YEL006W / YEA6

Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL006W / YEA6

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:3.72|P-value:1.14E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:4.35|P-value:8.17E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:4.10|P-value:2.46E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.19|P-value:7.63E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:3.54|P-value:2.30E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.29|P-value:5.67E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.97|P-value:4.33E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:3.63|P-value:1.62E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:4.66|P-value:2.00E-6 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.13|P-value:9.95E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.46|P-value:3.11E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:-4.61|P-value:2.38E-6 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.26|P-value:6.26E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:5.05|P-value:2.91E-7 ID:SGTC_535|Compound:2293-4129|FD-Score:5.56|P-value:1.89E-8 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.23|P-value:6.71E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:4.13|P-value:2.17E-5 ID:SGTC_697|Compound:0508-1955|FD-Score:-3.24|P-value:6.38E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.26|P-value:6.37E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:4.50|P-value:4.14E-6 ID:SGTC_954|Compound:1189-0853|FD-Score:5.35|P-value:5.80E-8 ID:SGTC_981|Compound:1488-1094|FD-Score:3.12|P-value:9.98E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:4.54|P-value:3.56E-6 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.56|P-value:2.12E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:4.05|P-value:3.02E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.38|P-value:3.95E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.86|P-value:6.32E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.21|P-value:1.52E-5 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.16|P-value:9.01E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.29|P-value:5.58E-4 ID:SGTC_1676|Compound:st018489|FD-Score:-3.32|P-value:4.88E-4 ID:SGTC_1891|Compound:st059073|FD-Score:-3.48|P-value:2.73E-4 ID:SGTC_1897|Compound:st060201|FD-Score:3.58|P-value:1.97E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.29|P-value:5.65E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:7.23|P-value:4.18E-13 ID:SGTC_2025|Compound:5147754|FD-Score:-3.59|P-value:1.79E-4 ID:SGTC_2037|Compound:5169046|FD-Score:3.73|P-value:1.14E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-4.21|P-value:1.45E-5 ID:SGTC_2176|Compound:5809774|FD-Score:-3.36|P-value:4.26E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.24|P-value:6.79E-4 ID:SGTC_2695|Compound:st077686|FD-Score:3.13|P-value:9.82E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.28|P-value:5.78E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.30|P-value:5.46E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.58|P-value:1.91E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.29|P-value:5.69E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.18|P-value:8.34E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.25|P-value:6.45E-4 ID:SGTC_3125|Compound:9127534|FD-Score:-3.88|P-value:5.89E-5 ID:SGTC_3342|Compound:9147791|FD-Score:-3.60|P-value:1.79E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:3.72|P-value:1.14E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:4.35|P-value:8.17E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:4.10|P-value:2.46E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.19|P-value:7.63E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:3.54|P-value:2.30E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.29|P-value:5.67E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.97|P-value:4.33E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:3.63|P-value:1.62E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:4.66|P-value:2.00E-6 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.13|P-value:9.95E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.46|P-value:3.11E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:-4.61|P-value:2.38E-6 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.26|P-value:6.26E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:5.05|P-value:2.91E-7 ID:SGTC_535|Compound:2293-4129|FD-Score:5.56|P-value:1.89E-8 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.23|P-value:6.71E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:4.13|P-value:2.17E-5 ID:SGTC_697|Compound:0508-1955|FD-Score:-3.24|P-value:6.38E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.26|P-value:6.37E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:4.50|P-value:4.14E-6 ID:SGTC_954|Compound:1189-0853|FD-Score:5.35|P-value:5.80E-8 ID:SGTC_981|Compound:1488-1094|FD-Score:3.12|P-value:9.98E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:4.54|P-value:3.56E-6 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.56|P-value:2.12E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:4.05|P-value:3.02E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.38|P-value:3.95E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.86|P-value:6.32E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.21|P-value:1.52E-5 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.16|P-value:9.01E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.29|P-value:5.58E-4 ID:SGTC_1676|Compound:st018489|FD-Score:-3.32|P-value:4.88E-4 ID:SGTC_1891|Compound:st059073|FD-Score:-3.48|P-value:2.73E-4 ID:SGTC_1897|Compound:st060201|FD-Score:3.58|P-value:1.97E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.29|P-value:5.65E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:7.23|P-value:4.18E-13 ID:SGTC_2025|Compound:5147754|FD-Score:-3.59|P-value:1.79E-4 ID:SGTC_2037|Compound:5169046|FD-Score:3.73|P-value:1.14E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-4.21|P-value:1.45E-5 ID:SGTC_2176|Compound:5809774|FD-Score:-3.36|P-value:4.26E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.24|P-value:6.79E-4 ID:SGTC_2695|Compound:st077686|FD-Score:3.13|P-value:9.82E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.28|P-value:5.78E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.30|P-value:5.46E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.58|P-value:1.91E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.29|P-value:5.69E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.18|P-value:8.34E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.25|P-value:6.45E-4 ID:SGTC_3125|Compound:9127534|FD-Score:-3.88|P-value:5.89E-5 ID:SGTC_3342|Compound:9147791|FD-Score:-3.60|P-value:1.79E-4

Top fitness defect scores for YEL006W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1926 methyl fluorone black 7.23 53.6 µM 4.18E-13 DNA intercalators 11 2.50E-13
2 SGTC_535 2293-4129 5.56 48.2 µM 1.89E-8 NEO1 30 1.38E-8
3 SGTC_954 1189-0853 5.35 2.9 µM 5.80E-8 endomembrane recycling 14 4.32E-8
4 SGTC_533 1222-0222 5.05 6.7 µM 2.91E-7 PDR1 10 2.24E-7
5 SGTC_205 1486-1330 4.66 71.9 µM 2.00E-6 11 1.59E-6
6 SGTC_999 4022-0066 4.54 22.7 µM 3.56E-6 Golgi 26 2.86E-6
7 SGTC_818 4072-2707 4.50 53.5 µM 4.14E-6 8 3.34E-6
8 SGTC_66 0109-0187 4.35 42.4 µM 8.17E-6 31 6.67E-6
9 SGTC_1250 0485-0349 4.21 40.2 µM 1.52E-5 26 1.25E-5
10 SGTC_633 0437-0093 4.13 97.7 µM 2.17E-5 DNA intercalators 8 1.80E-5
11 SGTC_67 0335-0847 4.10 266.0 µM 2.46E-5 ubiquinone biosynthesis & proteasome 113 2.05E-5
12 SGTC_1107 amlodipine 4.05 47.0 µM 3.02E-5 28 2.53E-5
13 SGTC_166 k072-0058 3.97 166.4 µM 4.33E-5 DNA intercalators 38 3.65E-5
14 SGTC_2037 5169046 3.73 200.0 µM 1.14E-4 60S ribosome export 17 9.75E-5
15 SGTC_9 0092-0002 3.72 10.4 µM 1.14E-4 37 9.79E-5
16 SGTC_203 k066-0004 3.63 30.9 µM 1.62E-4 RSC & ERG11 26 1.39E-4
17 SGTC_1897 st060201 3.58 15.0 µM 1.97E-4 mitochondrial processes 27 1.70E-4
18 SGTC_1089 terbinafine 3.56 2.2 µM 2.12E-4 24 1.83E-4
19 SGTC_131 0141-0277 3.54 33.9 µM 2.30E-4 55 1.99E-4
20 SGTC_380 3970-0968 3.46 6.0 µM 3.11E-4 23 2.71E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.166 3.32E-22 YIL144W TID3 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering
0.155 1.51E-19 YPL165C SET6 hom SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability
0.135 5.15E-15 YDL058W USO1 het Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex
0.124 6.55E-13 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.122 1.53E-12 YGL075C MPS2 het Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p
0.115 2.33E-11 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.114 3.46E-11 YER099C PRS2 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication
0.113 6.47E-11 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.111 1.22E-10 YOL035C_d YOL035C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.111 1.29E-10 YDR316W OMS1 hom Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations
0.105 9.71E-10 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.105 9.97E-10 YDR170C SEC7 het Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
0.104 1.69E-9 YPL197C_d YPL197C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B
0.104 1.77E-9 YGR156W PTI1 het Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
0.103 1.91E-9 YDR250C_d YDR250C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data