YDR495C / VPS3

Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR495C / VPS3

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:4.53|P-value:5.69E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:4.75|P-value:2.64E-5 ID:SGTC_52|Compound:0329-0193|FD-Score:6.50|P-value:1.67E-8 ID:SGTC_57|Compound:miconazole|FD-Score:-4.23|P-value:1.90E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.61|P-value:7.06E-11 ID:SGTC_70|Compound:0141-0289|FD-Score:6.50|P-value:1.62E-8 ID:SGTC_88|Compound:0180-0332|FD-Score:4.35|P-value:1.06E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:4.06|P-value:2.66E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:4.76|P-value:2.57E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:7.74|P-value:2.54E-11 ID:SGTC_119|Compound:0121-0043|FD-Score:6.60|P-value:1.04E-8 ID:SGTC_123|Compound:0083-0120|FD-Score:5.08|P-value:7.77E-6 ID:SGTC_124|Compound:0136-0217|FD-Score:6.25|P-value:5.45E-8 ID:SGTC_150|Compound:3970-0969|FD-Score:4.01|P-value:3.18E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.66|P-value:8.94E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:6.35|P-value:3.40E-8 ID:SGTC_172|Compound:1112-0046|FD-Score:4.95|P-value:1.25E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:4.79|P-value:2.28E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.60|P-value:9.59E-7 ID:SGTC_227|Compound:fluconazole|FD-Score:4.84|P-value:1.88E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:4.73|P-value:2.86E-5 ID:SGTC_245|Compound:methotrexate|FD-Score:4.04|P-value:2.88E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:7.66|P-value:3.86E-11 ID:SGTC_263|Compound:alizarin|FD-Score:5.76|P-value:4.81E-7 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.65|P-value:9.16E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:-4.15|P-value:2.49E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:4.68|P-value:3.41E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:4.16|P-value:1.96E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.67|P-value:4.31E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.64|P-value:4.82E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:5.01|P-value:1.01E-5 ID:SGTC_425|Compound:3825-7017|FD-Score:-3.83|P-value:6.65E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-4.47|P-value:8.70E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:3.68|P-value:8.46E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:3.91|P-value:4.34E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.96|P-value:4.50E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-4.09|P-value:2.94E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:7.37|P-value:1.93E-10 ID:SGTC_525|Compound:k781-2675|FD-Score:5.00|P-value:1.03E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:10.00|P-value:8.31E-18 ID:SGTC_535|Compound:2293-4129|FD-Score:4.33|P-value:1.12E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:3.82|P-value:5.69E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:5.30|P-value:3.28E-6 ID:SGTC_640|Compound:3381-0960|FD-Score:3.78|P-value:6.39E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:4.48|P-value:6.78E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:12.40|P-value:4.66E-26 ID:SGTC_751|Compound:0833-0568|FD-Score:5.34|P-value:2.80E-6 ID:SGTC_769|Compound:0302-0231|FD-Score:-3.87|P-value:5.88E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:6.44|P-value:2.18E-8 ID:SGTC_805|Compound:3852-0218|FD-Score:4.61|P-value:4.30E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:4.68|P-value:3.39E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:4.24|P-value:1.52E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:3.75|P-value:6.90E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.99|P-value:3.38E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:4.61|P-value:4.32E-5 ID:SGTC_934|Compound:2950-0684|FD-Score:-3.93|P-value:4.86E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.88|P-value:4.66E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.84|P-value:1.89E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.21|P-value:1.65E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:5.00|P-value:1.05E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:-4.33|P-value:1.37E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:5.71|P-value:5.94E-7 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.66|P-value:8.95E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:5.75|P-value:5.00E-7 ID:SGTC_1534|Compound:6-azauridine|FD-Score:6.39|P-value:2.80E-8 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:8.54|P-value:2.03E-13 ID:SGTC_1658|Compound:st012944|FD-Score:5.89|P-value:2.70E-7 ID:SGTC_1660|Compound:st012960|FD-Score:3.87|P-value:4.91E-4 ID:SGTC_1665|Compound:st014639|FD-Score:4.89|P-value:1.59E-5 ID:SGTC_1687|Compound:st020778|FD-Score:13.40|P-value:2.88E-30 ID:SGTC_1715|Compound:st032160|FD-Score:-4.08|P-value:3.10E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.38|P-value:1.18E-4 ID:SGTC_1754|Compound:st042065|FD-Score:6.54|P-value:1.39E-8 ID:SGTC_1760|Compound:st045453|FD-Score:11.30|P-value:5.58E-22 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.78|P-value:6.30E-4 ID:SGTC_1801|Compound:st050089|FD-Score:5.16|P-value:5.65E-6 ID:SGTC_1803|Compound:st050068|FD-Score:6.68|P-value:6.74E-9 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.43|P-value:2.31E-8 ID:SGTC_1877|Compound:wortmannin|FD-Score:7.35|P-value:2.15E-10 ID:SGTC_1878|Compound:temozolomide|FD-Score:-4.19|P-value:2.17E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-3.72|P-value:8.92E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-6.79|P-value:5.56E-9 ID:SGTC_2008|Compound:4012253|FD-Score:-7.60|P-value:7.49E-11 ID:SGTC_2011|Compound:4012611|FD-Score:5.42|P-value:2.03E-6 ID:SGTC_2012|Compound:4023501|FD-Score:10.40|P-value:6.38E-19 ID:SGTC_2020|Compound:4017018|FD-Score:4.43|P-value:8.02E-5 ID:SGTC_2077|Compound:5212015|FD-Score:4.30|P-value:1.23E-4 ID:SGTC_2135|Compound:5326629|FD-Score:4.40|P-value:8.86E-5 ID:SGTC_2200|Compound:6600604|FD-Score:4.68|P-value:3.38E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.48|P-value:8.28E-5 ID:SGTC_2443|Compound:5493264|FD-Score:3.65|P-value:9.25E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.08|P-value:2.50E-4 ID:SGTC_2537|Compound:larixol|FD-Score:4.43|P-value:8.05E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:8.44|P-value:3.94E-13 ID:SGTC_2570|Compound:licareol|FD-Score:4.22|P-value:1.62E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:8.18|P-value:1.87E-12 ID:SGTC_2661|Compound:dactinomycin|FD-Score:5.61|P-value:9.24E-7 ID:SGTC_2666|Compound:tannic acid|FD-Score:5.21|P-value:4.59E-6 ID:SGTC_2671|Compound:danthron|FD-Score:5.53|P-value:1.30E-6 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:5.38|P-value:2.34E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.30|P-value:4.19E-8 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.91|P-value:4.26E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.13|P-value:6.26E-6 ID:SGTC_2743|Compound:auranofin|FD-Score:4.85|P-value:1.86E-5 ID:SGTC_2829|Compound:7992743|FD-Score:5.12|P-value:6.52E-6 ID:SGTC_2890|Compound:9046729|FD-Score:4.52|P-value:5.90E-5 ID:SGTC_2954|Compound:9074818|FD-Score:-3.74|P-value:8.46E-4 ID:SGTC_2966|Compound:9084041|FD-Score:4.99|P-value:1.07E-5 ID:SGTC_2967|Compound:9089538|FD-Score:-6.43|P-value:3.05E-8 ID:SGTC_2968|Compound:9090663|FD-Score:5.35|P-value:2.65E-6 ID:SGTC_2973|Compound:9094665|FD-Score:-3.85|P-value:6.25E-4 ID:SGTC_3062|Compound:9077494|FD-Score:4.58|P-value:4.87E-5 ID:SGTC_3193|Compound:9111931|FD-Score:-5.29|P-value:4.35E-6 ID:SGTC_3200|Compound:9114385|FD-Score:4.80|P-value:2.15E-5 ID:SGTC_3222|Compound:9128301|FD-Score:-4.34|P-value:1.32E-4 ID:SGTC_3252|Compound:9135871|FD-Score:4.46|P-value:7.33E-5 ID:SGTC_3282|Compound:9108498|FD-Score:5.52|P-value:1.35E-6 ID:SGTC_3287|Compound:9117173|FD-Score:-5.01|P-value:1.28E-5 ID:SGTC_3340|Compound:9146634|FD-Score:-3.79|P-value:7.33E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:4.53|P-value:5.69E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:4.75|P-value:2.64E-5 ID:SGTC_52|Compound:0329-0193|FD-Score:6.50|P-value:1.67E-8 ID:SGTC_57|Compound:miconazole|FD-Score:-4.23|P-value:1.90E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.61|P-value:7.06E-11 ID:SGTC_70|Compound:0141-0289|FD-Score:6.50|P-value:1.62E-8 ID:SGTC_88|Compound:0180-0332|FD-Score:4.35|P-value:1.06E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:4.06|P-value:2.66E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:4.76|P-value:2.57E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:7.74|P-value:2.54E-11 ID:SGTC_119|Compound:0121-0043|FD-Score:6.60|P-value:1.04E-8 ID:SGTC_123|Compound:0083-0120|FD-Score:5.08|P-value:7.77E-6 ID:SGTC_124|Compound:0136-0217|FD-Score:6.25|P-value:5.45E-8 ID:SGTC_150|Compound:3970-0969|FD-Score:4.01|P-value:3.18E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.66|P-value:8.94E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:6.35|P-value:3.40E-8 ID:SGTC_172|Compound:1112-0046|FD-Score:4.95|P-value:1.25E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:4.79|P-value:2.28E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.60|P-value:9.59E-7 ID:SGTC_227|Compound:fluconazole|FD-Score:4.84|P-value:1.88E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:4.73|P-value:2.86E-5 ID:SGTC_245|Compound:methotrexate|FD-Score:4.04|P-value:2.88E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:7.66|P-value:3.86E-11 ID:SGTC_263|Compound:alizarin|FD-Score:5.76|P-value:4.81E-7 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.65|P-value:9.16E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:-4.15|P-value:2.49E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:4.68|P-value:3.41E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:4.16|P-value:1.96E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.67|P-value:4.31E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.64|P-value:4.82E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:5.01|P-value:1.01E-5 ID:SGTC_425|Compound:3825-7017|FD-Score:-3.83|P-value:6.65E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-4.47|P-value:8.70E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:3.68|P-value:8.46E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:3.91|P-value:4.34E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.96|P-value:4.50E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-4.09|P-value:2.94E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:7.37|P-value:1.93E-10 ID:SGTC_525|Compound:k781-2675|FD-Score:5.00|P-value:1.03E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:10.00|P-value:8.31E-18 ID:SGTC_535|Compound:2293-4129|FD-Score:4.33|P-value:1.12E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:3.82|P-value:5.69E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:5.30|P-value:3.28E-6 ID:SGTC_640|Compound:3381-0960|FD-Score:3.78|P-value:6.39E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:4.48|P-value:6.78E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:12.40|P-value:4.66E-26 ID:SGTC_751|Compound:0833-0568|FD-Score:5.34|P-value:2.80E-6 ID:SGTC_769|Compound:0302-0231|FD-Score:-3.87|P-value:5.88E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:6.44|P-value:2.18E-8 ID:SGTC_805|Compound:3852-0218|FD-Score:4.61|P-value:4.30E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:4.68|P-value:3.39E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:4.24|P-value:1.52E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:3.75|P-value:6.90E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.99|P-value:3.38E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:4.61|P-value:4.32E-5 ID:SGTC_934|Compound:2950-0684|FD-Score:-3.93|P-value:4.86E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.88|P-value:4.66E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.84|P-value:1.89E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.21|P-value:1.65E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:5.00|P-value:1.05E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:-4.33|P-value:1.37E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:5.71|P-value:5.94E-7 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.66|P-value:8.95E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:5.75|P-value:5.00E-7 ID:SGTC_1534|Compound:6-azauridine|FD-Score:6.39|P-value:2.80E-8 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:8.54|P-value:2.03E-13 ID:SGTC_1658|Compound:st012944|FD-Score:5.89|P-value:2.70E-7 ID:SGTC_1660|Compound:st012960|FD-Score:3.87|P-value:4.91E-4 ID:SGTC_1665|Compound:st014639|FD-Score:4.89|P-value:1.59E-5 ID:SGTC_1687|Compound:st020778|FD-Score:13.40|P-value:2.88E-30 ID:SGTC_1715|Compound:st032160|FD-Score:-4.08|P-value:3.10E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.38|P-value:1.18E-4 ID:SGTC_1754|Compound:st042065|FD-Score:6.54|P-value:1.39E-8 ID:SGTC_1760|Compound:st045453|FD-Score:11.30|P-value:5.58E-22 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.78|P-value:6.30E-4 ID:SGTC_1801|Compound:st050089|FD-Score:5.16|P-value:5.65E-6 ID:SGTC_1803|Compound:st050068|FD-Score:6.68|P-value:6.74E-9 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.43|P-value:2.31E-8 ID:SGTC_1877|Compound:wortmannin|FD-Score:7.35|P-value:2.15E-10 ID:SGTC_1878|Compound:temozolomide|FD-Score:-4.19|P-value:2.17E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-3.72|P-value:8.92E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-6.79|P-value:5.56E-9 ID:SGTC_2008|Compound:4012253|FD-Score:-7.60|P-value:7.49E-11 ID:SGTC_2011|Compound:4012611|FD-Score:5.42|P-value:2.03E-6 ID:SGTC_2012|Compound:4023501|FD-Score:10.40|P-value:6.38E-19 ID:SGTC_2020|Compound:4017018|FD-Score:4.43|P-value:8.02E-5 ID:SGTC_2077|Compound:5212015|FD-Score:4.30|P-value:1.23E-4 ID:SGTC_2135|Compound:5326629|FD-Score:4.40|P-value:8.86E-5 ID:SGTC_2200|Compound:6600604|FD-Score:4.68|P-value:3.38E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.48|P-value:8.28E-5 ID:SGTC_2443|Compound:5493264|FD-Score:3.65|P-value:9.25E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.08|P-value:2.50E-4 ID:SGTC_2537|Compound:larixol|FD-Score:4.43|P-value:8.05E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:8.44|P-value:3.94E-13 ID:SGTC_2570|Compound:licareol|FD-Score:4.22|P-value:1.62E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:8.18|P-value:1.87E-12 ID:SGTC_2661|Compound:dactinomycin|FD-Score:5.61|P-value:9.24E-7 ID:SGTC_2666|Compound:tannic acid|FD-Score:5.21|P-value:4.59E-6 ID:SGTC_2671|Compound:danthron|FD-Score:5.53|P-value:1.30E-6 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:5.38|P-value:2.34E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.30|P-value:4.19E-8 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.91|P-value:4.26E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.13|P-value:6.26E-6 ID:SGTC_2743|Compound:auranofin|FD-Score:4.85|P-value:1.86E-5 ID:SGTC_2829|Compound:7992743|FD-Score:5.12|P-value:6.52E-6 ID:SGTC_2890|Compound:9046729|FD-Score:4.52|P-value:5.90E-5 ID:SGTC_2954|Compound:9074818|FD-Score:-3.74|P-value:8.46E-4 ID:SGTC_2966|Compound:9084041|FD-Score:4.99|P-value:1.07E-5 ID:SGTC_2967|Compound:9089538|FD-Score:-6.43|P-value:3.05E-8 ID:SGTC_2968|Compound:9090663|FD-Score:5.35|P-value:2.65E-6 ID:SGTC_2973|Compound:9094665|FD-Score:-3.85|P-value:6.25E-4 ID:SGTC_3062|Compound:9077494|FD-Score:4.58|P-value:4.87E-5 ID:SGTC_3193|Compound:9111931|FD-Score:-5.29|P-value:4.35E-6 ID:SGTC_3200|Compound:9114385|FD-Score:4.80|P-value:2.15E-5 ID:SGTC_3222|Compound:9128301|FD-Score:-4.34|P-value:1.32E-4 ID:SGTC_3252|Compound:9135871|FD-Score:4.46|P-value:7.33E-5 ID:SGTC_3282|Compound:9108498|FD-Score:5.52|P-value:1.35E-6 ID:SGTC_3287|Compound:9117173|FD-Score:-5.01|P-value:1.28E-5 ID:SGTC_3340|Compound:9146634|FD-Score:-3.79|P-value:7.33E-4

Top fitness defect scores for YDR495C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1687 st020778 13.40 55.4 µM 2.88E-30 26 2.50E-41
2 SGTC_748 0136-0228 12.40 77.9 µM 4.66E-26 redox potentiating 6 1.79E-35
3 SGTC_1760 st045453 11.30 10.4 µM 5.58E-22 NEO1-PIK1 23 8.39E-30
4 SGTC_2012 4023501 10.40 200.0 µM 6.38E-19 1 1.49E-25
5 SGTC_528 3492-0019 10.00 172.0 µM 8.31E-18 calcium & mitochondrial duress 40 5.26E-24
6 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 8.54 54.9 µM 2.03E-13 redox potentiating 18 6.44E-18
7 SGTC_2567 aureobasidin a 8.44 60.0 nM 3.94E-13 19 1.61E-17
8 SGTC_2615 purpurogallin-4-carboxylic acid 8.18 100.0 µM 1.87E-12 redox potentiating 16 1.39E-16
9 SGTC_117 lucigenin 7.74 22.1 µM 2.54E-11 redox potentiating 18 5.17E-15
10 SGTC_255 tunicamycin 7.66 200.5 nM 3.86E-11 unfolded protein response 19 9.22E-15
11 SGTC_524 r073-0010 7.37 27.8 µM 1.93E-10 12 8.57E-14
12 SGTC_1877 wortmannin 7.35 25.0 µM 2.15E-10 29 9.92E-14
13 SGTC_1803 st050068 6.68 52.4 µM 6.74E-9 NEO1-PIK1 62 1.16E-11
14 SGTC_119 0121-0043 6.60 24.8 µM 1.04E-8 mitochondrial stress 20 2.12E-11
15 SGTC_1754 st042065 6.54 16.1 µM 1.39E-8 NEO1-PIK1 83 3.15E-11
16 SGTC_70 0141-0289 6.50 43.3 µM 1.62E-8 mitochondrial stress 66 3.89E-11
17 SGTC_52 0329-0193 6.50 875.0 nM 1.67E-8 TSC3-RPN4 7 4.05E-11
18 SGTC_790 1575-0012 6.44 79.1 µM 2.18E-8 TSC3-RPN4 4 5.86E-11
19 SGTC_1873 rapamycin 6.43 2.0 nM 2.31E-8 26 6.34E-11
20 SGTC_1534 6-azauridine 6.39 81.6 µM 2.80E-8 RNA pol III & RNase P/MRP 6 8.30E-11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.549 1.07E-263 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.523 1.99E-235 YOR036W PEP12 hom Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.443 3.57E-161 YOR089C VPS21 hom Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication
0.412 7.46E-138 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.385 1.47E-118 YAL002W VPS8 hom Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif
0.371 5.85E-110 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.347 1.61E-95 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.346 1.16E-94 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.344 1.16E-93 YDR080W VPS41 hom Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
0.337 1.22E-89 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.333 9.32E-88 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.317 2.61E-79 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.316 8.50E-79 YCL008C STP22 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype
0.314 8.86E-78 YPL120W VPS30 hom Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; ortholog of the higher eukaryotic gene Beclin 1
0.313 3.87E-77 YDL077C VAM6 hom Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p