YDR509W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR509W / YDR509W

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.70|P-value:2.52E-8 ID:SGTC_19|Compound:0279-0214|FD-Score:4.50|P-value:7.89E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:7.53|P-value:3.41E-13 ID:SGTC_66|Compound:0109-0187|FD-Score:4.44|P-value:1.01E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:10.30|P-value:5.01E-23 ID:SGTC_70|Compound:0141-0289|FD-Score:20.40|P-value:6.20E-84 ID:SGTC_119|Compound:0121-0043|FD-Score:3.23|P-value:9.41E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:6.19|P-value:1.65E-9 ID:SGTC_192|Compound:3455-0609|FD-Score:3.49|P-value:3.87E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:3.67|P-value:2.06E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:3.35|P-value:6.34E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:4.91|P-value:1.25E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:10.80|P-value:6.56E-25 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.15|P-value:4.13E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:6.87|P-value:2.72E-11 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.77|P-value:2.14E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.62|P-value:2.45E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.53|P-value:3.36E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:3.67|P-value:2.10E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.86|P-value:1.04E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.33|P-value:1.64E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:-4.02|P-value:8.78E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:6.90|P-value:2.20E-11 ID:SGTC_941|Compound:3237-0776|FD-Score:-5.03|P-value:1.20E-6 ID:SGTC_952|Compound:1185-0122|FD-Score:3.54|P-value:3.33E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:4.17|P-value:3.13E-5 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.94|P-value:7.67E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.99|P-value:8.69E-7 ID:SGTC_1626|Compound:st003712|FD-Score:4.65|P-value:4.08E-6 ID:SGTC_1627|Compound:st003713|FD-Score:6.33|P-value:7.17E-10 ID:SGTC_1656|Compound:st012921|FD-Score:-7.07|P-value:1.55E-11 ID:SGTC_1658|Compound:st012944|FD-Score:-4.46|P-value:1.50E-5 ID:SGTC_1662|Compound:st014054|FD-Score:3.39|P-value:5.44E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-3.48|P-value:5.86E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.21|P-value:5.12E-7 ID:SGTC_1742|Compound:st038235|FD-Score:5.90|P-value:8.53E-9 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.85|P-value:1.61E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.99|P-value:1.46E-6 ID:SGTC_1911|Compound:st060208|FD-Score:6.21|P-value:1.49E-9 ID:SGTC_1914|Compound:st062367|FD-Score:5.41|P-value:1.11E-7 ID:SGTC_1917|Compound:st066507|FD-Score:-3.91|P-value:1.28E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.33|P-value:6.63E-4 ID:SGTC_2033|Compound:5192550|FD-Score:3.41|P-value:5.04E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.31|P-value:7.04E-4 ID:SGTC_2133|Compound:5320837|FD-Score:4.97|P-value:9.47E-7 ID:SGTC_2183|Compound:6420625|FD-Score:4.24|P-value:2.39E-5 ID:SGTC_2188|Compound:6126565|FD-Score:-3.67|P-value:3.07E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.06|P-value:6.37E-7 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.61|P-value:4.01E-8 ID:SGTC_2271|Compound:7849410|FD-Score:-4.38|P-value:2.13E-5 ID:SGTC_2283|Compound:7944793|FD-Score:4.78|P-value:2.33E-6 ID:SGTC_2325|Compound:6158266|FD-Score:3.44|P-value:4.71E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.06|P-value:4.76E-5 ID:SGTC_2338|Compound:7999974|FD-Score:-3.44|P-value:6.67E-4 ID:SGTC_2370|Compound:9071495|FD-Score:4.26|P-value:2.17E-5 ID:SGTC_2513|Compound:baicalein|FD-Score:4.49|P-value:8.13E-6 ID:SGTC_2526|Compound:patulin|FD-Score:3.29|P-value:7.62E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:3.21|P-value:9.85E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.35|P-value:6.35E-4 ID:SGTC_2783|Compound:7738165|FD-Score:4.36|P-value:1.42E-5 ID:SGTC_2784|Compound:7567673|FD-Score:-6.83|P-value:6.86E-11 ID:SGTC_2813|Compound:7971799|FD-Score:4.00|P-value:6.02E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-4.38|P-value:2.11E-5 ID:SGTC_3110|Compound:9122132|FD-Score:-3.67|P-value:3.10E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.43|P-value:4.85E-4 ID:SGTC_3252|Compound:9135871|FD-Score:3.86|P-value:1.04E-4 ID:SGTC_3253|Compound:9135987|FD-Score:3.99|P-value:6.38E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-3.32|P-value:9.98E-4 ID:SGTC_3275|Compound:9138069|FD-Score:3.70|P-value:1.89E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.69|P-value:1.92E-4 ID:SGTC_3330|Compound:9141424|FD-Score:3.63|P-value:2.38E-4 ID:SGTC_3333|Compound:9141820|FD-Score:-5.04|P-value:1.18E-6 ID:SGTC_10|Compound:0279-0212|FD-Score:5.70|P-value:2.52E-8 ID:SGTC_19|Compound:0279-0214|FD-Score:4.50|P-value:7.89E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:7.53|P-value:3.41E-13 ID:SGTC_66|Compound:0109-0187|FD-Score:4.44|P-value:1.01E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:10.30|P-value:5.01E-23 ID:SGTC_70|Compound:0141-0289|FD-Score:20.40|P-value:6.20E-84 ID:SGTC_119|Compound:0121-0043|FD-Score:3.23|P-value:9.41E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:6.19|P-value:1.65E-9 ID:SGTC_192|Compound:3455-0609|FD-Score:3.49|P-value:3.87E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:3.67|P-value:2.06E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:3.35|P-value:6.34E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:4.91|P-value:1.25E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:10.80|P-value:6.56E-25 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.15|P-value:4.13E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:6.87|P-value:2.72E-11 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.77|P-value:2.14E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.62|P-value:2.45E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.53|P-value:3.36E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:3.67|P-value:2.10E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.86|P-value:1.04E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.33|P-value:1.64E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:-4.02|P-value:8.78E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:6.90|P-value:2.20E-11 ID:SGTC_941|Compound:3237-0776|FD-Score:-5.03|P-value:1.20E-6 ID:SGTC_952|Compound:1185-0122|FD-Score:3.54|P-value:3.33E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:4.17|P-value:3.13E-5 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.94|P-value:7.67E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.99|P-value:8.69E-7 ID:SGTC_1626|Compound:st003712|FD-Score:4.65|P-value:4.08E-6 ID:SGTC_1627|Compound:st003713|FD-Score:6.33|P-value:7.17E-10 ID:SGTC_1656|Compound:st012921|FD-Score:-7.07|P-value:1.55E-11 ID:SGTC_1658|Compound:st012944|FD-Score:-4.46|P-value:1.50E-5 ID:SGTC_1662|Compound:st014054|FD-Score:3.39|P-value:5.44E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-3.48|P-value:5.86E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.21|P-value:5.12E-7 ID:SGTC_1742|Compound:st038235|FD-Score:5.90|P-value:8.53E-9 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.85|P-value:1.61E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.99|P-value:1.46E-6 ID:SGTC_1911|Compound:st060208|FD-Score:6.21|P-value:1.49E-9 ID:SGTC_1914|Compound:st062367|FD-Score:5.41|P-value:1.11E-7 ID:SGTC_1917|Compound:st066507|FD-Score:-3.91|P-value:1.28E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.33|P-value:6.63E-4 ID:SGTC_2033|Compound:5192550|FD-Score:3.41|P-value:5.04E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.31|P-value:7.04E-4 ID:SGTC_2133|Compound:5320837|FD-Score:4.97|P-value:9.47E-7 ID:SGTC_2183|Compound:6420625|FD-Score:4.24|P-value:2.39E-5 ID:SGTC_2188|Compound:6126565|FD-Score:-3.67|P-value:3.07E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.06|P-value:6.37E-7 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.61|P-value:4.01E-8 ID:SGTC_2271|Compound:7849410|FD-Score:-4.38|P-value:2.13E-5 ID:SGTC_2283|Compound:7944793|FD-Score:4.78|P-value:2.33E-6 ID:SGTC_2325|Compound:6158266|FD-Score:3.44|P-value:4.71E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.06|P-value:4.76E-5 ID:SGTC_2338|Compound:7999974|FD-Score:-3.44|P-value:6.67E-4 ID:SGTC_2370|Compound:9071495|FD-Score:4.26|P-value:2.17E-5 ID:SGTC_2513|Compound:baicalein|FD-Score:4.49|P-value:8.13E-6 ID:SGTC_2526|Compound:patulin|FD-Score:3.29|P-value:7.62E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:3.21|P-value:9.85E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.35|P-value:6.35E-4 ID:SGTC_2783|Compound:7738165|FD-Score:4.36|P-value:1.42E-5 ID:SGTC_2784|Compound:7567673|FD-Score:-6.83|P-value:6.86E-11 ID:SGTC_2813|Compound:7971799|FD-Score:4.00|P-value:6.02E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-4.38|P-value:2.11E-5 ID:SGTC_3110|Compound:9122132|FD-Score:-3.67|P-value:3.10E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.43|P-value:4.85E-4 ID:SGTC_3252|Compound:9135871|FD-Score:3.86|P-value:1.04E-4 ID:SGTC_3253|Compound:9135987|FD-Score:3.99|P-value:6.38E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-3.32|P-value:9.98E-4 ID:SGTC_3275|Compound:9138069|FD-Score:3.70|P-value:1.89E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.69|P-value:1.92E-4 ID:SGTC_3330|Compound:9141424|FD-Score:3.63|P-value:2.38E-4 ID:SGTC_3333|Compound:9141820|FD-Score:-5.04|P-value:1.18E-6

Top fitness defect scores for YDR509W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_70 0141-0289 20.40 43.3 µM 6.20E-84 mitochondrial stress 1 8.96E-93
2 SGTC_236 1509-0011 10.80 5.3 µM 6.56E-25 179 2.86E-27
3 SGTC_68 0986-0284 10.30 82.8 µM 5.01E-23 5 3.48E-25
4 SGTC_63 0099-0242 7.53 26.7 µM 3.41E-13 mitochondrial stress 14 2.61E-14
5 SGTC_908 3448-7491 6.90 47.7 µM 2.20E-11 mitochondrial stress 29 2.59E-12
6 SGTC_310 1273-0058 6.87 1.1 µM 2.72E-11 mitochondrial stress 120 3.28E-12
7 SGTC_1627 st003713 6.33 25.6 µM 7.17E-10 calcium & mitochondrial duress 26 1.21E-10
8 SGTC_1911 st060208 6.21 74.3 µM 1.49E-9 4 2.71E-10
9 SGTC_173 1273-0061 6.19 2.7 µM 1.65E-9 mitochondrial stress 105 3.03E-10
10 SGTC_1742 st038235 5.90 28.9 µM 8.53E-9 mitochondrial stress 47 1.85E-9
11 SGTC_10 0279-0212 5.70 42.6 µM 2.52E-8 TRP & mitochondrial translation 35 6.11E-9
12 SGTC_2250 alverine citrate 5.61 130.0 µM 4.01E-8 69 1.02E-8
13 SGTC_1914 st062367 5.41 72.6 µM 1.11E-7 6 3.13E-8
14 SGTC_275 trichlorophene 5.15 5.7 µM 4.13E-7 mitochondrial stress 160 1.32E-7
15 SGTC_2232 chlorophetanol 5.06 41.5 µM 6.37E-7 TRP & mitochondrial translation 77 2.13E-7
16 SGTC_1451 4152-0210 4.99 104.0 µM 8.69E-7 7 2.99E-7
17 SGTC_2133 5320837 4.97 200.0 µM 9.47E-7 ERG2 11 3.29E-7
18 SGTC_211 3455-0679 4.91 143.5 µM 1.25E-6 4 4.46E-7
19 SGTC_2283 7944793 4.78 200.0 µM 2.33E-6 21 8.85E-7
20 SGTC_1626 st003712 4.65 1.8 µM 4.08E-6 14 1.64E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.435 1.32E-154 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.435 1.11E-154 YNL005C MRP7 hom Mitochondrial ribosomal protein of the large subunit
0.425 2.38E-147 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.421 2.93E-144 YNL284C MRPL10 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels
0.420 9.98E-144 YDR065W RRG1 hom Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.416 2.50E-140 YDR529C QCR7 hom Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly
0.411 8.27E-137 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.404 7.96E-132 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.397 2.88E-127 YJR144W MGM101 hom Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage
0.395 1.93E-125 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.395 2.31E-125 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.393 2.49E-124 YDR337W MRPS28 hom Mitochondrial ribosomal protein of the small subunit
0.392 9.48E-124 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.388 2.71E-121 YCR024C SLM5 hom Mitochondrial asparaginyl-tRNA synthetase
0.384 3.71E-118 YLR149C YLR149C hom Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress