YDR488C / PAC11

Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR488C / PAC11

Click on Significant Values for Screen Details ID:SGTC_143|Compound:4032-1194|FD-Score:2.94|P-value:5.10E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.16|P-value:2.09E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.73|P-value:1.64E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:4.56|P-value:2.05E-7 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.08|P-value:4.49E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-2.99|P-value:6.52E-4 ID:SGTC_458|Compound:nppb|FD-Score:2.91|P-value:5.75E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:2.77|P-value:9.80E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:5.30|P-value:2.16E-9 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.14|P-value:3.55E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:2.83|P-value:7.61E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.05|P-value:3.28E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:2.92|P-value:5.49E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.22|P-value:1.63E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.20|P-value:1.76E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:2.79|P-value:8.83E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:2.77|P-value:9.75E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:4.59|P-value:1.73E-7 ID:SGTC_1362|Compound:1611-0397|FD-Score:-3.75|P-value:2.50E-5 ID:SGTC_1366|Compound:1683-0113|FD-Score:-4.22|P-value:2.41E-6 ID:SGTC_1609|Compound:st001574|FD-Score:-4.47|P-value:6.50E-7 ID:SGTC_1691|Compound:st019933|FD-Score:2.82|P-value:8.11E-4 ID:SGTC_1793|Compound:st048256|FD-Score:2.93|P-value:5.20E-4 ID:SGTC_1908|Compound:st060353|FD-Score:5.78|P-value:7.70E-11 ID:SGTC_1911|Compound:st060208|FD-Score:-5.27|P-value:5.45E-9 ID:SGTC_1913|Compound:st060213|FD-Score:4.74|P-value:7.01E-8 ID:SGTC_1916|Compound:st067606|FD-Score:2.89|P-value:6.20E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.83|P-value:1.03E-5 ID:SGTC_2002|Compound:4023503|FD-Score:3.04|P-value:3.46E-4 ID:SGTC_2167|Compound:5876490|FD-Score:5.33|P-value:1.73E-9 ID:SGTC_2237|Compound:6667747|FD-Score:3.25|P-value:1.46E-4 ID:SGTC_2239|Compound:6685329|FD-Score:4.55|P-value:2.18E-7 ID:SGTC_2302|Compound:7771753|FD-Score:-4.33|P-value:1.36E-6 ID:SGTC_2327|Compound:6189656|FD-Score:-3.00|P-value:6.16E-4 ID:SGTC_2459|Compound:5811157|FD-Score:-3.38|P-value:1.35E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.82|P-value:1.84E-5 ID:SGTC_2467|Compound:5474540|FD-Score:-3.17|P-value:3.15E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.01|P-value:3.85E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.05|P-value:3.23E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:2.79|P-value:8.96E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.37|P-value:8.59E-5 ID:SGTC_2840|Compound:9008771|FD-Score:3.15|P-value:2.23E-4 ID:SGTC_3024|Compound:9090631|FD-Score:2.94|P-value:5.15E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:2.94|P-value:5.10E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.16|P-value:2.09E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.73|P-value:1.64E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:4.56|P-value:2.05E-7 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.08|P-value:4.49E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-2.99|P-value:6.52E-4 ID:SGTC_458|Compound:nppb|FD-Score:2.91|P-value:5.75E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:2.77|P-value:9.80E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:5.30|P-value:2.16E-9 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.14|P-value:3.55E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:2.83|P-value:7.61E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.05|P-value:3.28E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:2.92|P-value:5.49E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.22|P-value:1.63E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.20|P-value:1.76E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:2.79|P-value:8.83E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:2.77|P-value:9.75E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:4.59|P-value:1.73E-7 ID:SGTC_1362|Compound:1611-0397|FD-Score:-3.75|P-value:2.50E-5 ID:SGTC_1366|Compound:1683-0113|FD-Score:-4.22|P-value:2.41E-6 ID:SGTC_1609|Compound:st001574|FD-Score:-4.47|P-value:6.50E-7 ID:SGTC_1691|Compound:st019933|FD-Score:2.82|P-value:8.11E-4 ID:SGTC_1793|Compound:st048256|FD-Score:2.93|P-value:5.20E-4 ID:SGTC_1908|Compound:st060353|FD-Score:5.78|P-value:7.70E-11 ID:SGTC_1911|Compound:st060208|FD-Score:-5.27|P-value:5.45E-9 ID:SGTC_1913|Compound:st060213|FD-Score:4.74|P-value:7.01E-8 ID:SGTC_1916|Compound:st067606|FD-Score:2.89|P-value:6.20E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.83|P-value:1.03E-5 ID:SGTC_2002|Compound:4023503|FD-Score:3.04|P-value:3.46E-4 ID:SGTC_2167|Compound:5876490|FD-Score:5.33|P-value:1.73E-9 ID:SGTC_2237|Compound:6667747|FD-Score:3.25|P-value:1.46E-4 ID:SGTC_2239|Compound:6685329|FD-Score:4.55|P-value:2.18E-7 ID:SGTC_2302|Compound:7771753|FD-Score:-4.33|P-value:1.36E-6 ID:SGTC_2327|Compound:6189656|FD-Score:-3.00|P-value:6.16E-4 ID:SGTC_2459|Compound:5811157|FD-Score:-3.38|P-value:1.35E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.82|P-value:1.84E-5 ID:SGTC_2467|Compound:5474540|FD-Score:-3.17|P-value:3.15E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.01|P-value:3.85E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.05|P-value:3.23E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:2.79|P-value:8.96E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.37|P-value:8.59E-5 ID:SGTC_2840|Compound:9008771|FD-Score:3.15|P-value:2.23E-4 ID:SGTC_3024|Compound:9090631|FD-Score:2.94|P-value:5.15E-4

Top fitness defect scores for YDR488C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1908 st060353 5.78 56.5 µM 7.70E-11 RPP1 & pyrimidine depletion 8 3.73E-9
2 SGTC_2167 5876490 5.33 200.0 µM 1.73E-9 9 4.91E-8
3 SGTC_790 1575-0012 5.30 79.1 µM 2.16E-9 TSC3-RPN4 9 5.88E-8
4 SGTC_1913 st060213 4.74 96.1 µM 7.01E-8 14 1.05E-6
5 SGTC_1213 1315-0166 4.59 115.0 µM 1.73E-7 16 2.21E-6
6 SGTC_299 1273-0059 4.56 1.4 µM 2.05E-7 20 2.54E-6
7 SGTC_2239 6685329 4.55 187.6 µM 2.18E-7 14 2.67E-6
8 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 3.83 70.1 µM 1.03E-5 29 6.51E-5
9 SGTC_296 1222-0039 3.73 74.9 µM 1.64E-5 15 9.57E-5
10 SGTC_2616 abietic acid 3.37 100.0 µM 8.59E-5 50 3.77E-4
11 SGTC_2237 6667747 3.25 47.2 µM 1.46E-4 31 5.83E-4
12 SGTC_1171 0368-0077 3.22 21.4 µM 1.63E-4 36 6.40E-4
13 SGTC_1178 0988-0033 3.20 191.0 µM 1.76E-4 59 6.81E-4
14 SGTC_163 1327-0036 3.16 7.5 µM 2.09E-4 168 7.86E-4
15 SGTC_2840 9008771 3.15 71.4 µM 2.23E-4 28 8.30E-4
16 SGTC_2605 digitonin 3.05 300.0 nM 3.23E-4 75 0.00113
17 SGTC_1049 3226-0134 3.05 66.0 µM 3.28E-4 78 0.00114
18 SGTC_2002 4023503 3.04 131.0 µM 3.46E-4 mitochondrial processes 85 0.00119
19 SGTC_2495 cafestol 3.01 54.5 µM 3.85E-4 Golgi 68 0.00130
20 SGTC_143 4032-1194 2.94 15.7 µM 5.10E-4 144 0.00165

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 3.89E-13 YLR407W_p YLR407W_p hom Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus
0.124 6.54E-13 YOR292C_p YOR292C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene
0.114 3.34E-11 YER089C PTC2 hom Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication
0.111 1.04E-10 YNL339C YRF1-6 hom Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
0.108 3.67E-10 YIL044C AGE2 hom ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif
0.098 1.40E-8 YPL067C_p YPL067C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene
0.096 2.65E-8 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.096 2.69E-8 YOR288C MPD1 hom Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation
0.095 4.05E-8 YFR029W PTR3 het Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
0.092 8.57E-8 YGL053W PRM8 hom Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family
0.092 1.02E-7 YDR511W ACN9 hom Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes
0.090 1.85E-7 YDR419W RAD30 hom DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV
0.089 2.72E-7 YCL040W GLK1 hom Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication
0.088 3.40E-7 YGL074C_d YGL074C_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor
0.087 4.38E-7 YMR104C YPK2 hom Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; YPK2 has a paralog, YPK1, that arose from the whole genome duplication