YEL020C_p

Protein of unknown function with low sequence identity to Pdc1p; mRNA identified as translated by ribosome profiling data

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL020C / YEL020C

Click on Significant Values for Screen Details ID:SGTC_179|Compound:1273-0063|FD-Score:3.25|P-value:8.55E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.53|P-value:3.18E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.99|P-value:5.82E-5 ID:SGTC_833|Compound:3852-0053|FD-Score:3.55|P-value:3.00E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.79|P-value:1.27E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.85|P-value:1.40E-6 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.73|P-value:1.56E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:8.41|P-value:2.28E-16 ID:SGTC_1522|Compound:st012842|FD-Score:3.91|P-value:7.91E-5 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.86|P-value:9.41E-5 ID:SGTC_1676|Compound:st018489|FD-Score:5.25|P-value:1.94E-7 ID:SGTC_1678|Compound:st019265|FD-Score:-5.66|P-value:2.22E-8 ID:SGTC_1836|Compound:st055642|FD-Score:4.00|P-value:5.61E-5 ID:SGTC_2070|Compound:5230947|FD-Score:3.56|P-value:2.88E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:5.41|P-value:8.78E-8 ID:SGTC_2290|Compound:7904846|FD-Score:3.28|P-value:7.75E-4 ID:SGTC_2336|Compound:9001819|FD-Score:3.25|P-value:8.39E-4 ID:SGTC_2401|Compound:5128683|FD-Score:4.01|P-value:5.29E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-4.58|P-value:4.87E-6 ID:SGTC_2591|Compound:skatole|FD-Score:-3.68|P-value:1.91E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.27|P-value:8.00E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.28|P-value:7.53E-4 ID:SGTC_2817|Compound:7995342|FD-Score:3.34|P-value:6.21E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.31|P-value:6.79E-4 ID:SGTC_3124|Compound:9127567|FD-Score:-3.97|P-value:6.30E-5 ID:SGTC_3252|Compound:9135871|FD-Score:3.81|P-value:1.17E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:3.25|P-value:8.55E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.53|P-value:3.18E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.99|P-value:5.82E-5 ID:SGTC_833|Compound:3852-0053|FD-Score:3.55|P-value:3.00E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.79|P-value:1.27E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.85|P-value:1.40E-6 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.73|P-value:1.56E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:8.41|P-value:2.28E-16 ID:SGTC_1522|Compound:st012842|FD-Score:3.91|P-value:7.91E-5 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.86|P-value:9.41E-5 ID:SGTC_1676|Compound:st018489|FD-Score:5.25|P-value:1.94E-7 ID:SGTC_1678|Compound:st019265|FD-Score:-5.66|P-value:2.22E-8 ID:SGTC_1836|Compound:st055642|FD-Score:4.00|P-value:5.61E-5 ID:SGTC_2070|Compound:5230947|FD-Score:3.56|P-value:2.88E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:5.41|P-value:8.78E-8 ID:SGTC_2290|Compound:7904846|FD-Score:3.28|P-value:7.75E-4 ID:SGTC_2336|Compound:9001819|FD-Score:3.25|P-value:8.39E-4 ID:SGTC_2401|Compound:5128683|FD-Score:4.01|P-value:5.29E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-4.58|P-value:4.87E-6 ID:SGTC_2591|Compound:skatole|FD-Score:-3.68|P-value:1.91E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.27|P-value:8.00E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.28|P-value:7.53E-4 ID:SGTC_2817|Compound:7995342|FD-Score:3.34|P-value:6.21E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.31|P-value:6.79E-4 ID:SGTC_3124|Compound:9127567|FD-Score:-3.97|P-value:6.30E-5 ID:SGTC_3252|Compound:9135871|FD-Score:3.81|P-value:1.17E-4

Top fitness defect scores for YEL020C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1510 1123-0200 8.41 71.5 µM 2.28E-16 7 2.13E-17
2 SGTC_2131 toluylene red 5.41 5.3 µM 8.78E-8 60S ribosome export 2 3.23E-8
3 SGTC_1676 st018489 5.25 23.4 µM 1.94E-7 60S ribosome export 10 7.55E-8
4 SGTC_1247 0448-0043 4.85 5.8 µM 1.40E-6 ERG2 21 6.23E-7
5 SGTC_2401 5128683 4.01 200.0 µM 5.29E-5 37 3.01E-5
6 SGTC_1836 st055642 4.00 81.0 µM 5.61E-5 16 3.20E-5
7 SGTC_825 1988-2224 3.99 89.6 µM 5.82E-5 cell wall signaling 33 3.33E-5
8 SGTC_1522 st012842 3.91 45.6 µM 7.91E-5 RNA pol III & RNase P/MRP 27 4.63E-5
9 SGTC_1559 coumarin 343 3.86 70.1 µM 9.41E-5 15 5.56E-5
10 SGTC_3252 9135871 3.81 49.5 µM 1.17E-4 14 7.01E-5
11 SGTC_1226 3909-7979 3.79 35.4 µM 1.27E-4 45 7.65E-5
12 SGTC_1274 0865-0114 3.73 173.0 µM 1.56E-4 27 9.52E-5
13 SGTC_2070 5230947 3.56 200.0 µM 2.88E-4 16 1.84E-4
14 SGTC_833 3852-0053 3.55 558.0 µM 3.00E-4 25 1.92E-4
15 SGTC_500 h-89 3.53 112.0 µM 3.18E-4 cell wall signaling 42 2.04E-4
16 SGTC_2817 7995342 3.34 71.4 µM 6.21E-4 43 4.16E-4
17 SGTC_2807 7945238 3.28 52.0 µM 7.53E-4 59 5.12E-4
18 SGTC_2290 7904846 3.28 200.0 µM 7.75E-4 54 5.27E-4
19 SGTC_2750 bromebric acid 3.27 70.2 µM 8.00E-4 62 5.45E-4
20 SGTC_2336 9001819 3.25 198.7 µM 8.39E-4 heme biosynthesis & mitochondrial translocase 82 5.74E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.184 6.72E-27 YNL150W_d YNL150W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking
0.124 6.09E-13 YPL267W ACM1 hom Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein
0.115 1.99E-11 YER067W RGI1 hom Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress
0.105 1.24E-9 YDL080C THI3 hom Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis
0.098 1.36E-8 YGR254W ENO1 hom Enolase I, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose; protein abundance increases in response to DNA replication stress
0.096 2.77E-8 YBR068C BAP2 hom High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication
0.093 5.89E-8 YNL149C PGA2 het Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
0.089 2.30E-7 YGL235W_p YGL235W_p hom Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
0.088 3.01E-7 YLR174W IDP2 hom Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; IDP2 has a paralog, IDP3, that arose from the whole genome duplication
0.087 4.60E-7 YHR093W_d AHT1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region
0.085 8.44E-7 YOR367W SCP1 hom Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin
0.084 9.92E-7 YGR071C ENV11 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
0.084 1.01E-6 YBR171W SEC66 hom Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.082 1.91E-6 YMR101C SRT1 hom Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase
0.081 2.33E-6 YER139C RTR1 hom CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication