YDR537C_d

Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR537C / YDR537C

Click on Significant Values for Screen Details ID:SGTC_29|Compound:0299-0004|FD-Score:3.00|P-value:9.81E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:18.40|P-value:2.36E-82 ID:SGTC_58|Compound:0957-0393|FD-Score:28.10|P-value:8.10E-189 ID:SGTC_64|Compound:000l-0018|FD-Score:15.50|P-value:5.21E-59 ID:SGTC_67|Compound:0335-0847|FD-Score:4.62|P-value:8.53E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:15.40|P-value:6.77E-58 ID:SGTC_103|Compound:0844-0104|FD-Score:11.20|P-value:1.57E-31 ID:SGTC_107|Compound:0358-0022|FD-Score:9.85|P-value:7.20E-25 ID:SGTC_137|Compound:0438-0332|FD-Score:10.00|P-value:1.32E-25 ID:SGTC_138|Compound:0850-0259|FD-Score:3.86|P-value:3.31E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:9.08|P-value:1.96E-21 ID:SGTC_158|Compound:k038-0087|FD-Score:14.50|P-value:1.70E-51 ID:SGTC_163|Compound:1327-0036|FD-Score:6.93|P-value:3.24E-13 ID:SGTC_165|Compound:k038-0023|FD-Score:4.18|P-value:7.64E-6 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.15|P-value:4.68E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:3.42|P-value:2.06E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.30|P-value:3.30E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:6.13|P-value:1.02E-10 ID:SGTC_352|Compound:k048-0007|FD-Score:4.51|P-value:1.48E-6 ID:SGTC_504|Compound:lovastatin|FD-Score:3.03|P-value:8.90E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:3.23|P-value:4.24E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.36|P-value:2.58E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:19.10|P-value:1.40E-88 ID:SGTC_806|Compound:3966-4455|FD-Score:3.77|P-value:4.79E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:3.42|P-value:2.01E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.73|P-value:5.61E-5 ID:SGTC_871|Compound:0574-0004|FD-Score:6.14|P-value:9.52E-11 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.35|P-value:2.72E-4 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.06|P-value:8.02E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.80|P-value:2.77E-16 ID:SGTC_1167|Compound:k781-0610|FD-Score:-2.99|P-value:8.35E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:5.43|P-value:8.98E-9 ID:SGTC_1294|Compound:1000-1494|FD-Score:21.30|P-value:2.68E-109 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.29|P-value:3.32E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.81|P-value:4.11E-5 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.72|P-value:5.94E-5 ID:SGTC_1750|Compound:st081859|FD-Score:8.58|P-value:2.46E-19 ID:SGTC_1784|Compound:st039334|FD-Score:3.97|P-value:2.02E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.21|P-value:4.62E-4 ID:SGTC_2051|Compound:5263410|FD-Score:5.74|P-value:1.34E-9 ID:SGTC_2052|Compound:5265182|FD-Score:-3.78|P-value:3.61E-5 ID:SGTC_2105|Compound:5350118|FD-Score:4.75|P-value:4.43E-7 ID:SGTC_2110|Compound:5483698|FD-Score:3.03|P-value:8.86E-4 ID:SGTC_2111|Compound:5486399|FD-Score:4.96|P-value:1.36E-7 ID:SGTC_2259|Compound:7964009|FD-Score:3.37|P-value:2.50E-4 ID:SGTC_2429|Compound:5902844|FD-Score:4.12|P-value:1.02E-5 ID:SGTC_2430|Compound:5571206|FD-Score:4.25|P-value:5.33E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.27|P-value:4.82E-6 ID:SGTC_2698|Compound:st077697|FD-Score:3.46|P-value:1.71E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.42|P-value:2.07E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-4.61|P-value:6.74E-7 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.04|P-value:8.39E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.07|P-value:7.52E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.36|P-value:2.60E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-5.32|P-value:1.31E-8 ID:SGTC_2798|Compound:7813637|FD-Score:5.53|P-value:4.95E-9 ID:SGTC_2799|Compound:7812892|FD-Score:-3.63|P-value:6.87E-5 ID:SGTC_2861|Compound:9024595|FD-Score:-3.53|P-value:1.05E-4 ID:SGTC_2932|Compound:9016711|FD-Score:-3.77|P-value:3.79E-5 ID:SGTC_2939|Compound:9044578|FD-Score:3.33|P-value:2.92E-4 ID:SGTC_2976|Compound:9009005|FD-Score:-2.99|P-value:8.52E-4 ID:SGTC_2980|Compound:9014342|FD-Score:-3.22|P-value:3.59E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:8.81|P-value:2.93E-20 ID:SGTC_3060|Compound:1327-0027|FD-Score:7.19|P-value:4.40E-14 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.97|P-value:1.32E-7 ID:SGTC_3089|Compound:9117425|FD-Score:3.41|P-value:2.11E-4 ID:SGTC_3333|Compound:9141820|FD-Score:3.12|P-value:6.39E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:3.00|P-value:9.81E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:18.40|P-value:2.36E-82 ID:SGTC_58|Compound:0957-0393|FD-Score:28.10|P-value:8.10E-189 ID:SGTC_64|Compound:000l-0018|FD-Score:15.50|P-value:5.21E-59 ID:SGTC_67|Compound:0335-0847|FD-Score:4.62|P-value:8.53E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:15.40|P-value:6.77E-58 ID:SGTC_103|Compound:0844-0104|FD-Score:11.20|P-value:1.57E-31 ID:SGTC_107|Compound:0358-0022|FD-Score:9.85|P-value:7.20E-25 ID:SGTC_137|Compound:0438-0332|FD-Score:10.00|P-value:1.32E-25 ID:SGTC_138|Compound:0850-0259|FD-Score:3.86|P-value:3.31E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:9.08|P-value:1.96E-21 ID:SGTC_158|Compound:k038-0087|FD-Score:14.50|P-value:1.70E-51 ID:SGTC_163|Compound:1327-0036|FD-Score:6.93|P-value:3.24E-13 ID:SGTC_165|Compound:k038-0023|FD-Score:4.18|P-value:7.64E-6 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.15|P-value:4.68E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:3.42|P-value:2.06E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.30|P-value:3.30E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:6.13|P-value:1.02E-10 ID:SGTC_352|Compound:k048-0007|FD-Score:4.51|P-value:1.48E-6 ID:SGTC_504|Compound:lovastatin|FD-Score:3.03|P-value:8.90E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:3.23|P-value:4.24E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.36|P-value:2.58E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:19.10|P-value:1.40E-88 ID:SGTC_806|Compound:3966-4455|FD-Score:3.77|P-value:4.79E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:3.42|P-value:2.01E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.73|P-value:5.61E-5 ID:SGTC_871|Compound:0574-0004|FD-Score:6.14|P-value:9.52E-11 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.35|P-value:2.72E-4 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.06|P-value:8.02E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.80|P-value:2.77E-16 ID:SGTC_1167|Compound:k781-0610|FD-Score:-2.99|P-value:8.35E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:5.43|P-value:8.98E-9 ID:SGTC_1294|Compound:1000-1494|FD-Score:21.30|P-value:2.68E-109 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.29|P-value:3.32E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.81|P-value:4.11E-5 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.72|P-value:5.94E-5 ID:SGTC_1750|Compound:st081859|FD-Score:8.58|P-value:2.46E-19 ID:SGTC_1784|Compound:st039334|FD-Score:3.97|P-value:2.02E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.21|P-value:4.62E-4 ID:SGTC_2051|Compound:5263410|FD-Score:5.74|P-value:1.34E-9 ID:SGTC_2052|Compound:5265182|FD-Score:-3.78|P-value:3.61E-5 ID:SGTC_2105|Compound:5350118|FD-Score:4.75|P-value:4.43E-7 ID:SGTC_2110|Compound:5483698|FD-Score:3.03|P-value:8.86E-4 ID:SGTC_2111|Compound:5486399|FD-Score:4.96|P-value:1.36E-7 ID:SGTC_2259|Compound:7964009|FD-Score:3.37|P-value:2.50E-4 ID:SGTC_2429|Compound:5902844|FD-Score:4.12|P-value:1.02E-5 ID:SGTC_2430|Compound:5571206|FD-Score:4.25|P-value:5.33E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.27|P-value:4.82E-6 ID:SGTC_2698|Compound:st077697|FD-Score:3.46|P-value:1.71E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.42|P-value:2.07E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-4.61|P-value:6.74E-7 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.04|P-value:8.39E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.07|P-value:7.52E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.36|P-value:2.60E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-5.32|P-value:1.31E-8 ID:SGTC_2798|Compound:7813637|FD-Score:5.53|P-value:4.95E-9 ID:SGTC_2799|Compound:7812892|FD-Score:-3.63|P-value:6.87E-5 ID:SGTC_2861|Compound:9024595|FD-Score:-3.53|P-value:1.05E-4 ID:SGTC_2932|Compound:9016711|FD-Score:-3.77|P-value:3.79E-5 ID:SGTC_2939|Compound:9044578|FD-Score:3.33|P-value:2.92E-4 ID:SGTC_2976|Compound:9009005|FD-Score:-2.99|P-value:8.52E-4 ID:SGTC_2980|Compound:9014342|FD-Score:-3.22|P-value:3.59E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:8.81|P-value:2.93E-20 ID:SGTC_3060|Compound:1327-0027|FD-Score:7.19|P-value:4.40E-14 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.97|P-value:1.32E-7 ID:SGTC_3089|Compound:9117425|FD-Score:3.41|P-value:2.11E-4 ID:SGTC_3333|Compound:9141820|FD-Score:3.12|P-value:6.39E-4

Top fitness defect scores for YDR537C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 28.10 9.0 µM 8.10E-189 cell wall 3 1.50E-174
2 SGTC_1294 1000-1494 21.30 117.0 µM 2.68E-109 4 3.64E-101
3 SGTC_794 k038-0031 19.10 316.0 µM 1.40E-88 ubiquinone biosynthesis & proteasome 1 4.86E-82
4 SGTC_36 0335-0881 18.40 14.2 µM 2.36E-82 ubiquinone biosynthesis & proteasome 6 2.72E-76
5 SGTC_64 000l-0018 15.50 272.1 µM 5.21E-59 ubiquinone biosynthesis & proteasome 19 9.81E-55
6 SGTC_86 0417-1630 15.40 471.9 µM 6.77E-58 ubiquinone biosynthesis & proteasome 17 1.05E-53
7 SGTC_158 k038-0087 14.50 26.4 µM 1.70E-51 ubiquinone biosynthesis & proteasome 13 8.57E-48
8 SGTC_103 0844-0104 11.20 51.8 µM 1.57E-31 ERAD & cell cycle 26 2.40E-29
9 SGTC_137 0438-0332 10.00 85.4 µM 1.32E-25 ubiquinone biosynthesis & proteasome 23 7.23E-24
10 SGTC_107 0358-0022 9.85 2.7 µM 7.20E-25 SWF1 & branched chain AA biosynthesis 6 3.47E-23
11 SGTC_142 0335-0849 9.08 62.7 µM 1.96E-21 ubiquinone biosynthesis & proteasome 36 5.22E-20
12 SGTC_3059 1327-0034 8.81 3.0 µM 2.93E-20 15 6.38E-19
13 SGTC_1750 st081859 8.58 2.4 µM 2.46E-19 endomembrane recycling 56 4.57E-18
14 SGTC_1161 k007-0610 7.80 110.0 µM 2.77E-16 ERAD & cell cycle 25 3.04E-15
15 SGTC_3060 1327-0027 7.19 12.5 µM 4.40E-14 17 3.33E-13
16 SGTC_163 1327-0036 6.93 7.5 µM 3.24E-13 30 2.12E-12
17 SGTC_871 0574-0004 6.14 149.0 µM 9.52E-11 12 4.11E-10
18 SGTC_340 k038-0059 6.13 454.0 µM 1.02E-10 ubiquinone biosynthesis & proteasome 19 4.39E-10
19 SGTC_2051 5263410 5.74 176.0 µM 1.34E-9 5 4.78E-9
20 SGTC_2798 7813637 5.53 45.5 µM 4.95E-9 6 1.60E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.749 0 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.698 0 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.690 0 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.688 0 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.676 0 YJR129C_p YJR129C_p hom Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.672 0 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.655 0 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.616 0 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.451 9.32E-168 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.437 8.55E-157 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.433 1.10E-153 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.431 4.81E-152 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.431 2.08E-151 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.423 7.17E-146 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.423 1.79E-145 YPR107C YTH1 het Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation