YDR514C

Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR514C / YDR514C

Click on Significant Values for Screen Details ID:SGTC_88|Compound:0180-0332|FD-Score:3.53|P-value:1.42E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.35|P-value:2.88E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.33|P-value:3.15E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.04|P-value:9.33E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-4.75|P-value:5.77E-7 ID:SGTC_355|Compound:1311-2252|FD-Score:3.85|P-value:3.79E-5 ID:SGTC_356|Compound:1634-0012|FD-Score:-3.97|P-value:2.45E-5 ID:SGTC_357|Compound:1325-0123|FD-Score:-3.51|P-value:1.65E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.20|P-value:5.01E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:-4.14|P-value:1.16E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:3.10|P-value:7.09E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.24|P-value:4.32E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:3.12|P-value:6.83E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.50|P-value:1.64E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:5.22|P-value:4.17E-8 ID:SGTC_948|Compound:3448-0295|FD-Score:3.22|P-value:4.60E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.10|P-value:7.24E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.40|P-value:2.40E-4 ID:SGTC_1115|Compound:galangin|FD-Score:-3.13|P-value:6.92E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.55|P-value:1.43E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.10|P-value:7.17E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.67|P-value:8.14E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:-3.59|P-value:1.19E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.83|P-value:4.24E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:6.89|P-value:7.94E-13 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.42|P-value:2.18E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:4.04|P-value:1.68E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-7.35|P-value:2.62E-14 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.40|P-value:2.43E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-3.25|P-value:4.51E-4 ID:SGTC_1671|Compound:st016596|FD-Score:3.22|P-value:4.73E-4 ID:SGTC_1808|Compound:st050063|FD-Score:-3.20|P-value:5.42E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.05|P-value:8.58E-4 ID:SGTC_1896|Compound:st058441|FD-Score:-4.77|P-value:5.21E-7 ID:SGTC_1900|Compound:st060200|FD-Score:-3.29|P-value:3.84E-4 ID:SGTC_2086|Compound:5274770|FD-Score:4.89|P-value:2.60E-7 ID:SGTC_2087|Compound:5276107|FD-Score:5.00|P-value:1.40E-7 ID:SGTC_2097|Compound:5376186|FD-Score:4.83|P-value:3.48E-7 ID:SGTC_2098|Compound:5376439|FD-Score:3.88|P-value:3.34E-5 ID:SGTC_2253|Compound:7938677|FD-Score:3.84|P-value:3.92E-5 ID:SGTC_2280|Compound:7785178|FD-Score:-3.07|P-value:8.63E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-7.05|P-value:2.69E-13 ID:SGTC_2403|Compound:6032726|FD-Score:-4.04|P-value:1.76E-5 ID:SGTC_2434|Compound:5670830|FD-Score:3.25|P-value:4.27E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-4.38|P-value:3.74E-6 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.14|P-value:6.20E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.43|P-value:2.13E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.23|P-value:4.54E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-3.89|P-value:3.40E-5 ID:SGTC_2855|Compound:9016525|FD-Score:3.63|P-value:9.77E-5 ID:SGTC_2856|Compound:9022925|FD-Score:-3.99|P-value:2.26E-5 ID:SGTC_2870|Compound:9038528|FD-Score:4.23|P-value:7.07E-6 ID:SGTC_2874|Compound:9043904|FD-Score:-3.03|P-value:9.84E-4 ID:SGTC_2892|Compound:9047358|FD-Score:3.30|P-value:3.43E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.59|P-value:1.13E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.77|P-value:5.45E-5 ID:SGTC_3077|Compound:9117319|FD-Score:3.26|P-value:4.00E-4 ID:SGTC_3078|Compound:9116413|FD-Score:5.63|P-value:3.80E-9 ID:SGTC_3135|Compound:9127742|FD-Score:5.38|P-value:1.64E-8 ID:SGTC_3170|Compound:9103054|FD-Score:3.23|P-value:4.47E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.06|P-value:8.36E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-4.22|P-value:7.83E-6 ID:SGTC_3249|Compound:9135183|FD-Score:-4.02|P-value:1.92E-5 ID:SGTC_3265|Compound:9137266|FD-Score:3.33|P-value:3.06E-4 ID:SGTC_3270|Compound:9137563|FD-Score:-3.08|P-value:8.31E-4 ID:SGTC_3307|Compound:9126885|FD-Score:4.02|P-value:1.85E-5 ID:SGTC_88|Compound:0180-0332|FD-Score:3.53|P-value:1.42E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.35|P-value:2.88E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.33|P-value:3.15E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.04|P-value:9.33E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-4.75|P-value:5.77E-7 ID:SGTC_355|Compound:1311-2252|FD-Score:3.85|P-value:3.79E-5 ID:SGTC_356|Compound:1634-0012|FD-Score:-3.97|P-value:2.45E-5 ID:SGTC_357|Compound:1325-0123|FD-Score:-3.51|P-value:1.65E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.20|P-value:5.01E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:-4.14|P-value:1.16E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:3.10|P-value:7.09E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.24|P-value:4.32E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:3.12|P-value:6.83E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.50|P-value:1.64E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:5.22|P-value:4.17E-8 ID:SGTC_948|Compound:3448-0295|FD-Score:3.22|P-value:4.60E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.10|P-value:7.24E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.40|P-value:2.40E-4 ID:SGTC_1115|Compound:galangin|FD-Score:-3.13|P-value:6.92E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.55|P-value:1.43E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.10|P-value:7.17E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.67|P-value:8.14E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:-3.59|P-value:1.19E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.83|P-value:4.24E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:6.89|P-value:7.94E-13 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.42|P-value:2.18E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:4.04|P-value:1.68E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-7.35|P-value:2.62E-14 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.40|P-value:2.43E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-3.25|P-value:4.51E-4 ID:SGTC_1671|Compound:st016596|FD-Score:3.22|P-value:4.73E-4 ID:SGTC_1808|Compound:st050063|FD-Score:-3.20|P-value:5.42E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.05|P-value:8.58E-4 ID:SGTC_1896|Compound:st058441|FD-Score:-4.77|P-value:5.21E-7 ID:SGTC_1900|Compound:st060200|FD-Score:-3.29|P-value:3.84E-4 ID:SGTC_2086|Compound:5274770|FD-Score:4.89|P-value:2.60E-7 ID:SGTC_2087|Compound:5276107|FD-Score:5.00|P-value:1.40E-7 ID:SGTC_2097|Compound:5376186|FD-Score:4.83|P-value:3.48E-7 ID:SGTC_2098|Compound:5376439|FD-Score:3.88|P-value:3.34E-5 ID:SGTC_2253|Compound:7938677|FD-Score:3.84|P-value:3.92E-5 ID:SGTC_2280|Compound:7785178|FD-Score:-3.07|P-value:8.63E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-7.05|P-value:2.69E-13 ID:SGTC_2403|Compound:6032726|FD-Score:-4.04|P-value:1.76E-5 ID:SGTC_2434|Compound:5670830|FD-Score:3.25|P-value:4.27E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-4.38|P-value:3.74E-6 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.14|P-value:6.20E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.43|P-value:2.13E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.23|P-value:4.54E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-3.89|P-value:3.40E-5 ID:SGTC_2855|Compound:9016525|FD-Score:3.63|P-value:9.77E-5 ID:SGTC_2856|Compound:9022925|FD-Score:-3.99|P-value:2.26E-5 ID:SGTC_2870|Compound:9038528|FD-Score:4.23|P-value:7.07E-6 ID:SGTC_2874|Compound:9043904|FD-Score:-3.03|P-value:9.84E-4 ID:SGTC_2892|Compound:9047358|FD-Score:3.30|P-value:3.43E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.59|P-value:1.13E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.77|P-value:5.45E-5 ID:SGTC_3077|Compound:9117319|FD-Score:3.26|P-value:4.00E-4 ID:SGTC_3078|Compound:9116413|FD-Score:5.63|P-value:3.80E-9 ID:SGTC_3135|Compound:9127742|FD-Score:5.38|P-value:1.64E-8 ID:SGTC_3170|Compound:9103054|FD-Score:3.23|P-value:4.47E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.06|P-value:8.36E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-4.22|P-value:7.83E-6 ID:SGTC_3249|Compound:9135183|FD-Score:-4.02|P-value:1.92E-5 ID:SGTC_3265|Compound:9137266|FD-Score:3.33|P-value:3.06E-4 ID:SGTC_3270|Compound:9137563|FD-Score:-3.08|P-value:8.31E-4 ID:SGTC_3307|Compound:9126885|FD-Score:4.02|P-value:1.85E-5

Top fitness defect scores for YDR514C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1251 0490-5699 6.89 265.0 µM 7.94E-13 3 2.88E-12
2 SGTC_3078 9116413 5.63 49.5 µM 3.80E-9 unfolded protein response 11 9.12E-9
3 SGTC_3135 9127742 5.38 49.5 µM 1.64E-8 5 3.68E-8
4 SGTC_946 3434-1334 5.22 87.4 µM 4.17E-8 10 8.93E-8
5 SGTC_2087 5276107 5.00 200.0 µM 1.40E-7 5 2.83E-7
6 SGTC_2086 5274770 4.89 176.6 µM 2.60E-7 10 5.10E-7
7 SGTC_2097 5376186 4.83 200.0 µM 3.48E-7 6 6.73E-7
8 SGTC_2870 9038528 4.23 13.0 µM 7.07E-6 18 1.18E-5
9 SGTC_1404 3909-7820 4.04 48.3 µM 1.68E-5 60S ribosome export 9 2.70E-5
10 SGTC_3307 9126885 4.02 69.3 µM 1.85E-5 30 2.95E-5
11 SGTC_2098 5376439 3.88 882.5 nM 3.34E-5 13 5.18E-5
12 SGTC_355 1311-2252 3.85 105.0 µM 3.79E-5 21 5.85E-5
13 SGTC_2253 7938677 3.84 135.8 µM 3.92E-5 12 6.04E-5
14 SGTC_1249 0481-0015 3.83 10.2 µM 4.24E-5 27 6.51E-5
15 SGTC_3033 9090887 3.77 49.5 µM 5.45E-5 fatty acid desaturase (OLE1) 33 8.27E-5
16 SGTC_1170 0310-0127 3.67 64.8 µM 8.14E-5 36 1.21E-4
17 SGTC_2855 9016525 3.63 58.4 µM 9.77E-5 26 1.44E-4
18 SGTC_2896 9052656 3.59 71.4 µM 1.13E-4 endomembrane recycling 143 1.65E-4
19 SGTC_88 0180-0332 3.53 8.7 µM 1.42E-4 31 2.06E-4
20 SGTC_941 3237-0776 3.50 460.0 µM 1.64E-4 31 2.36E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.154 2.77E-19 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.140 3.27E-16 YNL339C YRF1-6 hom Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
0.124 6.51E-13 YFL051C_p YFL051C_p hom Putative protein of unknown function; YFL051C is not an essential gene
0.122 1.08E-12 YDR502C SAM2 hom S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication
0.116 1.75E-11 YDR513W GRX2 hom Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has a paralog, GRX1, that arose from the whole genome duplication
0.112 7.99E-11 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.112 8.80E-11 YFL044C OTU1 hom Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress
0.110 1.64E-10 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.109 2.26E-10 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.109 2.29E-10 YLR213C CRR1 hom Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.108 3.45E-10 YLR356W ATG33 hom Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes
0.108 3.31E-10 YGR209C TRX2 hom Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress
0.106 7.41E-10 YCR021C HSP30 hom Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
0.105 1.10E-9 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.104 1.47E-9 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol