YEL023C_p

Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL023C / YEL023C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:6.68|P-value:8.76E-12 ID:SGTC_13|Compound:0199-0087|FD-Score:3.26|P-value:5.29E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.11|P-value:9.02E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.21|P-value:6.45E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:4.09|P-value:2.01E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:5.05|P-value:1.88E-7 ID:SGTC_634|Compound:1611-4317|FD-Score:-3.15|P-value:6.97E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-4.27|P-value:7.68E-6 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.35|P-value:3.85E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.30|P-value:4.64E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.27|P-value:5.25E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:5.05|P-value:1.95E-7 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.26|P-value:5.34E-4 ID:SGTC_1690|Compound:st023502|FD-Score:4.20|P-value:1.23E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.35|P-value:6.18E-6 ID:SGTC_1937|Compound:st074714|FD-Score:5.06|P-value:1.86E-7 ID:SGTC_2136|Compound:5328288|FD-Score:3.41|P-value:3.13E-4 ID:SGTC_2383|Compound:9036125|FD-Score:3.47|P-value:2.45E-4 ID:SGTC_2488|Compound:5268135|FD-Score:-4.22|P-value:9.62E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.55|P-value:1.58E-4 ID:SGTC_2681|Compound:menadione|FD-Score:3.09|P-value:9.82E-4 ID:SGTC_2707|Compound:st078556|FD-Score:-3.21|P-value:5.62E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.41|P-value:3.12E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.93|P-value:3.96E-5 ID:SGTC_3299|Compound:9121982|FD-Score:3.84|P-value:5.87E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:6.68|P-value:8.76E-12 ID:SGTC_13|Compound:0199-0087|FD-Score:3.26|P-value:5.29E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.11|P-value:9.02E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.21|P-value:6.45E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:4.09|P-value:2.01E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:5.05|P-value:1.88E-7 ID:SGTC_634|Compound:1611-4317|FD-Score:-3.15|P-value:6.97E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-4.27|P-value:7.68E-6 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.35|P-value:3.85E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.30|P-value:4.64E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.27|P-value:5.25E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:5.05|P-value:1.95E-7 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.26|P-value:5.34E-4 ID:SGTC_1690|Compound:st023502|FD-Score:4.20|P-value:1.23E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.35|P-value:6.18E-6 ID:SGTC_1937|Compound:st074714|FD-Score:5.06|P-value:1.86E-7 ID:SGTC_2136|Compound:5328288|FD-Score:3.41|P-value:3.13E-4 ID:SGTC_2383|Compound:9036125|FD-Score:3.47|P-value:2.45E-4 ID:SGTC_2488|Compound:5268135|FD-Score:-4.22|P-value:9.62E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.55|P-value:1.58E-4 ID:SGTC_2681|Compound:menadione|FD-Score:3.09|P-value:9.82E-4 ID:SGTC_2707|Compound:st078556|FD-Score:-3.21|P-value:5.62E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.41|P-value:3.12E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.93|P-value:3.96E-5 ID:SGTC_3299|Compound:9121982|FD-Score:3.84|P-value:5.87E-5

Top fitness defect scores for YEL023C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_6 0844-0013 6.68 19.8 µM 8.76E-12 9 1.16E-11
2 SGTC_1937 st074714 5.06 47.2 µM 1.86E-7 19 2.15E-7
3 SGTC_632 0781-2353 5.05 4.7 µM 1.88E-7 Golgi 18 2.17E-7
4 SGTC_1375 2910-0797 5.05 186.0 µM 1.95E-7 11 2.25E-7
5 SGTC_1926 methyl fluorone black 4.35 53.6 µM 6.18E-6 DNA intercalators 50 6.81E-6
6 SGTC_1690 st023502 4.20 41.2 µM 1.23E-5 calcium & mitochondrial duress 6 1.35E-5
7 SGTC_626 0214-0009 4.09 33.0 µM 2.01E-5 copper-dependent oxidative stress 14 2.18E-5
8 SGTC_3008 9078912 3.93 71.4 µM 3.96E-5 19 4.25E-5
9 SGTC_3299 9121982 3.84 43.1 µM 5.87E-5 36 6.28E-5
10 SGTC_2383 9036125 3.47 200.0 µM 2.45E-4 12 2.57E-4
11 SGTC_2786 7743617 3.41 45.5 µM 3.12E-4 49 3.27E-4
12 SGTC_2136 5328288 3.41 199.3 µM 3.13E-4 34 3.28E-4
13 SGTC_1164 k060-0068 3.35 93.7 µM 3.85E-4 52 4.02E-4
14 SGTC_1195 1502-0147 3.30 41.1 µM 4.64E-4 50 4.84E-4
15 SGTC_1353 1498-1206 3.27 8.1 µM 5.25E-4 mitochondrial response to ROS 90 5.47E-4
16 SGTC_13 0199-0087 3.26 65.0 µM 5.29E-4 ERG2 25 5.51E-4
17 SGTC_1376 2910-0861 3.26 41.3 µM 5.34E-4 46 5.56E-4
18 SGTC_618 k072-0232 3.21 33.2 µM 6.45E-4 60S ribosome export 29 6.70E-4
19 SGTC_429 1112-0049 3.11 25.5 µM 9.02E-4 DNA damage response 72 9.34E-4
20 SGTC_2681 menadione 3.09 3.2 µM 9.82E-4 superoxide 52 0.00102

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 6.97E-15 YJL107C_p YJL107C_p hom Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
0.130 4.91E-14 YPL228W CET1 het Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
0.125 4.34E-13 YKR009C FOX2 hom Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
0.124 5.04E-13 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.122 1.10E-12 YPL160W CDC60 het Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
0.119 4.40E-12 YLR366W_d YLR366W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A
0.119 4.57E-12 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.117 1.33E-11 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.113 4.91E-11 YHR021W-A_p ECM12_p hom Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity
0.112 8.90E-11 YLR311C_d YLR311C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.111 1.23E-10 YKR011C YKR011C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress
0.110 1.58E-10 YKR043C SHB17 hom Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus
0.109 2.76E-10 YPL096W PNG1 hom Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p
0.108 2.99E-10 YER024W YAT2 hom Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane
0.108 3.55E-10 YDL018C ERP3 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport