YDR518W / EUG1

Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR518W / EUG1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.64|P-value:8.16E-7 ID:SGTC_19|Compound:0279-0214|FD-Score:3.07|P-value:7.33E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:5.27|P-value:2.51E-8 ID:SGTC_87|Compound:0100-0052|FD-Score:3.70|P-value:6.38E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.81|P-value:3.99E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:9.30|P-value:3.52E-22 ID:SGTC_141|Compound:0443-0274|FD-Score:3.28|P-value:3.49E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.65|P-value:8.00E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:3.17|P-value:5.19E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.64|P-value:8.57E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:4.10|P-value:1.12E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:6.67|P-value:2.80E-12 ID:SGTC_214|Compound:4373-3496|FD-Score:4.30|P-value:4.32E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:33.60|P-value:7.34E-265 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.31|P-value:3.08E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:16.70|P-value:1.09E-66 ID:SGTC_310|Compound:1273-0058|FD-Score:4.01|P-value:1.71E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:3.01|P-value:9.29E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:8.57|P-value:4.07E-19 ID:SGTC_420|Compound:mitomycin C|FD-Score:-3.12|P-value:6.56E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.57|P-value:1.13E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.31|P-value:3.05E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.18|P-value:5.25E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.65|P-value:8.04E-5 ID:SGTC_700|Compound:3453-2283|FD-Score:3.56|P-value:1.15E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:4.55|P-value:1.29E-6 ID:SGTC_820|Compound:1582-0060|FD-Score:3.47|P-value:1.65E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:7.33|P-value:1.75E-14 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.25|P-value:3.88E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.48|P-value:1.61E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.99|P-value:1.83E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:5.36|P-value:1.49E-8 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.56|P-value:1.23E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.35|P-value:2.59E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.44|P-value:1.98E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:-3.87|P-value:3.28E-5 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.71|P-value:6.07E-5 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.78|P-value:4.60E-5 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.14|P-value:5.77E-4 ID:SGTC_1635|Compound:st007035|FD-Score:11.00|P-value:2.99E-30 ID:SGTC_1652|Compound:st011932|FD-Score:3.31|P-value:3.12E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-4.61|P-value:9.80E-7 ID:SGTC_1711|Compound:st032263|FD-Score:-3.41|P-value:2.20E-4 ID:SGTC_1742|Compound:st038235|FD-Score:9.18|P-value:1.22E-21 ID:SGTC_1743|Compound:st037606|FD-Score:-3.23|P-value:4.32E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-3.03|P-value:9.16E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.15|P-value:5.60E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.97|P-value:3.78E-10 ID:SGTC_1800|Compound:st050079|FD-Score:-4.50|P-value:1.73E-6 ID:SGTC_1818|Compound:st052136|FD-Score:-3.20|P-value:4.95E-4 ID:SGTC_1822|Compound:st052468|FD-Score:3.10|P-value:6.73E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.03|P-value:8.52E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.94|P-value:2.25E-5 ID:SGTC_2021|Compound:4019055|FD-Score:-3.56|P-value:1.21E-4 ID:SGTC_2061|Compound:5245884|FD-Score:-3.49|P-value:1.62E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.01|P-value:9.30E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.59|P-value:1.04E-4 ID:SGTC_2148|Compound:5546263|FD-Score:3.21|P-value:4.44E-4 ID:SGTC_2183|Compound:6420625|FD-Score:3.91|P-value:2.57E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:6.10|P-value:1.39E-10 ID:SGTC_2361|Compound:9034121|FD-Score:3.70|P-value:6.54E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:2.99|P-value:9.82E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.95|P-value:2.38E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:-3.59|P-value:1.09E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-4.07|P-value:1.38E-5 ID:SGTC_2698|Compound:st077697|FD-Score:-4.15|P-value:9.56E-6 ID:SGTC_2716|Compound:st080858|FD-Score:3.17|P-value:5.13E-4 ID:SGTC_2875|Compound:9039966|FD-Score:-3.01|P-value:9.68E-4 ID:SGTC_3001|Compound:9076041|FD-Score:3.16|P-value:5.33E-4 ID:SGTC_3039|Compound:9090270|FD-Score:3.10|P-value:6.57E-4 ID:SGTC_3231|Compound:9132313|FD-Score:3.69|P-value:6.60E-5 ID:SGTC_3340|Compound:9146634|FD-Score:-3.16|P-value:5.72E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:4.64|P-value:8.16E-7 ID:SGTC_19|Compound:0279-0214|FD-Score:3.07|P-value:7.33E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:5.27|P-value:2.51E-8 ID:SGTC_87|Compound:0100-0052|FD-Score:3.70|P-value:6.38E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.81|P-value:3.99E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:9.30|P-value:3.52E-22 ID:SGTC_141|Compound:0443-0274|FD-Score:3.28|P-value:3.49E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.65|P-value:8.00E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:3.17|P-value:5.19E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.64|P-value:8.57E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:4.10|P-value:1.12E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:6.67|P-value:2.80E-12 ID:SGTC_214|Compound:4373-3496|FD-Score:4.30|P-value:4.32E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:33.60|P-value:7.34E-265 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.31|P-value:3.08E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:16.70|P-value:1.09E-66 ID:SGTC_310|Compound:1273-0058|FD-Score:4.01|P-value:1.71E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:3.01|P-value:9.29E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:8.57|P-value:4.07E-19 ID:SGTC_420|Compound:mitomycin C|FD-Score:-3.12|P-value:6.56E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.57|P-value:1.13E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.31|P-value:3.05E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.18|P-value:5.25E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.65|P-value:8.04E-5 ID:SGTC_700|Compound:3453-2283|FD-Score:3.56|P-value:1.15E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:4.55|P-value:1.29E-6 ID:SGTC_820|Compound:1582-0060|FD-Score:3.47|P-value:1.65E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:7.33|P-value:1.75E-14 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.25|P-value:3.88E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.48|P-value:1.61E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.99|P-value:1.83E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:5.36|P-value:1.49E-8 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.56|P-value:1.23E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.35|P-value:2.59E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.44|P-value:1.98E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:-3.87|P-value:3.28E-5 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.71|P-value:6.07E-5 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.78|P-value:4.60E-5 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.14|P-value:5.77E-4 ID:SGTC_1635|Compound:st007035|FD-Score:11.00|P-value:2.99E-30 ID:SGTC_1652|Compound:st011932|FD-Score:3.31|P-value:3.12E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-4.61|P-value:9.80E-7 ID:SGTC_1711|Compound:st032263|FD-Score:-3.41|P-value:2.20E-4 ID:SGTC_1742|Compound:st038235|FD-Score:9.18|P-value:1.22E-21 ID:SGTC_1743|Compound:st037606|FD-Score:-3.23|P-value:4.32E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-3.03|P-value:9.16E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.15|P-value:5.60E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.97|P-value:3.78E-10 ID:SGTC_1800|Compound:st050079|FD-Score:-4.50|P-value:1.73E-6 ID:SGTC_1818|Compound:st052136|FD-Score:-3.20|P-value:4.95E-4 ID:SGTC_1822|Compound:st052468|FD-Score:3.10|P-value:6.73E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.03|P-value:8.52E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.94|P-value:2.25E-5 ID:SGTC_2021|Compound:4019055|FD-Score:-3.56|P-value:1.21E-4 ID:SGTC_2061|Compound:5245884|FD-Score:-3.49|P-value:1.62E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.01|P-value:9.30E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.59|P-value:1.04E-4 ID:SGTC_2148|Compound:5546263|FD-Score:3.21|P-value:4.44E-4 ID:SGTC_2183|Compound:6420625|FD-Score:3.91|P-value:2.57E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:6.10|P-value:1.39E-10 ID:SGTC_2361|Compound:9034121|FD-Score:3.70|P-value:6.54E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:2.99|P-value:9.82E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.95|P-value:2.38E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:-3.59|P-value:1.09E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-4.07|P-value:1.38E-5 ID:SGTC_2698|Compound:st077697|FD-Score:-4.15|P-value:9.56E-6 ID:SGTC_2716|Compound:st080858|FD-Score:3.17|P-value:5.13E-4 ID:SGTC_2875|Compound:9039966|FD-Score:-3.01|P-value:9.68E-4 ID:SGTC_3001|Compound:9076041|FD-Score:3.16|P-value:5.33E-4 ID:SGTC_3039|Compound:9090270|FD-Score:3.10|P-value:6.57E-4 ID:SGTC_3231|Compound:9132313|FD-Score:3.69|P-value:6.60E-5 ID:SGTC_3340|Compound:9146634|FD-Score:-3.16|P-value:5.72E-4

Top fitness defect scores for YDR518W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 33.60 5.3 µM 7.34E-265 5 1.80E-248
2 SGTC_275 trichlorophene 16.70 5.7 µM 1.09E-66 mitochondrial stress 5 1.24E-62
3 SGTC_1635 st007035 11.00 42.4 µM 2.99E-30 68 1.85E-28
4 SGTC_134 0269-0018 9.30 6.9 µM 3.52E-22 44 6.85E-21
5 SGTC_1742 st038235 9.18 28.9 µM 1.22E-21 mitochondrial stress 16 2.20E-20
6 SGTC_386 1509-0011 8.57 3.1 µM 4.07E-19 57 5.11E-18
7 SGTC_908 3448-7491 7.33 47.7 µM 1.75E-14 mitochondrial stress 22 1.13E-13
8 SGTC_173 1273-0061 6.67 2.7 µM 2.80E-12 mitochondrial stress 94 1.32E-11
9 SGTC_2250 alverine citrate 6.10 130.0 µM 1.39E-10 50 5.15E-10
10 SGTC_1188 1403-0014 5.36 4.6 µM 1.49E-8 mitochondrial stress 21 4.14E-8
11 SGTC_70 0141-0289 5.27 43.3 µM 2.51E-8 mitochondrial stress 104 6.78E-8
12 SGTC_10 0279-0212 4.64 42.6 µM 8.16E-7 TRP & mitochondrial translation 80 1.78E-6
13 SGTC_732 3970-1727 4.55 52.7 µM 1.29E-6 5 2.73E-6
14 SGTC_214 4373-3496 4.30 70.0 µM 4.32E-6 48 8.50E-6
15 SGTC_168 3970-0862 4.10 530.5 µM 1.12E-5 113 2.08E-5
16 SGTC_310 1273-0058 4.01 1.1 µM 1.71E-5 mitochondrial stress 242 3.10E-5
17 SGTC_1150 3909-7983 3.99 10.9 µM 1.83E-5 21 3.29E-5
18 SGTC_1883 5-benzylidenerhodanine 3.94 20.0 µM 2.25E-5 TRP & mitochondrial translation 70 4.00E-5
19 SGTC_2183 6420625 3.91 130.5 µM 2.57E-5 mitochondrial processes 59 4.54E-5
20 SGTC_118 0083-0097 3.81 135.3 µM 3.99E-5 translation 149 6.86E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.730 0 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.714 0 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.683 0 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.683 0 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.669 0 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.668 0 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.666 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.659 0 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.648 0 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.642 0 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.642 0 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.635 0 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.634 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.634 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.631 0 YGL107C RMD9 hom Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes