YDR497C / ITR1

Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR497C / ITR1

Click on Significant Values for Screen Details ID:SGTC_72|Compound:0744-0168|FD-Score:-2.95|P-value:9.00E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.25|P-value:2.81E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:-3.25|P-value:2.86E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:4.15|P-value:5.27E-6 ID:SGTC_264|Compound:promethazine|FD-Score:-5.71|P-value:7.35E-10 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.95|P-value:1.36E-5 ID:SGTC_277|Compound:nystatin|FD-Score:-3.56|P-value:8.28E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:6.91|P-value:1.17E-13 ID:SGTC_310|Compound:1273-0058|FD-Score:5.42|P-value:4.51E-9 ID:SGTC_347|Compound:4534-1311|FD-Score:2.94|P-value:8.92E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-4.31|P-value:2.57E-6 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.14|P-value:4.38E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-4.28|P-value:2.99E-6 ID:SGTC_665|Compound:3914-0008|FD-Score:-5.18|P-value:2.02E-8 ID:SGTC_774|Compound:k060-0086|FD-Score:3.16|P-value:3.99E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:4.37|P-value:1.72E-6 ID:SGTC_785|Compound:1270-0111|FD-Score:-4.61|P-value:5.15E-7 ID:SGTC_791|Compound:1348-1292|FD-Score:-3.66|P-value:5.25E-5 ID:SGTC_1143|Compound:3454-2408|FD-Score:2.95|P-value:8.69E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.62|P-value:6.33E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.06|P-value:5.84E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.54|P-value:8.63E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:-3.32|P-value:2.20E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.85|P-value:2.00E-13 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.24|P-value:1.99E-11 ID:SGTC_1750|Compound:st081859|FD-Score:3.92|P-value:1.58E-5 ID:SGTC_1751|Compound:st044839|FD-Score:3.54|P-value:8.44E-5 ID:SGTC_1753|Compound:st043925|FD-Score:5.20|P-value:1.67E-8 ID:SGTC_1756|Compound:st041558|FD-Score:5.24|P-value:1.31E-8 ID:SGTC_1966|Compound:st070145|FD-Score:-4.10|P-value:7.08E-6 ID:SGTC_1975|Compound:st070967|FD-Score:5.31|P-value:8.73E-9 ID:SGTC_1976|Compound:st070609|FD-Score:4.38|P-value:1.64E-6 ID:SGTC_2014|Compound:4013930|FD-Score:4.41|P-value:1.43E-6 ID:SGTC_2032|Compound:5185112|FD-Score:-4.16|P-value:5.44E-6 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-3.18|P-value:3.79E-4 ID:SGTC_2117|Compound:5521686|FD-Score:-3.17|P-value:3.96E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.96|P-value:1.31E-5 ID:SGTC_2423|Compound:st077119|FD-Score:-3.10|P-value:5.25E-4 ID:SGTC_2425|Compound:5628681|FD-Score:4.07|P-value:7.98E-6 ID:SGTC_2427|Compound:5545055|FD-Score:3.93|P-value:1.49E-5 ID:SGTC_2429|Compound:5902844|FD-Score:3.82|P-value:2.53E-5 ID:SGTC_2436|Compound:5633522|FD-Score:2.99|P-value:7.46E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.35|P-value:1.87E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.43|P-value:1.42E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:2.95|P-value:8.70E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.27|P-value:2.74E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.91|P-value:1.76E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:-3.02|P-value:7.01E-4 ID:SGTC_2876|Compound:9059903|FD-Score:2.94|P-value:9.11E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-3.17|P-value:3.92E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-2.96|P-value:8.81E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-2.95|P-value:9.00E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.25|P-value:2.81E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:-3.25|P-value:2.86E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:4.15|P-value:5.27E-6 ID:SGTC_264|Compound:promethazine|FD-Score:-5.71|P-value:7.35E-10 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.95|P-value:1.36E-5 ID:SGTC_277|Compound:nystatin|FD-Score:-3.56|P-value:8.28E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:6.91|P-value:1.17E-13 ID:SGTC_310|Compound:1273-0058|FD-Score:5.42|P-value:4.51E-9 ID:SGTC_347|Compound:4534-1311|FD-Score:2.94|P-value:8.92E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-4.31|P-value:2.57E-6 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.14|P-value:4.38E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-4.28|P-value:2.99E-6 ID:SGTC_665|Compound:3914-0008|FD-Score:-5.18|P-value:2.02E-8 ID:SGTC_774|Compound:k060-0086|FD-Score:3.16|P-value:3.99E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:4.37|P-value:1.72E-6 ID:SGTC_785|Compound:1270-0111|FD-Score:-4.61|P-value:5.15E-7 ID:SGTC_791|Compound:1348-1292|FD-Score:-3.66|P-value:5.25E-5 ID:SGTC_1143|Compound:3454-2408|FD-Score:2.95|P-value:8.69E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.62|P-value:6.33E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.06|P-value:5.84E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.54|P-value:8.63E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:-3.32|P-value:2.20E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.85|P-value:2.00E-13 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.24|P-value:1.99E-11 ID:SGTC_1750|Compound:st081859|FD-Score:3.92|P-value:1.58E-5 ID:SGTC_1751|Compound:st044839|FD-Score:3.54|P-value:8.44E-5 ID:SGTC_1753|Compound:st043925|FD-Score:5.20|P-value:1.67E-8 ID:SGTC_1756|Compound:st041558|FD-Score:5.24|P-value:1.31E-8 ID:SGTC_1966|Compound:st070145|FD-Score:-4.10|P-value:7.08E-6 ID:SGTC_1975|Compound:st070967|FD-Score:5.31|P-value:8.73E-9 ID:SGTC_1976|Compound:st070609|FD-Score:4.38|P-value:1.64E-6 ID:SGTC_2014|Compound:4013930|FD-Score:4.41|P-value:1.43E-6 ID:SGTC_2032|Compound:5185112|FD-Score:-4.16|P-value:5.44E-6 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-3.18|P-value:3.79E-4 ID:SGTC_2117|Compound:5521686|FD-Score:-3.17|P-value:3.96E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.96|P-value:1.31E-5 ID:SGTC_2423|Compound:st077119|FD-Score:-3.10|P-value:5.25E-4 ID:SGTC_2425|Compound:5628681|FD-Score:4.07|P-value:7.98E-6 ID:SGTC_2427|Compound:5545055|FD-Score:3.93|P-value:1.49E-5 ID:SGTC_2429|Compound:5902844|FD-Score:3.82|P-value:2.53E-5 ID:SGTC_2436|Compound:5633522|FD-Score:2.99|P-value:7.46E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.35|P-value:1.87E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.43|P-value:1.42E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:2.95|P-value:8.70E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.27|P-value:2.74E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.91|P-value:1.76E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:-3.02|P-value:7.01E-4 ID:SGTC_2876|Compound:9059903|FD-Score:2.94|P-value:9.11E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-3.17|P-value:3.92E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-2.96|P-value:8.81E-4

Top fitness defect scores for YDR497C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_299 1273-0059 6.91 1.4 µM 1.17E-13 4 2.46E-12
2 SGTC_310 1273-0058 5.42 1.1 µM 4.51E-9 mitochondrial stress 167 3.03E-8
3 SGTC_1975 st070967 5.31 30.8 µM 8.73E-9 13 5.45E-8
4 SGTC_1756 st041558 5.24 35.5 µM 1.31E-8 2 7.83E-8
5 SGTC_1753 st043925 5.20 64.0 µM 1.67E-8 2 9.70E-8
6 SGTC_2014 4013930 4.41 200.0 µM 1.43E-6 18 5.15E-6
7 SGTC_1976 st070609 4.38 63.5 µM 1.64E-6 4 5.83E-6
8 SGTC_779 1360-0071 4.37 233.0 µM 1.72E-6 fatty acid desaturase (OLE1) 19 6.08E-6
9 SGTC_260 nsc-65238 4.15 4.0 µM 5.27E-6 endomembrane recycling 12 1.66E-5
10 SGTC_2425 5628681 4.07 7.8 µM 7.98E-6 21 2.40E-5
11 SGTC_2419 paclitaxel 3.96 166.5 µM 1.31E-5 40 3.73E-5
12 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 3.95 44.4 nM 1.36E-5 DNA damage response 30 3.86E-5
13 SGTC_2427 5545055 3.93 42.8 µM 1.49E-5 15 4.19E-5
14 SGTC_1750 st081859 3.92 2.4 µM 1.58E-5 endomembrane recycling 187 4.42E-5
15 SGTC_2429 5902844 3.82 64.4 µM 2.53E-5 28 6.72E-5
16 SGTC_1751 st044839 3.54 27.2 µM 8.44E-5 Golgi 16 1.98E-4
17 SGTC_1282 0886-0010 3.54 32.4 µM 8.63E-5 endomembrane recycling 42 2.02E-4
18 SGTC_2568 diosmetin 3.35 100.0 µM 1.87E-4 44 4.02E-4
19 SGTC_143 4032-1194 3.25 15.7 µM 2.81E-4 110 5.79E-4
20 SGTC_774 k060-0086 3.16 136.0 µM 3.99E-4 47 7.94E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.338 1.13E-90 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.307 4.00E-74 YJR146W_p YJR146W_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2
0.287 1.95E-64 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.268 3.30E-56 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.235 2.52E-43 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.230 2.13E-41 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.228 1.19E-40 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.227 1.84E-40 YDR517W GRH1 hom Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress
0.226 5.41E-40 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.221 3.11E-38 YDR133C_d YDR133C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
0.220 4.56E-38 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.220 5.65E-38 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.217 3.23E-37 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.217 7.59E-37 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.210 1.00E-34 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability