YEL009C / GCN4

Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL009C / GCN4

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:9.59|P-value:9.45E-10 ID:SGTC_14|Compound:0354-0009|FD-Score:5.26|P-value:5.22E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:7.62|P-value:9.49E-7 ID:SGTC_50|Compound:0929-0078|FD-Score:9.88|P-value:3.01E-10 ID:SGTC_51|Compound:1013-0126|FD-Score:13.20|P-value:6.34E-17 ID:SGTC_54|Compound:0159-0055|FD-Score:15.80|P-value:1.57E-23 ID:SGTC_68|Compound:0986-0284|FD-Score:5.07|P-value:7.96E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:6.21|P-value:5.32E-5 ID:SGTC_79|Compound:0052-0007|FD-Score:6.84|P-value:9.57E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:5.30|P-value:4.76E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:5.61|P-value:2.31E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:8.25|P-value:1.20E-7 ID:SGTC_167|Compound:3672-0051|FD-Score:7.92|P-value:3.66E-7 ID:SGTC_176|Compound:1486-1328|FD-Score:14.20|P-value:2.66E-19 ID:SGTC_180|Compound:1486-1293|FD-Score:14.90|P-value:3.62E-21 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-5.81|P-value:1.10E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:12.50|P-value:2.84E-15 ID:SGTC_285|Compound:1486-1325|FD-Score:10.50|P-value:2.05E-11 ID:SGTC_308|Compound:4092-1169|FD-Score:7.96|P-value:3.13E-7 ID:SGTC_409|Compound:arachidonic acid|FD-Score:8.39|P-value:7.61E-8 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:9.03|P-value:7.66E-9 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:6.65|P-value:1.65E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:9.02|P-value:8.14E-9 ID:SGTC_515|Compound:4092-1064|FD-Score:8.04|P-value:2.48E-7 ID:SGTC_542|Compound:3381-0244|FD-Score:6.67|P-value:1.53E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:5.50|P-value:3.02E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:7.50|P-value:1.36E-6 ID:SGTC_601|Compound:0986-0029|FD-Score:5.22|P-value:5.74E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:6.80|P-value:1.07E-5 ID:SGTC_636|Compound:0kpi-0074|FD-Score:12.10|P-value:2.00E-14 ID:SGTC_637|Compound:1181-0519|FD-Score:10.40|P-value:3.71E-11 ID:SGTC_651|Compound:3253-0966|FD-Score:5.58|P-value:2.47E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:5.31|P-value:4.60E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:5.56|P-value:2.60E-4 ID:SGTC_677|Compound:0929-0063|FD-Score:5.77|P-value:1.58E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:8.23|P-value:1.30E-7 ID:SGTC_727|Compound:3032-0951|FD-Score:5.15|P-value:6.57E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:6.99|P-value:6.14E-6 ID:SGTC_819|Compound:1013-0258|FD-Score:10.50|P-value:2.88E-11 ID:SGTC_821|Compound:1114-0266|FD-Score:5.23|P-value:5.62E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:11.90|P-value:3.54E-14 ID:SGTC_834|Compound:0312-0008|FD-Score:8.93|P-value:1.11E-8 ID:SGTC_838|Compound:0109-0203|FD-Score:-5.68|P-value:1.52E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:8.22|P-value:1.36E-7 ID:SGTC_862|Compound:0452-0056|FD-Score:7.03|P-value:5.53E-6 ID:SGTC_874|Compound:0599-0792|FD-Score:5.54|P-value:2.77E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:5.75|P-value:1.68E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:12.10|P-value:1.33E-14 ID:SGTC_1067|Compound:clotrimazole|FD-Score:5.43|P-value:3.53E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:5.63|P-value:2.23E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:4.98|P-value:9.55E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:6.04|P-value:8.14E-5 ID:SGTC_1104|Compound:tacrolimus|FD-Score:7.10|P-value:4.57E-6 ID:SGTC_1114|Compound:scopoletin|FD-Score:7.05|P-value:5.18E-6 ID:SGTC_1160|Compound:4092-0570|FD-Score:7.97|P-value:3.07E-7 ID:SGTC_1172|Compound:0370-0043|FD-Score:8.92|P-value:1.18E-8 ID:SGTC_1219|Compound:1469-0211|FD-Score:7.23|P-value:3.09E-6 ID:SGTC_1225|Compound:1216-0074|FD-Score:5.49|P-value:3.10E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:6.55|P-value:2.13E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:5.34|P-value:4.31E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:5.26|P-value:5.16E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:5.64|P-value:2.18E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:6.31|P-value:4.10E-5 ID:SGTC_1336|Compound:1486-0901|FD-Score:5.40|P-value:3.83E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:10.80|P-value:6.13E-12 ID:SGTC_1427|Compound:4048-4900|FD-Score:7.69|P-value:7.62E-7 ID:SGTC_1482|Compound:3346-2049|FD-Score:7.67|P-value:7.90E-7 ID:SGTC_1496|Compound:4469-0713|FD-Score:5.61|P-value:2.33E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:6.91|P-value:7.84E-6 ID:SGTC_1511|Compound:0906-3109|FD-Score:9.52|P-value:1.22E-9 ID:SGTC_1520|Compound:flindersine|FD-Score:8.19|P-value:1.47E-7 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:5.37|P-value:4.05E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-4.93|P-value:8.49E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:7.33|P-value:2.30E-6 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:7.59|P-value:1.02E-6 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:6.55|P-value:2.13E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.80|P-value:5.27E-7 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:8.02|P-value:2.61E-7 ID:SGTC_1603|Compound:st002045|FD-Score:11.90|P-value:4.16E-14 ID:SGTC_1617|Compound:st002906|FD-Score:11.60|P-value:1.51E-13 ID:SGTC_1636|Compound:st007707|FD-Score:15.60|P-value:6.67E-23 ID:SGTC_1649|Compound:st011737|FD-Score:8.72|P-value:2.41E-8 ID:SGTC_1654|Compound:st012436|FD-Score:4.96|P-value:9.97E-4 ID:SGTC_1655|Compound:st012546|FD-Score:7.66|P-value:8.17E-7 ID:SGTC_1671|Compound:st016596|FD-Score:6.93|P-value:7.30E-6 ID:SGTC_1673|Compound:st016611|FD-Score:8.20|P-value:1.43E-7 ID:SGTC_1697|Compound:st025554|FD-Score:12.50|P-value:2.80E-15 ID:SGTC_1715|Compound:st032160|FD-Score:5.08|P-value:7.75E-4 ID:SGTC_1752|Compound:st044819|FD-Score:7.32|P-value:2.34E-6 ID:SGTC_1757|Compound:st041620|FD-Score:7.61|P-value:9.59E-7 ID:SGTC_1764|Compound:st044502|FD-Score:5.73|P-value:1.73E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-4.88|P-value:9.41E-4 ID:SGTC_1797|Compound:st048695|FD-Score:7.10|P-value:4.56E-6 ID:SGTC_1824|Compound:st053723|FD-Score:5.83|P-value:1.36E-4 ID:SGTC_1881|Compound:5652484|FD-Score:13.20|P-value:6.86E-17 ID:SGTC_1882|Compound:5615643|FD-Score:18.40|P-value:2.99E-31 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:20.90|P-value:9.48E-40 ID:SGTC_1906|Compound:st060206|FD-Score:6.07|P-value:7.52E-5 ID:SGTC_1907|Compound:st060210|FD-Score:7.71|P-value:7.06E-7 ID:SGTC_1909|Compound:st060837|FD-Score:5.02|P-value:8.72E-4 ID:SGTC_1991|Compound:st073000|FD-Score:6.02|P-value:8.54E-5 ID:SGTC_2024|Compound:5144227|FD-Score:5.01|P-value:9.03E-4 ID:SGTC_2038|Compound:4100038|FD-Score:13.50|P-value:1.46E-17 ID:SGTC_2056|Compound:5235370|FD-Score:6.96|P-value:6.76E-6 ID:SGTC_2064|Compound:5220758|FD-Score:8.97|P-value:9.63E-9 ID:SGTC_2093|Compound:5331342|FD-Score:5.71|P-value:1.85E-4 ID:SGTC_2122|Compound:5258151|FD-Score:7.13|P-value:4.16E-6 ID:SGTC_2137|Compound:5261020|FD-Score:6.59|P-value:1.91E-5 ID:SGTC_2148|Compound:5546263|FD-Score:5.60|P-value:2.38E-4 ID:SGTC_2175|Compound:5807670|FD-Score:7.97|P-value:3.09E-7 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:12.80|P-value:3.89E-16 ID:SGTC_2238|Compound:6671620|FD-Score:9.77|P-value:4.71E-10 ID:SGTC_2254|Compound:7938975|FD-Score:7.46|P-value:1.55E-6 ID:SGTC_2278|Compound:7948257|FD-Score:5.37|P-value:4.06E-4 ID:SGTC_2286|Compound:7945697|FD-Score:5.34|P-value:4.39E-4 ID:SGTC_2332|Compound:7982454|FD-Score:8.13|P-value:1.83E-7 ID:SGTC_2384|Compound:9036245|FD-Score:11.70|P-value:1.24E-13 ID:SGTC_2445|Compound:5742597|FD-Score:6.37|P-value:3.43E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:6.13|P-value:6.41E-5 ID:SGTC_2472|Compound:5377652|FD-Score:6.37|P-value:3.48E-5 ID:SGTC_2478|Compound:5763493|FD-Score:11.20|P-value:1.15E-12 ID:SGTC_2486|Compound:5283202|FD-Score:10.60|P-value:1.31E-11 ID:SGTC_2488|Compound:5268135|FD-Score:19.00|P-value:3.66E-33 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:6.35|P-value:3.65E-5 ID:SGTC_2523|Compound:spermine|FD-Score:5.62|P-value:2.26E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:7.45|P-value:1.58E-6 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:17.20|P-value:2.22E-27 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:7.82|P-value:4.93E-7 ID:SGTC_2607|Compound:solasodine|FD-Score:5.72|P-value:1.79E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:6.86|P-value:9.15E-6 ID:SGTC_2650|Compound:prasterone|FD-Score:7.87|P-value:4.19E-7 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:5.61|P-value:2.34E-4 ID:SGTC_2678|Compound:equilin|FD-Score:5.31|P-value:4.64E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:8.38|P-value:7.83E-8 ID:SGTC_2699|Compound:st077704|FD-Score:6.22|P-value:5.19E-5 ID:SGTC_2717|Compound:st081029|FD-Score:8.18|P-value:1.53E-7 ID:SGTC_2725|Compound:haloperidol|FD-Score:10.70|P-value:9.52E-12 ID:SGTC_2741|Compound:miltefosine|FD-Score:6.47|P-value:2.64E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:14.60|P-value:3.09E-20 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:25.30|P-value:2.91E-57 ID:SGTC_2778|Compound:tioconazole|FD-Score:5.48|P-value:3.14E-4 ID:SGTC_2939|Compound:9044578|FD-Score:5.71|P-value:1.85E-4 ID:SGTC_2948|Compound:9070189|FD-Score:7.99|P-value:2.84E-7 ID:SGTC_2973|Compound:9094665|FD-Score:6.18|P-value:5.64E-5 ID:SGTC_2974|Compound:9094440|FD-Score:8.08|P-value:2.11E-7 ID:SGTC_3018|Compound:9082602|FD-Score:5.20|P-value:5.96E-4 ID:SGTC_3308|Compound:9128332|FD-Score:15.40|P-value:2.32E-22 ID:SGTC_3354|Compound:9151612|FD-Score:6.44|P-value:2.86E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:9.59|P-value:9.45E-10 ID:SGTC_14|Compound:0354-0009|FD-Score:5.26|P-value:5.22E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:7.62|P-value:9.49E-7 ID:SGTC_50|Compound:0929-0078|FD-Score:9.88|P-value:3.01E-10 ID:SGTC_51|Compound:1013-0126|FD-Score:13.20|P-value:6.34E-17 ID:SGTC_54|Compound:0159-0055|FD-Score:15.80|P-value:1.57E-23 ID:SGTC_68|Compound:0986-0284|FD-Score:5.07|P-value:7.96E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:6.21|P-value:5.32E-5 ID:SGTC_79|Compound:0052-0007|FD-Score:6.84|P-value:9.57E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:5.30|P-value:4.76E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:5.61|P-value:2.31E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:8.25|P-value:1.20E-7 ID:SGTC_167|Compound:3672-0051|FD-Score:7.92|P-value:3.66E-7 ID:SGTC_176|Compound:1486-1328|FD-Score:14.20|P-value:2.66E-19 ID:SGTC_180|Compound:1486-1293|FD-Score:14.90|P-value:3.62E-21 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-5.81|P-value:1.10E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:12.50|P-value:2.84E-15 ID:SGTC_285|Compound:1486-1325|FD-Score:10.50|P-value:2.05E-11 ID:SGTC_308|Compound:4092-1169|FD-Score:7.96|P-value:3.13E-7 ID:SGTC_409|Compound:arachidonic acid|FD-Score:8.39|P-value:7.61E-8 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:9.03|P-value:7.66E-9 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:6.65|P-value:1.65E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:9.02|P-value:8.14E-9 ID:SGTC_515|Compound:4092-1064|FD-Score:8.04|P-value:2.48E-7 ID:SGTC_542|Compound:3381-0244|FD-Score:6.67|P-value:1.53E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:5.50|P-value:3.02E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:7.50|P-value:1.36E-6 ID:SGTC_601|Compound:0986-0029|FD-Score:5.22|P-value:5.74E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:6.80|P-value:1.07E-5 ID:SGTC_636|Compound:0kpi-0074|FD-Score:12.10|P-value:2.00E-14 ID:SGTC_637|Compound:1181-0519|FD-Score:10.40|P-value:3.71E-11 ID:SGTC_651|Compound:3253-0966|FD-Score:5.58|P-value:2.47E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:5.31|P-value:4.60E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:5.56|P-value:2.60E-4 ID:SGTC_677|Compound:0929-0063|FD-Score:5.77|P-value:1.58E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:8.23|P-value:1.30E-7 ID:SGTC_727|Compound:3032-0951|FD-Score:5.15|P-value:6.57E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:6.99|P-value:6.14E-6 ID:SGTC_819|Compound:1013-0258|FD-Score:10.50|P-value:2.88E-11 ID:SGTC_821|Compound:1114-0266|FD-Score:5.23|P-value:5.62E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:11.90|P-value:3.54E-14 ID:SGTC_834|Compound:0312-0008|FD-Score:8.93|P-value:1.11E-8 ID:SGTC_838|Compound:0109-0203|FD-Score:-5.68|P-value:1.52E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:8.22|P-value:1.36E-7 ID:SGTC_862|Compound:0452-0056|FD-Score:7.03|P-value:5.53E-6 ID:SGTC_874|Compound:0599-0792|FD-Score:5.54|P-value:2.77E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:5.75|P-value:1.68E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:12.10|P-value:1.33E-14 ID:SGTC_1067|Compound:clotrimazole|FD-Score:5.43|P-value:3.53E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:5.63|P-value:2.23E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:4.98|P-value:9.55E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:6.04|P-value:8.14E-5 ID:SGTC_1104|Compound:tacrolimus|FD-Score:7.10|P-value:4.57E-6 ID:SGTC_1114|Compound:scopoletin|FD-Score:7.05|P-value:5.18E-6 ID:SGTC_1160|Compound:4092-0570|FD-Score:7.97|P-value:3.07E-7 ID:SGTC_1172|Compound:0370-0043|FD-Score:8.92|P-value:1.18E-8 ID:SGTC_1219|Compound:1469-0211|FD-Score:7.23|P-value:3.09E-6 ID:SGTC_1225|Compound:1216-0074|FD-Score:5.49|P-value:3.10E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:6.55|P-value:2.13E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:5.34|P-value:4.31E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:5.26|P-value:5.16E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:5.64|P-value:2.18E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:6.31|P-value:4.10E-5 ID:SGTC_1336|Compound:1486-0901|FD-Score:5.40|P-value:3.83E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:10.80|P-value:6.13E-12 ID:SGTC_1427|Compound:4048-4900|FD-Score:7.69|P-value:7.62E-7 ID:SGTC_1482|Compound:3346-2049|FD-Score:7.67|P-value:7.90E-7 ID:SGTC_1496|Compound:4469-0713|FD-Score:5.61|P-value:2.33E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:6.91|P-value:7.84E-6 ID:SGTC_1511|Compound:0906-3109|FD-Score:9.52|P-value:1.22E-9 ID:SGTC_1520|Compound:flindersine|FD-Score:8.19|P-value:1.47E-7 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:5.37|P-value:4.05E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-4.93|P-value:8.49E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:7.33|P-value:2.30E-6 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:7.59|P-value:1.02E-6 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:6.55|P-value:2.13E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.80|P-value:5.27E-7 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:8.02|P-value:2.61E-7 ID:SGTC_1603|Compound:st002045|FD-Score:11.90|P-value:4.16E-14 ID:SGTC_1617|Compound:st002906|FD-Score:11.60|P-value:1.51E-13 ID:SGTC_1636|Compound:st007707|FD-Score:15.60|P-value:6.67E-23 ID:SGTC_1649|Compound:st011737|FD-Score:8.72|P-value:2.41E-8 ID:SGTC_1654|Compound:st012436|FD-Score:4.96|P-value:9.97E-4 ID:SGTC_1655|Compound:st012546|FD-Score:7.66|P-value:8.17E-7 ID:SGTC_1671|Compound:st016596|FD-Score:6.93|P-value:7.30E-6 ID:SGTC_1673|Compound:st016611|FD-Score:8.20|P-value:1.43E-7 ID:SGTC_1697|Compound:st025554|FD-Score:12.50|P-value:2.80E-15 ID:SGTC_1715|Compound:st032160|FD-Score:5.08|P-value:7.75E-4 ID:SGTC_1752|Compound:st044819|FD-Score:7.32|P-value:2.34E-6 ID:SGTC_1757|Compound:st041620|FD-Score:7.61|P-value:9.59E-7 ID:SGTC_1764|Compound:st044502|FD-Score:5.73|P-value:1.73E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-4.88|P-value:9.41E-4 ID:SGTC_1797|Compound:st048695|FD-Score:7.10|P-value:4.56E-6 ID:SGTC_1824|Compound:st053723|FD-Score:5.83|P-value:1.36E-4 ID:SGTC_1881|Compound:5652484|FD-Score:13.20|P-value:6.86E-17 ID:SGTC_1882|Compound:5615643|FD-Score:18.40|P-value:2.99E-31 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:20.90|P-value:9.48E-40 ID:SGTC_1906|Compound:st060206|FD-Score:6.07|P-value:7.52E-5 ID:SGTC_1907|Compound:st060210|FD-Score:7.71|P-value:7.06E-7 ID:SGTC_1909|Compound:st060837|FD-Score:5.02|P-value:8.72E-4 ID:SGTC_1991|Compound:st073000|FD-Score:6.02|P-value:8.54E-5 ID:SGTC_2024|Compound:5144227|FD-Score:5.01|P-value:9.03E-4 ID:SGTC_2038|Compound:4100038|FD-Score:13.50|P-value:1.46E-17 ID:SGTC_2056|Compound:5235370|FD-Score:6.96|P-value:6.76E-6 ID:SGTC_2064|Compound:5220758|FD-Score:8.97|P-value:9.63E-9 ID:SGTC_2093|Compound:5331342|FD-Score:5.71|P-value:1.85E-4 ID:SGTC_2122|Compound:5258151|FD-Score:7.13|P-value:4.16E-6 ID:SGTC_2137|Compound:5261020|FD-Score:6.59|P-value:1.91E-5 ID:SGTC_2148|Compound:5546263|FD-Score:5.60|P-value:2.38E-4 ID:SGTC_2175|Compound:5807670|FD-Score:7.97|P-value:3.09E-7 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:12.80|P-value:3.89E-16 ID:SGTC_2238|Compound:6671620|FD-Score:9.77|P-value:4.71E-10 ID:SGTC_2254|Compound:7938975|FD-Score:7.46|P-value:1.55E-6 ID:SGTC_2278|Compound:7948257|FD-Score:5.37|P-value:4.06E-4 ID:SGTC_2286|Compound:7945697|FD-Score:5.34|P-value:4.39E-4 ID:SGTC_2332|Compound:7982454|FD-Score:8.13|P-value:1.83E-7 ID:SGTC_2384|Compound:9036245|FD-Score:11.70|P-value:1.24E-13 ID:SGTC_2445|Compound:5742597|FD-Score:6.37|P-value:3.43E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:6.13|P-value:6.41E-5 ID:SGTC_2472|Compound:5377652|FD-Score:6.37|P-value:3.48E-5 ID:SGTC_2478|Compound:5763493|FD-Score:11.20|P-value:1.15E-12 ID:SGTC_2486|Compound:5283202|FD-Score:10.60|P-value:1.31E-11 ID:SGTC_2488|Compound:5268135|FD-Score:19.00|P-value:3.66E-33 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:6.35|P-value:3.65E-5 ID:SGTC_2523|Compound:spermine|FD-Score:5.62|P-value:2.26E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:7.45|P-value:1.58E-6 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:17.20|P-value:2.22E-27 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:7.82|P-value:4.93E-7 ID:SGTC_2607|Compound:solasodine|FD-Score:5.72|P-value:1.79E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:6.86|P-value:9.15E-6 ID:SGTC_2650|Compound:prasterone|FD-Score:7.87|P-value:4.19E-7 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:5.61|P-value:2.34E-4 ID:SGTC_2678|Compound:equilin|FD-Score:5.31|P-value:4.64E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:8.38|P-value:7.83E-8 ID:SGTC_2699|Compound:st077704|FD-Score:6.22|P-value:5.19E-5 ID:SGTC_2717|Compound:st081029|FD-Score:8.18|P-value:1.53E-7 ID:SGTC_2725|Compound:haloperidol|FD-Score:10.70|P-value:9.52E-12 ID:SGTC_2741|Compound:miltefosine|FD-Score:6.47|P-value:2.64E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:14.60|P-value:3.09E-20 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:25.30|P-value:2.91E-57 ID:SGTC_2778|Compound:tioconazole|FD-Score:5.48|P-value:3.14E-4 ID:SGTC_2939|Compound:9044578|FD-Score:5.71|P-value:1.85E-4 ID:SGTC_2948|Compound:9070189|FD-Score:7.99|P-value:2.84E-7 ID:SGTC_2973|Compound:9094665|FD-Score:6.18|P-value:5.64E-5 ID:SGTC_2974|Compound:9094440|FD-Score:8.08|P-value:2.11E-7 ID:SGTC_3018|Compound:9082602|FD-Score:5.20|P-value:5.96E-4 ID:SGTC_3308|Compound:9128332|FD-Score:15.40|P-value:2.32E-22 ID:SGTC_3354|Compound:9151612|FD-Score:6.44|P-value:2.86E-5

Top fitness defect scores for YEL009C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2758 dehydroepiandrosterone 25.30 69.3 µM 2.91E-57 2 1.67E-141
2 SGTC_1883 5-benzylidenerhodanine 20.90 20.0 µM 9.48E-40 TRP & mitochondrial translation 4 2.07E-97
3 SGTC_2488 5268135 19.00 45.7 µM 3.66E-33 3 7.77E-81
4 SGTC_1882 5615643 18.40 20.0 µM 2.99E-31 TRP & mitochondrial translation 2 5.00E-76
5 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 17.20 63.6 µM 2.22E-27 1 2.70E-66
6 SGTC_54 0159-0055 15.80 9.0 µM 1.57E-23 ERG2 3 1.28E-56
7 SGTC_1636 st007707 15.60 68.9 µM 6.67E-23 3 4.87E-55
8 SGTC_3308 9128332 15.40 17.6 µM 2.32E-22 plasma membrane duress 10 1.11E-53
9 SGTC_180 1486-1293 14.90 102.8 µM 3.62E-21 7 1.11E-50
10 SGTC_2752 diclazuril 14.60 33.1 µM 3.09E-20 11 2.41E-48
11 SGTC_176 1486-1328 14.20 72.8 µM 2.66E-19 4 5.38E-46
12 SGTC_2038 4100038 13.50 31.0 µM 1.46E-17 plasma membrane duress 11 1.25E-41
13 SGTC_51 1013-0126 13.20 23.4 µM 6.34E-17 3 4.95E-40
14 SGTC_1881 5652484 13.20 16.0 µM 6.86E-17 TRP & mitochondrial translation 5 6.05E-40
15 SGTC_2232 chlorophetanol 12.80 41.5 µM 3.89E-16 TRP & mitochondrial translation 7 4.70E-38
16 SGTC_1697 st025554 12.50 27.7 µM 2.80E-15 2 6.61E-36
17 SGTC_278 4092-0821 12.50 23.9 µM 2.84E-15 plasma membrane duress 3 6.84E-36
18 SGTC_1041 0206-0046 12.10 107.0 µM 1.33E-14 4 3.26E-34
19 SGTC_636 0kpi-0074 12.10 126.0 µM 2.00E-14 2 9.15E-34
20 SGTC_823 0417-1665 11.90 178.0 µM 3.54E-14 3 3.79E-33

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.679 0 YDR007W TRP1 hom Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
0.648 0 YDR283C GCN2 hom Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control
0.643 0 YDR008C_d YDR008C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.642 0 YKR026C GCN3 hom Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
0.622 0 YDR354W TRP4 hom Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis
0.610 0 YGL026C TRP5 hom Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis
0.583 1.55E-303 YKL211C TRP3 hom Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
0.558 3.45E-273 YDR035W ARO3 hom 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan
0.551 6.42E-266 YGL117W_p YGL117W_p hom Putative protein of unknown function
0.550 7.73E-264 YER090W TRP2 hom Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p
0.487 6.85E-199 YFR009W GCN20 hom Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA
0.484 1.38E-195 YDR127W ARO1 hom Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids
0.292 8.46E-67 YGL148W ARO2 hom Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress
0.233 1.20E-42 YJL088W ARG3 hom Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine
0.171 2.25E-23 YKL077W_p YKL077W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole