HIPHOP chemogenomics database

YDR507C / GIN4

Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR507C / GIN4

Click on Significant Values for Screen Details

Top fitness defect scores for YDR507C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	10.80	5.3 µM	2.34E-29		175	1.26E-27
2	SGTC_310	1273-0058	9.46	1.1 µM	8.03E-23	mitochondrial stress	52	1.57E-21
3	SGTC_173	1273-0061	7.43	2.7 µM	9.22E-15	mitochondrial stress	80	5.27E-14
4	SGTC_3323	9138564	5.91	53.9 µM	5.95E-10		2	1.68E-9
5	SGTC_1354	1498-1681	5.89	81.0 µM	6.80E-10		3	1.90E-9
6	SGTC_2499	avocadenofuran	5.80	51.5 µM	1.24E-9		9	3.32E-9
7	SGTC_2232	chlorophetanol	5.64	41.5 µM	3.29E-9	TRP & mitochondrial translation	51	8.31E-9
8	SGTC_275	trichlorophene	5.19	5.7 µM	4.92E-8	mitochondrial stress	157	1.05E-7
9	SGTC_3043	9092303	5.05	49.5 µM	1.07E-7		3	2.19E-7
10	SGTC_800	3448-7362	4.98	155.0 µM	1.63E-7	translation	90	3.24E-7
11	SGTC_1742	st038235	4.91	28.9 µM	2.40E-7	mitochondrial stress	81	4.67E-7
12	SGTC_1351	1496-0003	4.74	46.5 µM	5.77E-7		12	1.06E-6
13	SGTC_778	3456-2434	4.46	196.0 µM	2.44E-6	mitochondrial response to ROS	59	4.13E-6
14	SGTC_2582	agaric acid	4.24	100.0 µM	6.89E-6	redox potentiating	289	1.10E-5
15	SGTC_2261	9010538	4.15	184.7 µM	1.09E-5		17	1.69E-5
16	SGTC_1843	st055809	4.14	45.5 µM	1.15E-5		12	1.77E-5
17	SGTC_1784	st039334	4.07	36.3 µM	1.52E-5		17	2.31E-5
18	SGTC_1454	4239-0054	4.05	42.6 µM	1.71E-5		33	2.58E-5
19	SGTC_831	k061-1017	4.05	217.0 µM	1.71E-5	translation	58	2.58E-5
20	SGTC_2602	kawain	4.02	100.0 µM	1.95E-5		25	2.93E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.404	8.40E-132	YGL064C	MRH4	hom	Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.403	1.84E-131	YMR228W	MTF1	hom	Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.402	4.66E-130	YMR287C	DSS1	hom	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.402	3.01E-130	YGR219W_d	YGR219W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C
0.397	2.65E-127	YER050C	RSM18	hom	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.396	2.01E-126	YLL033W	IRC19	hom	Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.394	1.05E-124	YGR102C	GTF1	hom	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.391	3.97E-123	YNL005C	MRP7	hom	Mitochondrial ribosomal protein of the large subunit
0.386	1.27E-119	YNL081C	SWS2	hom	Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.385	4.37E-119	YPL040C	ISM1	hom	Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.382	5.93E-117	YLR069C	MEF1	hom	Mitochondrial elongation factor involved in translational elongation
0.379	3.81E-115	YDR462W	MRPL28	hom	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.377	1.50E-113	YMR193W	MRPL24	hom	Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.376	5.64E-113	YDR194C	MSS116	hom	DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.374	5.26E-112	YNL184C_p	YNL184C_p	hom	Protein of unknown function; expressed at both mRNA and protein levels