HIPHOP chemogenomics database

YDR519W / FPR2

Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR519W / FPR2

Click on Significant Values for Screen Details

Top fitness defect scores for YDR519W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_310	1273-0058	13.10	1.1 µM	3.51E-32	mitochondrial stress	17	1.69E-39
2	SGTC_173	1273-0061	9.59	2.7 µM	4.10E-18	mitochondrial stress	43	4.56E-22
3	SGTC_236	1509-0011	6.46	5.3 µM	3.54E-9		278	5.23E-11
4	SGTC_2250	alverine citrate	6.06	130.0 µM	2.82E-8		51	6.80E-10
5	SGTC_2688	kanamycin b	5.69	96.7 µM	1.68E-7	calcium & mitochondrial duress	181	6.19E-9
6	SGTC_127	0180-0333	5.56	59.1 µM	3.19E-7	mitochondrial response to ROS	8	1.36E-8
7	SGTC_2833	9001315	5.40	45.5 µM	6.62E-7	amide catabolism	25	3.36E-8
8	SGTC_2232	chlorophetanol	5.37	41.5 µM	7.39E-7	TRP & mitochondrial translation	61	3.84E-8
9	SGTC_2370	9071495	5.27	200.0 µM	1.17E-6	mitochondrial processes	7	6.76E-8
10	SGTC_134	0269-0018	5.27	6.9 µM	1.18E-6		94	6.87E-8
11	SGTC_1742	st038235	5.19	28.9 µM	1.69E-6	mitochondrial stress	71	1.07E-7
12	SGTC_2610	ononetin	5.14	44.2 µM	2.12E-6		14	1.41E-7
13	SGTC_1092	toremifene	4.93	6.3 µM	4.95E-6		7	4.02E-7
14	SGTC_1597	7-benzyloxygramine	4.88	47.5 µM	6.20E-6	calcium & mitochondrial duress	70	5.30E-7
15	SGTC_2987	9018338	4.69	71.4 µM	1.36E-5	RPP1 & pyrimidine depletion	6	1.40E-6
16	SGTC_1623	st003709	4.63	20.3 µM	1.68E-5	calcium & mitochondrial duress	43	1.82E-6
17	SGTC_2750	bromebric acid	4.63	70.2 µM	1.72E-5		15	1.86E-6
18	SGTC_70	0141-0289	4.44	43.3 µM	3.57E-5	mitochondrial stress	143	4.58E-6
19	SGTC_275	trichlorophene	4.43	5.7 µM	3.60E-5	mitochondrial stress	202	4.63E-6
20	SGTC_133	0724-0033	4.39	378.9 µM	4.30E-5		20	5.76E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.446	9.87E-164	YER050C	RSM18	hom	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.437	1.28E-155	YLR260W	LCB5	hom	Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.424	6.13E-147	YNL081C	SWS2	hom	Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.424	1.35E-146	YPL040C	ISM1	hom	Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.409	3.34E-135	YMR193W	MRPL24	hom	Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.402	1.39E-130	YMR228W	MTF1	hom	Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.389	2.06E-121	YPL183W-A	RTC6	hom	Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.388	1.09E-120	YMR257C	PET111	hom	Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane
0.387	1.41E-120	YJL063C	MRPL8	hom	Mitochondrial ribosomal protein of the large subunit
0.385	8.11E-119	YLR069C	MEF1	hom	Mitochondrial elongation factor involved in translational elongation
0.384	5.99E-118	YKL138C	MRPL31	hom	Mitochondrial ribosomal protein of the large subunit
0.383	7.95E-118	YGR215W	RSM27	hom	Mitochondrial ribosomal protein of the small subunit
0.382	2.42E-117	YLR091W	GEP5	hom	Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine
0.382	4.07E-117	YHR147C	MRPL6	hom	Mitochondrial ribosomal protein of the large subunit
0.380	5.76E-116	YDR194C	MSS116	hom	DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing