YEL013W / VAC8

Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL013W / VAC8

Click on Significant Values for Screen Details ID:SGTC_125|Compound:0133-0007|FD-Score:3.48|P-value:1.15E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.44|P-value:1.33E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-3.45|P-value:1.34E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.64|P-value:6.09E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:-4.04|P-value:9.72E-6 ID:SGTC_483|Compound:fpl-64176|FD-Score:2.93|P-value:9.39E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.09|P-value:5.33E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:5.78|P-value:4.56E-10 ID:SGTC_580|Compound:1123-0028|FD-Score:3.34|P-value:1.98E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.08|P-value:5.55E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:3.10|P-value:5.07E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.89|P-value:1.87E-5 ID:SGTC_612|Compound:0302-0167|FD-Score:3.52|P-value:9.47E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:3.45|P-value:1.29E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.98|P-value:1.23E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:5.40|P-value:5.37E-9 ID:SGTC_1063|Compound:disulfiram|FD-Score:5.20|P-value:1.78E-8 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.40|P-value:1.57E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.64|P-value:5.71E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:4.27|P-value:2.99E-6 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.62|P-value:6.13E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.51|P-value:9.73E-5 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.63|P-value:6.03E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:2.98|P-value:7.87E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:4.22|P-value:3.81E-6 ID:SGTC_1362|Compound:1611-0397|FD-Score:4.22|P-value:3.92E-6 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.02|P-value:6.79E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.10|P-value:5.05E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.38|P-value:1.72E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:5.54|P-value:2.15E-9 ID:SGTC_1776|Compound:st049249|FD-Score:6.77|P-value:3.63E-13 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.01|P-value:7.16E-4 ID:SGTC_1945|Compound:st075991|FD-Score:-3.41|P-value:1.60E-4 ID:SGTC_1947|Compound:st076332|FD-Score:3.06|P-value:5.98E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.25|P-value:2.82E-4 ID:SGTC_1983|Compound:st071813|FD-Score:3.72|P-value:3.98E-5 ID:SGTC_2020|Compound:4017018|FD-Score:4.36|P-value:1.87E-6 ID:SGTC_2033|Compound:5192550|FD-Score:3.76|P-value:3.35E-5 ID:SGTC_2282|Compound:7944268|FD-Score:3.70|P-value:4.42E-5 ID:SGTC_2331|Compound:7980721|FD-Score:5.89|P-value:2.14E-10 ID:SGTC_2334|Compound:9017922|FD-Score:-3.50|P-value:1.09E-4 ID:SGTC_2338|Compound:7999974|FD-Score:-4.01|P-value:1.14E-5 ID:SGTC_2381|Compound:9035592|FD-Score:4.54|P-value:7.55E-7 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.05|P-value:6.10E-4 ID:SGTC_2430|Compound:5571206|FD-Score:4.48|P-value:1.03E-6 ID:SGTC_2526|Compound:patulin|FD-Score:3.20|P-value:3.46E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.13|P-value:5.88E-6 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:-3.24|P-value:3.08E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.07|P-value:5.82E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:7.87|P-value:3.85E-17 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-6.28|P-value:1.54E-11 ID:SGTC_2958|Compound:9077254|FD-Score:8.75|P-value:9.86E-21 ID:SGTC_3007|Compound:9078383|FD-Score:3.02|P-value:6.91E-4 ID:SGTC_3085|Compound:9117376|FD-Score:3.71|P-value:4.20E-5 ID:SGTC_3104|Compound:9120930|FD-Score:3.22|P-value:3.16E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.93|P-value:1.55E-5 ID:SGTC_3194|Compound:9111903|FD-Score:-3.85|P-value:2.40E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-3.53|P-value:9.63E-5 ID:SGTC_125|Compound:0133-0007|FD-Score:3.48|P-value:1.15E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.44|P-value:1.33E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-3.45|P-value:1.34E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.64|P-value:6.09E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:-4.04|P-value:9.72E-6 ID:SGTC_483|Compound:fpl-64176|FD-Score:2.93|P-value:9.39E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.09|P-value:5.33E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:5.78|P-value:4.56E-10 ID:SGTC_580|Compound:1123-0028|FD-Score:3.34|P-value:1.98E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.08|P-value:5.55E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:3.10|P-value:5.07E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.89|P-value:1.87E-5 ID:SGTC_612|Compound:0302-0167|FD-Score:3.52|P-value:9.47E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:3.45|P-value:1.29E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.98|P-value:1.23E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:5.40|P-value:5.37E-9 ID:SGTC_1063|Compound:disulfiram|FD-Score:5.20|P-value:1.78E-8 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.40|P-value:1.57E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.64|P-value:5.71E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:4.27|P-value:2.99E-6 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.62|P-value:6.13E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.51|P-value:9.73E-5 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.63|P-value:6.03E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:2.98|P-value:7.87E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:4.22|P-value:3.81E-6 ID:SGTC_1362|Compound:1611-0397|FD-Score:4.22|P-value:3.92E-6 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.02|P-value:6.79E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.10|P-value:5.05E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.38|P-value:1.72E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:5.54|P-value:2.15E-9 ID:SGTC_1776|Compound:st049249|FD-Score:6.77|P-value:3.63E-13 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.01|P-value:7.16E-4 ID:SGTC_1945|Compound:st075991|FD-Score:-3.41|P-value:1.60E-4 ID:SGTC_1947|Compound:st076332|FD-Score:3.06|P-value:5.98E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.25|P-value:2.82E-4 ID:SGTC_1983|Compound:st071813|FD-Score:3.72|P-value:3.98E-5 ID:SGTC_2020|Compound:4017018|FD-Score:4.36|P-value:1.87E-6 ID:SGTC_2033|Compound:5192550|FD-Score:3.76|P-value:3.35E-5 ID:SGTC_2282|Compound:7944268|FD-Score:3.70|P-value:4.42E-5 ID:SGTC_2331|Compound:7980721|FD-Score:5.89|P-value:2.14E-10 ID:SGTC_2334|Compound:9017922|FD-Score:-3.50|P-value:1.09E-4 ID:SGTC_2338|Compound:7999974|FD-Score:-4.01|P-value:1.14E-5 ID:SGTC_2381|Compound:9035592|FD-Score:4.54|P-value:7.55E-7 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.05|P-value:6.10E-4 ID:SGTC_2430|Compound:5571206|FD-Score:4.48|P-value:1.03E-6 ID:SGTC_2526|Compound:patulin|FD-Score:3.20|P-value:3.46E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.13|P-value:5.88E-6 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:-3.24|P-value:3.08E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.07|P-value:5.82E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:7.87|P-value:3.85E-17 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-6.28|P-value:1.54E-11 ID:SGTC_2958|Compound:9077254|FD-Score:8.75|P-value:9.86E-21 ID:SGTC_3007|Compound:9078383|FD-Score:3.02|P-value:6.91E-4 ID:SGTC_3085|Compound:9117376|FD-Score:3.71|P-value:4.20E-5 ID:SGTC_3104|Compound:9120930|FD-Score:3.22|P-value:3.16E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.93|P-value:1.55E-5 ID:SGTC_3194|Compound:9111903|FD-Score:-3.85|P-value:2.40E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-3.53|P-value:9.63E-5

Top fitness defect scores for YEL013W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2958 9077254 8.75 16.7 µM 9.86E-21 1 1.11E-18
2 SGTC_2594 a-mangostin 7.87 100.0 µM 3.85E-17 3 1.79E-15
3 SGTC_1776 st049249 6.77 45.9 µM 3.63E-13 1 6.35E-12
4 SGTC_2331 7980721 5.89 200.0 µM 2.14E-10 2 1.90E-9
5 SGTC_577 r071-0003 5.78 38.6 µM 4.56E-10 fatty acid desaturase (OLE1) 19 3.74E-9
6 SGTC_1538 2',3',6-trimethoxyflavanone 5.54 63.6 µM 2.15E-9 1 1.49E-8
7 SGTC_991 3996-0057 5.40 64.7 µM 5.37E-9 3 3.39E-8
8 SGTC_1063 disulfiram 5.20 1.8 µM 1.78E-8 6 9.93E-8
9 SGTC_2381 9035592 4.54 200.0 µM 7.55E-7 7 2.83E-6
10 SGTC_2430 5571206 4.48 200.0 µM 1.03E-6 42 3.74E-6
11 SGTC_2020 4017018 4.36 200.0 µM 1.87E-6 11 6.40E-6
12 SGTC_1106 tegaserod maleate 4.27 11.7 µM 2.99E-6 12 9.72E-6
13 SGTC_1328 1441-0025 4.22 69.2 µM 3.81E-6 4 1.21E-5
14 SGTC_1362 1611-0397 4.22 101.0 µM 3.92E-6 15 1.24E-5
15 SGTC_2540 epiandrosterone 4.13 100.0 µM 5.88E-6 50 1.78E-5
16 SGTC_834 0312-0008 3.98 75.7 µM 1.23E-5 NEO1 35 3.45E-5
17 SGTC_3188 9110789 3.93 49.5 µM 1.55E-5 iron homeostasis 23 4.25E-5
18 SGTC_604 1000-0114 3.89 314.0 µM 1.87E-5 22 5.03E-5
19 SGTC_2033 5192550 3.76 145.0 µM 3.35E-5 18 8.47E-5
20 SGTC_1983 st071813 3.72 46.9 µM 3.98E-5 RPP1 & pyrimidine depletion 27 9.89E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.100 6.49E-9 YGL234W ADE5,7 hom Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities
0.100 7.52E-9 YDR246W-A_p YDR246W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.096 2.27E-8 YLR176C RFX1 hom Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins
0.083 1.31E-6 YOL022C TSR4 het Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2
0.081 2.34E-6 YGR291C_d YGR291C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.081 2.77E-6 YMR303C ADH2 hom Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1
0.080 3.79E-6 YNL261W ORC5 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
0.077 7.08E-6 YDR214W AHA1 hom Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress
0.077 7.23E-6 YAL025C MAK16 het Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus
0.076 9.64E-6 YKR003W OSH6 hom Member of an oxysterol-binding protein family; overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion
0.074 1.99E-5 YCR010C ADY2 hom Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication
0.073 2.09E-5 YKL134C OCT1 hom Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis
0.071 3.51E-5 YJL199C_d MBB1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies
0.070 5.27E-5 YPL231W FAS2 het Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities
0.069 5.81E-5 YDR144C MKC7 hom GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p