YDR507C / GIN4

Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR507C / GIN4

Click on Significant Values for Screen Details ID:SGTC_19|Compound:0279-0214|FD-Score:3.17|P-value:6.24E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.87|P-value:3.72E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:3.82|P-value:4.64E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.24|P-value:4.83E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.55|P-value:1.42E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.29|P-value:3.88E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:7.43|P-value:9.22E-15 ID:SGTC_236|Compound:1509-0011|FD-Score:10.80|P-value:2.34E-29 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.19|P-value:4.92E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:9.46|P-value:8.03E-23 ID:SGTC_314|Compound:1671-0008|FD-Score:3.36|P-value:3.09E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.66|P-value:5.67E-5 ID:SGTC_357|Compound:1325-0123|FD-Score:3.73|P-value:6.75E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.26|P-value:2.86E-4 ID:SGTC_398|Compound:bronopol|FD-Score:3.31|P-value:3.70E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:-3.37|P-value:1.82E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.34|P-value:2.10E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.39|P-value:1.73E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:-3.88|P-value:2.10E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:-2.99|P-value:7.77E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.57|P-value:1.31E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.70|P-value:7.89E-5 ID:SGTC_761|Compound:k216-0224|FD-Score:3.21|P-value:5.32E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.58|P-value:1.29E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:4.46|P-value:2.44E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:4.98|P-value:1.63E-7 ID:SGTC_831|Compound:k061-1017|FD-Score:4.05|P-value:1.71E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:3.73|P-value:6.98E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:3.57|P-value:1.31E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.11|P-value:7.59E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.09|P-value:8.32E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.60|P-value:1.16E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:4.74|P-value:5.77E-7 ID:SGTC_1354|Compound:1498-1681|FD-Score:5.89|P-value:6.80E-10 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.05|P-value:1.71E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.45|P-value:2.11E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.35|P-value:1.97E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.31|P-value:3.70E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.94|P-value:2.81E-5 ID:SGTC_1627|Compound:st003713|FD-Score:3.46|P-value:2.04E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.88|P-value:3.62E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.87|P-value:2.28E-5 ID:SGTC_1722|Compound:st034304|FD-Score:3.19|P-value:5.74E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.91|P-value:2.40E-7 ID:SGTC_1784|Compound:st039334|FD-Score:4.07|P-value:1.52E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.78|P-value:3.39E-5 ID:SGTC_1843|Compound:st055809|FD-Score:4.14|P-value:1.15E-5 ID:SGTC_1988|Compound:st071872|FD-Score:3.17|P-value:6.25E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-7.10|P-value:5.19E-14 ID:SGTC_2052|Compound:5265182|FD-Score:3.10|P-value:8.01E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.30|P-value:2.45E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.48|P-value:1.92E-4 ID:SGTC_2190|Compound:6049624|FD-Score:3.13|P-value:7.10E-4 ID:SGTC_2213|Compound:7173844|FD-Score:3.35|P-value:3.17E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.64|P-value:3.29E-9 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.20|P-value:5.55E-4 ID:SGTC_2261|Compound:9010538|FD-Score:4.15|P-value:1.09E-5 ID:SGTC_2316|Compound:5844804|FD-Score:3.56|P-value:1.40E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.14|P-value:6.90E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.04|P-value:9.92E-4 ID:SGTC_2355|Compound:9061122|FD-Score:3.51|P-value:1.72E-4 ID:SGTC_2438|Compound:5259590|FD-Score:3.83|P-value:4.56E-5 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:5.80|P-value:1.24E-9 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.06|P-value:9.10E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.87|P-value:2.24E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.24|P-value:6.89E-6 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.77|P-value:5.68E-5 ID:SGTC_2602|Compound:kawain|FD-Score:4.02|P-value:1.95E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.05|P-value:6.17E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.90|P-value:3.36E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.40|P-value:2.60E-4 ID:SGTC_3003|Compound:9075612|FD-Score:3.42|P-value:2.38E-4 ID:SGTC_3043|Compound:9092303|FD-Score:5.05|P-value:1.07E-7 ID:SGTC_3142|Compound:9086498|FD-Score:-3.96|P-value:1.52E-5 ID:SGTC_3152|Compound:9099253|FD-Score:3.07|P-value:8.81E-4 ID:SGTC_3323|Compound:9138564|FD-Score:5.91|P-value:5.95E-10 ID:SGTC_3329|Compound:9141233|FD-Score:-4.18|P-value:5.31E-6 ID:SGTC_19|Compound:0279-0214|FD-Score:3.17|P-value:6.24E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.87|P-value:3.72E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:3.82|P-value:4.64E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.24|P-value:4.83E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.55|P-value:1.42E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.29|P-value:3.88E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:7.43|P-value:9.22E-15 ID:SGTC_236|Compound:1509-0011|FD-Score:10.80|P-value:2.34E-29 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.19|P-value:4.92E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:9.46|P-value:8.03E-23 ID:SGTC_314|Compound:1671-0008|FD-Score:3.36|P-value:3.09E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.66|P-value:5.67E-5 ID:SGTC_357|Compound:1325-0123|FD-Score:3.73|P-value:6.75E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.26|P-value:2.86E-4 ID:SGTC_398|Compound:bronopol|FD-Score:3.31|P-value:3.70E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:-3.37|P-value:1.82E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.34|P-value:2.10E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.39|P-value:1.73E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:-3.88|P-value:2.10E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:-2.99|P-value:7.77E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.57|P-value:1.31E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.70|P-value:7.89E-5 ID:SGTC_761|Compound:k216-0224|FD-Score:3.21|P-value:5.32E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.58|P-value:1.29E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:4.46|P-value:2.44E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:4.98|P-value:1.63E-7 ID:SGTC_831|Compound:k061-1017|FD-Score:4.05|P-value:1.71E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:3.73|P-value:6.98E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:3.57|P-value:1.31E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.11|P-value:7.59E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.09|P-value:8.32E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.60|P-value:1.16E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:4.74|P-value:5.77E-7 ID:SGTC_1354|Compound:1498-1681|FD-Score:5.89|P-value:6.80E-10 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.05|P-value:1.71E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.45|P-value:2.11E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.35|P-value:1.97E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.31|P-value:3.70E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.94|P-value:2.81E-5 ID:SGTC_1627|Compound:st003713|FD-Score:3.46|P-value:2.04E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.88|P-value:3.62E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.87|P-value:2.28E-5 ID:SGTC_1722|Compound:st034304|FD-Score:3.19|P-value:5.74E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.91|P-value:2.40E-7 ID:SGTC_1784|Compound:st039334|FD-Score:4.07|P-value:1.52E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.78|P-value:3.39E-5 ID:SGTC_1843|Compound:st055809|FD-Score:4.14|P-value:1.15E-5 ID:SGTC_1988|Compound:st071872|FD-Score:3.17|P-value:6.25E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-7.10|P-value:5.19E-14 ID:SGTC_2052|Compound:5265182|FD-Score:3.10|P-value:8.01E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.30|P-value:2.45E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.48|P-value:1.92E-4 ID:SGTC_2190|Compound:6049624|FD-Score:3.13|P-value:7.10E-4 ID:SGTC_2213|Compound:7173844|FD-Score:3.35|P-value:3.17E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.64|P-value:3.29E-9 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.20|P-value:5.55E-4 ID:SGTC_2261|Compound:9010538|FD-Score:4.15|P-value:1.09E-5 ID:SGTC_2316|Compound:5844804|FD-Score:3.56|P-value:1.40E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.14|P-value:6.90E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.04|P-value:9.92E-4 ID:SGTC_2355|Compound:9061122|FD-Score:3.51|P-value:1.72E-4 ID:SGTC_2438|Compound:5259590|FD-Score:3.83|P-value:4.56E-5 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:5.80|P-value:1.24E-9 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.06|P-value:9.10E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.87|P-value:2.24E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.24|P-value:6.89E-6 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.77|P-value:5.68E-5 ID:SGTC_2602|Compound:kawain|FD-Score:4.02|P-value:1.95E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.05|P-value:6.17E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.90|P-value:3.36E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.40|P-value:2.60E-4 ID:SGTC_3003|Compound:9075612|FD-Score:3.42|P-value:2.38E-4 ID:SGTC_3043|Compound:9092303|FD-Score:5.05|P-value:1.07E-7 ID:SGTC_3142|Compound:9086498|FD-Score:-3.96|P-value:1.52E-5 ID:SGTC_3152|Compound:9099253|FD-Score:3.07|P-value:8.81E-4 ID:SGTC_3323|Compound:9138564|FD-Score:5.91|P-value:5.95E-10 ID:SGTC_3329|Compound:9141233|FD-Score:-4.18|P-value:5.31E-6

Top fitness defect scores for YDR507C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 10.80 5.3 µM 2.34E-29 175 1.26E-27
2 SGTC_310 1273-0058 9.46 1.1 µM 8.03E-23 mitochondrial stress 52 1.57E-21
3 SGTC_173 1273-0061 7.43 2.7 µM 9.22E-15 mitochondrial stress 80 5.27E-14
4 SGTC_3323 9138564 5.91 53.9 µM 5.95E-10 2 1.68E-9
5 SGTC_1354 1498-1681 5.89 81.0 µM 6.80E-10 3 1.90E-9
6 SGTC_2499 avocadenofuran 5.80 51.5 µM 1.24E-9 9 3.32E-9
7 SGTC_2232 chlorophetanol 5.64 41.5 µM 3.29E-9 TRP & mitochondrial translation 51 8.31E-9
8 SGTC_275 trichlorophene 5.19 5.7 µM 4.92E-8 mitochondrial stress 157 1.05E-7
9 SGTC_3043 9092303 5.05 49.5 µM 1.07E-7 3 2.19E-7
10 SGTC_800 3448-7362 4.98 155.0 µM 1.63E-7 translation 90 3.24E-7
11 SGTC_1742 st038235 4.91 28.9 µM 2.40E-7 mitochondrial stress 81 4.67E-7
12 SGTC_1351 1496-0003 4.74 46.5 µM 5.77E-7 12 1.06E-6
13 SGTC_778 3456-2434 4.46 196.0 µM 2.44E-6 mitochondrial response to ROS 59 4.13E-6
14 SGTC_2582 agaric acid 4.24 100.0 µM 6.89E-6 redox potentiating 289 1.10E-5
15 SGTC_2261 9010538 4.15 184.7 µM 1.09E-5 17 1.69E-5
16 SGTC_1843 st055809 4.14 45.5 µM 1.15E-5 12 1.77E-5
17 SGTC_1784 st039334 4.07 36.3 µM 1.52E-5 17 2.31E-5
18 SGTC_1454 4239-0054 4.05 42.6 µM 1.71E-5 33 2.58E-5
19 SGTC_831 k061-1017 4.05 217.0 µM 1.71E-5 translation 58 2.58E-5
20 SGTC_2602 kawain 4.02 100.0 µM 1.95E-5 25 2.93E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.404 8.40E-132 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.403 1.84E-131 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.402 4.66E-130 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.402 3.01E-130 YGR219W_d YGR219W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C
0.397 2.65E-127 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.396 2.01E-126 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.394 1.05E-124 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.391 3.97E-123 YNL005C MRP7 hom Mitochondrial ribosomal protein of the large subunit
0.386 1.27E-119 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.385 4.37E-119 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.382 5.93E-117 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.379 3.81E-115 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.377 1.50E-113 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.376 5.64E-113 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.374 5.26E-112 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels