HIPHOP chemogenomics database

YEL017W / GTT3

Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery

Zygosity: Homozygous strain

fixedexpanded
Profile for YEL017W / GTT3

Click on Significant Values for Screen Details

Top fitness defect scores for YEL017W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_882	0843-0131	6.36	351.0 µM	3.94E-12		4	1.03E-10
2	SGTC_2633	5,7-dihydroxyisoflavone	6.23	100.0 µM	9.89E-12		6	2.29E-10
3	SGTC_881	0833-0569	6.17	170.0 µM	1.52E-11		1	3.32E-10
4	SGTC_2444	5485484	6.16	36.4 µM	1.64E-11		5	3.55E-10
5	SGTC_1403	3909-7815	5.34	62.9 µM	4.48E-9		6	4.59E-8
6	SGTC_2635	hydroquinidine	5.16	100.0 µM	1.44E-8		6	1.27E-7
7	SGTC_883	0850-0245	5.11	24.6 µM	1.88E-8	cell wall	12	1.60E-7
8	SGTC_928	2764-0428	4.66	58.7 µM	2.60E-7	cell wall	39	1.56E-6
9	SGTC_270	tamoxifen	4.57	5.5 µM	4.42E-7	NEO1	17	2.47E-6
10	SGTC_1390	3413-2614	4.32	145.0 µM	1.68E-6	fatty acid desaturase (OLE1)	14	7.88E-6
11	SGTC_2453	5731132	4.31	22.2 µM	1.79E-6		12	8.32E-6
12	SGTC_925	2064-1272	4.19	59.6 µM	3.27E-6		18	1.41E-5
13	SGTC_1676	st018489	3.98	23.4 µM	9.29E-6	60S ribosome export	33	3.49E-5
14	SGTC_1702	st027038	3.97	51.0 µM	9.62E-6		10	3.60E-5
15	SGTC_169	k015-0017	3.97	16.0 µM	9.63E-6		19	3.60E-5
16	SGTC_747	3448-8087	3.90	38.7 µM	1.37E-5		27	4.91E-5
17	SGTC_1396	3511-0007	3.85	98.6 µM	1.70E-5	mitochondrial processes	13	5.91E-5
18	SGTC_1280	0880-0253	3.84	10.1 µM	1.75E-5		20	6.06E-5
19	SGTC_3301	9125354	3.79	19.8 µM	2.21E-5		17	7.41E-5
20	SGTC_841	0251-0215	3.78	91.2 µM	2.35E-5		77	7.82E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.103	2.04E-9	YBR149W	ARA1	hom	NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product
0.102	3.52E-9	YDR355C_d	YDR355C_d	het	Dubious: Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified essential ORF SPC110/YDR356W
0.095	3.29E-8	YOL042W	NGL1	hom	Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.080	3.11E-6	YBR230C	OM14	hom	Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron
0.080	3.21E-6	YGR199W	PMT6	hom	Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases
0.079	4.86E-6	YDR233C	RTN1	hom	Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; mutant overexpressing RTN1 shows increase in tubular ER; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; more abundant than Rtn2p; member of the RTNLA subfamily; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; RTN1 has a paralog, RTN2, that arose from the whole genome duplication
0.078	6.49E-6	YEL014C_d	YEL014C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.076	1.01E-5	YPR122W	AXL1	hom	Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells
0.074	1.75E-5	YGL254W	FZF1	hom	Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress
0.074	1.81E-5	YER175W-A_p	YER175W-A_p	hom	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.074	1.93E-5	YLL051C	FRE6	hom	Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels
0.073	2.05E-5	YLR132C	USB1	het	Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants
0.071	3.72E-5	YLR446W_p	YLR446W_p	hom	Putative hexokinase; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene
0.070	4.53E-5	YKL100C_p	YKL100C_p	hom	Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene
0.069	7.14E-5	YNL054W	VAC7	hom	Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock