YEL017C-A / PMP2

Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL017C-A / PMP2

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:5.34|P-value:2.59E-7 ID:SGTC_17|Compound:0960-0276|FD-Score:5.94|P-value:1.15E-8 ID:SGTC_78|Compound:0336-0123|FD-Score:3.31|P-value:9.29E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:4.18|P-value:4.26E-5 ID:SGTC_125|Compound:0133-0007|FD-Score:3.88|P-value:1.33E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:4.77|P-value:3.74E-6 ID:SGTC_127|Compound:0180-0333|FD-Score:-3.34|P-value:8.09E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:3.92|P-value:1.16E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:4.26|P-value:3.06E-5 ID:SGTC_144|Compound:4161-2749|FD-Score:4.54|P-value:9.78E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:7.45|P-value:1.18E-12 ID:SGTC_146|Compound:3448-8650|FD-Score:5.31|P-value:3.04E-7 ID:SGTC_181|Compound:1447-1644|FD-Score:3.61|P-value:3.50E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.29|P-value:9.97E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:3.42|P-value:6.50E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:-4.22|P-value:3.48E-5 ID:SGTC_425|Compound:3825-7017|FD-Score:5.73|P-value:3.64E-8 ID:SGTC_427|Compound:1354-0053|FD-Score:4.22|P-value:3.64E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:5.01|P-value:1.23E-6 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.46|P-value:5.50E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-5.13|P-value:6.61E-7 ID:SGTC_1114|Compound:scopoletin|FD-Score:3.48|P-value:5.33E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.76|P-value:2.03E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:5.03|P-value:1.12E-6 ID:SGTC_1526|Compound:st051518|FD-Score:3.66|P-value:2.96E-4 ID:SGTC_1651|Compound:st011928|FD-Score:3.33|P-value:8.66E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.32|P-value:9.06E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.60|P-value:3.65E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.33|P-value:8.88E-4 ID:SGTC_1973|Compound:st070275|FD-Score:3.68|P-value:2.70E-4 ID:SGTC_2025|Compound:5147754|FD-Score:-3.98|P-value:8.82E-5 ID:SGTC_2027|Compound:5150920|FD-Score:-3.46|P-value:5.58E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-3.30|P-value:9.41E-4 ID:SGTC_2036|Compound:5160441|FD-Score:4.00|P-value:8.62E-5 ID:SGTC_2079|Compound:5212404|FD-Score:3.64|P-value:3.15E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.54|P-value:4.37E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-3.42|P-value:6.27E-4 ID:SGTC_2371|Compound:9071574|FD-Score:4.21|P-value:3.84E-5 ID:SGTC_2376|Compound:9072922|FD-Score:4.17|P-value:4.36E-5 ID:SGTC_2378|Compound:9074213|FD-Score:3.97|P-value:9.48E-5 ID:SGTC_2379|Compound:9035213|FD-Score:3.96|P-value:1.01E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.53|P-value:4.35E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.35|P-value:8.03E-4 ID:SGTC_2411|Compound:st077133|FD-Score:4.88|P-value:2.25E-6 ID:SGTC_2444|Compound:5485484|FD-Score:-3.45|P-value:5.66E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.34|P-value:8.08E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.48|P-value:5.35E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.70|P-value:2.51E-4 ID:SGTC_2805|Compound:7950783|FD-Score:-3.54|P-value:4.18E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:5.34|P-value:2.59E-7 ID:SGTC_17|Compound:0960-0276|FD-Score:5.94|P-value:1.15E-8 ID:SGTC_78|Compound:0336-0123|FD-Score:3.31|P-value:9.29E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:4.18|P-value:4.26E-5 ID:SGTC_125|Compound:0133-0007|FD-Score:3.88|P-value:1.33E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:4.77|P-value:3.74E-6 ID:SGTC_127|Compound:0180-0333|FD-Score:-3.34|P-value:8.09E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:3.92|P-value:1.16E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:4.26|P-value:3.06E-5 ID:SGTC_144|Compound:4161-2749|FD-Score:4.54|P-value:9.78E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:7.45|P-value:1.18E-12 ID:SGTC_146|Compound:3448-8650|FD-Score:5.31|P-value:3.04E-7 ID:SGTC_181|Compound:1447-1644|FD-Score:3.61|P-value:3.50E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.29|P-value:9.97E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:3.42|P-value:6.50E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:-4.22|P-value:3.48E-5 ID:SGTC_425|Compound:3825-7017|FD-Score:5.73|P-value:3.64E-8 ID:SGTC_427|Compound:1354-0053|FD-Score:4.22|P-value:3.64E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:5.01|P-value:1.23E-6 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.46|P-value:5.50E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-5.13|P-value:6.61E-7 ID:SGTC_1114|Compound:scopoletin|FD-Score:3.48|P-value:5.33E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.76|P-value:2.03E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:5.03|P-value:1.12E-6 ID:SGTC_1526|Compound:st051518|FD-Score:3.66|P-value:2.96E-4 ID:SGTC_1651|Compound:st011928|FD-Score:3.33|P-value:8.66E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.32|P-value:9.06E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.60|P-value:3.65E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.33|P-value:8.88E-4 ID:SGTC_1973|Compound:st070275|FD-Score:3.68|P-value:2.70E-4 ID:SGTC_2025|Compound:5147754|FD-Score:-3.98|P-value:8.82E-5 ID:SGTC_2027|Compound:5150920|FD-Score:-3.46|P-value:5.58E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-3.30|P-value:9.41E-4 ID:SGTC_2036|Compound:5160441|FD-Score:4.00|P-value:8.62E-5 ID:SGTC_2079|Compound:5212404|FD-Score:3.64|P-value:3.15E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.54|P-value:4.37E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-3.42|P-value:6.27E-4 ID:SGTC_2371|Compound:9071574|FD-Score:4.21|P-value:3.84E-5 ID:SGTC_2376|Compound:9072922|FD-Score:4.17|P-value:4.36E-5 ID:SGTC_2378|Compound:9074213|FD-Score:3.97|P-value:9.48E-5 ID:SGTC_2379|Compound:9035213|FD-Score:3.96|P-value:1.01E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.53|P-value:4.35E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.35|P-value:8.03E-4 ID:SGTC_2411|Compound:st077133|FD-Score:4.88|P-value:2.25E-6 ID:SGTC_2444|Compound:5485484|FD-Score:-3.45|P-value:5.66E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.34|P-value:8.08E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.48|P-value:5.35E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.70|P-value:2.51E-4 ID:SGTC_2805|Compound:7950783|FD-Score:-3.54|P-value:4.18E-4

Top fitness defect scores for YEL017C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_145 3737-0113 7.45 38.4 µM 1.18E-12 DNA intercalators 12 4.51E-14
2 SGTC_17 0960-0276 5.94 49.8 µM 1.15E-8 5 1.40E-9
3 SGTC_425 3825-7017 5.73 13.1 µM 3.64E-8 7 5.14E-9
4 SGTC_9 0092-0002 5.34 10.4 µM 2.59E-7 9 4.67E-8
5 SGTC_146 3448-8650 5.31 53.1 µM 3.04E-7 NEO1-PIK1 67 5.60E-8
6 SGTC_1493 4348-0038 5.03 111.0 µM 1.12E-6 RSC complex & mRNA processing 7 2.43E-7
7 SGTC_431 k089-0097 5.01 107.0 µM 1.23E-6 iron homeostasis 12 2.71E-7
8 SGTC_2411 st077133 4.88 39.9 µM 2.25E-6 RNA pol III & RNase P/MRP 14 5.33E-7
9 SGTC_126 0417-1624 4.77 672.5 µM 3.74E-6 DNA intercalators 12 9.44E-7
10 SGTC_144 4161-2749 4.54 112.4 µM 9.78E-6 DNA intercalators 18 2.78E-6
11 SGTC_143 4032-1194 4.26 15.7 µM 3.06E-5 52 1.00E-5
12 SGTC_427 1354-0053 4.22 47.3 µM 3.64E-5 14 1.22E-5
13 SGTC_2371 9071574 4.21 200.0 µM 3.84E-5 10 1.29E-5
14 SGTC_115 0527-0192 4.18 112.0 µM 4.26E-5 58 1.45E-5
15 SGTC_2376 9072922 4.17 81.3 µM 4.36E-5 20 1.49E-5
16 SGTC_2036 5160441 4.00 105.0 µM 8.62E-5 NEO1 77 3.21E-5
17 SGTC_2378 9074213 3.97 121.4 µM 9.48E-5 RSC complex & mRNA processing 19 3.57E-5
18 SGTC_2379 9035213 3.96 200.0 µM 1.01E-4 20 3.82E-5
19 SGTC_131 0141-0277 3.92 33.9 µM 1.16E-4 41 4.48E-5
20 SGTC_125 0133-0007 3.88 11.8 µM 1.33E-4 DNA intercalators 9 5.21E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.319 4.12E-80 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.252 1.89E-49 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.219 1.08E-37 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.211 6.87E-35 YMR030W RSF1 hom Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes
0.203 1.71E-32 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.198 8.74E-31 YKR064W OAF3 hom Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress
0.197 1.05E-30 YHR020W YHR020W het Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments
0.190 1.84E-28 YFL022C FRS2 het Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
0.186 1.72E-27 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.180 9.20E-26 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.177 7.24E-25 YKR079C TRZ1 het tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2
0.169 6.35E-23 YPR059C_d YPR059C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W
0.166 4.52E-22 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.158 4.10E-20 YBR182C-A_p YBR182C-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.157 5.29E-20 YBL008W-A_p YBL008W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR