YEL014C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL014C / YEL014C

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-2.81|P-value:9.85E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:-3.41|P-value:8.82E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:2.93|P-value:6.10E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.33|P-value:1.20E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.00|P-value:4.57E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:2.94|P-value:5.79E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.51|P-value:5.60E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:5.02|P-value:1.57E-8 ID:SGTC_314|Compound:1671-0008|FD-Score:4.53|P-value:2.85E-7 ID:SGTC_321|Compound:4534-3890|FD-Score:3.35|P-value:1.11E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:2.86|P-value:8.05E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:2.84|P-value:8.44E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:-2.93|P-value:6.34E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.43|P-value:5.15E-7 ID:SGTC_743|Compound:1275-0778|FD-Score:2.96|P-value:5.41E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:3.96|P-value:6.28E-6 ID:SGTC_856|Compound:0433-0016|FD-Score:3.66|P-value:2.68E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:3.60|P-value:3.47E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:4.22|P-value:1.62E-6 ID:SGTC_956|Compound:1185-0240|FD-Score:3.15|P-value:2.56E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.28|P-value:1.46E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:2.85|P-value:8.28E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:4.00|P-value:5.16E-6 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.42|P-value:7.88E-5 ID:SGTC_1070|Compound:indatraline|FD-Score:-2.86|P-value:8.32E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:2.87|P-value:7.54E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:-3.13|P-value:2.84E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:2.84|P-value:8.71E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:2.90|P-value:6.91E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.60|P-value:3.48E-5 ID:SGTC_1473|Compound:k844-0725|FD-Score:-3.56|P-value:4.55E-5 ID:SGTC_1531|Compound:st059297|FD-Score:3.05|P-value:3.84E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.23|P-value:1.79E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-2.87|P-value:7.89E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:3.73|P-value:1.96E-5 ID:SGTC_1731|Compound:st035964|FD-Score:2.97|P-value:5.18E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.01|P-value:4.53E-4 ID:SGTC_1914|Compound:st062367|FD-Score:-3.13|P-value:2.89E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.82|P-value:1.23E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.81|P-value:1.40E-5 ID:SGTC_2255|Compound:7941087|FD-Score:-2.99|P-value:4.95E-4 ID:SGTC_2444|Compound:5485484|FD-Score:4.29|P-value:1.12E-6 ID:SGTC_2452|Compound:5863136|FD-Score:3.58|P-value:3.83E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.06|P-value:3.84E-4 ID:SGTC_2700|Compound:st077718|FD-Score:3.72|P-value:2.04E-5 ID:SGTC_2708|Compound:st078559|FD-Score:3.03|P-value:4.14E-4 ID:SGTC_2822|Compound:7994718|FD-Score:-3.03|P-value:4.23E-4 ID:SGTC_2832|Compound:7992762|FD-Score:2.90|P-value:6.76E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-2.81|P-value:9.85E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:-3.41|P-value:8.82E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:2.93|P-value:6.10E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.33|P-value:1.20E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.00|P-value:4.57E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:2.94|P-value:5.79E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.51|P-value:5.60E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:5.02|P-value:1.57E-8 ID:SGTC_314|Compound:1671-0008|FD-Score:4.53|P-value:2.85E-7 ID:SGTC_321|Compound:4534-3890|FD-Score:3.35|P-value:1.11E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:2.86|P-value:8.05E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:2.84|P-value:8.44E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:-2.93|P-value:6.34E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.43|P-value:5.15E-7 ID:SGTC_743|Compound:1275-0778|FD-Score:2.96|P-value:5.41E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:3.96|P-value:6.28E-6 ID:SGTC_856|Compound:0433-0016|FD-Score:3.66|P-value:2.68E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:3.60|P-value:3.47E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:4.22|P-value:1.62E-6 ID:SGTC_956|Compound:1185-0240|FD-Score:3.15|P-value:2.56E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.28|P-value:1.46E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:2.85|P-value:8.28E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:4.00|P-value:5.16E-6 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.42|P-value:7.88E-5 ID:SGTC_1070|Compound:indatraline|FD-Score:-2.86|P-value:8.32E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:2.87|P-value:7.54E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:-3.13|P-value:2.84E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:2.84|P-value:8.71E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:2.90|P-value:6.91E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.60|P-value:3.48E-5 ID:SGTC_1473|Compound:k844-0725|FD-Score:-3.56|P-value:4.55E-5 ID:SGTC_1531|Compound:st059297|FD-Score:3.05|P-value:3.84E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.23|P-value:1.79E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-2.87|P-value:7.89E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:3.73|P-value:1.96E-5 ID:SGTC_1731|Compound:st035964|FD-Score:2.97|P-value:5.18E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.01|P-value:4.53E-4 ID:SGTC_1914|Compound:st062367|FD-Score:-3.13|P-value:2.89E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.82|P-value:1.23E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.81|P-value:1.40E-5 ID:SGTC_2255|Compound:7941087|FD-Score:-2.99|P-value:4.95E-4 ID:SGTC_2444|Compound:5485484|FD-Score:4.29|P-value:1.12E-6 ID:SGTC_2452|Compound:5863136|FD-Score:3.58|P-value:3.83E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.06|P-value:3.84E-4 ID:SGTC_2700|Compound:st077718|FD-Score:3.72|P-value:2.04E-5 ID:SGTC_2708|Compound:st078559|FD-Score:3.03|P-value:4.14E-4 ID:SGTC_2822|Compound:7994718|FD-Score:-3.03|P-value:4.23E-4 ID:SGTC_2832|Compound:7992762|FD-Score:2.90|P-value:6.76E-4

Top fitness defect scores for YEL014C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_169 k015-0017 5.02 16.0 µM 1.57E-8 9 2.64E-7
2 SGTC_314 1671-0008 4.53 2.7 µM 2.85E-7 32 2.91E-6
3 SGTC_682 0kpi-0099 4.43 17.0 µM 5.15E-7 54 4.75E-6
4 SGTC_2444 5485484 4.29 36.4 µM 1.12E-6 27 9.06E-6
5 SGTC_953 1188-0045 4.22 9.7 µM 1.62E-6 60S ribosome export 22 1.23E-5
6 SGTC_1021 4476-0760 4.00 85.3 µM 5.16E-6 22 3.21E-5
7 SGTC_748 0136-0228 3.96 77.9 µM 6.28E-6 redox potentiating 76 3.78E-5
8 SGTC_1994 st072947 3.82 40.9 µM 1.23E-5 22 6.59E-5
9 SGTC_1561 5-methoxyflavone 3.73 52.9 µM 1.96E-5 9 9.73E-5
10 SGTC_2700 st077718 3.72 96.8 µM 2.04E-5 18 1.01E-4
11 SGTC_856 0433-0016 3.66 11.3 µM 2.68E-5 19 1.26E-4
12 SGTC_893 0958-0369 3.60 48.9 µM 3.47E-5 34 1.56E-4
13 SGTC_1367 1812-0510 3.60 76.9 µM 3.48E-5 33 1.57E-4
14 SGTC_2452 5863136 3.58 48.4 µM 3.83E-5 36 1.70E-4
15 SGTC_1062 mesoridazine 3.42 14.2 µM 7.88E-5 32 3.09E-4
16 SGTC_321 4534-3890 3.35 65.3 µM 1.11E-4 RPP1 & pyrimidine depletion 13 4.10E-4
17 SGTC_65 0798-0905 3.33 35.0 µM 1.20E-4 calcium & mitochondrial duress 128 4.38E-4
18 SGTC_958 1222-0007 3.28 33.0 µM 1.46E-4 54 5.17E-4
19 SGTC_1542 7-hydroxy-3'-methoxyflavone 3.23 49.7 µM 1.79E-4 41 6.12E-4
20 SGTC_956 1185-0240 3.15 191.0 µM 2.56E-4 52 8.24E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.182 2.07E-26 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.116 1.57E-11 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.103 2.17E-9 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.102 3.95E-9 YNR035C ARC35 het Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin
0.101 4.20E-9 YKL041W VPS24 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway
0.098 1.45E-8 YBR249C ARO4 hom 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress
0.097 1.90E-8 YOR058C ASE1 hom Mitotic spindle midzone localized protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress
0.090 1.68E-7 YKL013C ARC19 het Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
0.087 4.11E-7 YJL203W PRP21 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly
0.087 4.20E-7 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.087 4.37E-7 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.084 1.17E-6 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.083 1.32E-6 YPR002W PDH1 hom Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate
0.082 2.21E-6 YDR510W SMT3 het Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2
0.078 6.49E-6 YEL017W GTT3 hom Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery