YEL010W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL010W / YEL010W

Click on Significant Values for Screen Details ID:SGTC_370|Compound:0180-0345|FD-Score:4.56|P-value:1.59E-7 ID:SGTC_438|Compound:sphingosine|FD-Score:3.71|P-value:1.52E-5 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:-3.62|P-value:4.11E-5 ID:SGTC_510|Compound:ag-490|FD-Score:3.37|P-value:7.50E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:-2.93|P-value:7.48E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.30|P-value:9.94E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:3.08|P-value:2.56E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-4.86|P-value:5.30E-8 ID:SGTC_620|Compound:0109-0052|FD-Score:3.47|P-value:4.80E-5 ID:SGTC_713|Compound:1488-1073|FD-Score:4.52|P-value:2.07E-7 ID:SGTC_716|Compound:1683-5115|FD-Score:4.33|P-value:6.02E-7 ID:SGTC_720|Compound:r052-1644|FD-Score:3.70|P-value:1.58E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:3.78|P-value:1.08E-5 ID:SGTC_822|Compound:1487-0950|FD-Score:3.52|P-value:3.72E-5 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.03|P-value:3.13E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.53|P-value:3.59E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.22|P-value:2.34E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.11|P-value:2.29E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:3.56|P-value:3.16E-5 ID:SGTC_1402|Compound:3909-7673|FD-Score:4.21|P-value:1.15E-6 ID:SGTC_1637|Compound:st007924|FD-Score:3.93|P-value:5.15E-6 ID:SGTC_1645|Compound:Cervolide|FD-Score:2.79|P-value:8.13E-4 ID:SGTC_1654|Compound:st012436|FD-Score:2.90|P-value:5.39E-4 ID:SGTC_1904|Compound:st060225|FD-Score:-3.15|P-value:3.14E-4 ID:SGTC_1988|Compound:st071872|FD-Score:2.87|P-value:6.08E-4 ID:SGTC_2237|Compound:6667747|FD-Score:3.13|P-value:2.09E-4 ID:SGTC_2253|Compound:7938677|FD-Score:2.98|P-value:3.93E-4 ID:SGTC_2262|Compound:9014885|FD-Score:4.52|P-value:2.02E-7 ID:SGTC_2693|Compound:st077581|FD-Score:3.11|P-value:2.28E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-3.23|P-value:2.29E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.40|P-value:6.46E-5 ID:SGTC_2780|Compound:5215298|FD-Score:3.33|P-value:9.00E-5 ID:SGTC_2886|Compound:9058944|FD-Score:2.80|P-value:7.82E-4 ID:SGTC_2888|Compound:9058547|FD-Score:3.22|P-value:1.45E-4 ID:SGTC_2898|Compound:9056270|FD-Score:4.72|P-value:6.29E-8 ID:SGTC_2990|Compound:9074105|FD-Score:-3.26|P-value:2.02E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.37|P-value:7.35E-5 ID:SGTC_370|Compound:0180-0345|FD-Score:4.56|P-value:1.59E-7 ID:SGTC_438|Compound:sphingosine|FD-Score:3.71|P-value:1.52E-5 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:-3.62|P-value:4.11E-5 ID:SGTC_510|Compound:ag-490|FD-Score:3.37|P-value:7.50E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:-2.93|P-value:7.48E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.30|P-value:9.94E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:3.08|P-value:2.56E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-4.86|P-value:5.30E-8 ID:SGTC_620|Compound:0109-0052|FD-Score:3.47|P-value:4.80E-5 ID:SGTC_713|Compound:1488-1073|FD-Score:4.52|P-value:2.07E-7 ID:SGTC_716|Compound:1683-5115|FD-Score:4.33|P-value:6.02E-7 ID:SGTC_720|Compound:r052-1644|FD-Score:3.70|P-value:1.58E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:3.78|P-value:1.08E-5 ID:SGTC_822|Compound:1487-0950|FD-Score:3.52|P-value:3.72E-5 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.03|P-value:3.13E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.53|P-value:3.59E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.22|P-value:2.34E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.11|P-value:2.29E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:3.56|P-value:3.16E-5 ID:SGTC_1402|Compound:3909-7673|FD-Score:4.21|P-value:1.15E-6 ID:SGTC_1637|Compound:st007924|FD-Score:3.93|P-value:5.15E-6 ID:SGTC_1645|Compound:Cervolide|FD-Score:2.79|P-value:8.13E-4 ID:SGTC_1654|Compound:st012436|FD-Score:2.90|P-value:5.39E-4 ID:SGTC_1904|Compound:st060225|FD-Score:-3.15|P-value:3.14E-4 ID:SGTC_1988|Compound:st071872|FD-Score:2.87|P-value:6.08E-4 ID:SGTC_2237|Compound:6667747|FD-Score:3.13|P-value:2.09E-4 ID:SGTC_2253|Compound:7938677|FD-Score:2.98|P-value:3.93E-4 ID:SGTC_2262|Compound:9014885|FD-Score:4.52|P-value:2.02E-7 ID:SGTC_2693|Compound:st077581|FD-Score:3.11|P-value:2.28E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-3.23|P-value:2.29E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.40|P-value:6.46E-5 ID:SGTC_2780|Compound:5215298|FD-Score:3.33|P-value:9.00E-5 ID:SGTC_2886|Compound:9058944|FD-Score:2.80|P-value:7.82E-4 ID:SGTC_2888|Compound:9058547|FD-Score:3.22|P-value:1.45E-4 ID:SGTC_2898|Compound:9056270|FD-Score:4.72|P-value:6.29E-8 ID:SGTC_2990|Compound:9074105|FD-Score:-3.26|P-value:2.02E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.37|P-value:7.35E-5

Top fitness defect scores for YEL010W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2898 9056270 4.72 58.4 µM 6.29E-8 2 1.19E-6
2 SGTC_370 0180-0345 4.56 38.7 µM 1.59E-7 DNA intercalators 7 2.52E-6
3 SGTC_2262 9014885 4.52 67.5 µM 2.02E-7 2 3.06E-6
4 SGTC_713 1488-1073 4.52 324.0 µM 2.07E-7 ERG2 11 3.12E-6
5 SGTC_716 1683-5115 4.33 658.0 µM 6.02E-7 13 7.44E-6
6 SGTC_1402 3909-7673 4.21 35.9 µM 1.15E-6 18 1.26E-5
7 SGTC_1637 st007924 3.93 17.4 µM 5.15E-6 19 4.27E-5
8 SGTC_813 k007-0158 3.78 173.0 µM 1.08E-5 fatty acid desaturase (OLE1) 47 7.78E-5
9 SGTC_438 sphingosine 3.71 6.7 µM 1.52E-5 29 1.03E-4
10 SGTC_720 r052-1644 3.70 49.9 µM 1.58E-5 TSC3-RPN4 32 1.07E-4
11 SGTC_1398 3558-0053 3.56 112.0 µM 3.16E-5 4 1.87E-4
12 SGTC_1263 0774-1208 3.53 64.8 µM 3.59E-5 64 2.07E-4
13 SGTC_822 1487-0950 3.52 154.0 µM 3.72E-5 27 2.14E-4
14 SGTC_620 0109-0052 3.47 432.0 µM 4.80E-5 32 2.63E-4
15 SGTC_2751 anetholtrithion 3.40 17.2 µM 6.46E-5 42 3.34E-4
16 SGTC_2997 9067075 3.37 71.4 µM 7.35E-5 unfolded protein response 77 3.72E-4
17 SGTC_510 ag-490 3.37 170.0 µM 7.50E-5 7 3.78E-4
18 SGTC_2780 5215298 3.33 71.4 µM 9.00E-5 65 4.38E-4
19 SGTC_553 k007-0256 3.30 45.7 µM 9.94E-5 heme biosynthesis & mitochondrial translocase 46 4.75E-4
20 SGTC_2888 9058547 3.22 13.0 µM 1.45E-4 24 6.45E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.150 1.86E-18 YDR294C DPL1 hom Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
0.142 1.38E-16 YDR134C YDR134C hom Hypothetical protein; YDR134C has a paralog, CCW12, that arose from the whole genome duplication
0.127 1.34E-13 YOR062C_p YOR062C_p hom Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.116 1.87E-11 YDR119W_p VBA4_p hom Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene
0.109 2.09E-10 YOR093C_p YOR093C_p hom Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents
0.107 5.20E-10 YGL263W COS12 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.103 2.37E-9 YGL109W_d YGL109W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C
0.097 2.09E-8 YOR293C-A_p YOR293C-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.092 1.07E-7 YDL131W LYS21 hom Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication
0.089 2.68E-7 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.088 3.15E-7 YFR029W PTR3 het Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
0.087 4.93E-7 YMR048W CSM3 hom Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress
0.086 5.95E-7 YDL171C GLT1 hom NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source
0.086 6.96E-7 YPL175W SPT14 het UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins
0.085 8.75E-7 YPL184C MRN1 hom RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation