YDR527W / RBA50

Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR527W / RBA50

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.53|P-value:2.73E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:-3.27|P-value:6.41E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:4.12|P-value:2.83E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.69|P-value:1.55E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:19.50|P-value:4.76E-82 ID:SGTC_114|Compound:0364-0001|FD-Score:4.11|P-value:2.87E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:3.65|P-value:1.76E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:5.98|P-value:2.33E-9 ID:SGTC_184|Compound:1494-0393|FD-Score:3.66|P-value:1.74E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:6.73|P-value:2.16E-11 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.96|P-value:5.32E-5 ID:SGTC_222|Compound:nsc-310342|FD-Score:3.26|P-value:7.10E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.90|P-value:6.70E-5 ID:SGTC_274|Compound:sirtinol|FD-Score:12.60|P-value:3.33E-35 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.44|P-value:6.80E-6 ID:SGTC_354|Compound:2783-3500|FD-Score:3.87|P-value:7.73E-5 ID:SGTC_395|Compound:anisomycin|FD-Score:-3.40|P-value:4.04E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:8.58|P-value:2.13E-17 ID:SGTC_594|Compound:1487-1584|FD-Score:7.57|P-value:6.01E-14 ID:SGTC_611|Compound:3453-1652|FD-Score:8.84|P-value:2.37E-18 ID:SGTC_639|Compound:0833-0042|FD-Score:4.16|P-value:2.30E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:-3.92|P-value:5.67E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:3.32|P-value:5.84E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:4.61|P-value:3.21E-6 ID:SGTC_860|Compound:0443-0016|FD-Score:4.30|P-value:1.27E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:5.48|P-value:4.12E-8 ID:SGTC_897|Compound:1000-0139|FD-Score:5.69|P-value:1.24E-8 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.22|P-value:8.19E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.22|P-value:1.83E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.57|P-value:2.18E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.39|P-value:4.58E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:28.70|P-value:1.24E-174 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.20|P-value:8.64E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.79|P-value:1.40E-6 ID:SGTC_1139|Compound:k015-0024|FD-Score:-3.21|P-value:7.93E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.49|P-value:3.22E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:4.04|P-value:3.81E-5 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.39|P-value:4.51E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:-3.34|P-value:4.98E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:-3.33|P-value:5.19E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:4.50|P-value:5.35E-6 ID:SGTC_1367|Compound:1812-0510|FD-Score:15.70|P-value:1.05E-53 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.70|P-value:1.47E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:7.67|P-value:2.90E-14 ID:SGTC_1604|Compound:st002052|FD-Score:8.80|P-value:3.24E-18 ID:SGTC_1643|Compound:st009866|FD-Score:4.83|P-value:1.12E-6 ID:SGTC_1661|Compound:st013063|FD-Score:5.30|P-value:1.05E-7 ID:SGTC_1722|Compound:st034304|FD-Score:5.03|P-value:4.32E-7 ID:SGTC_1723|Compound:st034307|FD-Score:3.40|P-value:4.48E-4 ID:SGTC_1773|Compound:st048542|FD-Score:7.01|P-value:3.16E-12 ID:SGTC_1863|Compound:st057641|FD-Score:3.32|P-value:5.76E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.42|P-value:4.06E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.72|P-value:1.38E-4 ID:SGTC_2004|Compound:4023728|FD-Score:39.60|P-value:0 ID:SGTC_2006|Compound:4011487|FD-Score:3.87|P-value:7.62E-5 ID:SGTC_2009|Compound:4012297|FD-Score:-3.42|P-value:3.76E-4 ID:SGTC_2018|Compound:5133068|FD-Score:5.87|P-value:4.37E-9 ID:SGTC_2019|Compound:4016004|FD-Score:5.70|P-value:1.17E-8 ID:SGTC_2067|Compound:5224629|FD-Score:5.61|P-value:1.94E-8 ID:SGTC_2151|Compound:5563267|FD-Score:9.70|P-value:9.73E-22 ID:SGTC_2225|Compound:6654152|FD-Score:3.50|P-value:3.12E-4 ID:SGTC_2246|Compound:7293507|FD-Score:13.20|P-value:7.01E-39 ID:SGTC_2309|Compound:7664088|FD-Score:3.33|P-value:5.73E-4 ID:SGTC_2311|Compound:7694451|FD-Score:4.20|P-value:2.00E-5 ID:SGTC_2323|Compound:6148992|FD-Score:6.69|P-value:2.80E-11 ID:SGTC_2348|Compound:9022543|FD-Score:6.73|P-value:2.10E-11 ID:SGTC_2361|Compound:9034121|FD-Score:3.29|P-value:6.53E-4 ID:SGTC_2362|Compound:9071156|FD-Score:3.17|P-value:9.75E-4 ID:SGTC_2400|Compound:5203494|FD-Score:5.13|P-value:2.50E-7 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.56|P-value:2.57E-8 ID:SGTC_2408|Compound:sulbentine|FD-Score:10.80|P-value:1.10E-26 ID:SGTC_2411|Compound:st077133|FD-Score:3.44|P-value:3.83E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.25|P-value:7.42E-4 ID:SGTC_2430|Compound:5571206|FD-Score:6.09|P-value:1.25E-9 ID:SGTC_2466|Compound:5983409|FD-Score:6.62|P-value:4.31E-11 ID:SGTC_2470|Compound:5664817|FD-Score:3.16|P-value:0.00100 ID:SGTC_2474|Compound:5321570|FD-Score:3.79|P-value:1.06E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:4.36|P-value:9.92E-6 ID:SGTC_2534|Compound:helenine|FD-Score:6.37|P-value:2.18E-10 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.00|P-value:4.59E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.82|P-value:9.17E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:4.01|P-value:4.30E-5 ID:SGTC_2601|Compound:securinine|FD-Score:4.58|P-value:3.69E-6 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.27|P-value:6.94E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.60|P-value:3.31E-6 ID:SGTC_2624|Compound:nerol|FD-Score:-3.37|P-value:4.55E-4 ID:SGTC_2711|Compound:st079103|FD-Score:3.51|P-value:2.98E-4 ID:SGTC_2783|Compound:7738165|FD-Score:3.91|P-value:6.43E-5 ID:SGTC_2799|Compound:7812892|FD-Score:3.56|P-value:2.45E-4 ID:SGTC_2902|Compound:5787006|FD-Score:3.40|P-value:4.36E-4 ID:SGTC_2921|Compound:7974240|FD-Score:30.10|P-value:6.04E-192 ID:SGTC_3180|Compound:9109287|FD-Score:3.33|P-value:5.68E-4 ID:SGTC_3181|Compound:9108277|FD-Score:4.47|P-value:6.09E-6 ID:SGTC_3188|Compound:9110789|FD-Score:-3.41|P-value:3.86E-4 ID:SGTC_3236|Compound:9132701|FD-Score:3.18|P-value:9.36E-4 ID:SGTC_3282|Compound:9108498|FD-Score:6.94|P-value:5.43E-12 ID:SGTC_3303|Compound:9125618|FD-Score:3.33|P-value:5.56E-4 ID:SGTC_3317|Compound:9138495|FD-Score:7.05|P-value:2.52E-12 ID:SGTC_7|Compound:0192-1582|FD-Score:3.53|P-value:2.73E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:-3.27|P-value:6.41E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:4.12|P-value:2.83E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.69|P-value:1.55E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:19.50|P-value:4.76E-82 ID:SGTC_114|Compound:0364-0001|FD-Score:4.11|P-value:2.87E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:3.65|P-value:1.76E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:5.98|P-value:2.33E-9 ID:SGTC_184|Compound:1494-0393|FD-Score:3.66|P-value:1.74E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:6.73|P-value:2.16E-11 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.96|P-value:5.32E-5 ID:SGTC_222|Compound:nsc-310342|FD-Score:3.26|P-value:7.10E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.90|P-value:6.70E-5 ID:SGTC_274|Compound:sirtinol|FD-Score:12.60|P-value:3.33E-35 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.44|P-value:6.80E-6 ID:SGTC_354|Compound:2783-3500|FD-Score:3.87|P-value:7.73E-5 ID:SGTC_395|Compound:anisomycin|FD-Score:-3.40|P-value:4.04E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:8.58|P-value:2.13E-17 ID:SGTC_594|Compound:1487-1584|FD-Score:7.57|P-value:6.01E-14 ID:SGTC_611|Compound:3453-1652|FD-Score:8.84|P-value:2.37E-18 ID:SGTC_639|Compound:0833-0042|FD-Score:4.16|P-value:2.30E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:-3.92|P-value:5.67E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:3.32|P-value:5.84E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:4.61|P-value:3.21E-6 ID:SGTC_860|Compound:0443-0016|FD-Score:4.30|P-value:1.27E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:5.48|P-value:4.12E-8 ID:SGTC_897|Compound:1000-0139|FD-Score:5.69|P-value:1.24E-8 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.22|P-value:8.19E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.22|P-value:1.83E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.57|P-value:2.18E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.39|P-value:4.58E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:28.70|P-value:1.24E-174 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.20|P-value:8.64E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.79|P-value:1.40E-6 ID:SGTC_1139|Compound:k015-0024|FD-Score:-3.21|P-value:7.93E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.49|P-value:3.22E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:4.04|P-value:3.81E-5 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.39|P-value:4.51E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:-3.34|P-value:4.98E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:-3.33|P-value:5.19E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:4.50|P-value:5.35E-6 ID:SGTC_1367|Compound:1812-0510|FD-Score:15.70|P-value:1.05E-53 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.70|P-value:1.47E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:7.67|P-value:2.90E-14 ID:SGTC_1604|Compound:st002052|FD-Score:8.80|P-value:3.24E-18 ID:SGTC_1643|Compound:st009866|FD-Score:4.83|P-value:1.12E-6 ID:SGTC_1661|Compound:st013063|FD-Score:5.30|P-value:1.05E-7 ID:SGTC_1722|Compound:st034304|FD-Score:5.03|P-value:4.32E-7 ID:SGTC_1723|Compound:st034307|FD-Score:3.40|P-value:4.48E-4 ID:SGTC_1773|Compound:st048542|FD-Score:7.01|P-value:3.16E-12 ID:SGTC_1863|Compound:st057641|FD-Score:3.32|P-value:5.76E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.42|P-value:4.06E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.72|P-value:1.38E-4 ID:SGTC_2004|Compound:4023728|FD-Score:39.60|P-value:0 ID:SGTC_2006|Compound:4011487|FD-Score:3.87|P-value:7.62E-5 ID:SGTC_2009|Compound:4012297|FD-Score:-3.42|P-value:3.76E-4 ID:SGTC_2018|Compound:5133068|FD-Score:5.87|P-value:4.37E-9 ID:SGTC_2019|Compound:4016004|FD-Score:5.70|P-value:1.17E-8 ID:SGTC_2067|Compound:5224629|FD-Score:5.61|P-value:1.94E-8 ID:SGTC_2151|Compound:5563267|FD-Score:9.70|P-value:9.73E-22 ID:SGTC_2225|Compound:6654152|FD-Score:3.50|P-value:3.12E-4 ID:SGTC_2246|Compound:7293507|FD-Score:13.20|P-value:7.01E-39 ID:SGTC_2309|Compound:7664088|FD-Score:3.33|P-value:5.73E-4 ID:SGTC_2311|Compound:7694451|FD-Score:4.20|P-value:2.00E-5 ID:SGTC_2323|Compound:6148992|FD-Score:6.69|P-value:2.80E-11 ID:SGTC_2348|Compound:9022543|FD-Score:6.73|P-value:2.10E-11 ID:SGTC_2361|Compound:9034121|FD-Score:3.29|P-value:6.53E-4 ID:SGTC_2362|Compound:9071156|FD-Score:3.17|P-value:9.75E-4 ID:SGTC_2400|Compound:5203494|FD-Score:5.13|P-value:2.50E-7 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.56|P-value:2.57E-8 ID:SGTC_2408|Compound:sulbentine|FD-Score:10.80|P-value:1.10E-26 ID:SGTC_2411|Compound:st077133|FD-Score:3.44|P-value:3.83E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.25|P-value:7.42E-4 ID:SGTC_2430|Compound:5571206|FD-Score:6.09|P-value:1.25E-9 ID:SGTC_2466|Compound:5983409|FD-Score:6.62|P-value:4.31E-11 ID:SGTC_2470|Compound:5664817|FD-Score:3.16|P-value:0.00100 ID:SGTC_2474|Compound:5321570|FD-Score:3.79|P-value:1.06E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:4.36|P-value:9.92E-6 ID:SGTC_2534|Compound:helenine|FD-Score:6.37|P-value:2.18E-10 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.00|P-value:4.59E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.82|P-value:9.17E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:4.01|P-value:4.30E-5 ID:SGTC_2601|Compound:securinine|FD-Score:4.58|P-value:3.69E-6 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.27|P-value:6.94E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.60|P-value:3.31E-6 ID:SGTC_2624|Compound:nerol|FD-Score:-3.37|P-value:4.55E-4 ID:SGTC_2711|Compound:st079103|FD-Score:3.51|P-value:2.98E-4 ID:SGTC_2783|Compound:7738165|FD-Score:3.91|P-value:6.43E-5 ID:SGTC_2799|Compound:7812892|FD-Score:3.56|P-value:2.45E-4 ID:SGTC_2902|Compound:5787006|FD-Score:3.40|P-value:4.36E-4 ID:SGTC_2921|Compound:7974240|FD-Score:30.10|P-value:6.04E-192 ID:SGTC_3180|Compound:9109287|FD-Score:3.33|P-value:5.68E-4 ID:SGTC_3181|Compound:9108277|FD-Score:4.47|P-value:6.09E-6 ID:SGTC_3188|Compound:9110789|FD-Score:-3.41|P-value:3.86E-4 ID:SGTC_3236|Compound:9132701|FD-Score:3.18|P-value:9.36E-4 ID:SGTC_3282|Compound:9108498|FD-Score:6.94|P-value:5.43E-12 ID:SGTC_3303|Compound:9125618|FD-Score:3.33|P-value:5.56E-4 ID:SGTC_3317|Compound:9138495|FD-Score:7.05|P-value:2.52E-12

Top fitness defect scores for YDR527W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2004 4023728 39.60 41.9 µM 0 1 0 25.50
2 SGTC_2921 7974240 30.10 10.7 µM 6.04E-192 1 2.27E-199 14.60
3 SGTC_1069 diphenylcyclopropenone 28.70 8.5 µM 1.24E-174 1 2.18E-181 18.80
4 SGTC_87 0100-0052 19.50 35.5 µM 4.76E-82 1 3.27E-85 7.28
5 SGTC_1367 1812-0510 15.70 76.9 µM 1.05E-53 1 9.11E-56 6.12
6 SGTC_2246 7293507 13.20 91.6 µM 7.01E-39 1 2.31E-40 4.56
7 SGTC_274 sirtinol 12.60 40.1 µM 3.33E-35 1 1.53E-36 4.35
8 SGTC_2408 sulbentine 10.80 18.4 µM 1.10E-26 2 1.09E-27 0.22
9 SGTC_2151 5563267 9.70 85.4 µM 9.73E-22 3 1.50E-22 0.03
10 SGTC_611 3453-1652 8.84 23.7 µM 2.37E-18 3 4.98E-19 0.09
11 SGTC_1604 st002052 8.80 72.4 µM 3.24E-18 TSC3-RPN4 2 6.87E-19 2.88
12 SGTC_589 1227-0070 8.58 34.1 µM 2.13E-17 1 4.88E-18 2.58
13 SGTC_1585 2',4'-dihydroxychalcone 7.67 10.4 µM 2.90E-14 2 8.81E-15 0.78
14 SGTC_594 1487-1584 7.57 10.8 µM 6.01E-14 1 1.88E-14 1.34
15 SGTC_3317 9138495 7.05 8.8 µM 2.52E-12 4 9.12E-13 0.97
16 SGTC_1773 st048542 7.01 73.6 µM 3.16E-12 6 1.15E-12 0.17
17 SGTC_3282 9108498 6.94 15.5 µM 5.43E-12 4 2.02E-12 0.32
18 SGTC_2348 9022543 6.73 33.4 µM 2.10E-11 mitochondrial processes 15 8.26E-12 0.18
19 SGTC_210 3551-0445 6.73 56.8 µM 2.16E-11 6 8.51E-12 0.93
20 SGTC_2323 6148992 6.69 148.3 µM 2.80E-11 5 1.11E-11 0.38

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.458 2.37E-173 YOR262W GPN2 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B; required for establishment of sister chromatid cohesion
0.449 5.45E-166 YLR243W GPN3 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p
0.427 7.55E-149 YMR185W RTP1 het Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene
0.356 1.13E-100 YOR207C RET1 het Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
0.221 2.67E-38 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.218 1.75E-37 YNL148C ALF1 hom Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance
0.214 4.90E-36 YAL024C LTE1 hom Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures
0.207 1.20E-33 YNL298W CLA4 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p
0.201 6.75E-32 YGR083C GCD2 het Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.201 8.91E-32 YPR085C ASA1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1
0.200 1.40E-31 YDR041W RSM10 het Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
0.193 2.13E-29 YML124C TUB3 hom Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication
0.176 9.64E-25 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.175 2.42E-24 YNL112W DBP2 het ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites
0.173 4.25E-24 YML058W SML1 hom Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase