YEL005C / VAB2

Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL005C / VAB2

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.56|P-value:1.57E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.10|P-value:8.48E-4 ID:SGTC_228|Compound:caffeine|FD-Score:3.40|P-value:2.94E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:4.45|P-value:3.47E-6 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.62|P-value:1.22E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:3.75|P-value:7.47E-5 ID:SGTC_490|Compound:phenamil|FD-Score:3.32|P-value:3.90E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.05|P-value:2.12E-5 ID:SGTC_588|Compound:3970-1144|FD-Score:-5.06|P-value:1.50E-7 ID:SGTC_606|Compound:k015-0008|FD-Score:4.09|P-value:1.79E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:3.06|P-value:9.96E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:3.16|P-value:6.88E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:3.07|P-value:9.55E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:7.10|P-value:3.48E-13 ID:SGTC_883|Compound:0850-0245|FD-Score:3.09|P-value:8.83E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.83|P-value:5.20E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:5.40|P-value:2.33E-8 ID:SGTC_945|Compound:3381-0768|FD-Score:-6.32|P-value:7.80E-11 ID:SGTC_996|Compound:3970-0799|FD-Score:4.37|P-value:5.02E-6 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.31|P-value:4.03E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.69|P-value:9.48E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:-3.11|P-value:8.25E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.38|P-value:3.18E-4 ID:SGTC_1629|Compound:st005085|FD-Score:3.13|P-value:7.65E-4 ID:SGTC_1665|Compound:st014639|FD-Score:3.48|P-value:2.16E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.24|P-value:5.88E-8 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.15|P-value:7.14E-4 ID:SGTC_1889|Compound:st059080|FD-Score:-3.26|P-value:4.89E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.88|P-value:4.35E-5 ID:SGTC_1919|Compound:st067113|FD-Score:3.56|P-value:1.58E-4 ID:SGTC_1927|Compound:st060202|FD-Score:-3.66|P-value:1.07E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.16|P-value:6.89E-4 ID:SGTC_1935|Compound:st074532|FD-Score:4.02|P-value:2.44E-5 ID:SGTC_1937|Compound:st074714|FD-Score:3.64|P-value:1.16E-4 ID:SGTC_1970|Compound:st070122|FD-Score:-4.26|P-value:8.06E-6 ID:SGTC_1996|Compound:st072960|FD-Score:3.27|P-value:4.74E-4 ID:SGTC_2110|Compound:5483698|FD-Score:3.08|P-value:9.10E-4 ID:SGTC_2185|Compound:6113692|FD-Score:4.42|P-value:3.90E-6 ID:SGTC_2244|Compound:6635614|FD-Score:3.24|P-value:5.24E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.09|P-value:8.97E-4 ID:SGTC_2388|Compound:9080168|FD-Score:3.19|P-value:6.24E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-4.00|P-value:2.55E-5 ID:SGTC_2483|Compound:5729050|FD-Score:-3.37|P-value:3.17E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.35|P-value:3.58E-4 ID:SGTC_2646|Compound:retinol|FD-Score:-3.67|P-value:1.01E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.64|P-value:1.12E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:9.66|P-value:7.08E-23 ID:SGTC_2735|Compound:sertaconazole|FD-Score:3.41|P-value:2.79E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:6.28|P-value:1.04E-10 ID:SGTC_2823|Compound:7987624|FD-Score:-3.14|P-value:7.44E-4 ID:SGTC_2840|Compound:9008771|FD-Score:-3.35|P-value:3.51E-4 ID:SGTC_2843|Compound:9000894|FD-Score:-3.41|P-value:2.79E-4 ID:SGTC_2847|Compound:9005661|FD-Score:-4.18|P-value:1.16E-5 ID:SGTC_2977|Compound:9011197|FD-Score:6.91|P-value:1.40E-12 ID:SGTC_3037|Compound:9091026|FD-Score:3.65|P-value:1.11E-4 ID:SGTC_3047|Compound:9092122|FD-Score:-3.84|P-value:4.97E-5 ID:SGTC_3068|Compound:9116768|FD-Score:3.08|P-value:9.17E-4 ID:SGTC_3070|Compound:9117005|FD-Score:4.12|P-value:1.56E-5 ID:SGTC_3147|Compound:9097027|FD-Score:3.41|P-value:2.86E-4 ID:SGTC_3156|Compound:9099931|FD-Score:4.45|P-value:3.38E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.56|P-value:1.57E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.10|P-value:8.48E-4 ID:SGTC_228|Compound:caffeine|FD-Score:3.40|P-value:2.94E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:4.45|P-value:3.47E-6 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.62|P-value:1.22E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:3.75|P-value:7.47E-5 ID:SGTC_490|Compound:phenamil|FD-Score:3.32|P-value:3.90E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.05|P-value:2.12E-5 ID:SGTC_588|Compound:3970-1144|FD-Score:-5.06|P-value:1.50E-7 ID:SGTC_606|Compound:k015-0008|FD-Score:4.09|P-value:1.79E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:3.06|P-value:9.96E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:3.16|P-value:6.88E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:3.07|P-value:9.55E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:7.10|P-value:3.48E-13 ID:SGTC_883|Compound:0850-0245|FD-Score:3.09|P-value:8.83E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.83|P-value:5.20E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:5.40|P-value:2.33E-8 ID:SGTC_945|Compound:3381-0768|FD-Score:-6.32|P-value:7.80E-11 ID:SGTC_996|Compound:3970-0799|FD-Score:4.37|P-value:5.02E-6 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.31|P-value:4.03E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.69|P-value:9.48E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:-3.11|P-value:8.25E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.38|P-value:3.18E-4 ID:SGTC_1629|Compound:st005085|FD-Score:3.13|P-value:7.65E-4 ID:SGTC_1665|Compound:st014639|FD-Score:3.48|P-value:2.16E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.24|P-value:5.88E-8 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.15|P-value:7.14E-4 ID:SGTC_1889|Compound:st059080|FD-Score:-3.26|P-value:4.89E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.88|P-value:4.35E-5 ID:SGTC_1919|Compound:st067113|FD-Score:3.56|P-value:1.58E-4 ID:SGTC_1927|Compound:st060202|FD-Score:-3.66|P-value:1.07E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.16|P-value:6.89E-4 ID:SGTC_1935|Compound:st074532|FD-Score:4.02|P-value:2.44E-5 ID:SGTC_1937|Compound:st074714|FD-Score:3.64|P-value:1.16E-4 ID:SGTC_1970|Compound:st070122|FD-Score:-4.26|P-value:8.06E-6 ID:SGTC_1996|Compound:st072960|FD-Score:3.27|P-value:4.74E-4 ID:SGTC_2110|Compound:5483698|FD-Score:3.08|P-value:9.10E-4 ID:SGTC_2185|Compound:6113692|FD-Score:4.42|P-value:3.90E-6 ID:SGTC_2244|Compound:6635614|FD-Score:3.24|P-value:5.24E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.09|P-value:8.97E-4 ID:SGTC_2388|Compound:9080168|FD-Score:3.19|P-value:6.24E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-4.00|P-value:2.55E-5 ID:SGTC_2483|Compound:5729050|FD-Score:-3.37|P-value:3.17E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.35|P-value:3.58E-4 ID:SGTC_2646|Compound:retinol|FD-Score:-3.67|P-value:1.01E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.64|P-value:1.12E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:9.66|P-value:7.08E-23 ID:SGTC_2735|Compound:sertaconazole|FD-Score:3.41|P-value:2.79E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:6.28|P-value:1.04E-10 ID:SGTC_2823|Compound:7987624|FD-Score:-3.14|P-value:7.44E-4 ID:SGTC_2840|Compound:9008771|FD-Score:-3.35|P-value:3.51E-4 ID:SGTC_2843|Compound:9000894|FD-Score:-3.41|P-value:2.79E-4 ID:SGTC_2847|Compound:9005661|FD-Score:-4.18|P-value:1.16E-5 ID:SGTC_2977|Compound:9011197|FD-Score:6.91|P-value:1.40E-12 ID:SGTC_3037|Compound:9091026|FD-Score:3.65|P-value:1.11E-4 ID:SGTC_3047|Compound:9092122|FD-Score:-3.84|P-value:4.97E-5 ID:SGTC_3068|Compound:9116768|FD-Score:3.08|P-value:9.17E-4 ID:SGTC_3070|Compound:9117005|FD-Score:4.12|P-value:1.56E-5 ID:SGTC_3147|Compound:9097027|FD-Score:3.41|P-value:2.86E-4 ID:SGTC_3156|Compound:9099931|FD-Score:4.45|P-value:3.38E-6

Top fitness defect scores for YEL005C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2688 kanamycin b 9.66 96.7 µM 7.08E-23 calcium & mitochondrial duress 31 2.14E-22
2 SGTC_877 0771-0151 7.10 33.1 µM 3.48E-13 1 6.32E-13
3 SGTC_2977 9011197 6.91 71.4 µM 1.40E-12 3 2.46E-12
4 SGTC_2777 climbazole 6.28 1.5 µM 1.04E-10 iron homeostasis 9 1.66E-10
5 SGTC_922 1866-0035 5.40 480.0 µM 2.33E-8 excess fatty acid 27 3.29E-8
6 SGTC_1712 st032288 5.24 53.4 µM 5.88E-8 calcium & mitochondrial duress 104 8.14E-8
7 SGTC_3156 9099931 4.45 49.5 µM 3.38E-6 4 4.27E-6
8 SGTC_308 4092-1169 4.45 104.0 µM 3.47E-6 plasma membrane duress 36 4.39E-6
9 SGTC_2185 6113692 4.42 200.0 µM 3.90E-6 ergosterol biosynthesis 7 4.92E-6
10 SGTC_996 3970-0799 4.37 1.8 µM 5.02E-6 69 6.30E-6
11 SGTC_3070 9117005 4.12 49.5 µM 1.56E-5 3 1.91E-5
12 SGTC_606 k015-0008 4.09 38.6 µM 1.79E-5 11 2.18E-5
13 SGTC_528 3492-0019 4.05 172.0 µM 2.12E-5 calcium & mitochondrial duress 212 2.58E-5
14 SGTC_1935 st074532 4.02 41.6 µM 2.44E-5 29 2.96E-5
15 SGTC_400 oxethazaine 3.75 37.5 µM 7.47E-5 calcium & mitochondrial duress 25 8.84E-5
16 SGTC_1153 4055-0057 3.69 267.0 µM 9.48E-5 35 1.12E-4
17 SGTC_3037 9091026 3.65 49.5 µM 1.11E-4 NEO1-PIK1 142 1.30E-4
18 SGTC_1937 st074714 3.64 47.2 µM 1.16E-4 50 1.36E-4
19 SGTC_1919 st067113 3.56 52.3 µM 1.58E-4 TSC3-RPN4 43 1.84E-4
20 SGTC_1665 st014639 3.48 11.4 µM 2.16E-4 NEO1 37 2.50E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.214 5.81E-36 YDR466W PKH3 hom Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
0.195 4.59E-30 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.192 2.54E-29 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.185 3.61E-27 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.180 6.12E-26 YBR287W_p YBR287W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene
0.180 7.36E-26 YKL061W_p BLI1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome
0.178 3.66E-25 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.167 2.06E-22 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.159 2.21E-20 YGR237C_p YGR237C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.157 5.19E-20 YMR099C YMR099C hom Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
0.157 6.34E-20 YOR086C TCB1 hom Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.157 6.88E-20 YHL002W HSE1 hom Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
0.157 7.41E-20 YBL051C PIN4 hom Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
0.155 2.15E-19 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.148 7.68E-18 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies