YDR535C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene.

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR535C / YDR535C

Click on Significant Values for Screen Details ID:SGTC_355|Compound:1311-2252|FD-Score:-3.16|P-value:8.93E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:4.09|P-value:5.36E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:3.66|P-value:2.70E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:4.36|P-value:1.79E-5 ID:SGTC_747|Compound:3448-8087|FD-Score:4.30|P-value:2.29E-5 ID:SGTC_845|Compound:0330-0138|FD-Score:4.75|P-value:3.25E-6 ID:SGTC_866|Compound:0495-0101|FD-Score:7.60|P-value:1.85E-13 ID:SGTC_870|Compound:0573-2213|FD-Score:5.02|P-value:9.13E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:4.17|P-value:3.86E-5 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.36|P-value:7.69E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:4.21|P-value:3.26E-5 ID:SGTC_1078|Compound:idebenone|FD-Score:3.91|P-value:1.08E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.37|P-value:7.52E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.07|P-value:5.88E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:-4.01|P-value:3.98E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.36|P-value:7.75E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:4.94|P-value:1.33E-6 ID:SGTC_1358|Compound:1509-0022|FD-Score:8.55|P-value:1.43E-16 ID:SGTC_1363|Compound:1636-0063|FD-Score:4.22|P-value:3.18E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.41|P-value:6.44E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.91|P-value:1.07E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.48|P-value:5.06E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.80|P-value:1.64E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:4.22|P-value:3.14E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.34|P-value:8.17E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.34|P-value:8.17E-4 ID:SGTC_1667|Compound:st014849|FD-Score:3.41|P-value:6.42E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.85|P-value:1.38E-4 ID:SGTC_1821|Compound:st053465|FD-Score:3.60|P-value:3.41E-4 ID:SGTC_1983|Compound:st071813|FD-Score:4.09|P-value:5.38E-5 ID:SGTC_2017|Compound:5132927|FD-Score:3.46|P-value:5.50E-4 ID:SGTC_2067|Compound:5224629|FD-Score:7.35|P-value:1.11E-12 ID:SGTC_2138|Compound:5575593|FD-Score:3.28|P-value:9.96E-4 ID:SGTC_2174|Compound:5790901|FD-Score:7.16|P-value:3.98E-12 ID:SGTC_2177|Compound:5811945|FD-Score:3.39|P-value:6.86E-4 ID:SGTC_2264|Compound:7948757|FD-Score:3.79|P-value:1.67E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.33|P-value:8.36E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.81|P-value:1.56E-4 ID:SGTC_2327|Compound:6189656|FD-Score:4.68|P-value:4.44E-6 ID:SGTC_2339|Compound:9000433|FD-Score:4.27|P-value:2.63E-5 ID:SGTC_2340|Compound:7987427|FD-Score:3.36|P-value:7.59E-4 ID:SGTC_2453|Compound:5731132|FD-Score:5.54|P-value:6.68E-8 ID:SGTC_2464|Compound:5717415|FD-Score:3.82|P-value:1.55E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.46|P-value:5.42E-4 ID:SGTC_2484|Compound:5809818|FD-Score:3.65|P-value:2.78E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:5.52|P-value:7.64E-8 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.34|P-value:8.24E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.17|P-value:8.42E-4 ID:SGTC_2646|Compound:retinol|FD-Score:4.30|P-value:2.33E-5 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-3.15|P-value:9.05E-4 ID:SGTC_2821|Compound:7996764|FD-Score:5.57|P-value:5.75E-8 ID:SGTC_2836|Compound:9010338|FD-Score:3.86|P-value:1.32E-4 ID:SGTC_2871|Compound:9038510|FD-Score:5.52|P-value:7.54E-8 ID:SGTC_2906|Compound:7926292|FD-Score:5.60|P-value:5.00E-8 ID:SGTC_2926|Compound:9010726|FD-Score:3.66|P-value:2.68E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.47|P-value:5.34E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.38|P-value:7.17E-4 ID:SGTC_3104|Compound:9120930|FD-Score:5.70|P-value:2.93E-8 ID:SGTC_3107|Compound:9121808|FD-Score:-4.17|P-value:2.06E-5 ID:SGTC_3280|Compound:9140961|FD-Score:3.71|P-value:2.29E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.16|P-value:8.93E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:4.09|P-value:5.36E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:3.66|P-value:2.70E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:4.36|P-value:1.79E-5 ID:SGTC_747|Compound:3448-8087|FD-Score:4.30|P-value:2.29E-5 ID:SGTC_845|Compound:0330-0138|FD-Score:4.75|P-value:3.25E-6 ID:SGTC_866|Compound:0495-0101|FD-Score:7.60|P-value:1.85E-13 ID:SGTC_870|Compound:0573-2213|FD-Score:5.02|P-value:9.13E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:4.17|P-value:3.86E-5 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.36|P-value:7.69E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:4.21|P-value:3.26E-5 ID:SGTC_1078|Compound:idebenone|FD-Score:3.91|P-value:1.08E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.37|P-value:7.52E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.07|P-value:5.88E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:-4.01|P-value:3.98E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.36|P-value:7.75E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:4.94|P-value:1.33E-6 ID:SGTC_1358|Compound:1509-0022|FD-Score:8.55|P-value:1.43E-16 ID:SGTC_1363|Compound:1636-0063|FD-Score:4.22|P-value:3.18E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.41|P-value:6.44E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.91|P-value:1.07E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.48|P-value:5.06E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.80|P-value:1.64E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:4.22|P-value:3.14E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.34|P-value:8.17E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.34|P-value:8.17E-4 ID:SGTC_1667|Compound:st014849|FD-Score:3.41|P-value:6.42E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.85|P-value:1.38E-4 ID:SGTC_1821|Compound:st053465|FD-Score:3.60|P-value:3.41E-4 ID:SGTC_1983|Compound:st071813|FD-Score:4.09|P-value:5.38E-5 ID:SGTC_2017|Compound:5132927|FD-Score:3.46|P-value:5.50E-4 ID:SGTC_2067|Compound:5224629|FD-Score:7.35|P-value:1.11E-12 ID:SGTC_2138|Compound:5575593|FD-Score:3.28|P-value:9.96E-4 ID:SGTC_2174|Compound:5790901|FD-Score:7.16|P-value:3.98E-12 ID:SGTC_2177|Compound:5811945|FD-Score:3.39|P-value:6.86E-4 ID:SGTC_2264|Compound:7948757|FD-Score:3.79|P-value:1.67E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.33|P-value:8.36E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.81|P-value:1.56E-4 ID:SGTC_2327|Compound:6189656|FD-Score:4.68|P-value:4.44E-6 ID:SGTC_2339|Compound:9000433|FD-Score:4.27|P-value:2.63E-5 ID:SGTC_2340|Compound:7987427|FD-Score:3.36|P-value:7.59E-4 ID:SGTC_2453|Compound:5731132|FD-Score:5.54|P-value:6.68E-8 ID:SGTC_2464|Compound:5717415|FD-Score:3.82|P-value:1.55E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.46|P-value:5.42E-4 ID:SGTC_2484|Compound:5809818|FD-Score:3.65|P-value:2.78E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:5.52|P-value:7.64E-8 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.34|P-value:8.24E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.17|P-value:8.42E-4 ID:SGTC_2646|Compound:retinol|FD-Score:4.30|P-value:2.33E-5 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-3.15|P-value:9.05E-4 ID:SGTC_2821|Compound:7996764|FD-Score:5.57|P-value:5.75E-8 ID:SGTC_2836|Compound:9010338|FD-Score:3.86|P-value:1.32E-4 ID:SGTC_2871|Compound:9038510|FD-Score:5.52|P-value:7.54E-8 ID:SGTC_2906|Compound:7926292|FD-Score:5.60|P-value:5.00E-8 ID:SGTC_2926|Compound:9010726|FD-Score:3.66|P-value:2.68E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.47|P-value:5.34E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.38|P-value:7.17E-4 ID:SGTC_3104|Compound:9120930|FD-Score:5.70|P-value:2.93E-8 ID:SGTC_3107|Compound:9121808|FD-Score:-4.17|P-value:2.06E-5 ID:SGTC_3280|Compound:9140961|FD-Score:3.71|P-value:2.29E-4

Top fitness defect scores for YDR535C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1358 1509-0022 8.55 2.5 µM 1.43E-16 2 6.17E-18
2 SGTC_866 0495-0101 7.60 262.0 µM 1.85E-13 60S ribosome export 2 1.43E-14
3 SGTC_2067 5224629 7.35 34.1 µM 1.11E-12 1 9.96E-14
4 SGTC_2174 5790901 7.16 200.0 µM 3.98E-12 tubulin folding & SWR complex 14 3.96E-13
5 SGTC_3104 9120930 5.70 49.5 µM 2.93E-8 1 6.13E-9
6 SGTC_2906 7926292 5.60 26.4 µM 5.00E-8 6 1.10E-8
7 SGTC_2821 7996764 5.57 71.4 µM 5.75E-8 11 1.27E-8
8 SGTC_2453 5731132 5.54 22.2 µM 6.68E-8 4 1.50E-8
9 SGTC_2871 9038510 5.52 13.0 µM 7.54E-8 3 1.71E-8
10 SGTC_2532 xanthone 5.52 78.9 µM 7.64E-8 11 1.74E-8
11 SGTC_870 0573-2213 5.02 57.6 µM 9.13E-7 ERG2 6 2.56E-7
12 SGTC_1354 1498-1681 4.94 81.0 µM 1.33E-6 5 3.85E-7
13 SGTC_845 0330-0138 4.75 4.5 µM 3.25E-6 8 1.02E-6
14 SGTC_2327 6189656 4.68 200.0 µM 4.44E-6 12 1.43E-6
15 SGTC_734 2023-0417 4.36 80.0 µM 1.79E-5 ergosterol biosynthesis 8 6.52E-6
16 SGTC_747 3448-8087 4.30 38.7 µM 2.29E-5 20 8.50E-6
17 SGTC_2646 retinol 4.30 96.8 µM 2.33E-5 4 8.68E-6
18 SGTC_2339 9000433 4.27 200.0 µM 2.63E-5 29 9.90E-6
19 SGTC_1592 4',5'-dihydroxyflavone 4.22 8.8 µM 3.14E-5 60S ribosome export 8 1.20E-5
20 SGTC_1363 1636-0063 4.22 10.4 µM 3.18E-5 Golgi 19 1.22E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.082 2.19E-6 YBR203W COS111 hom Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.076 1.17E-5 YJL061W NUP82 het Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup159p, and Nup116p)
0.075 1.39E-5 YDL047W SIT4 hom Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
0.072 2.63E-5 YDR387C_p YDR387C_p hom Putative transporter, member of the sugar porter family; YDR387C is not an essential gene
0.071 3.66E-5 YIL131C FKH1 hom Forkhead family transcription factor; has a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; binds to the recombination enhancer near HML, and regulates donor preference during mating-type switching by positioning HML near the MAT locus through FHA-domain mediated interactions with proteins near the DSB; FKH1 has a paralog, FKH2, that arose from the whole genome duplication
0.070 5.21E-5 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.068 8.78E-5 YNL132W KRE33 het Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
0.066 1.27E-4 YGL262W_p YGL262W_p hom Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene
0.065 1.58E-4 YLR431C ATG23 hom Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p
0.063 2.59E-4 YFR022W ROG3 hom Protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; proposed to regulate the endocytosis of plasma membrane proteins; ROG3 has a paralog, ROD1, that arose from the whole genome duplication
0.062 2.99E-4 YOR264W DSE3 hom Daughter cell-specific protein, may help establish daughter fate; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.062 3.37E-4 YLR152C_p YLR152C_p hom Putative protein of unknown function; YLR152C is not an essential gene
0.060 4.80E-4 YKL066W_d YKL066W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
0.060 4.85E-4 YDR490C PKH1 hom Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p
0.060 5.51E-4 YOR310C NOP58 het Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA