YDR500C / RPL37B

Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR500C / RPL37B

Click on Significant Values for Screen Details ID:SGTC_13|Compound:0199-0087|FD-Score:3.23|P-value:6.57E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.56|P-value:4.81E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:5.05|P-value:3.61E-7 ID:SGTC_185|Compound:k048-0037|FD-Score:3.18|P-value:7.75E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:3.45|P-value:3.15E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.50|P-value:5.82E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.79|P-value:2.15E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.29|P-value:3.05E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:5.38|P-value:6.74E-8 ID:SGTC_371|Compound:0195-0006|FD-Score:3.68|P-value:1.35E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.00|P-value:9.67E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:3.20|P-value:7.22E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:4.16|P-value:2.02E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:6.03|P-value:1.83E-9 ID:SGTC_782|Compound:0083-0095|FD-Score:3.96|P-value:4.59E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:4.47|P-value:5.50E-6 ID:SGTC_788|Compound:1182-0090|FD-Score:3.28|P-value:5.60E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:-3.85|P-value:1.72E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:3.85|P-value:7.06E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.50|P-value:5.87E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:-4.53|P-value:1.15E-5 ID:SGTC_1008|Compound:4106-0037|FD-Score:-3.95|P-value:1.16E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:5.03|P-value:4.00E-7 ID:SGTC_1022|Compound:4477-0945|FD-Score:5.38|P-value:6.79E-8 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.53|P-value:2.36E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.41|P-value:3.60E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.69|P-value:1.31E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.61|P-value:1.73E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.78|P-value:2.22E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.55|P-value:4.90E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.36|P-value:4.28E-4 ID:SGTC_1612|Compound:st002233|FD-Score:3.55|P-value:2.19E-4 ID:SGTC_1619|Compound:st003326|FD-Score:3.42|P-value:3.52E-4 ID:SGTC_1652|Compound:st011932|FD-Score:-3.35|P-value:9.59E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.65|P-value:1.49E-4 ID:SGTC_2124|Compound:5246320|FD-Score:5.58|P-value:2.38E-8 ID:SGTC_2192|Compound:5915882|FD-Score:3.56|P-value:2.07E-4 ID:SGTC_2212|Compound:7123476|FD-Score:3.14|P-value:8.93E-4 ID:SGTC_2480|Compound:5767542|FD-Score:-3.49|P-value:5.94E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:-3.97|P-value:1.08E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.82|P-value:8.11E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.40|P-value:3.66E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-8.35|P-value:1.39E-15 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.15|P-value:8.61E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.75|P-value:2.47E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.37|P-value:7.12E-8 ID:SGTC_2815|Compound:7968870|FD-Score:3.21|P-value:6.98E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.61|P-value:1.74E-4 ID:SGTC_2988|Compound:9073640|FD-Score:3.30|P-value:5.25E-4 ID:SGTC_2999|Compound:9069765|FD-Score:4.07|P-value:3.00E-5 ID:SGTC_3007|Compound:9078383|FD-Score:3.88|P-value:6.24E-5 ID:SGTC_3055|Compound:9094636|FD-Score:-3.61|P-value:4.06E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.26|P-value:6.08E-4 ID:SGTC_3192|Compound:9110362|FD-Score:-3.82|P-value:1.88E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-4.16|P-value:5.13E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-4.10|P-value:6.69E-5 ID:SGTC_3297|Compound:9117502|FD-Score:4.02|P-value:3.62E-5 ID:SGTC_13|Compound:0199-0087|FD-Score:3.23|P-value:6.57E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.56|P-value:4.81E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:5.05|P-value:3.61E-7 ID:SGTC_185|Compound:k048-0037|FD-Score:3.18|P-value:7.75E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:3.45|P-value:3.15E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.50|P-value:5.82E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.79|P-value:2.15E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.29|P-value:3.05E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:5.38|P-value:6.74E-8 ID:SGTC_371|Compound:0195-0006|FD-Score:3.68|P-value:1.35E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.00|P-value:9.67E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:3.20|P-value:7.22E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:4.16|P-value:2.02E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:6.03|P-value:1.83E-9 ID:SGTC_782|Compound:0083-0095|FD-Score:3.96|P-value:4.59E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:4.47|P-value:5.50E-6 ID:SGTC_788|Compound:1182-0090|FD-Score:3.28|P-value:5.60E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:-3.85|P-value:1.72E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:3.85|P-value:7.06E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.50|P-value:5.87E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:-4.53|P-value:1.15E-5 ID:SGTC_1008|Compound:4106-0037|FD-Score:-3.95|P-value:1.16E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:5.03|P-value:4.00E-7 ID:SGTC_1022|Compound:4477-0945|FD-Score:5.38|P-value:6.79E-8 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.53|P-value:2.36E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.41|P-value:3.60E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.69|P-value:1.31E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.61|P-value:1.73E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.78|P-value:2.22E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.55|P-value:4.90E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.36|P-value:4.28E-4 ID:SGTC_1612|Compound:st002233|FD-Score:3.55|P-value:2.19E-4 ID:SGTC_1619|Compound:st003326|FD-Score:3.42|P-value:3.52E-4 ID:SGTC_1652|Compound:st011932|FD-Score:-3.35|P-value:9.59E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.65|P-value:1.49E-4 ID:SGTC_2124|Compound:5246320|FD-Score:5.58|P-value:2.38E-8 ID:SGTC_2192|Compound:5915882|FD-Score:3.56|P-value:2.07E-4 ID:SGTC_2212|Compound:7123476|FD-Score:3.14|P-value:8.93E-4 ID:SGTC_2480|Compound:5767542|FD-Score:-3.49|P-value:5.94E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:-3.97|P-value:1.08E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.82|P-value:8.11E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.40|P-value:3.66E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-8.35|P-value:1.39E-15 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.15|P-value:8.61E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.75|P-value:2.47E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.37|P-value:7.12E-8 ID:SGTC_2815|Compound:7968870|FD-Score:3.21|P-value:6.98E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.61|P-value:1.74E-4 ID:SGTC_2988|Compound:9073640|FD-Score:3.30|P-value:5.25E-4 ID:SGTC_2999|Compound:9069765|FD-Score:4.07|P-value:3.00E-5 ID:SGTC_3007|Compound:9078383|FD-Score:3.88|P-value:6.24E-5 ID:SGTC_3055|Compound:9094636|FD-Score:-3.61|P-value:4.06E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.26|P-value:6.08E-4 ID:SGTC_3192|Compound:9110362|FD-Score:-3.82|P-value:1.88E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-4.16|P-value:5.13E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-4.10|P-value:6.69E-5 ID:SGTC_3297|Compound:9117502|FD-Score:4.02|P-value:3.62E-5

Top fitness defect scores for YDR500C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_764 1951-2361 6.03 146.0 µM 1.83E-9 6 8.09E-10
2 SGTC_2124 5246320 5.58 200.0 µM 2.38E-8 heme biosynthesis & mitochondrial translocase 4 1.24E-8
3 SGTC_361 000s-0510 5.38 1.4 µM 6.74E-8 9 3.74E-8
4 SGTC_1022 4477-0945 5.38 21.3 µM 6.79E-8 6 3.77E-8
5 SGTC_2688 kanamycin b 5.37 96.7 µM 7.12E-8 calcium & mitochondrial duress 206 3.96E-8
6 SGTC_118 0083-0097 5.05 135.3 µM 3.61E-7 translation 53 2.22E-7
7 SGTC_1021 4476-0760 5.03 85.3 µM 4.00E-7 9 2.48E-7
8 SGTC_787 4152-0075 4.47 138.0 µM 5.50E-6 14 3.98E-6
9 SGTC_519 k048-0011 4.16 62.8 µM 2.02E-5 17 1.57E-5
10 SGTC_2999 9069765 4.07 71.4 µM 3.00E-5 amide catabolism 22 2.39E-5
11 SGTC_3297 9117502 4.02 71.4 µM 3.62E-5 8 2.91E-5
12 SGTC_782 0083-0095 3.96 30.5 µM 4.59E-5 25 3.73E-5
13 SGTC_3007 9078383 3.88 71.4 µM 6.24E-5 15 5.16E-5
14 SGTC_853 0419-0306 3.85 21.0 µM 7.06E-5 14 5.88E-5
15 SGTC_2573 2',4'-dihydroxychalcone 3.82 15.0 µM 8.11E-5 56 6.80E-5
16 SGTC_1127 asiatic acid 3.69 681.4 nM 1.31E-4 29 1.13E-4
17 SGTC_371 0195-0006 3.68 7.4 µM 1.35E-4 25 1.17E-4
18 SGTC_1792 st045773 3.65 43.6 µM 1.49E-4 39 1.29E-4
19 SGTC_1506 4226-2149 3.61 212.0 µM 1.73E-4 39 1.51E-4
20 SGTC_2907 7721985 3.61 69.9 µM 1.74E-4 35 1.52E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.205 3.67E-33 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.174 2.36E-24 YGR159C NSR1 hom Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.157 5.86E-20 YDR156W RPA14 hom RNA polymerase I subunit A14
0.155 1.50E-19 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.155 2.13E-19 YDR447C RPS17B hom Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.147 8.87E-18 YDL081C RPP1A hom Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
0.134 7.10E-15 YLL045C RPL8B hom Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication
0.132 1.78E-14 YDL136W RPL35B hom Ribosomal 60S subunit protein L35B; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35B has a paralog, RPL35A, that arose from the whole genome duplication
0.131 3.03E-14 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.129 5.67E-14 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.128 1.18E-13 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.126 2.12E-13 YGR160W_d YGR160W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.126 2.40E-13 YDR163W CWC15 hom Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p
0.123 1.04E-12 YPL125W KAP120 hom Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p
0.122 1.07E-12 YGR227W DIE2 hom Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1