YDR526C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR526C / YDR526C

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:4.81|P-value:7.47E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:4.01|P-value:7.93E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:-4.76|P-value:6.85E-5 ID:SGTC_197|Compound:4544-0043|FD-Score:10.60|P-value:1.96E-17 ID:SGTC_207|Compound:4185-0010|FD-Score:4.68|P-value:1.10E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:4.15|P-value:5.44E-4 ID:SGTC_298|Compound:1391-0729|FD-Score:-3.90|P-value:8.85E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:4.61|P-value:1.41E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:4.02|P-value:7.67E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.05|P-value:8.74E-7 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:4.34|P-value:3.16E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:4.33|P-value:3.17E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:5.76|P-value:2.68E-6 ID:SGTC_615|Compound:k087-0205|FD-Score:3.93|P-value:9.90E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:4.58|P-value:1.53E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:5.46|P-value:8.07E-6 ID:SGTC_951|Compound:1171-0579|FD-Score:15.20|P-value:1.49E-33 ID:SGTC_1026|Compound:k007-1105|FD-Score:6.77|P-value:4.28E-8 ID:SGTC_1055|Compound:3448-0672|FD-Score:5.20|P-value:2.06E-5 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.97|P-value:8.80E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.85|P-value:1.92E-6 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.91|P-value:5.43E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:-4.08|P-value:5.38E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:4.62|P-value:1.36E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:10.90|P-value:2.78E-18 ID:SGTC_1255|Compound:0566-0045|FD-Score:-5.05|P-value:2.65E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:4.04|P-value:7.30E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:4.85|P-value:6.61E-5 ID:SGTC_1404|Compound:3909-7820|FD-Score:-4.11|P-value:4.96E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:4.42|P-value:2.49E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:-4.60|P-value:1.14E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-4.36|P-value:2.42E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:-3.98|P-value:7.00E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:6.57|P-value:1.03E-7 ID:SGTC_1716|Compound:st033144|FD-Score:4.91|P-value:5.37E-5 ID:SGTC_1717|Compound:st033143|FD-Score:4.01|P-value:8.01E-4 ID:SGTC_1750|Compound:st081859|FD-Score:6.80|P-value:3.81E-8 ID:SGTC_1754|Compound:st042065|FD-Score:4.30|P-value:3.47E-4 ID:SGTC_1780|Compound:st038448|FD-Score:4.05|P-value:7.05E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-3.92|P-value:8.27E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-4.65|P-value:9.65E-5 ID:SGTC_1829|Compound:berberine|FD-Score:-6.39|P-value:1.63E-7 ID:SGTC_1916|Compound:st067606|FD-Score:-6.47|P-value:1.17E-7 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-4.80|P-value:6.12E-5 ID:SGTC_1959|Compound:st077091|FD-Score:6.99|P-value:1.67E-8 ID:SGTC_1968|Compound:st069590|FD-Score:15.20|P-value:8.43E-34 ID:SGTC_2021|Compound:4019055|FD-Score:10.30|P-value:1.82E-16 ID:SGTC_2036|Compound:5160441|FD-Score:9.48|P-value:3.08E-14 ID:SGTC_2066|Compound:5222451|FD-Score:-5.13|P-value:2.03E-5 ID:SGTC_2156|Compound:5649887|FD-Score:4.61|P-value:1.40E-4 ID:SGTC_2193|Compound:5925765|FD-Score:5.33|P-value:1.30E-5 ID:SGTC_2198|Compound:6589944|FD-Score:-4.13|P-value:4.63E-4 ID:SGTC_2286|Compound:7945697|FD-Score:5.40|P-value:9.98E-6 ID:SGTC_2289|Compound:7946404|FD-Score:-3.88|P-value:9.29E-4 ID:SGTC_2363|Compound:9053361|FD-Score:6.33|P-value:2.82E-7 ID:SGTC_2482|Compound:5981709|FD-Score:5.46|P-value:8.11E-6 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:4.12|P-value:5.84E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-4.39|P-value:2.19E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:7.59|P-value:9.44E-10 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.66|P-value:1.18E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-4.20|P-value:3.76E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.18|P-value:4.07E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:-4.07|P-value:5.57E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-4.29|P-value:2.93E-4 ID:SGTC_2784|Compound:7567673|FD-Score:4.77|P-value:8.47E-5 ID:SGTC_2824|Compound:7998404|FD-Score:7.68|P-value:6.13E-10 ID:SGTC_2826|Compound:7992541|FD-Score:-4.75|P-value:7.13E-5 ID:SGTC_2827|Compound:7993847|FD-Score:8.68|P-value:3.18E-12 ID:SGTC_2867|Compound:9039098|FD-Score:5.79|P-value:2.44E-6 ID:SGTC_2980|Compound:9014342|FD-Score:-5.26|P-value:1.28E-5 ID:SGTC_2986|Compound:9022445|FD-Score:4.19|P-value:4.83E-4 ID:SGTC_3003|Compound:9075612|FD-Score:4.10|P-value:6.11E-4 ID:SGTC_3039|Compound:9090270|FD-Score:4.54|P-value:1.73E-4 ID:SGTC_3098|Compound:9119039|FD-Score:5.36|P-value:1.18E-5 ID:SGTC_3112|Compound:9123419|FD-Score:5.19|P-value:2.09E-5 ID:SGTC_3123|Compound:9126162|FD-Score:-5.18|P-value:1.68E-5 ID:SGTC_3142|Compound:9086498|FD-Score:8.59|P-value:5.27E-12 ID:SGTC_3152|Compound:9099253|FD-Score:7.87|P-value:2.37E-10 ID:SGTC_3161|Compound:9100388|FD-Score:6.43|P-value:1.87E-7 ID:SGTC_3188|Compound:9110789|FD-Score:8.06|P-value:8.86E-11 ID:SGTC_3208|Compound:9114115|FD-Score:-7.04|P-value:9.19E-9 ID:SGTC_3219|Compound:9131112|FD-Score:7.80|P-value:3.32E-10 ID:SGTC_3285|Compound:9112818|FD-Score:4.13|P-value:5.75E-4 ID:SGTC_3304|Compound:9125678|FD-Score:4.49|P-value:2.00E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:4.81|P-value:7.47E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:4.01|P-value:7.93E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:-4.76|P-value:6.85E-5 ID:SGTC_197|Compound:4544-0043|FD-Score:10.60|P-value:1.96E-17 ID:SGTC_207|Compound:4185-0010|FD-Score:4.68|P-value:1.10E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:4.15|P-value:5.44E-4 ID:SGTC_298|Compound:1391-0729|FD-Score:-3.90|P-value:8.85E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:4.61|P-value:1.41E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:4.02|P-value:7.67E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.05|P-value:8.74E-7 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:4.34|P-value:3.16E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:4.33|P-value:3.17E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:5.76|P-value:2.68E-6 ID:SGTC_615|Compound:k087-0205|FD-Score:3.93|P-value:9.90E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:4.58|P-value:1.53E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:5.46|P-value:8.07E-6 ID:SGTC_951|Compound:1171-0579|FD-Score:15.20|P-value:1.49E-33 ID:SGTC_1026|Compound:k007-1105|FD-Score:6.77|P-value:4.28E-8 ID:SGTC_1055|Compound:3448-0672|FD-Score:5.20|P-value:2.06E-5 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.97|P-value:8.80E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.85|P-value:1.92E-6 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.91|P-value:5.43E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:-4.08|P-value:5.38E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:4.62|P-value:1.36E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:10.90|P-value:2.78E-18 ID:SGTC_1255|Compound:0566-0045|FD-Score:-5.05|P-value:2.65E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:4.04|P-value:7.30E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:4.85|P-value:6.61E-5 ID:SGTC_1404|Compound:3909-7820|FD-Score:-4.11|P-value:4.96E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:4.42|P-value:2.49E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:-4.60|P-value:1.14E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-4.36|P-value:2.42E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:-3.98|P-value:7.00E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:6.57|P-value:1.03E-7 ID:SGTC_1716|Compound:st033144|FD-Score:4.91|P-value:5.37E-5 ID:SGTC_1717|Compound:st033143|FD-Score:4.01|P-value:8.01E-4 ID:SGTC_1750|Compound:st081859|FD-Score:6.80|P-value:3.81E-8 ID:SGTC_1754|Compound:st042065|FD-Score:4.30|P-value:3.47E-4 ID:SGTC_1780|Compound:st038448|FD-Score:4.05|P-value:7.05E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-3.92|P-value:8.27E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-4.65|P-value:9.65E-5 ID:SGTC_1829|Compound:berberine|FD-Score:-6.39|P-value:1.63E-7 ID:SGTC_1916|Compound:st067606|FD-Score:-6.47|P-value:1.17E-7 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-4.80|P-value:6.12E-5 ID:SGTC_1959|Compound:st077091|FD-Score:6.99|P-value:1.67E-8 ID:SGTC_1968|Compound:st069590|FD-Score:15.20|P-value:8.43E-34 ID:SGTC_2021|Compound:4019055|FD-Score:10.30|P-value:1.82E-16 ID:SGTC_2036|Compound:5160441|FD-Score:9.48|P-value:3.08E-14 ID:SGTC_2066|Compound:5222451|FD-Score:-5.13|P-value:2.03E-5 ID:SGTC_2156|Compound:5649887|FD-Score:4.61|P-value:1.40E-4 ID:SGTC_2193|Compound:5925765|FD-Score:5.33|P-value:1.30E-5 ID:SGTC_2198|Compound:6589944|FD-Score:-4.13|P-value:4.63E-4 ID:SGTC_2286|Compound:7945697|FD-Score:5.40|P-value:9.98E-6 ID:SGTC_2289|Compound:7946404|FD-Score:-3.88|P-value:9.29E-4 ID:SGTC_2363|Compound:9053361|FD-Score:6.33|P-value:2.82E-7 ID:SGTC_2482|Compound:5981709|FD-Score:5.46|P-value:8.11E-6 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:4.12|P-value:5.84E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-4.39|P-value:2.19E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:7.59|P-value:9.44E-10 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.66|P-value:1.18E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-4.20|P-value:3.76E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.18|P-value:4.07E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:-4.07|P-value:5.57E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-4.29|P-value:2.93E-4 ID:SGTC_2784|Compound:7567673|FD-Score:4.77|P-value:8.47E-5 ID:SGTC_2824|Compound:7998404|FD-Score:7.68|P-value:6.13E-10 ID:SGTC_2826|Compound:7992541|FD-Score:-4.75|P-value:7.13E-5 ID:SGTC_2827|Compound:7993847|FD-Score:8.68|P-value:3.18E-12 ID:SGTC_2867|Compound:9039098|FD-Score:5.79|P-value:2.44E-6 ID:SGTC_2980|Compound:9014342|FD-Score:-5.26|P-value:1.28E-5 ID:SGTC_2986|Compound:9022445|FD-Score:4.19|P-value:4.83E-4 ID:SGTC_3003|Compound:9075612|FD-Score:4.10|P-value:6.11E-4 ID:SGTC_3039|Compound:9090270|FD-Score:4.54|P-value:1.73E-4 ID:SGTC_3098|Compound:9119039|FD-Score:5.36|P-value:1.18E-5 ID:SGTC_3112|Compound:9123419|FD-Score:5.19|P-value:2.09E-5 ID:SGTC_3123|Compound:9126162|FD-Score:-5.18|P-value:1.68E-5 ID:SGTC_3142|Compound:9086498|FD-Score:8.59|P-value:5.27E-12 ID:SGTC_3152|Compound:9099253|FD-Score:7.87|P-value:2.37E-10 ID:SGTC_3161|Compound:9100388|FD-Score:6.43|P-value:1.87E-7 ID:SGTC_3188|Compound:9110789|FD-Score:8.06|P-value:8.86E-11 ID:SGTC_3208|Compound:9114115|FD-Score:-7.04|P-value:9.19E-9 ID:SGTC_3219|Compound:9131112|FD-Score:7.80|P-value:3.32E-10 ID:SGTC_3285|Compound:9112818|FD-Score:4.13|P-value:5.75E-4 ID:SGTC_3304|Compound:9125678|FD-Score:4.49|P-value:2.00E-4

Top fitness defect scores for YDR526C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1968 st069590 15.20 43.6 µM 8.43E-34 3 1.46E-52 4.18
2 SGTC_951 1171-0579 15.20 82.7 µM 1.49E-33 cell wall 2 3.60E-52 6.71
3 SGTC_1230 0170-0365 10.90 3.8 µM 2.78E-18 endomembrane recycling 5 5.23E-28 0.20
4 SGTC_197 4544-0043 10.60 41.6 µM 1.96E-17 endomembrane recycling 5 1.15E-26 1.88
5 SGTC_2021 4019055 10.30 173.0 µM 1.82E-16 endomembrane recycling 8 3.87E-25 1.51
6 SGTC_2036 5160441 9.48 105.0 µM 3.08E-14 NEO1 5 1.28E-21 0.37
7 SGTC_2827 7993847 8.68 71.4 µM 3.18E-12 1 1.94E-18 2.16
8 SGTC_3142 9086498 8.59 49.5 µM 5.27E-12 iron homeostasis 13 4.32E-18 0.85
9 SGTC_3188 9110789 8.06 49.5 µM 8.86E-11 iron homeostasis 1 3.70E-16 2.54
10 SGTC_3152 9099253 7.87 49.5 µM 2.37E-10 NEO1-PIK1 8 1.75E-15 0.57
11 SGTC_3219 9131112 7.80 49.5 µM 3.32E-10 Golgi 4 2.98E-15 1.89
12 SGTC_2824 7998404 7.68 52.0 µM 6.13E-10 2 7.81E-15 1.87
13 SGTC_2619 obliquin 7.59 87.9 µM 9.44E-10 cell wall 9 1.54E-14 0.31
14 SGTC_1959 st077091 6.99 55.8 µM 1.67E-8 RPP1 & pyrimidine depletion 8 1.42E-12 0.15
15 SGTC_1750 st081859 6.80 2.4 µM 3.81E-8 endomembrane recycling 14 5.22E-12 0.59
16 SGTC_1026 k007-1105 6.77 30.6 µM 4.28E-8 ERAD & cell cycle 9 6.26E-12 0.10
17 SGTC_1679 4130-1276 6.57 6.7 µM 1.03E-7 Golgi 13 2.48E-11 0.65
18 SGTC_3161 9100388 6.43 49.5 µM 1.87E-7 iron homeostasis 3 6.35E-11 0.27
19 SGTC_2363 9053361 6.33 176.0 µM 2.82E-7 Golgi 3 1.21E-10 0.77
20 SGTC_453 enantio-paf c16 6.05 10.0 µM 8.74E-7 5 7.19E-10 0.22

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.366 4.31E-107 YDR081C PDC2 het Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions
0.258 8.42E-52 YCR093W CDC39 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.195 5.75E-30 YDR435C PPM1 hom Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits
0.190 2.04E-28 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.180 9.43E-26 YER133W GLC7 het Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest
0.176 7.17E-25 YHR007C ERG11 het Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p
0.164 1.13E-21 YKR031C SPO14 hom Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions
0.163 2.97E-21 YMR134W ERG29 het Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes
0.162 4.57E-21 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.153 4.35E-19 YGL116W CDC20 het Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
0.151 1.27E-18 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.151 1.54E-18 YKL145W RPT1 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance
0.151 1.72E-18 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.150 2.02E-18 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.145 2.80E-17 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p