YDR524W-C_p

Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR524W-C / YDR524W-C

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:4.17|P-value:6.43E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:3.51|P-value:6.33E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:3.54|P-value:5.59E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.83|P-value:2.16E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:3.56|P-value:5.33E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:3.50|P-value:6.48E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:4.25|P-value:4.73E-5 ID:SGTC_125|Compound:0133-0007|FD-Score:3.42|P-value:8.34E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:4.60|P-value:1.19E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.49|P-value:6.64E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:5.09|P-value:1.47E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:4.23|P-value:5.06E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:5.04|P-value:1.82E-6 ID:SGTC_205|Compound:1486-1330|FD-Score:3.61|P-value:4.47E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.49|P-value:6.57E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.39|P-value:9.21E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:5.05|P-value:1.73E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:3.54|P-value:5.66E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.46|P-value:7.30E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.41|P-value:8.52E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.88|P-value:1.79E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:4.02|P-value:1.10E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:-4.44|P-value:2.50E-5 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.51|P-value:6.19E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.61|P-value:4.56E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.44|P-value:7.69E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.69|P-value:8.17E-6 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.39|P-value:9.05E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.40|P-value:8.80E-4 ID:SGTC_1760|Compound:st045453|FD-Score:4.60|P-value:1.20E-5 ID:SGTC_1770|Compound:st043884|FD-Score:3.46|P-value:7.27E-4 ID:SGTC_1781|Compound:st038725|FD-Score:6.86|P-value:1.51E-10 ID:SGTC_1797|Compound:st048695|FD-Score:5.61|P-value:1.28E-7 ID:SGTC_1800|Compound:st050079|FD-Score:4.49|P-value:1.83E-5 ID:SGTC_1907|Compound:st060210|FD-Score:5.04|P-value:1.82E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.06|P-value:9.34E-5 ID:SGTC_2186|Compound:6124449|FD-Score:3.82|P-value:2.25E-4 ID:SGTC_2332|Compound:7982454|FD-Score:4.36|P-value:3.09E-5 ID:SGTC_2361|Compound:9034121|FD-Score:4.48|P-value:1.90E-5 ID:SGTC_2363|Compound:9053361|FD-Score:4.06|P-value:9.38E-5 ID:SGTC_2472|Compound:5377652|FD-Score:-3.97|P-value:1.43E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:4.43|P-value:2.33E-5 ID:SGTC_2555|Compound:cholic acid|FD-Score:5.07|P-value:1.62E-6 ID:SGTC_2556|Compound:citropten|FD-Score:4.27|P-value:4.30E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.18|P-value:9.60E-7 ID:SGTC_2769|Compound:toremifene|FD-Score:-3.69|P-value:3.75E-4 ID:SGTC_2800|Compound:7887935|FD-Score:4.02|P-value:1.08E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.80|P-value:2.39E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.50|P-value:6.38E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-3.95|P-value:1.54E-4 ID:SGTC_3324|Compound:9138759|FD-Score:3.38|P-value:9.37E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:4.17|P-value:6.43E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:3.51|P-value:6.33E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:3.54|P-value:5.59E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.83|P-value:2.16E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:3.56|P-value:5.33E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:3.50|P-value:6.48E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:4.25|P-value:4.73E-5 ID:SGTC_125|Compound:0133-0007|FD-Score:3.42|P-value:8.34E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:4.60|P-value:1.19E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.49|P-value:6.64E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:5.09|P-value:1.47E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:4.23|P-value:5.06E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:5.04|P-value:1.82E-6 ID:SGTC_205|Compound:1486-1330|FD-Score:3.61|P-value:4.47E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.49|P-value:6.57E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.39|P-value:9.21E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:5.05|P-value:1.73E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:3.54|P-value:5.66E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.46|P-value:7.30E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.41|P-value:8.52E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.88|P-value:1.79E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:4.02|P-value:1.10E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:-4.44|P-value:2.50E-5 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.51|P-value:6.19E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.61|P-value:4.56E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.44|P-value:7.69E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.69|P-value:8.17E-6 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.39|P-value:9.05E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.40|P-value:8.80E-4 ID:SGTC_1760|Compound:st045453|FD-Score:4.60|P-value:1.20E-5 ID:SGTC_1770|Compound:st043884|FD-Score:3.46|P-value:7.27E-4 ID:SGTC_1781|Compound:st038725|FD-Score:6.86|P-value:1.51E-10 ID:SGTC_1797|Compound:st048695|FD-Score:5.61|P-value:1.28E-7 ID:SGTC_1800|Compound:st050079|FD-Score:4.49|P-value:1.83E-5 ID:SGTC_1907|Compound:st060210|FD-Score:5.04|P-value:1.82E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.06|P-value:9.34E-5 ID:SGTC_2186|Compound:6124449|FD-Score:3.82|P-value:2.25E-4 ID:SGTC_2332|Compound:7982454|FD-Score:4.36|P-value:3.09E-5 ID:SGTC_2361|Compound:9034121|FD-Score:4.48|P-value:1.90E-5 ID:SGTC_2363|Compound:9053361|FD-Score:4.06|P-value:9.38E-5 ID:SGTC_2472|Compound:5377652|FD-Score:-3.97|P-value:1.43E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:4.43|P-value:2.33E-5 ID:SGTC_2555|Compound:cholic acid|FD-Score:5.07|P-value:1.62E-6 ID:SGTC_2556|Compound:citropten|FD-Score:4.27|P-value:4.30E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.18|P-value:9.60E-7 ID:SGTC_2769|Compound:toremifene|FD-Score:-3.69|P-value:3.75E-4 ID:SGTC_2800|Compound:7887935|FD-Score:4.02|P-value:1.08E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.80|P-value:2.39E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.50|P-value:6.38E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-3.95|P-value:1.54E-4 ID:SGTC_3324|Compound:9138759|FD-Score:3.38|P-value:9.37E-4

Top fitness defect scores for YDR524W-C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1781 st038725 6.86 66.3 µM 1.51E-10 NEO1 42 3.42E-12
2 SGTC_1797 st048695 5.61 56.8 µM 1.28E-7 NEO1 46 1.01E-8
3 SGTC_2688 kanamycin b 5.18 96.7 µM 9.60E-7 calcium & mitochondrial duress 229 1.09E-7
4 SGTC_145 3737-0113 5.09 38.4 µM 1.47E-6 DNA intercalators 40 1.80E-7
5 SGTC_2555 cholic acid 5.07 100.0 µM 1.62E-6 6 2.02E-7
6 SGTC_708 3448-5400 5.05 146.0 µM 1.73E-6 17 2.18E-7
7 SGTC_1907 st060210 5.04 83.7 µM 1.82E-6 8 2.31E-7
8 SGTC_184 1494-0393 5.04 24.7 µM 1.82E-6 30 2.31E-7
9 SGTC_1341 1486-1360 4.69 280.0 µM 8.17E-6 6 1.36E-6
10 SGTC_126 0417-1624 4.60 672.5 µM 1.19E-5 DNA intercalators 16 2.12E-6
11 SGTC_1760 st045453 4.60 10.4 µM 1.20E-5 NEO1-PIK1 120 2.14E-6
12 SGTC_1800 st050079 4.49 29.1 µM 1.83E-5 NEO1-PIK1 95 3.53E-6
13 SGTC_2361 9034121 4.48 116.0 µM 1.90E-5 RSC complex & mRNA processing 13 3.69E-6
14 SGTC_2543 pimpinellin 4.43 60.7 µM 2.33E-5 Golgi 7 4.68E-6
15 SGTC_2332 7982454 4.36 138.9 µM 3.09E-5 35 6.53E-6
16 SGTC_2556 citropten 4.27 84.6 µM 4.30E-5 21 9.64E-6
17 SGTC_115 0527-0192 4.25 112.0 µM 4.73E-5 57 1.08E-5
18 SGTC_146 3448-8650 4.23 53.1 µM 5.06E-5 NEO1-PIK1 120 1.17E-5
19 SGTC_17 0960-0276 4.17 49.8 µM 6.43E-5 24 1.55E-5
20 SGTC_1926 methyl fluorone black 4.06 53.6 µM 9.34E-5 DNA intercalators 56 2.41E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.190 1.84E-28 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.178 3.13E-25 YDR524C-B_p YDR524C-B_p hom Putative protein of unknown function; YDR524C-B has a paralog, YCL048W-A, that arose from the whole genome duplication
0.169 8.95E-23 YGL198W YIP4 hom Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
0.165 6.55E-22 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.164 1.10E-21 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.164 1.28E-21 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.163 2.64E-21 YNL124W NAF1 het RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
0.160 1.00E-20 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.159 2.27E-20 YDR125C ECM18 hom Protein of unknown function; ECM18 has a paralog, ICT1, that arose from the whole genome duplication
0.158 2.83E-20 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.156 1.01E-19 YOL159C-A YOL159C-A hom Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species
0.155 2.28E-19 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.152 8.53E-19 YFL022C FRS2 het Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
0.152 1.12E-18 YPL197C_d YPL197C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B
0.149 4.83E-18 YEL017C-A PMP2 hom Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication