YDR525W-A / SNA2

Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR525W-A / SNA2

Click on Significant Values for Screen Details ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.60|P-value:1.56E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.26|P-value:5.53E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:3.83|P-value:6.43E-5 ID:SGTC_331|Compound:k048-0133|FD-Score:3.28|P-value:5.18E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:6.67|P-value:1.31E-11 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.45|P-value:2.83E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-4.78|P-value:8.81E-7 ID:SGTC_552|Compound:k242-0005|FD-Score:-3.97|P-value:3.66E-5 ID:SGTC_557|Compound:1315-0110|FD-Score:4.15|P-value:1.62E-5 ID:SGTC_559|Compound:1550-0661|FD-Score:3.86|P-value:5.63E-5 ID:SGTC_583|Compound:1488-1091|FD-Score:3.24|P-value:5.91E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:4.60|P-value:2.08E-6 ID:SGTC_615|Compound:k087-0205|FD-Score:3.36|P-value:3.92E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.65|P-value:1.31E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:3.34|P-value:4.23E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.03|P-value:2.83E-5 ID:SGTC_754|Compound:3474-0146|FD-Score:5.18|P-value:1.11E-7 ID:SGTC_761|Compound:k216-0224|FD-Score:4.00|P-value:3.20E-5 ID:SGTC_766|Compound:1391-0721|FD-Score:3.17|P-value:7.70E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.96|P-value:3.48E-7 ID:SGTC_877|Compound:0771-0151|FD-Score:3.13|P-value:8.60E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.27|P-value:5.53E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.82|P-value:6.54E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:5.20|P-value:9.79E-8 ID:SGTC_986|Compound:1493-0483|FD-Score:5.90|P-value:1.78E-9 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.99|P-value:3.23E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:7.65|P-value:9.90E-15 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.78|P-value:7.78E-5 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.57|P-value:1.75E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.43|P-value:3.02E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:-3.29|P-value:5.08E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.86|P-value:5.60E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:5.69|P-value:6.18E-9 ID:SGTC_1374|Compound:2889-5571|FD-Score:-7.14|P-value:4.76E-13 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.88|P-value:5.27E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:5.86|P-value:2.33E-9 ID:SGTC_1491|Compound:4138-0063|FD-Score:3.51|P-value:2.26E-4 ID:SGTC_1518|Compound:st038567|FD-Score:3.28|P-value:5.24E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.12|P-value:8.94E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.28|P-value:5.14E-4 ID:SGTC_1805|Compound:st050013|FD-Score:4.24|P-value:1.12E-5 ID:SGTC_1855|Compound:st056195|FD-Score:-3.76|P-value:8.51E-5 ID:SGTC_1856|Compound:st057054|FD-Score:5.61|P-value:1.01E-8 ID:SGTC_1859|Compound:st055998|FD-Score:-3.61|P-value:1.54E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.20|P-value:6.72E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.22|P-value:1.19E-5 ID:SGTC_2168|Compound:5727979|FD-Score:3.75|P-value:8.87E-5 ID:SGTC_2216|Compound:7189485|FD-Score:3.31|P-value:4.66E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.34|P-value:4.10E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.37|P-value:3.68E-4 ID:SGTC_2385|Compound:9074692|FD-Score:4.03|P-value:2.82E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.56|P-value:1.86E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.22|P-value:6.35E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.87|P-value:5.58E-7 ID:SGTC_2585|Compound:alliin|FD-Score:3.73|P-value:9.59E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:4.84|P-value:6.51E-7 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.31|P-value:4.66E-4 ID:SGTC_2821|Compound:7996764|FD-Score:5.33|P-value:4.75E-8 ID:SGTC_2830|Compound:7992007|FD-Score:3.51|P-value:2.24E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-3.23|P-value:6.27E-4 ID:SGTC_2945|Compound:9067681|FD-Score:3.25|P-value:5.79E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.68|P-value:1.18E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.66|P-value:1.26E-4 ID:SGTC_3175|Compound:9106517|FD-Score:4.38|P-value:5.84E-6 ID:SGTC_3222|Compound:9128301|FD-Score:3.37|P-value:3.73E-4 ID:SGTC_3232|Compound:9132874|FD-Score:-3.16|P-value:7.96E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.60|P-value:1.56E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.26|P-value:5.53E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:3.83|P-value:6.43E-5 ID:SGTC_331|Compound:k048-0133|FD-Score:3.28|P-value:5.18E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:6.67|P-value:1.31E-11 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.45|P-value:2.83E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-4.78|P-value:8.81E-7 ID:SGTC_552|Compound:k242-0005|FD-Score:-3.97|P-value:3.66E-5 ID:SGTC_557|Compound:1315-0110|FD-Score:4.15|P-value:1.62E-5 ID:SGTC_559|Compound:1550-0661|FD-Score:3.86|P-value:5.63E-5 ID:SGTC_583|Compound:1488-1091|FD-Score:3.24|P-value:5.91E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:4.60|P-value:2.08E-6 ID:SGTC_615|Compound:k087-0205|FD-Score:3.36|P-value:3.92E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.65|P-value:1.31E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:3.34|P-value:4.23E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.03|P-value:2.83E-5 ID:SGTC_754|Compound:3474-0146|FD-Score:5.18|P-value:1.11E-7 ID:SGTC_761|Compound:k216-0224|FD-Score:4.00|P-value:3.20E-5 ID:SGTC_766|Compound:1391-0721|FD-Score:3.17|P-value:7.70E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.96|P-value:3.48E-7 ID:SGTC_877|Compound:0771-0151|FD-Score:3.13|P-value:8.60E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.27|P-value:5.53E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.82|P-value:6.54E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:5.20|P-value:9.79E-8 ID:SGTC_986|Compound:1493-0483|FD-Score:5.90|P-value:1.78E-9 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.99|P-value:3.23E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:7.65|P-value:9.90E-15 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.78|P-value:7.78E-5 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.57|P-value:1.75E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.43|P-value:3.02E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:-3.29|P-value:5.08E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.86|P-value:5.60E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:5.69|P-value:6.18E-9 ID:SGTC_1374|Compound:2889-5571|FD-Score:-7.14|P-value:4.76E-13 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.88|P-value:5.27E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:5.86|P-value:2.33E-9 ID:SGTC_1491|Compound:4138-0063|FD-Score:3.51|P-value:2.26E-4 ID:SGTC_1518|Compound:st038567|FD-Score:3.28|P-value:5.24E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.12|P-value:8.94E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.28|P-value:5.14E-4 ID:SGTC_1805|Compound:st050013|FD-Score:4.24|P-value:1.12E-5 ID:SGTC_1855|Compound:st056195|FD-Score:-3.76|P-value:8.51E-5 ID:SGTC_1856|Compound:st057054|FD-Score:5.61|P-value:1.01E-8 ID:SGTC_1859|Compound:st055998|FD-Score:-3.61|P-value:1.54E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.20|P-value:6.72E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.22|P-value:1.19E-5 ID:SGTC_2168|Compound:5727979|FD-Score:3.75|P-value:8.87E-5 ID:SGTC_2216|Compound:7189485|FD-Score:3.31|P-value:4.66E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.34|P-value:4.10E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.37|P-value:3.68E-4 ID:SGTC_2385|Compound:9074692|FD-Score:4.03|P-value:2.82E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.56|P-value:1.86E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.22|P-value:6.35E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.87|P-value:5.58E-7 ID:SGTC_2585|Compound:alliin|FD-Score:3.73|P-value:9.59E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:4.84|P-value:6.51E-7 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.31|P-value:4.66E-4 ID:SGTC_2821|Compound:7996764|FD-Score:5.33|P-value:4.75E-8 ID:SGTC_2830|Compound:7992007|FD-Score:3.51|P-value:2.24E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-3.23|P-value:6.27E-4 ID:SGTC_2945|Compound:9067681|FD-Score:3.25|P-value:5.79E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.68|P-value:1.18E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.66|P-value:1.26E-4 ID:SGTC_3175|Compound:9106517|FD-Score:4.38|P-value:5.84E-6 ID:SGTC_3222|Compound:9128301|FD-Score:3.37|P-value:3.73E-4 ID:SGTC_3232|Compound:9132874|FD-Score:-3.16|P-value:7.96E-4

Top fitness defect scores for YDR525W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1178 0988-0033 7.65 191.0 µM 9.90E-15 1 9.96E-15
2 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 6.67 150.0 µM 1.31E-11 Golgi 14 1.32E-11
3 SGTC_986 1493-0483 5.90 84.0 µM 1.78E-9 2 1.79E-9
4 SGTC_1483 3453-0561 5.86 55.9 µM 2.33E-9 2 2.35E-9
5 SGTC_1369 1866-0067 5.69 208.0 µM 6.18E-9 RPP1 & pyrimidine depletion 11 6.22E-9
6 SGTC_1856 st057054 5.61 55.7 µM 1.01E-8 8 1.02E-8
7 SGTC_2821 7996764 5.33 71.4 µM 4.75E-8 14 4.79E-8
8 SGTC_952 1185-0122 5.20 232.0 µM 9.79E-8 8 9.85E-8
9 SGTC_754 3474-0146 5.18 171.0 µM 1.11E-7 copper-dependent oxidative stress 8 1.12E-7
10 SGTC_768 0384-0033 4.96 77.3 µM 3.48E-7 fatty acid desaturase (OLE1) 55 3.51E-7
11 SGTC_2755 lomerizine 4.84 42.7 µM 6.51E-7 14 6.55E-7
12 SGTC_612 0302-0167 4.60 22.4 µM 2.08E-6 copper-dependent oxidative stress 20 2.10E-6
13 SGTC_3175 9106517 4.38 49.5 µM 5.84E-6 iron homeostasis 12 5.88E-6
14 SGTC_1805 st050013 4.24 60.3 µM 1.12E-5 4 1.12E-5
15 SGTC_2131 toluylene red 4.22 5.3 µM 1.19E-5 60S ribosome export 17 1.20E-5
16 SGTC_557 1315-0110 4.15 16.2 µM 1.62E-5 Golgi 19 1.63E-5
17 SGTC_2385 9074692 4.03 200.0 µM 2.82E-5 41 2.83E-5
18 SGTC_708 3448-5400 4.03 146.0 µM 2.83E-5 40 2.84E-5
19 SGTC_761 k216-0224 4.00 480.0 µM 3.20E-5 18 3.22E-5
20 SGTC_1156 4092-0367 3.99 4.9 µM 3.23E-5 19 3.25E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 6.05E-12 YLR054C OSW2 hom Protein of unknown function proposed to be involved in the assembly of the spore wall
0.113 5.09E-11 YKL063C_p YKL063C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
0.103 2.46E-9 YDL201W TRM8 hom Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.097 1.75E-8 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.096 2.54E-8 YLL034C RIX7 het Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions
0.089 2.11E-7 YLR409C UTP21 het Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma
0.088 3.41E-7 YDR356W SPC110 het Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner
0.082 2.24E-6 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.080 3.53E-6 YGL236C MTO1 hom Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants
0.074 2.03E-5 YPR123C_d YPR123C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR
0.073 2.45E-5 YHR066W SSF1 hom Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication
0.073 2.54E-5 YGR177C ATF2 hom Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking
0.073 2.60E-5 YMR060C SAM37 hom Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability
0.072 2.87E-5 YGR160W_d YGR160W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.072 2.96E-5 YLR046C_p YLR046C_p hom Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance