YDR510W / SMT3

Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR510W / SMT3

Click on Significant Values for Screen Details ID:SGTC_52|Compound:0329-0193|FD-Score:-2.96|P-value:5.42E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:4.31|P-value:9.99E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:5.30|P-value:2.58E-9 ID:SGTC_165|Compound:k038-0023|FD-Score:2.98|P-value:5.04E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:4.47|P-value:4.18E-7 ID:SGTC_257|Compound:daunorubicin|FD-Score:-2.96|P-value:5.40E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:3.35|P-value:1.09E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.21|P-value:2.00E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:2.97|P-value:5.29E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.19|P-value:2.21E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:4.00|P-value:5.10E-6 ID:SGTC_571|Compound:k831-0106|FD-Score:3.54|P-value:4.82E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:3.39|P-value:9.48E-5 ID:SGTC_738|Compound:1315-0003|FD-Score:4.09|P-value:3.24E-6 ID:SGTC_903|Compound:1134-0042|FD-Score:2.81|P-value:9.85E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.00|P-value:4.66E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:-2.91|P-value:6.53E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.17|P-value:2.29E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:7.62|P-value:2.11E-17 ID:SGTC_935|Compound:2996-0153|FD-Score:3.03|P-value:4.23E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:5.36|P-value:1.68E-9 ID:SGTC_976|Compound:1348-1067|FD-Score:-3.77|P-value:1.54E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:-3.22|P-value:1.86E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:2.85|P-value:8.55E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.14|P-value:2.63E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:2.99|P-value:4.94E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:4.39|P-value:6.51E-7 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.54|P-value:4.84E-5 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.50|P-value:5.81E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:-3.75|P-value:1.77E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:2.83|P-value:8.91E-4 ID:SGTC_1699|Compound:st031318|FD-Score:2.80|P-value:9.95E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.10|P-value:3.21E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:2.88|P-value:7.54E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.38|P-value:9.63E-5 ID:SGTC_1991|Compound:st073000|FD-Score:3.18|P-value:2.24E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.06|P-value:3.70E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.20|P-value:2.08E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.22|P-value:1.92E-4 ID:SGTC_2428|Compound:5615643|FD-Score:3.10|P-value:3.13E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.17|P-value:2.37E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.57|P-value:4.08E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.67|P-value:2.51E-5 ID:SGTC_2646|Compound:retinol|FD-Score:3.27|P-value:1.53E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.73|P-value:1.94E-5 ID:SGTC_2810|Compound:7959871|FD-Score:-2.92|P-value:6.30E-4 ID:SGTC_2865|Compound:9030313|FD-Score:-3.11|P-value:2.99E-4 ID:SGTC_2873|Compound:9040596|FD-Score:-3.31|P-value:1.28E-4 ID:SGTC_2878|Compound:9043973|FD-Score:-2.93|P-value:6.06E-4 ID:SGTC_2936|Compound:9038235|FD-Score:2.87|P-value:7.77E-4 ID:SGTC_2980|Compound:9014342|FD-Score:-3.29|P-value:1.38E-4 ID:SGTC_3099|Compound:9120367|FD-Score:-2.81|P-value:9.72E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.98|P-value:5.59E-6 ID:SGTC_3233|Compound:9132340|FD-Score:4.10|P-value:3.16E-6 ID:SGTC_52|Compound:0329-0193|FD-Score:-2.96|P-value:5.42E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:4.31|P-value:9.99E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:5.30|P-value:2.58E-9 ID:SGTC_165|Compound:k038-0023|FD-Score:2.98|P-value:5.04E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:4.47|P-value:4.18E-7 ID:SGTC_257|Compound:daunorubicin|FD-Score:-2.96|P-value:5.40E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:3.35|P-value:1.09E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.21|P-value:2.00E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:2.97|P-value:5.29E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.19|P-value:2.21E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:4.00|P-value:5.10E-6 ID:SGTC_571|Compound:k831-0106|FD-Score:3.54|P-value:4.82E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:3.39|P-value:9.48E-5 ID:SGTC_738|Compound:1315-0003|FD-Score:4.09|P-value:3.24E-6 ID:SGTC_903|Compound:1134-0042|FD-Score:2.81|P-value:9.85E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.00|P-value:4.66E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:-2.91|P-value:6.53E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.17|P-value:2.29E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:7.62|P-value:2.11E-17 ID:SGTC_935|Compound:2996-0153|FD-Score:3.03|P-value:4.23E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:5.36|P-value:1.68E-9 ID:SGTC_976|Compound:1348-1067|FD-Score:-3.77|P-value:1.54E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:-3.22|P-value:1.86E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:2.85|P-value:8.55E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.14|P-value:2.63E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:2.99|P-value:4.94E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:4.39|P-value:6.51E-7 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.54|P-value:4.84E-5 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.50|P-value:5.81E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:-3.75|P-value:1.77E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:2.83|P-value:8.91E-4 ID:SGTC_1699|Compound:st031318|FD-Score:2.80|P-value:9.95E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.10|P-value:3.21E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:2.88|P-value:7.54E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.38|P-value:9.63E-5 ID:SGTC_1991|Compound:st073000|FD-Score:3.18|P-value:2.24E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.06|P-value:3.70E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.20|P-value:2.08E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.22|P-value:1.92E-4 ID:SGTC_2428|Compound:5615643|FD-Score:3.10|P-value:3.13E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.17|P-value:2.37E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.57|P-value:4.08E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.67|P-value:2.51E-5 ID:SGTC_2646|Compound:retinol|FD-Score:3.27|P-value:1.53E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.73|P-value:1.94E-5 ID:SGTC_2810|Compound:7959871|FD-Score:-2.92|P-value:6.30E-4 ID:SGTC_2865|Compound:9030313|FD-Score:-3.11|P-value:2.99E-4 ID:SGTC_2873|Compound:9040596|FD-Score:-3.31|P-value:1.28E-4 ID:SGTC_2878|Compound:9043973|FD-Score:-2.93|P-value:6.06E-4 ID:SGTC_2936|Compound:9038235|FD-Score:2.87|P-value:7.77E-4 ID:SGTC_2980|Compound:9014342|FD-Score:-3.29|P-value:1.38E-4 ID:SGTC_3099|Compound:9120367|FD-Score:-2.81|P-value:9.72E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.98|P-value:5.59E-6 ID:SGTC_3233|Compound:9132340|FD-Score:4.10|P-value:3.16E-6

Top fitness defect scores for YDR510W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_930 2810-3379 7.62 265.0 µM 2.11E-17 1 1.25E-14 3.44
2 SGTC_937 3122-0005 5.36 46.7 µM 1.68E-9 3 4.13E-8 0.64
3 SGTC_163 1327-0036 5.30 7.5 µM 2.58E-9 36 5.88E-8 0.48
4 SGTC_169 k015-0017 4.47 16.0 µM 4.18E-7 1 3.95E-6 0.47
5 SGTC_1276 0871-0068 4.39 94.2 µM 6.51E-7 3 5.70E-6 0.12
6 SGTC_148 3253-0744 4.31 288.0 µM 9.99E-7 5 8.13E-6 0.12
7 SGTC_3233 9132340 4.10 49.5 µM 3.16E-6 6 2.11E-5 0.11
8 SGTC_738 1315-0003 4.09 72.4 µM 3.24E-6 6 2.15E-5 0.42
9 SGTC_530 4358-1714 4.00 28.0 µM 5.10E-6 5 3.14E-5 0.12
10 SGTC_3210 9128157 3.98 49.5 µM 5.59E-6 13 3.38E-5 0.09
11 SGTC_2808 7946468 3.73 45.5 µM 1.94E-5 6 9.52E-5 0.03
12 SGTC_2481 5478948 3.57 45.2 µM 4.08E-5 PDR1 11 1.76E-4 0.04
13 SGTC_571 k831-0106 3.54 44.2 µM 4.82E-5 9 2.02E-4 0.01
14 SGTC_1373 2887-0003 3.54 58.5 µM 4.84E-5 Golgi 16 2.03E-4 0.02
15 SGTC_1382 3002-2117 3.50 298.0 µM 5.81E-5 5 2.37E-4 0.17
16 SGTC_720 r052-1644 3.39 49.9 µM 9.48E-5 TSC3-RPN4 15 3.55E-4 0.15
17 SGTC_1915 st067105 3.38 30.6 µM 9.63E-5 RNA pol III & RNase P/MRP 42 3.60E-4 0.03
18 SGTC_282 k297-0036 3.35 65.7 µM 1.09E-4 7 4.00E-4 0.03
19 SGTC_2646 retinol 3.27 96.8 µM 1.53E-4 9 5.30E-4 0.11
20 SGTC_2407 paclitaxel 3.22 400.0 µM 1.92E-4 12 6.40E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 7.47E-14 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.127 1.33E-13 YDR088C SLU7 het RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
0.127 1.35E-13 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.127 1.68E-13 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.125 3.39E-13 YDR079C-A TFB5 hom Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair
0.125 3.78E-13 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.122 1.55E-12 YBR249C ARO4 hom 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress
0.118 8.24E-12 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.112 7.04E-11 YOL084W PHM7 hom Protein of unknown function; expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; protein abundance increases in response to DNA replication stress
0.109 2.28E-10 YNR025C_d YNR025C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase
0.105 1.11E-9 YNL200C YNL200C hom NADHX epimerase; catalyzes isomerization of (R)- and (S)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.099 1.06E-8 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.092 9.83E-8 YER089C PTC2 hom Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication
0.091 1.38E-7 YBR030W RKM3 hom Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein
0.090 1.61E-7 YDR381W YRA1 het RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member