YDR541C_p

Putative dihydrokaempferol 4-reductase

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR541C / YDR541C

Click on Significant Values for Screen Details ID:SGTC_142|Compound:0335-0849|FD-Score:3.71|P-value:1.79E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:3.55|P-value:3.14E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-4.49|P-value:9.12E-6 ID:SGTC_526|Compound:4469-0568|FD-Score:-6.88|P-value:2.35E-11 ID:SGTC_529|Compound:4076-0302|FD-Score:3.91|P-value:8.50E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:-5.66|P-value:3.15E-8 ID:SGTC_534|Compound:k292-0788|FD-Score:4.53|P-value:6.65E-6 ID:SGTC_536|Compound:3852-0578|FD-Score:5.34|P-value:1.41E-7 ID:SGTC_537|Compound:1334-0398|FD-Score:4.71|P-value:3.00E-6 ID:SGTC_595|Compound:3909-8003|FD-Score:3.28|P-value:7.91E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:-3.73|P-value:1.87E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:3.40|P-value:5.27E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.80|P-value:1.30E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:3.57|P-value:2.98E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:-4.21|P-value:2.88E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:4.67|P-value:3.49E-6 ID:SGTC_962|Compound:1254-0300|FD-Score:3.78|P-value:1.38E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.93|P-value:7.73E-5 ID:SGTC_1062|Compound:mesoridazine|FD-Score:4.20|P-value:2.63E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.48|P-value:3.98E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.16|P-value:3.17E-5 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.53|P-value:3.78E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:-3.31|P-value:8.11E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:3.22|P-value:9.49E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.37|P-value:5.89E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.38|P-value:1.27E-5 ID:SGTC_1496|Compound:4469-0713|FD-Score:-3.50|P-value:4.16E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:4.45|P-value:9.20E-6 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.57|P-value:3.34E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.77|P-value:1.42E-4 ID:SGTC_1567|Compound:st069303|FD-Score:7.33|P-value:9.77E-13 ID:SGTC_1568|Compound:digitonin|FD-Score:6.19|P-value:1.39E-9 ID:SGTC_1622|Compound:st003707|FD-Score:4.42|P-value:1.05E-5 ID:SGTC_1629|Compound:st005085|FD-Score:3.50|P-value:3.75E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.58|P-value:2.85E-4 ID:SGTC_1784|Compound:st039334|FD-Score:4.53|P-value:6.75E-6 ID:SGTC_1786|Compound:berberine|FD-Score:5.32|P-value:1.56E-7 ID:SGTC_1788|Compound:fluconazole|FD-Score:-4.41|P-value:1.29E-5 ID:SGTC_2188|Compound:6126565|FD-Score:3.31|P-value:7.18E-4 ID:SGTC_2225|Compound:6654152|FD-Score:3.91|P-value:8.35E-5 ID:SGTC_2314|Compound:7727897|FD-Score:4.60|P-value:4.91E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.35|P-value:6.18E-4 ID:SGTC_2426|Compound:5582046|FD-Score:-3.47|P-value:4.74E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.57|P-value:3.35E-4 ID:SGTC_2545|Compound:solidagenone|FD-Score:-3.89|P-value:1.02E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:-4.64|P-value:4.62E-6 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.74|P-value:2.53E-6 ID:SGTC_2683|Compound:piperine|FD-Score:3.35|P-value:6.30E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.54|P-value:3.22E-4 ID:SGTC_2838|Compound:9002687|FD-Score:4.10|P-value:3.92E-5 ID:SGTC_3146|Compound:9095609|FD-Score:3.37|P-value:5.96E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.71|P-value:1.79E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:3.55|P-value:3.14E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-4.49|P-value:9.12E-6 ID:SGTC_526|Compound:4469-0568|FD-Score:-6.88|P-value:2.35E-11 ID:SGTC_529|Compound:4076-0302|FD-Score:3.91|P-value:8.50E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:-5.66|P-value:3.15E-8 ID:SGTC_534|Compound:k292-0788|FD-Score:4.53|P-value:6.65E-6 ID:SGTC_536|Compound:3852-0578|FD-Score:5.34|P-value:1.41E-7 ID:SGTC_537|Compound:1334-0398|FD-Score:4.71|P-value:3.00E-6 ID:SGTC_595|Compound:3909-8003|FD-Score:3.28|P-value:7.91E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:-3.73|P-value:1.87E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:3.40|P-value:5.27E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.80|P-value:1.30E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:3.57|P-value:2.98E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:-4.21|P-value:2.88E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:4.67|P-value:3.49E-6 ID:SGTC_962|Compound:1254-0300|FD-Score:3.78|P-value:1.38E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.93|P-value:7.73E-5 ID:SGTC_1062|Compound:mesoridazine|FD-Score:4.20|P-value:2.63E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.48|P-value:3.98E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.16|P-value:3.17E-5 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.53|P-value:3.78E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:-3.31|P-value:8.11E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:3.22|P-value:9.49E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.37|P-value:5.89E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.38|P-value:1.27E-5 ID:SGTC_1496|Compound:4469-0713|FD-Score:-3.50|P-value:4.16E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:4.45|P-value:9.20E-6 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.57|P-value:3.34E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.77|P-value:1.42E-4 ID:SGTC_1567|Compound:st069303|FD-Score:7.33|P-value:9.77E-13 ID:SGTC_1568|Compound:digitonin|FD-Score:6.19|P-value:1.39E-9 ID:SGTC_1622|Compound:st003707|FD-Score:4.42|P-value:1.05E-5 ID:SGTC_1629|Compound:st005085|FD-Score:3.50|P-value:3.75E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.58|P-value:2.85E-4 ID:SGTC_1784|Compound:st039334|FD-Score:4.53|P-value:6.75E-6 ID:SGTC_1786|Compound:berberine|FD-Score:5.32|P-value:1.56E-7 ID:SGTC_1788|Compound:fluconazole|FD-Score:-4.41|P-value:1.29E-5 ID:SGTC_2188|Compound:6126565|FD-Score:3.31|P-value:7.18E-4 ID:SGTC_2225|Compound:6654152|FD-Score:3.91|P-value:8.35E-5 ID:SGTC_2314|Compound:7727897|FD-Score:4.60|P-value:4.91E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.35|P-value:6.18E-4 ID:SGTC_2426|Compound:5582046|FD-Score:-3.47|P-value:4.74E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.57|P-value:3.35E-4 ID:SGTC_2545|Compound:solidagenone|FD-Score:-3.89|P-value:1.02E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:-4.64|P-value:4.62E-6 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.74|P-value:2.53E-6 ID:SGTC_2683|Compound:piperine|FD-Score:3.35|P-value:6.30E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.54|P-value:3.22E-4 ID:SGTC_2838|Compound:9002687|FD-Score:4.10|P-value:3.92E-5 ID:SGTC_3146|Compound:9095609|FD-Score:3.37|P-value:5.96E-4

Top fitness defect scores for YDR541C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1567 st069303 7.33 68.4 µM 9.77E-13 mitochondrial processes 2 1.17E-13
2 SGTC_1568 digitonin 6.19 820.0 nM 1.39E-9 sphingolipid biosynthesis & PDR1 10 3.06E-10
3 SGTC_536 3852-0578 5.34 10.6 µM 1.41E-7 4 4.59E-8
4 SGTC_1786 berberine 5.32 21.6 µM 1.56E-7 60S ribosome export 11 5.10E-8
5 SGTC_2562 3',7'-dimethoxyflavone 4.74 64.9 µM 2.53E-6 13 1.04E-6
6 SGTC_537 1334-0398 4.71 209.0 µM 3.00E-6 10 1.26E-6
7 SGTC_831 k061-1017 4.67 217.0 µM 3.49E-6 translation 29 1.48E-6
8 SGTC_2314 7727897 4.60 200.0 µM 4.91E-6 7 2.14E-6
9 SGTC_534 k292-0788 4.53 63.4 µM 6.65E-6 mitochondrial processes 18 2.97E-6
10 SGTC_1784 st039334 4.53 36.3 µM 6.75E-6 10 3.02E-6
11 SGTC_1502 4534-4282 4.45 27.7 µM 9.20E-6 5 4.22E-6
12 SGTC_1622 st003707 4.42 19.4 µM 1.05E-5 calcium & mitochondrial duress 25 4.88E-6
13 SGTC_1495 4469-0029 4.38 237.0 µM 1.27E-5 91 5.96E-6
14 SGTC_1062 mesoridazine 4.20 14.2 µM 2.63E-5 16 1.31E-5
15 SGTC_1083 didemethylchlorpromazine sulfoxide 4.16 707.4 nM 3.17E-5 redox potentiating 66 1.61E-5
16 SGTC_2838 9002687 4.10 71.4 µM 3.92E-5 fatty acid desaturase (OLE1) 21 2.02E-5
17 SGTC_1039 k821-0043 3.93 94.0 µM 7.73E-5 Golgi 23 4.21E-5
18 SGTC_2225 6654152 3.91 15.4 µM 8.35E-5 18 4.58E-5
19 SGTC_529 4076-0302 3.91 30.3 µM 8.50E-5 mitochondrial processes 20 4.66E-5
20 SGTC_815 1582-0027 3.80 36.9 µM 1.30E-4 33 7.36E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 6.52E-12 YPL011C TAF3 het TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
0.114 4.20E-11 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.113 4.99E-11 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.108 3.48E-10 YHR195W NVJ1 hom Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN)
0.104 1.61E-9 YHR073W OSH3 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.100 7.40E-9 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.095 3.64E-8 YIL041W GVP36 hom BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis
0.090 1.84E-7 YGL103W RPL28 het Ribosomal 60S subunit protein L28; homologous to mammalian ribosomal protein L27A and bacterial L15; may have peptidyl transferase activity; can mutate to cycloheximide resistance
0.089 2.12E-7 YPR079W MRL1 hom Membrane protein; has similarity to mammalian mannose-6-phosphate receptors; possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; protein abundance increases in response to DNA replication stress
0.088 3.32E-7 YML070W DAK1 hom Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
0.087 4.09E-7 YIL076W SEC28 hom Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth; protein abundance increases in response to DNA replication stress
0.085 9.02E-7 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.083 1.73E-6 YDL134C PPH21 hom Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication
0.082 2.06E-6 YDR387C_p YDR387C_p hom Putative transporter, member of the sugar porter family; YDR387C is not an essential gene
0.082 2.23E-6 YKR065C PAM17 hom Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress