Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YDR489W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.120 | 2.88E-12 | YNL188W | KAR1 | het | Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p |
0.107 | 5.79E-10 | YML005W | TRM12 | hom | S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA |
0.104 | 1.49E-9 | YBR242W_p | YBR242W_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene |
0.098 | 1.21E-8 | YMR180C | CTL1 | hom | RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm |
0.092 | 8.33E-8 | YDL029W | ARP2 | het | Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity |
0.090 | 1.93E-7 | YLR328W | NMA1 | hom | Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication |
0.087 | 4.68E-7 | YML003W_p | YML003W_p | hom | Putative protein of unknown function |
0.086 | 6.45E-7 | YDL072C | YET3 | hom | Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress |
0.082 | 2.11E-6 | YHL024W | RIM4 | hom | Putative RNA-binding protein required for the expression of early and middle sporulation genes |
0.081 | 2.90E-6 | YPL164C | MLH3 | hom | Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability |
0.080 | 3.92E-6 | YDR070C | FMP16 | hom | Protein of unknown function; may be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress |
0.079 | 4.81E-6 | YMR173W | DDR48 | hom | DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress |
0.078 | 6.65E-6 | YEL041W | YEF1 | hom | ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication |
0.077 | 8.05E-6 | YEL016C | NPP2 | hom | Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication |
0.075 | 1.23E-5 | YDR473C | PRP3 | het | Splicing factor, component of the U4/U6-U5 snRNP complex |