YDR513W / GRX2

Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has a paralog, GRX1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR513W / GRX2

Click on Significant Values for Screen Details ID:SGTC_212|Compound:3807-4682|FD-Score:3.21|P-value:2.97E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.04|P-value:6.03E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.29|P-value:2.32E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:4.75|P-value:1.98E-7 ID:SGTC_608|Compound:k048-0125|FD-Score:4.20|P-value:3.69E-6 ID:SGTC_667|Compound:1498-1044|FD-Score:-3.32|P-value:2.03E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:-2.91|P-value:9.65E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:3.69|P-value:4.02E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:2.90|P-value:9.72E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:4.84|P-value:1.14E-7 ID:SGTC_940|Compound:3232-1287|FD-Score:4.93|P-value:6.96E-8 ID:SGTC_945|Compound:3381-0768|FD-Score:2.97|P-value:7.61E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:4.89|P-value:8.77E-8 ID:SGTC_988|Compound:1497-1057|FD-Score:3.39|P-value:1.43E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.58|P-value:6.46E-5 ID:SGTC_1288|Compound:0973-0013|FD-Score:-3.29|P-value:2.27E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-2.93|P-value:9.17E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.01|P-value:6.50E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.26|P-value:2.44E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:-3.07|P-value:5.40E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:-3.71|P-value:3.93E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.92|P-value:1.47E-5 ID:SGTC_1521|Compound:st012942|FD-Score:3.01|P-value:6.58E-4 ID:SGTC_1608|Compound:st001473|FD-Score:-3.25|P-value:2.72E-4 ID:SGTC_1609|Compound:st001574|FD-Score:-3.19|P-value:3.36E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-5.89|P-value:1.74E-10 ID:SGTC_1718|Compound:roemerine|FD-Score:7.00|P-value:4.02E-14 ID:SGTC_1825|Compound:st052143|FD-Score:4.29|P-value:2.24E-6 ID:SGTC_1885|Compound:st057546|FD-Score:3.15|P-value:3.81E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.14|P-value:3.92E-4 ID:SGTC_2009|Compound:4012297|FD-Score:-3.51|P-value:9.19E-5 ID:SGTC_2324|Compound:6149169|FD-Score:3.31|P-value:2.00E-4 ID:SGTC_2348|Compound:9022543|FD-Score:-2.94|P-value:8.91E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-4.00|P-value:1.04E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:5.86|P-value:1.94E-10 ID:SGTC_2586|Compound:curcumin|FD-Score:5.28|P-value:8.46E-9 ID:SGTC_2696|Compound:st077691|FD-Score:4.99|P-value:4.82E-8 ID:SGTC_3211|Compound:9128781|FD-Score:5.14|P-value:1.99E-8 ID:SGTC_212|Compound:3807-4682|FD-Score:3.21|P-value:2.97E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.04|P-value:6.03E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.29|P-value:2.32E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:4.75|P-value:1.98E-7 ID:SGTC_608|Compound:k048-0125|FD-Score:4.20|P-value:3.69E-6 ID:SGTC_667|Compound:1498-1044|FD-Score:-3.32|P-value:2.03E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:-2.91|P-value:9.65E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:3.69|P-value:4.02E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:2.90|P-value:9.72E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:4.84|P-value:1.14E-7 ID:SGTC_940|Compound:3232-1287|FD-Score:4.93|P-value:6.96E-8 ID:SGTC_945|Compound:3381-0768|FD-Score:2.97|P-value:7.61E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:4.89|P-value:8.77E-8 ID:SGTC_988|Compound:1497-1057|FD-Score:3.39|P-value:1.43E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.58|P-value:6.46E-5 ID:SGTC_1288|Compound:0973-0013|FD-Score:-3.29|P-value:2.27E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-2.93|P-value:9.17E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.01|P-value:6.50E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.26|P-value:2.44E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:-3.07|P-value:5.40E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:-3.71|P-value:3.93E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.92|P-value:1.47E-5 ID:SGTC_1521|Compound:st012942|FD-Score:3.01|P-value:6.58E-4 ID:SGTC_1608|Compound:st001473|FD-Score:-3.25|P-value:2.72E-4 ID:SGTC_1609|Compound:st001574|FD-Score:-3.19|P-value:3.36E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-5.89|P-value:1.74E-10 ID:SGTC_1718|Compound:roemerine|FD-Score:7.00|P-value:4.02E-14 ID:SGTC_1825|Compound:st052143|FD-Score:4.29|P-value:2.24E-6 ID:SGTC_1885|Compound:st057546|FD-Score:3.15|P-value:3.81E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.14|P-value:3.92E-4 ID:SGTC_2009|Compound:4012297|FD-Score:-3.51|P-value:9.19E-5 ID:SGTC_2324|Compound:6149169|FD-Score:3.31|P-value:2.00E-4 ID:SGTC_2348|Compound:9022543|FD-Score:-2.94|P-value:8.91E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-4.00|P-value:1.04E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:5.86|P-value:1.94E-10 ID:SGTC_2586|Compound:curcumin|FD-Score:5.28|P-value:8.46E-9 ID:SGTC_2696|Compound:st077691|FD-Score:4.99|P-value:4.82E-8 ID:SGTC_3211|Compound:9128781|FD-Score:5.14|P-value:1.99E-8

Top fitness defect scores for YDR513W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1718 roemerine 7.00 11.9 µM 4.02E-14 redox potentiating 12 1.31E-12
2 SGTC_2584 androsterone 5.86 48.7 µM 1.94E-10 cell wall 62 2.30E-9
3 SGTC_2586 curcumin 5.28 80.0 µM 8.46E-9 iron homeostasis 28 6.39E-8
4 SGTC_3211 9128781 5.14 49.5 µM 1.99E-8 33 1.36E-7
5 SGTC_2696 st077691 4.99 74.3 µM 4.82E-8 15 2.97E-7
6 SGTC_940 3232-1287 4.93 54.8 µM 6.96E-8 NEO1 15 4.10E-7
7 SGTC_946 3434-1334 4.89 87.4 µM 8.77E-8 12 5.02E-7
8 SGTC_939 1165-0479 4.84 45.3 µM 1.14E-7 12 6.35E-7
9 SGTC_607 4491-0986 4.75 66.8 µM 1.98E-7 heme requiring 13 1.03E-6
10 SGTC_1825 st052143 4.29 62.6 µM 2.24E-6 9 8.76E-6
11 SGTC_608 k048-0125 4.20 159.0 µM 3.69E-6 24 1.36E-5
12 SGTC_803 4488-1585 3.69 147.0 µM 4.02E-5 18 1.12E-4
13 SGTC_1004 4084-0029 3.58 199.0 µM 6.46E-5 26 1.70E-4
14 SGTC_988 1497-1057 3.39 103.0 µM 1.43E-4 22 3.43E-4
15 SGTC_2324 6149169 3.31 200.0 µM 2.00E-4 32 4.62E-4
16 SGTC_1350 1495-0454 3.26 146.0 µM 2.44E-4 59 5.52E-4
17 SGTC_212 3807-4682 3.21 38.8 µM 2.97E-4 tubulin folding & SWR complex 120 6.56E-4
18 SGTC_1885 st057546 3.15 99.9 µM 3.81E-4 44 8.18E-4
19 SGTC_2004 4023728 3.14 41.9 µM 3.92E-4 66 8.39E-4
20 SGTC_1334 1486-0610 3.01 236.0 µM 6.50E-4 60S ribosome export 57 0.00131

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.164 1.12E-21 YKL185W ASH1 hom Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate
0.162 4.49E-21 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.143 8.68E-17 YLR363W-A YLR363W-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication stress
0.138 8.24E-16 YOR195W SLK19 hom Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate
0.129 5.34E-14 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.128 9.68E-14 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.128 1.02E-13 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.126 2.22E-13 YHR042W NCP1 het NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
0.118 6.03E-12 YOL140W ARG8 hom Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
0.118 5.82E-12 YGR123C PPT1 hom Protein serine/threonine phosphatase, regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth
0.116 1.72E-11 YJR149W_p YJR149W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.116 1.75E-11 YDR514C YDR514C hom Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication
0.114 3.06E-11 YGL047W ALG13 het Catalytic component of UDP-GlcNAc transferase; required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases; protein abundance increases in response to DNA replication stress
0.112 7.19E-11 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.109 2.72E-10 YDL224C WHI4 hom Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication