|Compound:nocodazole|FD-Score:6.75|P-value:1.39E-8 ID:SGTC_1959|Compound:st077091|FD-Score:4.25|P-value:2.49E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.94|P-value:6.29E-4 ID:SGTC_2061|Compound:5245884|FD-Score:7.06|P-value:3.00E-9 ID:SGTC_2077|Compound:5212015|FD-Score:3.91|P-value:6.79E-4 ID:SGTC_2090|Compound:5301565|FD-Score:4.98|P-value:2.15E-5 ID:SGTC_2125|Compound:5246583|FD-Score:7.86|P-value:4.64E-11 ID:SGTC_2141|Compound:5621638|FD-Score:10.10|P-value:2.67E-17 ID:SGTC_2166|Compound:5933061|FD-Score:8.06|P-value:1.49E-11 ID:SGTC_2174|Compound:5790901|FD-Score:14.10|P-value:1.43E-31 ID:SGTC_2186|Compound:6124449|FD-Score:4.80|P-value:4.11E-5 ID:SGTC_2200|Compound:6600604|FD-Score:11.70|P-value:2.66E-22 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.60|P-value:8.16E-5 ID:SGTC_2254|Compound:7938975|FD-Score:5.18|P-value:1.06E-5 ID:SGTC_2255|Compound:7941087|FD-Score:5.01|P-value:1.97E-5 ID:SGTC_2269|Compound:7935389|FD-Score:3.78|P-value:9.93E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.14|P-value:3.52E-4 ID:SGTC_2319|Compound:6033012|FD-Score:12.20|P-value:2.97E-24 ID:SGTC_2352|Compound:9027995|FD-Score:7.68|P-value:1.25E-10 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.89|P-value:7.31E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:4.55|P-value:9.61E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.88|P-value:5.50E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:5.00|P-value:2.04E-5 ID:SGTC_2701|Compound:st077767|FD-Score:5.09|P-value:1.44E-5 ID:SGTC_2711|Compound:st079103|FD-Score:4.62|P-value:7.61E-5 ID:SGTC_2743|Compound:auranofin|FD-Score:6.19|P-value:1.80E-7 ID:SGTC_2786|Compound:7743617|FD-Score:-4.16|P-value:2.32E-4 ID:SGTC_2788|Compound:5282734|FD-Score:-4.69|P-value:4.13E-5 ID:SGTC_2836|Compound:9010338|FD-Score:3.79|P-value:9.67E-4 ID:SGTC_2912|Compound:7964298|FD-Score:4.90|P-value:2.93E-5 ID:SGTC_2974|Compound:9094440|FD-Score:3.87|P-value:7.76E-4 ID:SGTC_2983|Compound:9022671|FD-Score:3.82|P-value:8.83E-4 ID:SGTC_2997|Compound:9067075|FD-Score:6.46|P-value:5.15E-8 ID:SGTC_3030|Compound:9087619|FD-Score:4.27|P-value:2.30E-4 ID:SGTC_3071|Compound:9117417|FD-Score:4.83|P-value:3.71E-5 ID:SGTC_3078|Compound:9116413|FD-Score:4.36|P-value:1.77E-4 ID:SGTC_3101|Compound:9120531|FD-Score:4.14|P-value:3.47E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.33|P-value:1.94E-4 ID:SGTC_3277|Compound:9138724|FD-Score:4.88|P-value:3.04E-5 ID:SGTC_3294|Compound:9122953|FD-Score:4.48|P-value:1.18E-4 ID:SGTC_3306|Compound:9127676|FD-Score:5.23|P-value:8.71E-6 ID:SGTC_3311|Compound:9131146|FD-Score:5.37|P-value:5.06E-6 ID:SGTC_3317|Compound:9138495|FD-Score:5.57|P-value:2.31E-6 ID:SGTC_3350|Compound:9150499|FD-Score:4.33|P-value:1.96E-4 ID:SGTC_3356|Compound:9151811|FD-Score:3.91|P-value:6.82E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:3.86|P-value:7.93E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:4.74|P-value:5.01E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:10.50|P-value:2.63E-18 ID:SGTC_86|Compound:0417-1630|FD-Score:4.24|P-value:2.53E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:6.01|P-value:3.76E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:5.66|P-value:1.61E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:9.31|P-value:7.64E-15 ID:SGTC_158|Compound:k038-0087|FD-Score:6.76|P-value:1.28E-8 ID:SGTC_172|Compound:1112-0046|FD-Score:5.34|P-value:5.76E-6 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.68|P-value:9.70E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:10.40|P-value:4.28E-18 ID:SGTC_212|Compound:3807-4682|FD-Score:9.34|P-value:6.32E-15 ID:SGTC_214|Compound:4373-3496|FD-Score:4.43|P-value:1.43E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:7.35|P-value:6.92E-10 ID:SGTC_227|Compound:fluconazole|FD-Score:5.58|P-value:2.28E-6 ID:SGTC_229|Compound:benomyl|FD-Score:10.70|P-value:5.38E-19 ID:SGTC_286|Compound:k060-0067|FD-Score:4.35|P-value:1.84E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:5.42|P-value:4.23E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:5.62|P-value:1.94E-6 ID:SGTC_366|Compound:0181-0206|FD-Score:3.94|P-value:6.31E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:8.55|P-value:8.60E-13 ID:SGTC_408|Compound:cantharidin|FD-Score:3.87|P-value:7.80E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.08|P-value:1.50E-5 ID:SGTC_447|Compound:ml7|FD-Score:4.92|P-value:2.70E-5 ID:SGTC_502|Compound:l-744,832|FD-Score:4.73|P-value:5.28E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:10.30|P-value:1.12E-17 ID:SGTC_528|Compound:3492-0019|FD-Score:4.10|P-value:3.90E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:4.10|P-value:3.96E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.05|P-value:4.57E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:7.42|P-value:4.94E-10 ID:SGTC_642|Compound:0335-0876|FD-Score:4.18|P-value:3.06E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:8.32|P-value:3.46E-12 ID:SGTC_794|Compound:k038-0031|FD-Score:6.48|P-value:4.78E-8 ID:SGTC_825|Compound:1988-2224|FD-Score:4.88|P-value:3.10E-5 ID:SGTC_871|Compound:0574-0004|FD-Score:7.62|P-value:1.71E-10 ID:SGTC_897|Compound:1000-0139|FD-Score:10.50|P-value:1.99E-18 ID:SGTC_975|Compound:1335-0046|FD-Score:6.24|P-value:1.40E-7 ID:SGTC_987|Compound:1497-1013|FD-Score:-5.04|P-value:1.16E-5 ID:SGTC_1090|Compound:efavirenz|FD-Score:4.11|P-value:3.84E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.89|P-value:7.24E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:4.37|P-value:1.71E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:-3.84|P-value:6.06E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:4.10|P-value:3.96E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:4.39|P-value:1.60E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:9.69|P-value:6.16E-16 ID:SGTC_1374|Compound:2889-5571|FD-Score:7.62|P-value:1.66E-10 ID:SGTC_1433|Compound:4060-0023|FD-Score:5.34|P-value:5.66E-6 ID:SGTC_1636|Compound:st007707|FD-Score:-4.18|P-value:2.23E-4 ID:SGTC_1643|Compound:st009866|FD-Score:8.33|P-value:3.17E-12 ID:SGTC_1712|Compound:st032288|FD-Score:3.85|P-value:8.09E-4 ID:SGTC_1730|Compound:st033808|FD-Score:4.14|P-value:3.44E-4 ID:SGTC_1754|Compound:st042065|FD-Score:5.71|P-value:1.35E-6 ID:SGTC_1755|Compound:st041960|FD-Score:5.67|P-value:1.55E-6 ID:SGTC_1760|Compound:st045453|FD-Score:5.39|P-value:4.77E-6 ID:SGTC_1803|Compound:st050068|FD-Score:6.80|P-value:1.06E-8 ID:SGTC_1875|Compound:nocodazole|FD-Score:6.75|P-value:1.39E-8 ID:SGTC_1959|Compound:st077091|FD-Score:4.25|P-value:2.49E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.94|P-value:6.29E-4 ID:SGTC_2061|Compound:5245884|FD-Score:7.06|P-value:3.00E-9 ID:SGTC_2077|Compound:5212015|FD-Score:3.91|P-value:6.79E-4 ID:SGTC_2090|Compound:5301565|FD-Score:4.98|P-value:2.15E-5 ID:SGTC_2125|Compound:5246583|FD-Score:7.86|P-value:4.64E-11 ID:SGTC_2141|Compound:5621638|FD-Score:10.10|P-value:2.67E-17 ID:SGTC_2166|Compound:5933061|FD-Score:8.06|P-value:1.49E-11 ID:SGTC_2174|Compound:5790901|FD-Score:14.10|P-value:1.43E-31 ID:SGTC_2186|Compound:6124449|FD-Score:4.80|P-value:4.11E-5 ID:SGTC_2200|Compound:6600604|FD-Score:11.70|P-value:2.66E-22 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.60|P-value:8.16E-5 ID:SGTC_2254|Compound:7938975|FD-Score:5.18|P-value:1.06E-5 ID:SGTC_2255|Compound:7941087|FD-Score:5.01|P-value:1.97E-5 ID:SGTC_2269|Compound:7935389|FD-Score:3.78|P-value:9.93E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.14|P-value:3.52E-4 ID:SGTC_2319|Compound:6033012|FD-Score:12.20|P-value:2.97E-24 ID:SGTC_2352|Compound:9027995|FD-Score:7.68|P-value:1.25E-10 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.89|P-value:7.31E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:4.55|P-value:9.61E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.88|P-value:5.50E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:5.00|P-value:2.04E-5 ID:SGTC_2701|Compound:st077767|FD-Score:5.09|P-value:1.44E-5 ID:SGTC_2711|Compound:st079103|FD-Score:4.62|P-value:7.61E-5 ID:SGTC_2743|Compound:auranofin|FD-Score:6.19|P-value:1.80E-7 ID:SGTC_2786|Compound:7743617|FD-Score:-4.16|P-value:2.32E-4 ID:SGTC_2788|Compound:5282734|FD-Score:-4.69|P-value:4.13E-5 ID:SGTC_2836|Compound:9010338|FD-Score:3.79|P-value:9.67E-4 ID:SGTC_2912|Compound:7964298|FD-Score:4.90|P-value:2.93E-5 ID:SGTC_2974|Compound:9094440|FD-Score:3.87|P-value:7.76E-4 ID:SGTC_2983|Compound:9022671|FD-Score:3.82|P-value:8.83E-4 ID:SGTC_2997|Compound:9067075|FD-Score:6.46|P-value:5.15E-8 ID:SGTC_3030|Compound:9087619|FD-Score:4.27|P-value:2.30E-4 ID:SGTC_3071|Compound:9117417|FD-Score:4.83|P-value:3.71E-5 ID:SGTC_3078|Compound:9116413|FD-Score:4.36|P-value:1.77E-4 ID:SGTC_3101|Compound:9120531|FD-Score:4.14|P-value:3.47E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.33|P-value:1.94E-4 ID:SGTC_3277|Compound:9138724|FD-Score:4.88|P-value:3.04E-5 ID:SGTC_3294|Compound:9122953|FD-Score:4.48|P-value:1.18E-4 ID:SGTC_3306|Compound:9127676|FD-Score:5.23|P-value:8.71E-6 ID:SGTC_3311|Compound:9131146|FD-Score:5.37|P-value:5.06E-6 ID:SGTC_3317|Compound:9138495|FD-Score:5.57|P-value:2.31E-6 ID:SGTC_3350|Compound:9150499|FD-Score:4.33|P-value:1.96E-4 ID:SGTC_3356|Compound:9151811|FD-Score:3.91|P-value:6.82E-4

Top fitness defect scores for YDR485C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2174 5790901 14.10 200.0 µM 1.43E-31 tubulin folding & SWR complex 5 3.10E-45
2 SGTC_2319 6033012 12.20 152.6 µM 2.97E-24 tubulin folding & SWR complex 5 1.33E-34
3 SGTC_2200 6600604 11.70 21.9 µM 2.66E-22 tubulin folding & SWR complex 10 9.14E-32
4 SGTC_229 benomyl 10.70 22.9 µM 5.38E-19 tubulin folding & SWR complex 10 5.83E-27
5 SGTC_897 1000-0139 10.50 31.4 µM 1.99E-18 4 3.89E-26
6 SGTC_67 0335-0847 10.50 266.0 µM 2.63E-18 ubiquinone biosynthesis & proteasome 20 5.84E-26
7 SGTC_210 3551-0445 10.40 56.8 µM 4.28E-18 13 1.19E-25
8 SGTC_514 4466-0038 10.30 2.6 nM 1.12E-17 cell wall 19 4.81E-25
9 SGTC_2141 5621638 10.10 7.7 µM 2.67E-17 tubulin folding & SWR complex 5 1.69E-24
10 SGTC_1326 1431-2094 9.69 10.8 µM 6.16E-16 tubulin folding & SWR complex 6 1.62E-22
11 SGTC_212 3807-4682 9.34 38.8 µM 6.32E-15 tubulin folding & SWR complex 9 4.76E-21
12 SGTC_149 3970-0822 9.31 46.1 µM 7.64E-15 tubulin folding & SWR complex 12 6.27E-21
13 SGTC_367 0335-0881 8.55 7.1 µM 8.60E-13 ubiquinone biosynthesis & proteasome 9 5.96E-18
14 SGTC_1643 st009866 8.33 20.2 µM 3.17E-12 14 3.97E-17
15 SGTC_673 1082-0474 8.32 110.0 µM 3.46E-12 RSC complex & mRNA processing 15 4.50E-17
16 SGTC_2166 5933061 8.06 31.5 µM 1.49E-11 tubulin folding & SWR complex 5 3.75E-16
17 SGTC_2125 5246583 7.86 200.0 µM 4.64E-11 tubulin folding & SWR complex 9 1.95E-15
18 SGTC_2352 9027995 7.68 87.8 µM 1.25E-10 tubulin folding & SWR complex 5 8.22E-15
19 SGTC_1374 2889-5571 7.62 141.0 µM 1.66E-10 RSC complex & mRNA processing 6 1.24E-14
20 SGTC_871 0574-0004 7.62 149.0 µM 1.71E-10 8 1.29E-14

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.671 0 YLR085C ARP6 hom Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.633 0 YML041C VPS71 hom Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.617 0 YAL011W SWC3 hom Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
0.608 0 YDR334W SWR1 hom Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.528 2.61E-240 YBR231C SWC5 hom Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress
0.512 1.16E-223 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.485 1.44E-197 YML124C TUB3 hom Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication
0.446 1.47E-163 YOL012C HTZ1 hom Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
0.428 2.23E-149 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.390 1.82E-122 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.261 1.63E-53 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.256 1.64E-51 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.249 1.29E-48 YNL107W YAF9 hom Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain
0.242 5.25E-46 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.225 9.83E-40 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes