YDR524C-B_p

Putative protein of unknown function; YDR524C-B has a paralog, YCL048W-A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR524C-B / YDR524C-B

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:7.14|P-value:2.12E-10 ID:SGTC_50|Compound:0929-0078|FD-Score:4.24|P-value:1.04E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:3.60|P-value:8.23E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:3.93|P-value:2.90E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:4.08|P-value:1.77E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.61|P-value:2.75E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:5.43|P-value:9.96E-7 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.88|P-value:3.48E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:4.81|P-value:1.30E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:4.74|P-value:1.67E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:-4.00|P-value:2.33E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.68|P-value:6.42E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.93|P-value:2.94E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.80|P-value:1.36E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:3.96|P-value:2.68E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.54|P-value:9.92E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.68|P-value:6.35E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.94|P-value:2.81E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-4.96|P-value:7.02E-6 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:4.30|P-value:8.31E-5 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.92|P-value:3.02E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-8.30|P-value:1.91E-13 ID:SGTC_1311|Compound:1190-0148|FD-Score:6.14|P-value:3.82E-8 ID:SGTC_1312|Compound:1218-2183|FD-Score:-4.31|P-value:8.27E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:-3.63|P-value:7.44E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:6.32|P-value:1.61E-8 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.97|P-value:2.58E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.46|P-value:4.84E-5 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.66|P-value:6.79E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.96|P-value:2.66E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.90|P-value:3.19E-4 ID:SGTC_1724|Compound:st037281|FD-Score:5.09|P-value:4.16E-6 ID:SGTC_1745|Compound:st081495|FD-Score:3.70|P-value:5.99E-4 ID:SGTC_1754|Compound:st042065|FD-Score:7.32|P-value:7.47E-11 ID:SGTC_1760|Compound:st045453|FD-Score:5.54|P-value:6.18E-7 ID:SGTC_1781|Compound:st038725|FD-Score:8.16|P-value:4.61E-13 ID:SGTC_1800|Compound:st050079|FD-Score:4.37|P-value:6.54E-5 ID:SGTC_1801|Compound:st050089|FD-Score:3.85|P-value:3.82E-4 ID:SGTC_1803|Compound:st050068|FD-Score:5.76|P-value:2.29E-7 ID:SGTC_1846|Compound:st056244|FD-Score:4.11|P-value:1.64E-4 ID:SGTC_1851|Compound:st056236|FD-Score:-3.72|P-value:5.68E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.90|P-value:3.28E-4 ID:SGTC_2126|Compound:5251174|FD-Score:-4.06|P-value:1.88E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:4.12|P-value:1.57E-4 ID:SGTC_2133|Compound:5320837|FD-Score:5.65|P-value:3.91E-7 ID:SGTC_2289|Compound:7946404|FD-Score:4.89|P-value:9.34E-6 ID:SGTC_2320|Compound:7373003|FD-Score:3.65|P-value:7.12E-4 ID:SGTC_2387|Compound:9077560|FD-Score:3.78|P-value:4.78E-4 ID:SGTC_2488|Compound:5268135|FD-Score:5.58|P-value:5.22E-7 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-4.79|P-value:1.39E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:3.58|P-value:8.70E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.55|P-value:9.62E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:4.06|P-value:1.91E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:6.79|P-value:1.43E-9 ID:SGTC_2799|Compound:7812892|FD-Score:-5.27|P-value:2.04E-6 ID:SGTC_2853|Compound:9015042|FD-Score:4.11|P-value:1.63E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.69|P-value:6.26E-4 ID:SGTC_3013|Compound:9080133|FD-Score:-3.63|P-value:7.45E-4 ID:SGTC_3017|Compound:9080681|FD-Score:3.62|P-value:7.78E-4 ID:SGTC_3037|Compound:9091026|FD-Score:8.68|P-value:1.54E-14 ID:SGTC_3041|Compound:9091929|FD-Score:3.64|P-value:7.16E-4 ID:SGTC_3043|Compound:9092303|FD-Score:4.21|P-value:1.17E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.43|P-value:5.35E-5 ID:SGTC_3284|Compound:9108171|FD-Score:4.13|P-value:1.49E-4 ID:SGTC_3303|Compound:9125618|FD-Score:4.12|P-value:1.55E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:7.14|P-value:2.12E-10 ID:SGTC_50|Compound:0929-0078|FD-Score:4.24|P-value:1.04E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:3.60|P-value:8.23E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:3.93|P-value:2.90E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:4.08|P-value:1.77E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.61|P-value:2.75E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:5.43|P-value:9.96E-7 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.88|P-value:3.48E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:4.81|P-value:1.30E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:4.74|P-value:1.67E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:-4.00|P-value:2.33E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.68|P-value:6.42E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.93|P-value:2.94E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.80|P-value:1.36E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:3.96|P-value:2.68E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.54|P-value:9.92E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.68|P-value:6.35E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.94|P-value:2.81E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-4.96|P-value:7.02E-6 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:4.30|P-value:8.31E-5 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.92|P-value:3.02E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-8.30|P-value:1.91E-13 ID:SGTC_1311|Compound:1190-0148|FD-Score:6.14|P-value:3.82E-8 ID:SGTC_1312|Compound:1218-2183|FD-Score:-4.31|P-value:8.27E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:-3.63|P-value:7.44E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:6.32|P-value:1.61E-8 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.97|P-value:2.58E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.46|P-value:4.84E-5 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.66|P-value:6.79E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.96|P-value:2.66E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.90|P-value:3.19E-4 ID:SGTC_1724|Compound:st037281|FD-Score:5.09|P-value:4.16E-6 ID:SGTC_1745|Compound:st081495|FD-Score:3.70|P-value:5.99E-4 ID:SGTC_1754|Compound:st042065|FD-Score:7.32|P-value:7.47E-11 ID:SGTC_1760|Compound:st045453|FD-Score:5.54|P-value:6.18E-7 ID:SGTC_1781|Compound:st038725|FD-Score:8.16|P-value:4.61E-13 ID:SGTC_1800|Compound:st050079|FD-Score:4.37|P-value:6.54E-5 ID:SGTC_1801|Compound:st050089|FD-Score:3.85|P-value:3.82E-4 ID:SGTC_1803|Compound:st050068|FD-Score:5.76|P-value:2.29E-7 ID:SGTC_1846|Compound:st056244|FD-Score:4.11|P-value:1.64E-4 ID:SGTC_1851|Compound:st056236|FD-Score:-3.72|P-value:5.68E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.90|P-value:3.28E-4 ID:SGTC_2126|Compound:5251174|FD-Score:-4.06|P-value:1.88E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:4.12|P-value:1.57E-4 ID:SGTC_2133|Compound:5320837|FD-Score:5.65|P-value:3.91E-7 ID:SGTC_2289|Compound:7946404|FD-Score:4.89|P-value:9.34E-6 ID:SGTC_2320|Compound:7373003|FD-Score:3.65|P-value:7.12E-4 ID:SGTC_2387|Compound:9077560|FD-Score:3.78|P-value:4.78E-4 ID:SGTC_2488|Compound:5268135|FD-Score:5.58|P-value:5.22E-7 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-4.79|P-value:1.39E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:3.58|P-value:8.70E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.55|P-value:9.62E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:4.06|P-value:1.91E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:6.79|P-value:1.43E-9 ID:SGTC_2799|Compound:7812892|FD-Score:-5.27|P-value:2.04E-6 ID:SGTC_2853|Compound:9015042|FD-Score:4.11|P-value:1.63E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.69|P-value:6.26E-4 ID:SGTC_3013|Compound:9080133|FD-Score:-3.63|P-value:7.45E-4 ID:SGTC_3017|Compound:9080681|FD-Score:3.62|P-value:7.78E-4 ID:SGTC_3037|Compound:9091026|FD-Score:8.68|P-value:1.54E-14 ID:SGTC_3041|Compound:9091929|FD-Score:3.64|P-value:7.16E-4 ID:SGTC_3043|Compound:9092303|FD-Score:4.21|P-value:1.17E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.43|P-value:5.35E-5 ID:SGTC_3284|Compound:9108171|FD-Score:4.13|P-value:1.49E-4 ID:SGTC_3303|Compound:9125618|FD-Score:4.12|P-value:1.55E-4

Top fitness defect scores for YDR524C-B deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3037 9091026 8.68 49.5 µM 1.54E-14 NEO1-PIK1 8 1.94E-18
2 SGTC_1781 st038725 8.16 66.3 µM 4.61E-13 NEO1 31 1.62E-16
3 SGTC_1754 st042065 7.32 16.1 µM 7.47E-11 NEO1-PIK1 65 1.21E-13
4 SGTC_43 0570-0105 7.14 72.5 µM 2.12E-10 ERG2 22 4.70E-13
5 SGTC_2737 bleomycin 6.79 30.5 nM 1.43E-9 Golgi 25 5.63E-12
6 SGTC_1318 1280-3875 6.32 124.0 µM 1.61E-8 1 1.31E-10
7 SGTC_1311 1190-0148 6.14 100.0 µM 3.82E-8 azole & statin 8 4.00E-10
8 SGTC_1803 st050068 5.76 52.4 µM 2.29E-7 NEO1-PIK1 91 4.09E-9
9 SGTC_2133 5320837 5.65 200.0 µM 3.91E-7 ERG2 6 8.17E-9
10 SGTC_2488 5268135 5.58 45.7 µM 5.22E-7 20 1.19E-8
11 SGTC_1760 st045453 5.54 10.4 µM 6.18E-7 NEO1-PIK1 92 1.48E-8
12 SGTC_236 1509-0011 5.43 5.3 µM 9.96E-7 305 2.74E-8
13 SGTC_1724 st037281 5.09 8.3 µM 4.16E-6 18 1.74E-7
14 SGTC_2289 7946404 4.89 165.1 µM 9.34E-6 60 4.97E-7
15 SGTC_517 1365-0151 4.81 113.0 µM 1.30E-5 20 7.63E-7
16 SGTC_708 3448-5400 4.80 146.0 µM 1.36E-5 22 8.07E-7
17 SGTC_535 2293-4129 4.74 48.2 µM 1.67E-5 NEO1 45 1.06E-6
18 SGTC_221 trifluoperazine 4.61 10.3 µM 2.75E-5 NEO1-PIK1 180 2.01E-6
19 SGTC_1380 2291-0730 4.46 164.0 µM 4.84E-5 15 4.16E-6
20 SGTC_1800 st050079 4.37 29.1 µM 6.54E-5 NEO1-PIK1 103 6.14E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.253 2.43E-50 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.239 1.05E-44 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.238 2.78E-44 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.228 9.04E-41 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.222 1.17E-38 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.220 4.10E-38 YAR042W SWH1 hom Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction
0.220 4.84E-38 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.217 4.85E-37 YJL124C LSM1 hom Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
0.215 1.97E-36 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.213 7.37E-36 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.212 2.44E-35 YLR057W MNL2 hom Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene
0.210 8.43E-35 YOL159C-A YOL159C-A hom Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species
0.207 8.09E-34 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.199 3.23E-31 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.197 9.78E-31 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex