YDR519W / FPR2

Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR519W / FPR2

Click on Significant Values for Screen Details ID:SGTC_63|Compound:0099-0242|FD-Score:4.12|P-value:1.12E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.44|P-value:3.57E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.57|P-value:6.95E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.76|P-value:3.90E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:5.56|P-value:3.19E-7 ID:SGTC_133|Compound:0724-0033|FD-Score:4.39|P-value:4.30E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:5.27|P-value:1.18E-6 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.25|P-value:6.40E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.86|P-value:2.54E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:9.59|P-value:4.10E-18 ID:SGTC_211|Compound:3455-0679|FD-Score:3.96|P-value:1.94E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:6.46|P-value:3.54E-9 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.43|P-value:3.60E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:13.10|P-value:3.51E-32 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.26|P-value:6.18E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:3.65|P-value:5.53E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.92|P-value:2.29E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:4.26|P-value:6.83E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:4.24|P-value:7.49E-5 ID:SGTC_1092|Compound:toremifene|FD-Score:4.93|P-value:4.95E-6 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.26|P-value:6.86E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:-3.73|P-value:3.89E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.88|P-value:6.20E-6 ID:SGTC_1623|Compound:st003709|FD-Score:4.63|P-value:1.68E-5 ID:SGTC_1684|Compound:st024538|FD-Score:3.85|P-value:2.89E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:4.02|P-value:1.59E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-5.01|P-value:3.18E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.46|P-value:9.10E-4 ID:SGTC_1742|Compound:st038235|FD-Score:5.19|P-value:1.69E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.34|P-value:4.55E-5 ID:SGTC_1941|Compound:st076221|FD-Score:-4.15|P-value:9.22E-5 ID:SGTC_1950|Compound:st077106|FD-Score:-4.94|P-value:4.25E-6 ID:SGTC_1952|Compound:st077036|FD-Score:-3.75|P-value:3.65E-4 ID:SGTC_1968|Compound:st069590|FD-Score:-3.88|P-value:2.39E-4 ID:SGTC_2016|Compound:5121758|FD-Score:4.07|P-value:1.35E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-3.94|P-value:1.93E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.37|P-value:7.39E-7 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.70|P-value:4.64E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:6.06|P-value:2.82E-8 ID:SGTC_2283|Compound:7944793|FD-Score:4.21|P-value:8.20E-5 ID:SGTC_2288|Compound:7946289|FD-Score:-3.59|P-value:6.13E-4 ID:SGTC_2370|Compound:9071495|FD-Score:5.27|P-value:1.17E-6 ID:SGTC_2526|Compound:patulin|FD-Score:4.29|P-value:6.13E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:5.14|P-value:2.12E-6 ID:SGTC_2625|Compound:euphol|FD-Score:-3.56|P-value:6.59E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.69|P-value:1.68E-7 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.65|P-value:4.93E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.63|P-value:1.72E-5 ID:SGTC_2814|Compound:7977482|FD-Score:-4.48|P-value:2.76E-5 ID:SGTC_2833|Compound:9001315|FD-Score:5.40|P-value:6.62E-7 ID:SGTC_2900|Compound:5328528|FD-Score:3.87|P-value:2.71E-4 ID:SGTC_2987|Compound:9018338|FD-Score:4.69|P-value:1.36E-5 ID:SGTC_3149|Compound:9097855|FD-Score:-3.79|P-value:3.15E-4 ID:SGTC_3178|Compound:9107506|FD-Score:3.82|P-value:3.13E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.56|P-value:6.58E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:4.12|P-value:1.12E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.44|P-value:3.57E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.57|P-value:6.95E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.76|P-value:3.90E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:5.56|P-value:3.19E-7 ID:SGTC_133|Compound:0724-0033|FD-Score:4.39|P-value:4.30E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:5.27|P-value:1.18E-6 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.25|P-value:6.40E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.86|P-value:2.54E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:9.59|P-value:4.10E-18 ID:SGTC_211|Compound:3455-0679|FD-Score:3.96|P-value:1.94E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:6.46|P-value:3.54E-9 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.43|P-value:3.60E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:13.10|P-value:3.51E-32 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.26|P-value:6.18E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:3.65|P-value:5.53E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.92|P-value:2.29E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:4.26|P-value:6.83E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:4.24|P-value:7.49E-5 ID:SGTC_1092|Compound:toremifene|FD-Score:4.93|P-value:4.95E-6 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.26|P-value:6.86E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:-3.73|P-value:3.89E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.88|P-value:6.20E-6 ID:SGTC_1623|Compound:st003709|FD-Score:4.63|P-value:1.68E-5 ID:SGTC_1684|Compound:st024538|FD-Score:3.85|P-value:2.89E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:4.02|P-value:1.59E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-5.01|P-value:3.18E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.46|P-value:9.10E-4 ID:SGTC_1742|Compound:st038235|FD-Score:5.19|P-value:1.69E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.34|P-value:4.55E-5 ID:SGTC_1941|Compound:st076221|FD-Score:-4.15|P-value:9.22E-5 ID:SGTC_1950|Compound:st077106|FD-Score:-4.94|P-value:4.25E-6 ID:SGTC_1952|Compound:st077036|FD-Score:-3.75|P-value:3.65E-4 ID:SGTC_1968|Compound:st069590|FD-Score:-3.88|P-value:2.39E-4 ID:SGTC_2016|Compound:5121758|FD-Score:4.07|P-value:1.35E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-3.94|P-value:1.93E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.37|P-value:7.39E-7 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.70|P-value:4.64E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:6.06|P-value:2.82E-8 ID:SGTC_2283|Compound:7944793|FD-Score:4.21|P-value:8.20E-5 ID:SGTC_2288|Compound:7946289|FD-Score:-3.59|P-value:6.13E-4 ID:SGTC_2370|Compound:9071495|FD-Score:5.27|P-value:1.17E-6 ID:SGTC_2526|Compound:patulin|FD-Score:4.29|P-value:6.13E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:5.14|P-value:2.12E-6 ID:SGTC_2625|Compound:euphol|FD-Score:-3.56|P-value:6.59E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.69|P-value:1.68E-7 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.65|P-value:4.93E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.63|P-value:1.72E-5 ID:SGTC_2814|Compound:7977482|FD-Score:-4.48|P-value:2.76E-5 ID:SGTC_2833|Compound:9001315|FD-Score:5.40|P-value:6.62E-7 ID:SGTC_2900|Compound:5328528|FD-Score:3.87|P-value:2.71E-4 ID:SGTC_2987|Compound:9018338|FD-Score:4.69|P-value:1.36E-5 ID:SGTC_3149|Compound:9097855|FD-Score:-3.79|P-value:3.15E-4 ID:SGTC_3178|Compound:9107506|FD-Score:3.82|P-value:3.13E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.56|P-value:6.58E-4

Top fitness defect scores for YDR519W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 13.10 1.1 µM 3.51E-32 mitochondrial stress 17 1.69E-39
2 SGTC_173 1273-0061 9.59 2.7 µM 4.10E-18 mitochondrial stress 43 4.56E-22
3 SGTC_236 1509-0011 6.46 5.3 µM 3.54E-9 278 5.23E-11
4 SGTC_2250 alverine citrate 6.06 130.0 µM 2.82E-8 51 6.80E-10
5 SGTC_2688 kanamycin b 5.69 96.7 µM 1.68E-7 calcium & mitochondrial duress 181 6.19E-9
6 SGTC_127 0180-0333 5.56 59.1 µM 3.19E-7 mitochondrial response to ROS 8 1.36E-8
7 SGTC_2833 9001315 5.40 45.5 µM 6.62E-7 amide catabolism 25 3.36E-8
8 SGTC_2232 chlorophetanol 5.37 41.5 µM 7.39E-7 TRP & mitochondrial translation 61 3.84E-8
9 SGTC_2370 9071495 5.27 200.0 µM 1.17E-6 mitochondrial processes 7 6.76E-8
10 SGTC_134 0269-0018 5.27 6.9 µM 1.18E-6 94 6.87E-8
11 SGTC_1742 st038235 5.19 28.9 µM 1.69E-6 mitochondrial stress 71 1.07E-7
12 SGTC_2610 ononetin 5.14 44.2 µM 2.12E-6 14 1.41E-7
13 SGTC_1092 toremifene 4.93 6.3 µM 4.95E-6 7 4.02E-7
14 SGTC_1597 7-benzyloxygramine 4.88 47.5 µM 6.20E-6 calcium & mitochondrial duress 70 5.30E-7
15 SGTC_2987 9018338 4.69 71.4 µM 1.36E-5 RPP1 & pyrimidine depletion 6 1.40E-6
16 SGTC_1623 st003709 4.63 20.3 µM 1.68E-5 calcium & mitochondrial duress 43 1.82E-6
17 SGTC_2750 bromebric acid 4.63 70.2 µM 1.72E-5 15 1.86E-6
18 SGTC_70 0141-0289 4.44 43.3 µM 3.57E-5 mitochondrial stress 143 4.58E-6
19 SGTC_275 trichlorophene 4.43 5.7 µM 3.60E-5 mitochondrial stress 202 4.63E-6
20 SGTC_133 0724-0033 4.39 378.9 µM 4.30E-5 20 5.76E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.446 9.87E-164 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.437 1.28E-155 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.424 6.13E-147 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.424 1.35E-146 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.409 3.34E-135 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.402 1.39E-130 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.389 2.06E-121 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.388 1.09E-120 YMR257C PET111 hom Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane
0.387 1.41E-120 YJL063C MRPL8 hom Mitochondrial ribosomal protein of the large subunit
0.385 8.11E-119 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.384 5.99E-118 YKL138C MRPL31 hom Mitochondrial ribosomal protein of the large subunit
0.383 7.95E-118 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.382 2.42E-117 YLR091W GEP5 hom Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine
0.382 4.07E-117 YHR147C MRPL6 hom Mitochondrial ribosomal protein of the large subunit
0.380 5.76E-116 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing