YEL017W / GTT3

Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL017W / GTT3

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:3.41|P-value:1.20E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.56|P-value:6.20E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.25|P-value:2.40E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-2.94|P-value:7.97E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:3.97|P-value:9.63E-6 ID:SGTC_254|Compound:nsc-64875|FD-Score:-4.45|P-value:8.47E-7 ID:SGTC_270|Compound:tamoxifen|FD-Score:4.57|P-value:4.42E-7 ID:SGTC_618|Compound:k072-0232|FD-Score:3.52|P-value:7.45E-5 ID:SGTC_747|Compound:3448-8087|FD-Score:3.90|P-value:1.37E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:3.78|P-value:2.35E-5 ID:SGTC_860|Compound:0443-0016|FD-Score:2.90|P-value:9.05E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.32|P-value:1.79E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:3.23|P-value:2.52E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:6.17|P-value:1.52E-11 ID:SGTC_882|Compound:0843-0131|FD-Score:6.36|P-value:3.94E-12 ID:SGTC_883|Compound:0850-0245|FD-Score:5.11|P-value:1.88E-8 ID:SGTC_912|Compound:3474-0017|FD-Score:3.10|P-value:4.16E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-2.94|P-value:7.79E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:4.19|P-value:3.27E-6 ID:SGTC_928|Compound:2764-0428|FD-Score:4.66|P-value:2.60E-7 ID:SGTC_929|Compound:2805-0021|FD-Score:-3.43|P-value:1.13E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.37|P-value:1.43E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:-4.75|P-value:1.61E-7 ID:SGTC_979|Compound:1426-2828|FD-Score:3.03|P-value:5.55E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:-3.04|P-value:5.49E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:-3.53|P-value:7.44E-5 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.77|P-value:2.47E-5 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.27|P-value:2.17E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:-3.74|P-value:2.86E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.94|P-value:1.14E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.07|P-value:4.75E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:-3.41|P-value:1.23E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.84|P-value:1.75E-5 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.70|P-value:3.34E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.58|P-value:5.73E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.32|P-value:1.68E-6 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.85|P-value:1.70E-5 ID:SGTC_1403|Compound:3909-7815|FD-Score:5.34|P-value:4.48E-9 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:3.00|P-value:6.27E-4 ID:SGTC_1571|Compound:st070080|FD-Score:2.90|P-value:9.10E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.98|P-value:9.29E-6 ID:SGTC_1702|Compound:st027038|FD-Score:3.97|P-value:9.62E-6 ID:SGTC_1739|Compound:st037196|FD-Score:3.30|P-value:1.90E-4 ID:SGTC_1979|Compound:st071809|FD-Score:3.12|P-value:3.91E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.44|P-value:1.06E-4 ID:SGTC_2099|Compound:5377090|FD-Score:-3.20|P-value:2.92E-4 ID:SGTC_2225|Compound:6654152|FD-Score:3.27|P-value:2.15E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.18|P-value:3.04E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-3.62|P-value:5.08E-5 ID:SGTC_2444|Compound:5485484|FD-Score:6.16|P-value:1.64E-11 ID:SGTC_2445|Compound:5742597|FD-Score:3.52|P-value:7.65E-5 ID:SGTC_2453|Compound:5731132|FD-Score:4.31|P-value:1.79E-6 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:6.23|P-value:9.89E-12 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:5.16|P-value:1.44E-8 ID:SGTC_2949|Compound:9072542|FD-Score:3.21|P-value:2.71E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.62|P-value:4.97E-5 ID:SGTC_3030|Compound:9087619|FD-Score:3.77|P-value:2.43E-5 ID:SGTC_3045|Compound:9092950|FD-Score:-3.59|P-value:5.68E-5 ID:SGTC_3093|Compound:9117344|FD-Score:3.00|P-value:6.13E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-4.13|P-value:4.48E-6 ID:SGTC_3290|Compound:9121031|FD-Score:-3.64|P-value:4.52E-5 ID:SGTC_3296|Compound:9122258|FD-Score:-4.89|P-value:7.29E-8 ID:SGTC_3301|Compound:9125354|FD-Score:3.79|P-value:2.21E-5 ID:SGTC_3315|Compound:9136395|FD-Score:3.60|P-value:5.30E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:3.41|P-value:1.20E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.56|P-value:6.20E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.25|P-value:2.40E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-2.94|P-value:7.97E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:3.97|P-value:9.63E-6 ID:SGTC_254|Compound:nsc-64875|FD-Score:-4.45|P-value:8.47E-7 ID:SGTC_270|Compound:tamoxifen|FD-Score:4.57|P-value:4.42E-7 ID:SGTC_618|Compound:k072-0232|FD-Score:3.52|P-value:7.45E-5 ID:SGTC_747|Compound:3448-8087|FD-Score:3.90|P-value:1.37E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:3.78|P-value:2.35E-5 ID:SGTC_860|Compound:0443-0016|FD-Score:2.90|P-value:9.05E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.32|P-value:1.79E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:3.23|P-value:2.52E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:6.17|P-value:1.52E-11 ID:SGTC_882|Compound:0843-0131|FD-Score:6.36|P-value:3.94E-12 ID:SGTC_883|Compound:0850-0245|FD-Score:5.11|P-value:1.88E-8 ID:SGTC_912|Compound:3474-0017|FD-Score:3.10|P-value:4.16E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-2.94|P-value:7.79E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:4.19|P-value:3.27E-6 ID:SGTC_928|Compound:2764-0428|FD-Score:4.66|P-value:2.60E-7 ID:SGTC_929|Compound:2805-0021|FD-Score:-3.43|P-value:1.13E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.37|P-value:1.43E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:-4.75|P-value:1.61E-7 ID:SGTC_979|Compound:1426-2828|FD-Score:3.03|P-value:5.55E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:-3.04|P-value:5.49E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:-3.53|P-value:7.44E-5 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.77|P-value:2.47E-5 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.27|P-value:2.17E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:-3.74|P-value:2.86E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.94|P-value:1.14E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.07|P-value:4.75E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:-3.41|P-value:1.23E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.84|P-value:1.75E-5 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.70|P-value:3.34E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.58|P-value:5.73E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.32|P-value:1.68E-6 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.85|P-value:1.70E-5 ID:SGTC_1403|Compound:3909-7815|FD-Score:5.34|P-value:4.48E-9 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:3.00|P-value:6.27E-4 ID:SGTC_1571|Compound:st070080|FD-Score:2.90|P-value:9.10E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.98|P-value:9.29E-6 ID:SGTC_1702|Compound:st027038|FD-Score:3.97|P-value:9.62E-6 ID:SGTC_1739|Compound:st037196|FD-Score:3.30|P-value:1.90E-4 ID:SGTC_1979|Compound:st071809|FD-Score:3.12|P-value:3.91E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.44|P-value:1.06E-4 ID:SGTC_2099|Compound:5377090|FD-Score:-3.20|P-value:2.92E-4 ID:SGTC_2225|Compound:6654152|FD-Score:3.27|P-value:2.15E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.18|P-value:3.04E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-3.62|P-value:5.08E-5 ID:SGTC_2444|Compound:5485484|FD-Score:6.16|P-value:1.64E-11 ID:SGTC_2445|Compound:5742597|FD-Score:3.52|P-value:7.65E-5 ID:SGTC_2453|Compound:5731132|FD-Score:4.31|P-value:1.79E-6 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:6.23|P-value:9.89E-12 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:5.16|P-value:1.44E-8 ID:SGTC_2949|Compound:9072542|FD-Score:3.21|P-value:2.71E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.62|P-value:4.97E-5 ID:SGTC_3030|Compound:9087619|FD-Score:3.77|P-value:2.43E-5 ID:SGTC_3045|Compound:9092950|FD-Score:-3.59|P-value:5.68E-5 ID:SGTC_3093|Compound:9117344|FD-Score:3.00|P-value:6.13E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-4.13|P-value:4.48E-6 ID:SGTC_3290|Compound:9121031|FD-Score:-3.64|P-value:4.52E-5 ID:SGTC_3296|Compound:9122258|FD-Score:-4.89|P-value:7.29E-8 ID:SGTC_3301|Compound:9125354|FD-Score:3.79|P-value:2.21E-5 ID:SGTC_3315|Compound:9136395|FD-Score:3.60|P-value:5.30E-5

Top fitness defect scores for YEL017W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_882 0843-0131 6.36 351.0 µM 3.94E-12 4 1.03E-10
2 SGTC_2633 5,7-dihydroxyisoflavone 6.23 100.0 µM 9.89E-12 6 2.29E-10
3 SGTC_881 0833-0569 6.17 170.0 µM 1.52E-11 1 3.32E-10
4 SGTC_2444 5485484 6.16 36.4 µM 1.64E-11 5 3.55E-10
5 SGTC_1403 3909-7815 5.34 62.9 µM 4.48E-9 6 4.59E-8
6 SGTC_2635 hydroquinidine 5.16 100.0 µM 1.44E-8 6 1.27E-7
7 SGTC_883 0850-0245 5.11 24.6 µM 1.88E-8 cell wall 12 1.60E-7
8 SGTC_928 2764-0428 4.66 58.7 µM 2.60E-7 cell wall 39 1.56E-6
9 SGTC_270 tamoxifen 4.57 5.5 µM 4.42E-7 NEO1 17 2.47E-6
10 SGTC_1390 3413-2614 4.32 145.0 µM 1.68E-6 fatty acid desaturase (OLE1) 14 7.88E-6
11 SGTC_2453 5731132 4.31 22.2 µM 1.79E-6 12 8.32E-6
12 SGTC_925 2064-1272 4.19 59.6 µM 3.27E-6 18 1.41E-5
13 SGTC_1676 st018489 3.98 23.4 µM 9.29E-6 60S ribosome export 33 3.49E-5
14 SGTC_1702 st027038 3.97 51.0 µM 9.62E-6 10 3.60E-5
15 SGTC_169 k015-0017 3.97 16.0 µM 9.63E-6 19 3.60E-5
16 SGTC_747 3448-8087 3.90 38.7 µM 1.37E-5 27 4.91E-5
17 SGTC_1396 3511-0007 3.85 98.6 µM 1.70E-5 mitochondrial processes 13 5.91E-5
18 SGTC_1280 0880-0253 3.84 10.1 µM 1.75E-5 20 6.06E-5
19 SGTC_3301 9125354 3.79 19.8 µM 2.21E-5 17 7.41E-5
20 SGTC_841 0251-0215 3.78 91.2 µM 2.35E-5 77 7.82E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.103 2.04E-9 YBR149W ARA1 hom NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product
0.102 3.52E-9 YDR355C_d YDR355C_d het Dubious: Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified essential ORF SPC110/YDR356W
0.095 3.29E-8 YOL042W NGL1 hom Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.080 3.11E-6 YBR230C OM14 hom Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron
0.080 3.21E-6 YGR199W PMT6 hom Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases
0.079 4.86E-6 YDR233C RTN1 hom Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; mutant overexpressing RTN1 shows increase in tubular ER; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; more abundant than Rtn2p; member of the RTNLA subfamily; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; RTN1 has a paralog, RTN2, that arose from the whole genome duplication
0.078 6.49E-6 YEL014C_d YEL014C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.076 1.01E-5 YPR122W AXL1 hom Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells
0.074 1.75E-5 YGL254W FZF1 hom Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress
0.074 1.81E-5 YER175W-A_p YER175W-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.074 1.93E-5 YLL051C FRE6 hom Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels
0.073 2.05E-5 YLR132C USB1 het Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants
0.071 3.72E-5 YLR446W_p YLR446W_p hom Putative hexokinase; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene
0.070 4.53E-5 YKL100C_p YKL100C_p hom Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene
0.069 7.14E-5 YNL054W VAC7 hom Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock