YDR536W / STL1

Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR536W / STL1

Click on Significant Values for Screen Details ID:SGTC_216|Compound:k038-0035|FD-Score:-3.68|P-value:3.35E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:5.49|P-value:9.26E-8 ID:SGTC_276|Compound:colchicine|FD-Score:5.84|P-value:1.46E-8 ID:SGTC_396|Compound:dithiazanine|FD-Score:-4.30|P-value:3.40E-5 ID:SGTC_442|Compound:cape|FD-Score:-4.57|P-value:1.13E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.76|P-value:2.53E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:4.52|P-value:8.53E-6 ID:SGTC_588|Compound:3970-1144|FD-Score:6.20|P-value:2.05E-9 ID:SGTC_620|Compound:0109-0052|FD-Score:3.62|P-value:2.71E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:4.57|P-value:6.65E-6 ID:SGTC_933|Compound:2914-0560|FD-Score:3.48|P-value:4.38E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.28|P-value:8.38E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.44|P-value:1.20E-5 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.37|P-value:6.26E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.66|P-value:2.39E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.39|P-value:5.94E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:5.22|P-value:3.57E-7 ID:SGTC_1674|Compound:st016616|FD-Score:5.21|P-value:3.59E-7 ID:SGTC_1802|Compound:st050112|FD-Score:3.35|P-value:6.74E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.40|P-value:5.77E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.38|P-value:6.17E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.35|P-value:1.71E-5 ID:SGTC_2121|Compound:5257820|FD-Score:-3.71|P-value:3.05E-4 ID:SGTC_2171|Compound:5739187|FD-Score:3.32|P-value:7.48E-4 ID:SGTC_2220|Compound:6782180|FD-Score:3.42|P-value:5.32E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.24|P-value:9.68E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.86|P-value:1.13E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.30|P-value:8.00E-4 ID:SGTC_2369|Compound:9071472|FD-Score:3.97|P-value:7.48E-5 ID:SGTC_2385|Compound:9074692|FD-Score:3.82|P-value:1.31E-4 ID:SGTC_2390|Compound:9097792|FD-Score:5.79|P-value:1.97E-8 ID:SGTC_2412|Compound:st077135|FD-Score:3.42|P-value:5.35E-4 ID:SGTC_2456|Compound:5770359|FD-Score:5.18|P-value:4.29E-7 ID:SGTC_2600|Compound:tangeritin|FD-Score:9.38|P-value:3.85E-19 ID:SGTC_2643|Compound:anethole|FD-Score:-4.19|P-value:5.35E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.34|P-value:1.77E-5 ID:SGTC_2821|Compound:7996764|FD-Score:5.50|P-value:8.78E-8 ID:SGTC_2823|Compound:7987624|FD-Score:5.84|P-value:1.49E-8 ID:SGTC_2835|Compound:9006588|FD-Score:8.06|P-value:1.21E-14 ID:SGTC_3142|Compound:9086498|FD-Score:3.62|P-value:2.74E-4 ID:SGTC_3198|Compound:9112019|FD-Score:3.29|P-value:8.26E-4 ID:SGTC_3237|Compound:9133362|FD-Score:-3.52|P-value:5.81E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:-3.68|P-value:3.35E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:5.49|P-value:9.26E-8 ID:SGTC_276|Compound:colchicine|FD-Score:5.84|P-value:1.46E-8 ID:SGTC_396|Compound:dithiazanine|FD-Score:-4.30|P-value:3.40E-5 ID:SGTC_442|Compound:cape|FD-Score:-4.57|P-value:1.13E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.76|P-value:2.53E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:4.52|P-value:8.53E-6 ID:SGTC_588|Compound:3970-1144|FD-Score:6.20|P-value:2.05E-9 ID:SGTC_620|Compound:0109-0052|FD-Score:3.62|P-value:2.71E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:4.57|P-value:6.65E-6 ID:SGTC_933|Compound:2914-0560|FD-Score:3.48|P-value:4.38E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.28|P-value:8.38E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.44|P-value:1.20E-5 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.37|P-value:6.26E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.66|P-value:2.39E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.39|P-value:5.94E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:5.22|P-value:3.57E-7 ID:SGTC_1674|Compound:st016616|FD-Score:5.21|P-value:3.59E-7 ID:SGTC_1802|Compound:st050112|FD-Score:3.35|P-value:6.74E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.40|P-value:5.77E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.38|P-value:6.17E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.35|P-value:1.71E-5 ID:SGTC_2121|Compound:5257820|FD-Score:-3.71|P-value:3.05E-4 ID:SGTC_2171|Compound:5739187|FD-Score:3.32|P-value:7.48E-4 ID:SGTC_2220|Compound:6782180|FD-Score:3.42|P-value:5.32E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.24|P-value:9.68E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.86|P-value:1.13E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.30|P-value:8.00E-4 ID:SGTC_2369|Compound:9071472|FD-Score:3.97|P-value:7.48E-5 ID:SGTC_2385|Compound:9074692|FD-Score:3.82|P-value:1.31E-4 ID:SGTC_2390|Compound:9097792|FD-Score:5.79|P-value:1.97E-8 ID:SGTC_2412|Compound:st077135|FD-Score:3.42|P-value:5.35E-4 ID:SGTC_2456|Compound:5770359|FD-Score:5.18|P-value:4.29E-7 ID:SGTC_2600|Compound:tangeritin|FD-Score:9.38|P-value:3.85E-19 ID:SGTC_2643|Compound:anethole|FD-Score:-4.19|P-value:5.35E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.34|P-value:1.77E-5 ID:SGTC_2821|Compound:7996764|FD-Score:5.50|P-value:8.78E-8 ID:SGTC_2823|Compound:7987624|FD-Score:5.84|P-value:1.49E-8 ID:SGTC_2835|Compound:9006588|FD-Score:8.06|P-value:1.21E-14 ID:SGTC_3142|Compound:9086498|FD-Score:3.62|P-value:2.74E-4 ID:SGTC_3198|Compound:9112019|FD-Score:3.29|P-value:8.26E-4 ID:SGTC_3237|Compound:9133362|FD-Score:-3.52|P-value:5.81E-4

Top fitness defect scores for YDR536W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2600 tangeritin 9.38 88.0 µM 3.85E-19 2 3.44E-21
2 SGTC_2835 9006588 8.06 71.4 µM 1.21E-14 3 3.92E-16
3 SGTC_588 3970-1144 6.20 52.9 µM 2.05E-9 4 2.85E-10
4 SGTC_276 colchicine 5.84 750.0 µM 1.46E-8 2 2.57E-9
5 SGTC_2823 7987624 5.84 58.4 µM 1.49E-8 4 2.62E-9
6 SGTC_2390 9097792 5.79 176.6 µM 1.97E-8 3 3.58E-9
7 SGTC_2821 7996764 5.50 71.4 µM 8.78E-8 12 1.91E-8
8 SGTC_274 sirtinol 5.49 40.1 µM 9.26E-8 7 2.02E-8
9 SGTC_1564 D-Arginine 5.22 115.0 µM 3.57E-7 13 9.15E-8
10 SGTC_1674 st016616 5.21 23.6 µM 3.59E-7 7 9.19E-8
11 SGTC_2456 5770359 5.18 74.5 µM 4.29E-7 4 1.12E-7
12 SGTC_650 1328-0195 4.57 38.0 µM 6.65E-6 8 2.38E-6
13 SGTC_584 0986-0246 4.52 15.4 µM 8.53E-6 heme requiring 4 3.15E-6
14 SGTC_1370 2001-0092 4.44 44.6 µM 1.20E-5 20 4.59E-6
15 SGTC_2019 4016004 4.35 108.0 µM 1.71E-5 17 6.82E-6
16 SGTC_2765 myclobutanil 4.34 7.7 µM 1.77E-5 azole & statin 40 7.08E-6
17 SGTC_2369 9071472 3.97 200.0 µM 7.48E-5 15 3.52E-5
18 SGTC_2296 7971656 3.86 126.5 µM 1.13E-4 45 5.59E-5
19 SGTC_2385 9074692 3.82 200.0 µM 1.31E-4 47 6.57E-5
20 SGTC_1455 4262-0120 3.66 131.0 µM 2.39E-4 plasma membrane duress 28 1.28E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 8.77E-12 YLR140W_d YLR140W_d het Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I
0.115 2.15E-11 YGR103W NOP7 het Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G0 and the initiation of cell proliferation
0.112 7.92E-11 YOL036W_p YOL036W_p hom Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication
0.106 8.68E-10 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.103 2.19E-9 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.102 3.83E-9 YDR056C_p YDR056C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein
0.098 1.17E-8 YKL026C GPX1 hom Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
0.096 2.95E-8 YBR278W DPB3 hom Third-largest subunit of DNA polymerase II (DNA polymerase epsilon); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; mRNA abundance peaks at the G1/S boundary of the cell cycle; DPB3 has a paralog, DLS1, that arose from the whole genome duplication
0.090 1.83E-7 YER175C TMT1 hom Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle
0.089 2.16E-7 YLR141W RRN5 het Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p
0.088 3.21E-7 YML057W CMP2 hom Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
0.087 4.00E-7 YBR291C CTP1 hom Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family
0.085 7.19E-7 YOR051C ETT1 hom Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough
0.083 1.55E-6 YLR104W_p LCL2_p hom Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD)
0.081 2.34E-6 YLR115W CFT2 het Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein.