YDR531W / CAB1

Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR531W / CAB1

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:4.33|P-value:1.86E-6 ID:SGTC_29|Compound:0299-0004|FD-Score:-3.68|P-value:3.26E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:5.74|P-value:4.08E-10 ID:SGTC_145|Compound:3737-0113|FD-Score:3.89|P-value:1.69E-5 ID:SGTC_297|Compound:0986-0032|FD-Score:3.23|P-value:2.93E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:-3.39|P-value:1.15E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-2.87|P-value:8.85E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:3.34|P-value:1.87E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.87|P-value:9.59E-8 ID:SGTC_643|Compound:k048-0106|FD-Score:-3.32|P-value:1.55E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.34|P-value:1.84E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:-2.85|P-value:9.40E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.17|P-value:2.80E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:-3.58|P-value:4.97E-5 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.33|P-value:1.98E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.88|P-value:1.73E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.57|P-value:5.26E-5 ID:SGTC_1724|Compound:st037281|FD-Score:-2.91|P-value:7.52E-4 ID:SGTC_1752|Compound:st044819|FD-Score:3.98|P-value:1.08E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.08|P-value:4.02E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.03|P-value:6.20E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.23|P-value:2.96E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-3.36|P-value:1.29E-4 ID:SGTC_2009|Compound:4012297|FD-Score:-3.84|P-value:1.51E-5 ID:SGTC_2104|Compound:5389443|FD-Score:3.99|P-value:1.02E-5 ID:SGTC_2107|Compound:5363541|FD-Score:3.01|P-value:6.71E-4 ID:SGTC_2248|Compound:tofa|FD-Score:6.25|P-value:1.10E-11 ID:SGTC_2329|Compound:6138490|FD-Score:4.18|P-value:4.00E-6 ID:SGTC_2364|Compound:9055074|FD-Score:-4.03|P-value:6.09E-6 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:2.97|P-value:8.01E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-2.88|P-value:8.49E-4 ID:SGTC_2591|Compound:skatole|FD-Score:-3.87|P-value:1.35E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:-4.52|P-value:4.81E-7 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.68|P-value:3.22E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-3.21|P-value:2.44E-4 ID:SGTC_3356|Compound:9151811|FD-Score:-3.24|P-value:2.10E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:4.33|P-value:1.86E-6 ID:SGTC_29|Compound:0299-0004|FD-Score:-3.68|P-value:3.26E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:5.74|P-value:4.08E-10 ID:SGTC_145|Compound:3737-0113|FD-Score:3.89|P-value:1.69E-5 ID:SGTC_297|Compound:0986-0032|FD-Score:3.23|P-value:2.93E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:-3.39|P-value:1.15E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-2.87|P-value:8.85E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:3.34|P-value:1.87E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.87|P-value:9.59E-8 ID:SGTC_643|Compound:k048-0106|FD-Score:-3.32|P-value:1.55E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.34|P-value:1.84E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:-2.85|P-value:9.40E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.17|P-value:2.80E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:-3.58|P-value:4.97E-5 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.33|P-value:1.98E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.88|P-value:1.73E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.57|P-value:5.26E-5 ID:SGTC_1724|Compound:st037281|FD-Score:-2.91|P-value:7.52E-4 ID:SGTC_1752|Compound:st044819|FD-Score:3.98|P-value:1.08E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.08|P-value:4.02E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.03|P-value:6.20E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.23|P-value:2.96E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-3.36|P-value:1.29E-4 ID:SGTC_2009|Compound:4012297|FD-Score:-3.84|P-value:1.51E-5 ID:SGTC_2104|Compound:5389443|FD-Score:3.99|P-value:1.02E-5 ID:SGTC_2107|Compound:5363541|FD-Score:3.01|P-value:6.71E-4 ID:SGTC_2248|Compound:tofa|FD-Score:6.25|P-value:1.10E-11 ID:SGTC_2329|Compound:6138490|FD-Score:4.18|P-value:4.00E-6 ID:SGTC_2364|Compound:9055074|FD-Score:-4.03|P-value:6.09E-6 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:2.97|P-value:8.01E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-2.88|P-value:8.49E-4 ID:SGTC_2591|Compound:skatole|FD-Score:-3.87|P-value:1.35E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:-4.52|P-value:4.81E-7 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.68|P-value:3.22E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-3.21|P-value:2.44E-4 ID:SGTC_3356|Compound:9151811|FD-Score:-3.24|P-value:2.10E-4

Top fitness defect scores for YDR531W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2248 tofa 6.25 1.1 µM 1.10E-11 sphingolipid biosynthesis & PDR1 15 2.03E-10 0.31
2 SGTC_124 0136-0217 5.74 7.1 µM 4.08E-10 mitochondrial stress 10 4.74E-9 0.14
3 SGTC_451 chloral hydrate 4.87 100.0 µM 9.59E-8 8 5.54E-7 0.16
4 SGTC_4 0960-0234 4.33 25.7 µM 1.86E-6 Golgi 10 7.38E-6 0.10
5 SGTC_2329 6138490 4.18 200.0 µM 4.00E-6 10 1.44E-5 0.28
6 SGTC_2104 5389443 3.99 200.0 µM 1.02E-5 6 3.28E-5 0.16
7 SGTC_1752 st044819 3.98 83.0 µM 1.08E-5 8 3.45E-5 0.17
8 SGTC_145 3737-0113 3.89 38.4 µM 1.69E-5 DNA intercalators 52 5.10E-5 0.02
9 SGTC_1579 chlormadinone acetate 3.88 49.4 µM 1.73E-5 6 5.21E-5 0.24
10 SGTC_734 2023-0417 3.34 80.0 µM 1.84E-4 ergosterol biosynthesis 19 4.14E-4 0.14
11 SGTC_349 k015-0014 3.34 24.0 µM 1.87E-4 13 4.20E-4 0.00
12 SGTC_1455 4262-0120 3.33 131.0 µM 1.98E-4 plasma membrane duress 10 4.42E-4 0.02
13 SGTC_297 0986-0032 3.23 24.0 µM 2.93E-4 60S ribosome export 9 6.24E-4 0.13
14 SGTC_1935 st074532 3.23 41.6 µM 2.96E-4 14 6.29E-4 0.00
15 SGTC_1894 3',6'-dihydroxyflavone 3.03 78.7 µM 6.20E-4 17 0.00121 0.03
16 SGTC_2107 5363541 3.01 170.2 µM 6.71E-4 19 0.00129 0.07
17 SGTC_2506 ethyl hematommate 2.97 54.2 µM 8.01E-4 RPP1 & pyrimidine depletion 14 0.00151 0.10
18 SGTC_1203 3992-3522 2.85 103.0 µM 0.00122 26 0.00219 0.02
19 SGTC_871 0574-0004 2.85 149.0 µM 0.00123 42 0.00220 0.06
20 SGTC_3340 9146634 2.79 11.1 µM 0.00150 14 0.00262 0.24

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.169 7.86E-23 YLR327C TMA10 hom Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress
0.153 5.60E-19 YGL112C TAF6 het Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
0.149 4.17E-18 YKL216W URA1 hom Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
0.133 9.41E-15 YPL028W ERG10 het Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
0.115 2.53E-11 YOR109W INP53 hom Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains
0.114 3.07E-11 YKL088W CAB3 het Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC
0.111 1.38E-10 YLR323C CWC24 het Spliceosome assembly factor, essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; has similarity to S. pombe Cwf24p
0.109 2.12E-10 YNL312W RFA2 het Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress
0.108 4.16E-10 YJL203W PRP21 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly
0.107 5.37E-10 YOR087W YVC1 hom Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock
0.104 1.43E-9 YFL009W CDC4 het F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p
0.101 4.75E-9 YMR047C NUP116 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup159p)
0.100 6.78E-9 YNL268W LYP1 hom Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
0.097 2.06E-8 YGL007C-A_p YGL007C-A_p hom Putative protein of unknown function, identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; deletion exhibits slow-growth phenotype; computationally predicted to have a role in cell budding
0.096 2.19E-8 YIL144W TID3 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering