YEL007W / MIT1

Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL007W / MIT1

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:12.00|P-value:4.84E-39 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.04|P-value:5.61E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.35|P-value:3.52E-9 ID:SGTC_161|Compound:4065-0411|FD-Score:3.45|P-value:9.02E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:4.84|P-value:8.08E-8 ID:SGTC_210|Compound:3551-0445|FD-Score:3.70|P-value:3.03E-5 ID:SGTC_211|Compound:3455-0679|FD-Score:-3.05|P-value:5.37E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:2.93|P-value:7.31E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.72|P-value:2.76E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:4.01|P-value:6.86E-6 ID:SGTC_773|Compound:4358-1457|FD-Score:2.91|P-value:7.78E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:2.97|P-value:6.24E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:-3.13|P-value:4.02E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.03|P-value:4.90E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:-3.07|P-value:4.99E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:2.93|P-value:7.32E-4 ID:SGTC_1567|Compound:st069303|FD-Score:2.89|P-value:8.42E-4 ID:SGTC_1729|Compound:st035615|FD-Score:-2.91|P-value:9.18E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.18|P-value:2.78E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.04|P-value:4.89E-4 ID:SGTC_1941|Compound:st076221|FD-Score:5.02|P-value:2.76E-8 ID:SGTC_1948|Compound:st076329|FD-Score:5.85|P-value:1.24E-10 ID:SGTC_2033|Compound:5192550|FD-Score:-4.11|P-value:5.07E-6 ID:SGTC_2044|Compound:5102272|FD-Score:-5.70|P-value:4.72E-10 ID:SGTC_2219|Compound:9098279|FD-Score:3.00|P-value:5.50E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-5.04|P-value:3.05E-8 ID:SGTC_2491|Compound:paeonol|FD-Score:3.14|P-value:3.22E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.08|P-value:4.10E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:15.60|P-value:6.53E-64 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-4.92|P-value:6.46E-8 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.28|P-value:1.76E-6 ID:SGTC_2640|Compound:pentamidine|FD-Score:5.25|P-value:6.58E-9 ID:SGTC_2657|Compound:nystatin|FD-Score:3.61|P-value:4.59E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:3.09|P-value:3.91E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-3.29|P-value:2.13E-4 ID:SGTC_2827|Compound:7993847|FD-Score:3.84|P-value:1.59E-5 ID:SGTC_2858|Compound:9025781|FD-Score:4.87|P-value:6.48E-8 ID:SGTC_2873|Compound:9040596|FD-Score:-3.03|P-value:5.92E-4 ID:SGTC_2880|Compound:9042983|FD-Score:3.16|P-value:3.03E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.17|P-value:2.93E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.17|P-value:3.49E-4 ID:SGTC_3112|Compound:9123419|FD-Score:-2.94|P-value:8.36E-4 ID:SGTC_3133|Compound:9127736|FD-Score:3.59|P-value:4.87E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-3.42|P-value:1.24E-4 ID:SGTC_3261|Compound:9137475|FD-Score:2.95|P-value:6.73E-4 ID:SGTC_3276|Compound:9139060|FD-Score:-3.56|P-value:6.76E-5 ID:SGTC_3308|Compound:9128332|FD-Score:3.00|P-value:5.70E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:12.00|P-value:4.84E-39 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.04|P-value:5.61E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.35|P-value:3.52E-9 ID:SGTC_161|Compound:4065-0411|FD-Score:3.45|P-value:9.02E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:4.84|P-value:8.08E-8 ID:SGTC_210|Compound:3551-0445|FD-Score:3.70|P-value:3.03E-5 ID:SGTC_211|Compound:3455-0679|FD-Score:-3.05|P-value:5.37E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:2.93|P-value:7.31E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.72|P-value:2.76E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:4.01|P-value:6.86E-6 ID:SGTC_773|Compound:4358-1457|FD-Score:2.91|P-value:7.78E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:2.97|P-value:6.24E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:-3.13|P-value:4.02E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.03|P-value:4.90E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:-3.07|P-value:4.99E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:2.93|P-value:7.32E-4 ID:SGTC_1567|Compound:st069303|FD-Score:2.89|P-value:8.42E-4 ID:SGTC_1729|Compound:st035615|FD-Score:-2.91|P-value:9.18E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.18|P-value:2.78E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.04|P-value:4.89E-4 ID:SGTC_1941|Compound:st076221|FD-Score:5.02|P-value:2.76E-8 ID:SGTC_1948|Compound:st076329|FD-Score:5.85|P-value:1.24E-10 ID:SGTC_2033|Compound:5192550|FD-Score:-4.11|P-value:5.07E-6 ID:SGTC_2044|Compound:5102272|FD-Score:-5.70|P-value:4.72E-10 ID:SGTC_2219|Compound:9098279|FD-Score:3.00|P-value:5.50E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-5.04|P-value:3.05E-8 ID:SGTC_2491|Compound:paeonol|FD-Score:3.14|P-value:3.22E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.08|P-value:4.10E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:15.60|P-value:6.53E-64 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-4.92|P-value:6.46E-8 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.28|P-value:1.76E-6 ID:SGTC_2640|Compound:pentamidine|FD-Score:5.25|P-value:6.58E-9 ID:SGTC_2657|Compound:nystatin|FD-Score:3.61|P-value:4.59E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:3.09|P-value:3.91E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-3.29|P-value:2.13E-4 ID:SGTC_2827|Compound:7993847|FD-Score:3.84|P-value:1.59E-5 ID:SGTC_2858|Compound:9025781|FD-Score:4.87|P-value:6.48E-8 ID:SGTC_2873|Compound:9040596|FD-Score:-3.03|P-value:5.92E-4 ID:SGTC_2880|Compound:9042983|FD-Score:3.16|P-value:3.03E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.17|P-value:2.93E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.17|P-value:3.49E-4 ID:SGTC_3112|Compound:9123419|FD-Score:-2.94|P-value:8.36E-4 ID:SGTC_3133|Compound:9127736|FD-Score:3.59|P-value:4.87E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-3.42|P-value:1.24E-4 ID:SGTC_3261|Compound:9137475|FD-Score:2.95|P-value:6.73E-4 ID:SGTC_3276|Compound:9139060|FD-Score:-3.56|P-value:6.76E-5 ID:SGTC_3308|Compound:9128332|FD-Score:3.00|P-value:5.70E-4

Top fitness defect scores for YEL007W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 15.60 100.0 µM 6.53E-64 redox potentiating 13 4.17E-55
2 SGTC_8 0354-0001 12.00 70.0 µM 4.84E-39 3 9.72E-34
3 SGTC_1948 st076329 5.85 66.6 µM 1.24E-10 4 2.51E-9
4 SGTC_58 0957-0393 5.35 9.0 µM 3.52E-9 cell wall 252 4.46E-8
5 SGTC_2640 pentamidine 5.25 10.4 µM 6.58E-9 mitochondrial processes 11 7.64E-8
6 SGTC_1941 st076221 5.02 61.8 µM 2.76E-8 sphingolipid biosynthesis & PDR1 47 2.62E-7
7 SGTC_2858 9025781 4.87 9.0 µM 6.48E-8 sphingolipid biosynthesis & PDR1 70 5.47E-7
8 SGTC_188 3229-0966 4.84 278.5 µM 8.08E-8 16 6.61E-7
9 SGTC_2636 apigenin dimethyl ether 4.28 100.0 µM 1.76E-6 34 9.39E-6
10 SGTC_568 1193-0097 4.01 7.5 µM 6.86E-6 ERAD & cell cycle 146 3.03E-5
11 SGTC_2827 7993847 3.84 71.4 µM 1.59E-5 30 6.25E-5
12 SGTC_384 k007-0144 3.72 5.2 µM 2.76E-5 ERAD & cell cycle 66 1.00E-4
13 SGTC_210 3551-0445 3.70 56.8 µM 3.03E-5 70 1.09E-4
14 SGTC_2657 nystatin 3.61 74.4 µM 4.59E-5 21 1.56E-4
15 SGTC_3133 9127736 3.59 49.5 µM 4.87E-5 32 1.64E-4
16 SGTC_161 4065-0411 3.45 162.2 µM 9.02E-5 90 2.79E-4
17 SGTC_1908 st060353 3.18 56.5 µM 2.78E-4 RPP1 & pyrimidine depletion 71 7.39E-4
18 SGTC_2920 7982904 3.17 15.8 µM 2.93E-4 50 7.72E-4
19 SGTC_2880 9042983 3.16 58.4 µM 3.03E-4 fatty acid desaturase (OLE1) 61 7.95E-4
20 SGTC_2491 paeonol 3.14 100.0 µM 3.22E-4 21 8.38E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.438 3.99E-157 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.346 1.26E-94 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.319 2.29E-80 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.314 1.29E-77 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.309 3.74E-75 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.296 1.16E-68 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.289 2.07E-65 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.278 1.74E-60 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.276 9.58E-60 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.274 1.02E-58 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.271 2.38E-57 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.266 2.25E-55 YER072W VTC1 hom Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress
0.264 1.18E-54 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.260 4.31E-53 YMR214W SCJ1 hom One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
0.259 1.96E-52 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p