YDR539W / FDC1

Putative phenylacrylic acid decarboxylase; essential for the decarboxylation of aromatic carboxylic acids to the corresponding vinyl derivatives; homolog of E. coli UbiD; GFP-fusion protein localizes to the cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR539W / FDC1

Click on Significant Values for Screen Details ID:SGTC_249|Compound:wiskostatin|FD-Score:3.57|P-value:1.37E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.60|P-value:1.21E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:4.09|P-value:1.54E-5 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.81|P-value:4.66E-7 ID:SGTC_489|Compound:paxilline|FD-Score:3.17|P-value:6.05E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:6.06|P-value:3.46E-10 ID:SGTC_578|Compound:3460-0051|FD-Score:3.45|P-value:2.15E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:4.07|P-value:1.64E-5 ID:SGTC_588|Compound:3970-1144|FD-Score:4.33|P-value:5.06E-6 ID:SGTC_598|Compound:3937-0236|FD-Score:3.80|P-value:5.26E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:4.76|P-value:6.15E-7 ID:SGTC_664|Compound:1222-0054|FD-Score:4.25|P-value:7.49E-6 ID:SGTC_684|Compound:1140-0066|FD-Score:3.30|P-value:3.83E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.08|P-value:8.32E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.37|P-value:2.96E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:4.51|P-value:2.10E-6 ID:SGTC_910|Compound:3454-3003|FD-Score:3.24|P-value:4.74E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.32|P-value:3.57E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.04|P-value:9.47E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.18|P-value:5.95E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:4.83|P-value:4.40E-7 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.07|P-value:8.61E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:4.76|P-value:6.26E-7 ID:SGTC_1640|Compound:st009078|FD-Score:3.12|P-value:7.33E-4 ID:SGTC_1908|Compound:st060353|FD-Score:4.09|P-value:1.56E-5 ID:SGTC_1910|Compound:st062352|FD-Score:3.04|P-value:9.45E-4 ID:SGTC_2033|Compound:5192550|FD-Score:4.31|P-value:5.48E-6 ID:SGTC_2063|Compound:5246145|FD-Score:3.64|P-value:1.03E-4 ID:SGTC_2141|Compound:5621638|FD-Score:3.11|P-value:7.48E-4 ID:SGTC_2317|Compound:5986382|FD-Score:-3.78|P-value:6.39E-5 ID:SGTC_2327|Compound:6189656|FD-Score:4.98|P-value:1.91E-7 ID:SGTC_2329|Compound:6138490|FD-Score:3.19|P-value:5.69E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.95|P-value:2.81E-5 ID:SGTC_2430|Compound:5571206|FD-Score:3.05|P-value:9.40E-4 ID:SGTC_2481|Compound:5478948|FD-Score:-4.34|P-value:5.57E-6 ID:SGTC_2483|Compound:5729050|FD-Score:3.18|P-value:5.81E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.08|P-value:8.39E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.07|P-value:8.61E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.19|P-value:6.12E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-3.18|P-value:6.53E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:4.13|P-value:1.28E-5 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.03|P-value:9.82E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.51|P-value:1.87E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.44|P-value:2.51E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.41|P-value:2.54E-4 ID:SGTC_2829|Compound:7992743|FD-Score:4.85|P-value:3.78E-7 ID:SGTC_2834|Compound:9001755|FD-Score:6.58|P-value:1.06E-11 ID:SGTC_2955|Compound:9076254|FD-Score:6.79|P-value:2.34E-12 ID:SGTC_2971|Compound:9092186|FD-Score:-5.54|P-value:9.92E-9 ID:SGTC_3177|Compound:9107506|FD-Score:6.32|P-value:6.16E-11 ID:SGTC_3306|Compound:9127676|FD-Score:3.87|P-value:3.92E-5 ID:SGTC_3321|Compound:9137793|FD-Score:3.64|P-value:1.04E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-3.08|P-value:9.24E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:3.57|P-value:1.37E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.60|P-value:1.21E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:4.09|P-value:1.54E-5 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.81|P-value:4.66E-7 ID:SGTC_489|Compound:paxilline|FD-Score:3.17|P-value:6.05E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:6.06|P-value:3.46E-10 ID:SGTC_578|Compound:3460-0051|FD-Score:3.45|P-value:2.15E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:4.07|P-value:1.64E-5 ID:SGTC_588|Compound:3970-1144|FD-Score:4.33|P-value:5.06E-6 ID:SGTC_598|Compound:3937-0236|FD-Score:3.80|P-value:5.26E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:4.76|P-value:6.15E-7 ID:SGTC_664|Compound:1222-0054|FD-Score:4.25|P-value:7.49E-6 ID:SGTC_684|Compound:1140-0066|FD-Score:3.30|P-value:3.83E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.08|P-value:8.32E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.37|P-value:2.96E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:4.51|P-value:2.10E-6 ID:SGTC_910|Compound:3454-3003|FD-Score:3.24|P-value:4.74E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.32|P-value:3.57E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.04|P-value:9.47E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.18|P-value:5.95E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:4.83|P-value:4.40E-7 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.07|P-value:8.61E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:4.76|P-value:6.26E-7 ID:SGTC_1640|Compound:st009078|FD-Score:3.12|P-value:7.33E-4 ID:SGTC_1908|Compound:st060353|FD-Score:4.09|P-value:1.56E-5 ID:SGTC_1910|Compound:st062352|FD-Score:3.04|P-value:9.45E-4 ID:SGTC_2033|Compound:5192550|FD-Score:4.31|P-value:5.48E-6 ID:SGTC_2063|Compound:5246145|FD-Score:3.64|P-value:1.03E-4 ID:SGTC_2141|Compound:5621638|FD-Score:3.11|P-value:7.48E-4 ID:SGTC_2317|Compound:5986382|FD-Score:-3.78|P-value:6.39E-5 ID:SGTC_2327|Compound:6189656|FD-Score:4.98|P-value:1.91E-7 ID:SGTC_2329|Compound:6138490|FD-Score:3.19|P-value:5.69E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.95|P-value:2.81E-5 ID:SGTC_2430|Compound:5571206|FD-Score:3.05|P-value:9.40E-4 ID:SGTC_2481|Compound:5478948|FD-Score:-4.34|P-value:5.57E-6 ID:SGTC_2483|Compound:5729050|FD-Score:3.18|P-value:5.81E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.08|P-value:8.39E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.07|P-value:8.61E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.19|P-value:6.12E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-3.18|P-value:6.53E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:4.13|P-value:1.28E-5 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.03|P-value:9.82E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.51|P-value:1.87E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.44|P-value:2.51E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.41|P-value:2.54E-4 ID:SGTC_2829|Compound:7992743|FD-Score:4.85|P-value:3.78E-7 ID:SGTC_2834|Compound:9001755|FD-Score:6.58|P-value:1.06E-11 ID:SGTC_2955|Compound:9076254|FD-Score:6.79|P-value:2.34E-12 ID:SGTC_2971|Compound:9092186|FD-Score:-5.54|P-value:9.92E-9 ID:SGTC_3177|Compound:9107506|FD-Score:6.32|P-value:6.16E-11 ID:SGTC_3306|Compound:9127676|FD-Score:3.87|P-value:3.92E-5 ID:SGTC_3321|Compound:9137793|FD-Score:3.64|P-value:1.04E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-3.08|P-value:9.24E-4

Top fitness defect scores for YDR539W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2955 9076254 6.79 12.2 µM 2.34E-12 2 5.55E-12
2 SGTC_2834 9001755 6.58 58.4 µM 1.06E-11 7 2.39E-11
3 SGTC_3177 9107506 6.32 49.5 µM 6.16E-11 ERG2 2 1.31E-10
4 SGTC_565 1418-0001 6.06 44.5 µM 3.46E-10 1 6.96E-10
5 SGTC_2327 6189656 4.98 200.0 µM 1.91E-7 8 3.12E-7
6 SGTC_2829 7992743 4.85 58.4 µM 3.78E-7 18 6.03E-7
7 SGTC_1183 1254-0324 4.83 198.0 µM 4.40E-7 8 6.99E-7
8 SGTC_436 n,n-dimethylsphingosine 4.81 3.3 µM 4.66E-7 14 7.39E-7
9 SGTC_654 1124-0271 4.76 80.9 µM 6.15E-7 9 9.66E-7
10 SGTC_1316 1272-0050 4.76 65.9 µM 6.26E-7 2 9.81E-7
11 SGTC_889 0919-1524 4.51 82.7 µM 2.10E-6 7 3.17E-6
12 SGTC_588 3970-1144 4.33 52.9 µM 5.06E-6 20 7.40E-6
13 SGTC_2033 5192550 4.31 145.0 µM 5.48E-6 8 8.00E-6
14 SGTC_664 1222-0054 4.25 14.9 µM 7.49E-6 sphingolipid biosynthesis & PDR1 31 1.08E-5
15 SGTC_2659 sanguinarine 4.13 24.2 µM 1.28E-5 22 1.82E-5
16 SGTC_435 c-PAF 4.09 6.7 µM 1.54E-5 37 2.17E-5
17 SGTC_1908 st060353 4.09 56.5 µM 1.56E-5 RPP1 & pyrimidine depletion 32 2.20E-5
18 SGTC_584 0986-0246 4.07 15.4 µM 1.64E-5 heme requiring 11 2.31E-5
19 SGTC_2379 9035213 3.95 200.0 µM 2.81E-5 21 3.88E-5
20 SGTC_3306 9127676 3.87 59.8 µM 3.92E-5 24 5.36E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.68E-9 YDR232W HEM1 het 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
0.094 5.68E-8 YJL183W MNN11 hom Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p
0.089 2.49E-7 YLR080W EMP46 hom Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
0.086 5.62E-7 YAL020C ATS1 hom Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle
0.080 3.18E-6 YLR101C_d YLR101C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W
0.080 3.65E-6 YJL146W IDS2 hom Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation
0.079 5.17E-6 YDR043C NRG1 hom Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; NRG1 has a paralog, NRG2, that arose from the whole genome duplication
0.078 6.61E-6 YJL217W REE1 hom Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle
0.077 8.06E-6 YLR164W SHH4 hom Mitochondrial inner membrane protein of unknown function; similar to Tim18p and Sdh4p; a fraction copurifies with Sdh3p, but Shh4p is neither a stoichiometric subunit of succinate dehydrogenase nor of the TIM22 translocase; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
0.077 8.55E-6 YCR020W-B HTL1 hom Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.075 1.25E-5 YPR149W NCE102 hom Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)
0.075 1.43E-5 YER176W ECM32 hom DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes
0.073 2.04E-5 YHR086W NAM8 hom RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function
0.073 2.29E-5 YJL127C-B_p YJL127C-B_p hom Putative protein of unknown function; identified based on homology to the filamentous fungus, Ashbya gossypii
0.073 2.29E-5 YDR454C GUK1 het Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins