Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YDR519W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.446 | 9.87E-164 | YER050C | RSM18 | hom | Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein |
0.437 | 1.28E-155 | YLR260W | LCB5 | hom | Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules |
0.424 | 6.13E-147 | YNL081C | SWS2 | hom | Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency |
0.424 | 1.35E-146 | YPL040C | ISM1 | hom | Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth |
0.409 | 3.34E-135 | YMR193W | MRPL24 | hom | Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene |
0.402 | 1.39E-130 | YMR228W | MTF1 | hom | Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation |
0.389 | 2.06E-121 | YPL183W-A | RTC6 | hom | Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress |
0.388 | 1.09E-120 | YMR257C | PET111 | hom | Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane |
0.387 | 1.41E-120 | YJL063C | MRPL8 | hom | Mitochondrial ribosomal protein of the large subunit |
0.385 | 8.11E-119 | YLR069C | MEF1 | hom | Mitochondrial elongation factor involved in translational elongation |
0.384 | 5.99E-118 | YKL138C | MRPL31 | hom | Mitochondrial ribosomal protein of the large subunit |
0.383 | 7.95E-118 | YGR215W | RSM27 | hom | Mitochondrial ribosomal protein of the small subunit |
0.382 | 2.42E-117 | YLR091W | GEP5 | hom | Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine |
0.382 | 4.07E-117 | YHR147C | MRPL6 | hom | Mitochondrial ribosomal protein of the large subunit |
0.380 | 5.76E-116 | YDR194C | MSS116 | hom | DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing |